indd
|
|
- このか きちや
- 7 years ago
- Views:
Transcription
1 Molecular Targeted Therapy for Lung Cancer from a Pharmaceutical Point of Viewe Naho SASAKI epidermal growth factor receptor tyrosine kinase inhibitor :EGFR-TKI vascular endothelial growth factor:vegf mg ph ph phauc mg Cmax. AUC Key words
2 mg mg CYP A CYP A CYP A AUC CYP A AUC CYP A CYP A ph H ph INR PT-INR CYP A CYP A CYP A AUC CYP A CYP A AUC Cmax CYP AAUC in vitrougt A UGT A
3 H.. EGFR SPF..
4 .... PS PS..
5 mg/kg + +
6
7 . JO VEGFNO NONa / mmhg mmhg Common Terminology Critetia for Adverse Events Ver.. VEGF VEGF /..L
8 /. /. G-CSF.. EGFR-mutation.... Wacker B, Nagrani T, Weinberg J, et al:correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase studies. Clin Cancer Ras,:-,... Sane DC, Brosnihan KB. Angiogenic growth factors and hypertension. Angiogegesis.: -,. Saif MW, Mehra R. Incidence and management of bevacizumabrelated toxicities in colorectal cancer. Expert Opin Drug Saf. : -,.
第79回_プログラム.indd
Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons. Phase I clinical trial using peptide vaccine for human vascular endothelial
More information立命館21_松本先生.indd
2143-552010 1 2 () 1 2 3 456 78- Key Words 1 3 12007 2 3 508 19992008 1 23 4 43 2120107 4 2008 1992 2003 2005 1989 2008 4 2 2-1 10 4 4 6 5 4 5 2946 1 155 11 41 44 45 4 2-2 2003 1 21 2 1 3 4 5 6 7 3 2120107
More information立命館20_服部先生.indd
20 93-105 2010 2 () ' - 1 ( ) ( ' 2005) Key Words 2 1967 93 20 2010 1 94 1 ' 2002 2 2 1996 1996 1999 2 2 2 1993 1999 4 1 2 1985 1989 1986 1994 4 1 2 1 1 4 2 4 4 1 4 1966 4 10-1970 20 1993-1972 95 20 2010
More information1996 2000 2004 1984 2005 7150 000 9 500 9 4 13 10 95 11 11 12 20002004 9 70
14 2006 1 Key Words 2002 3 1 2 3 3 1 2 3 1969 1987 69 1996 2000 2004 1984 2005 7150 000 9 500 9 4 13 10 95 11 11 12 20002004 9 70 14 2006 1 15 71 72 1 22 6 32 9 200 6 3 1 2 2000 10 1 2003 10 2005 6 5 4
More information立命館16_坂下.indd
1669-792008 1 - ' 85- -108 ' Key words 1 2 2003 69 1620082 5 3 1990 1997 4 5 2001 1307 6 7 1 1 1 1996 100 2 1997 71 3 1998 71 4 1999 96 5 2000 95 6 2001 145 7 2002 191 8 2003 174 9 2004 120 10 2005 122
More information立命館人間科学研究No.10
1 77 5 Key words 1 23 3 11417 14310045 20022004 2 2003 20022005 20022004 2 10200511 3 2003 1152003 59 1995 3 32003 19932002 20032003 2005 20052005 4 1997 2000521986 2001 42001 3 1981 6 1 7 5 1000248 1632647
More information立命館21_川端先生.indd
21 119-132 2010 ( ) ' Key Words 119 21 2010 7 1962 2001 2001 2007 1982 1988 1997 2007 1997 1998 1863 1880 1 1998 1998 2001 1599 120 121 1599 1695 8 1695 1714 4 1714 1715 5 1715 100 1812 9 1812 1864 2001
More information立命館14_前田.indd
1499-1122007 1 ) ) ) ) ) (1) -- ) ) ) ) ) ) ( ) ) ' ) ) ) ) - 1) 2)' 3) Key words 19811994 1721 99 1420073 100 20012004 2005 2004 2002 33 34 10 1987 45 20002003 2002 1 1 2000 1 1 2001 2 200341 12004 2
More information立命館17_坂下.indd
1793-1052008 1 () -- -- - Key words 1 93 1720088 2 3 2003 15 1996 50 3040 2 3 4050 50 10 1980 1995 1950 1958 1968 1972 94 95 1987 4 4 70 3 3 1 2000 2001 4 1720088 96 2001 2003 2 1978 1990 1997 130 2 3
More information立命館人間科学研究No.10
49 00 7 Key words 980 995 50 0005 90 997 99 990 994 99 99 99990 99 996 988988 994 99 995 995 995 994 984 988 986 997 997 00 995 00 5 7 5 5 999 997 997 998 6 998 999 997 997 998 0040000 994 996 000 00 5
More information立命館19_椎原他.indd
191-132009 1 ( ) ' Key Words 1 11 12007 2007 200520062 201120062 7558 4009 1 1920098 2007 2 2000 028 2005 1999 12 1999 13 1968 2 3 '1992 2007 2001 20052001 1977 2005 2005 2007 21 21 22 461927 3 13 1920098
More information立命館人間科学研究No.10
61 10 1990 Key words 1 102005 11 62 2000 1 1920 10 1892 63 1 1 19 100 1914 100 1 1 20 1 2 102005 11 64 1946 21 4 1947 1949 1947 22 1 3 1956 1959 1958 2 1964 65 2 10 1975 7080 70 2 1 1987 1990 40 1989 1989
More information立命館19_徳田.indd
1991-1022009 1 2 () )--) 28 2827 1 2 Key Words 1 (1721 2000 20012001 20082009 91 1920098 92 20042004 2004 2001 12 2005 20082009 2005 3 1997 200820096 2007 2 20082009 93 20012001 12 2008 2009 19611966 1
More informationNL11
information September, 2007 1 2 Japanese Association for Molecular Target Therapy of Cancer News Letter No.11 September, 2007 3 2007 4 Japanese Association for Molecular Target Therapy of Cancer News Letter
More informationサイトメトリー12-1.indd
Cell Growth Inhibition and Apoptosis in Cancer Cells Kazuki Omoteyama, Shoichi Inoue and Alaa-eldin Salah-eldin Department of Environmental Medicine and Informatics, Graduate School of Environmental Earth
More informationVol. 4, No
1 0.005 71 2 0.005 72 3 0.005 73 4 0.005 74 5 0.005 KRM 75 6 0.005 76 7 0.005 77 8 0.005 78 9 0.005 79 10 0.005 80 11 0.005 TS 81 12 0.005 TOA 82 13 0.005 83 14 0.005 84 15 0.005 NS 85 16 0.005 86 17 0.005
More informationuntitled
PS3 10% 2-1 2-2 2-3 2 23 2-4 1 2 3 4 2-5 2.3.1 1 24 812 2-6 5 5% : (CVC) 5 2-7 CTZ 24 24 2-8 2.3.2 23 5HT3 12 2-9 2.3.3 12 12 23 710 13 5-FU 2-10 2.3.4 24 10 20 5-FU 2-11 2-12 (CTZ) 5HT3 H1 Achm (CTZ)
More informationMicrosoft Word - 表紙資料2-4
(1) / 130 g 25 g 520% 170 g 30 g 560% 70 mg 600 mg 11.6% 0 10.5 mg 0% (1) (2) / 50100 g 25 g 200400% 50100 g 30 g 167333% 5001000 mg 600 mg 83167% 1020 mg 10.5 mg 95190% (2) / (1) 45.6 g 30 g 152% (2)
More informationMicrosoft Word - ランチョンプレゼンテーション詳細.doc
PS1-1-1 PS1-1-2 PS1-1-3 PS1-1-4 PS1-1-5 PS1-1-6 PS1-1-7 PS1-1-8 PS1-1-9 1 25 12:4514:18 25 12:4513:15 B PS1-1-10 PS1-2-1 PS1-2-2 PS1-2-3 PS1-2-4 PS1-2-5 PS1-2-6 25 13:1513:36 B PS1-2-7 PS1-3-1 PS1-3-2
More informationスライド 1
QOL 1 Goldberg, JCO 22:23-30, 2004 N9741: Oxaliplatin in First Line (US) IR 200 mg/m 2 OX 85 mg/m 2 every 3 weeks Efficacy IFL FOLFOX4 > IFL IROX FOLFOX4 IROX OS TTP RR 15.0 mo 6.9 mo 31 % P=0.0001 P=0.0014
More informationISSN 慈大 2017 feb 呼吸器疾患研究会誌 Jikei Journal of Chest Diseases 豊胸術後にシェーグレン症候群と胸膜肥厚を認めたヒトアジュバント病の 1 例花田豪郎ほか 1 第 90 回研究会記録 2 胸部 CT でスリガラス状陰影
ISSN 2189-9770 慈大 2017 feb. 29-1 呼吸器疾患研究会誌 Jikei Journal of Chest Diseases 豊胸術後にシェーグレン症候群と胸膜肥厚を認めたヒトアジュバント病の 1 例花田豪郎ほか 1 第 90 回研究会記録 2 胸部 CT でスリガラス状陰影を呈した左肺腫瘍の 1 切除例米山果織ほか 3 肺がんの新しい薬物療法 免疫チェックポイント阻害薬 滝口裕一
More information( ) ver.2015_01 2
1 1.1 1.2 1.3 2 ( ) 2.1 2.2 2.3 2.4 3 4 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 5 5.1 5.2 5.3 5.4 6 6.1 6.2 6.3 7 7.1 7.2 7.3 8 ver.2015_01 2 1 1.1 1.2 1.3 ver.2015_01 3 2 2.1 2.2 2.3 ver.2015_01 4 2.4 ver.2015_01
More informationヤフー株式会社 株主通信VOL.16
01 260,602264,402 122,795125,595 64,84366,493 107110 120,260123,060 0 500 300 400 200 100 700 600 800 39.8% 23.7% 36.6% 26.6% 21.1% 52.4% 545 700 0 50 200 150 100 250 300 350 312 276 151 171 02 03 04 POINT
More informationp01.qxd
2 s 1 1 2 6 2 POINT 23 23 32 15 3 4 s 1 3 2 4 6 2 7003800 1600 1200 45 5 3 11 POINT 2 7003800 7 11 7003800 8 12 9 10 POINT 2003 5 s 45700 3800 5 6 s3 1 POINT POINT 45 2700 3800 7 s 5 8 s3 1 POINT POINT
More information株主通信:第18期 中間
19 01 02 03 04 290,826 342,459 1,250,678 276,387 601,695 2,128,760 31,096 114,946 193,064 45,455 18,478 10,590 199,810 22,785 2,494 3,400,763 284,979 319,372 1,197,774 422,502 513,081 2,133,357 25,023
More informationワタベウェディング株式会社
1 2 3 4 140,000 100,000 60,000 20,000 0 0 5 10 15 20 25 30 35 40 45 50 55 60 65 70 5 6 71 2 13 14 7 8 9 10 11 12 1 2 2 point 1 point 2 1 1 3 point 3 4 4 5 6 point 4 point 5 point 6 13 14 15 16 point 17
More informationuntitled
1 2 3 4 5 6 7 Point 60,000 50,000 40,000 30,000 20,000 10,000 0 29,979 41,972 31,726 45,468 35,837 37,251 24,000 20,000 16,000 12,000 8,000 4,000 0 16,795 22,071 20,378 14 13 12 11 10 0 12.19 12.43 12.40
More information株主通信 第16 期 報告書
10 15 01 02 1 2 3 03 04 4 05 06 5 153,476 232,822 6,962 19,799 133,362 276,221 344,360 440,112 412,477 846,445 164,935 422,265 1,433,645 26,694 336,206 935,497 352,675 451,321 1,739,493 30,593 48,894 153,612
More information-- 0 500 1000 1500 2000 2500 3000 () 0% 20% 40% 60%23 47.5% 16.0% 26.8% 27.6% 10,000 -- 350 322 300 286 250 200 150 100 50 0 20 21 22 23 24 25 26 27 28 29 -- ) 300 280 260 240 163,558 165,000 160,000
More information1003shinseihin.pdf
1 1 1 2 2 3 4 4 P.14 2 P.5 3 P.620 6 7 8 9 10 11 13 14 18 20 00 P.21 1 1 2 3 4 5 2 6 P7 P14 P13 P11 P14 P13 P11 3 P13 7 8 9 10 Point! Point! 11 12 13 14 Point! Point! 15 16 17 18 19 Point! Point! 20 21
More information1. 2001 10 2 480 2003 8 1.6 5 2. 90 3. 4. 5. 5 60 6. 1 2 2 2 4 5 5 6 6 6 7 10 10 10 12 12 12 14 14 15 15 60 15 17 17 18 2001 10 2 480 2003 8 1.6 5 1 1.8 3.6 1 6.8 1.5 3 3 5 6065 70 5 1.22004 1 1 2002 4
More information20mg CTD 2.4 2.4 2.4... 5 2.4.1... 5 2.4.2... 7 2.4.3... 10 2.4.4... 13 2.4.5... 18 2.4.6... 20 3 2.4 2.4 2.4.1 JNS002 ( HSPC) N-(Carbonyl-methoxypolyethylene glycol 2000)-1,2- distearoyl-sn-glycero-3-phosphoethanolamine
More informationE3200 BV FOLFOX4 FOLFOX4 PFS % 0.42, 0.65 p< log-rank % FOLFOX4 8.6% FOLFOX % FOLFOX4 259/ % FOL
E3200 BV FOLFOX4 FOLFOX4 PFS 4.5 7.5 0.518 95% 0.42, 0.65 p
More informationSpecial IssueDiagnoses and therapeutic agents for age-related diseases Reviews Original Case reports β Medicinal drugs affecting on clinical laboratory blood test results and adverse effects of them
More informationNL10
Information September, 2006 1 2 Japanese Association for Molecular Target Therapy of Cancer News Letter No.10 September, 2006 3 2006 4 Japanese Association for Molecular Target Therapy of Cancer News Letter
More informationNL16-1_0329
No.16-1 March. 2012 JAMTTC News Letter http://jamttc.umin.jp/ Japanese Association for Molecular Target Therapy of Cancer 135-85503-8-31 TEL: 03-3520-0111 ext.5413 FAX: 03-3570-0484 ...1 JAMTTC2012...2...3...4...5
More informationBiotinylated Kinases BTNABL(ABL1) Tyrosineprotein kinase ABL1 Biotinylated N 2 Nterminal DYKDDDDK カルタヘナ 80 BTNACTR2B(ACVR2B) Activin r
2. ビオチン化キナーゼタンパク質 Biotinylated Kinases 表面プラズモン共鳴 (SPR) やバイオレイヤー干渉法 (BLI) といった物質間の相互作用を評価する系 ( 解析機器 ) でご利用いただけるビオチン化キナーゼタンパク質を販売しております これらの解析機器で低分子化合物の創薬研究 開発を行なう際 リガンドとする標的分子蛋白質を活性 構造を保持したままセンサー表面に固定化
More informationFeb THE JAPANESE JOURNAL OF ANTIBIOTICS Tebipenem pivoxil 1 1, Meiji Seika 2 Meiji Seika G 3 Meiji Seika Tebipen
Feb. 2016 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 1 53 53 Tebipenem pivoxil 1 1, 3 2 2 1 1 Meiji Seika 2 Meiji Seika G 3 Meiji Seika 2015 12 15 Tebipenem pivoxil 10% 2010 4 2013 3 3,547 3,540 3,540 3,331
More information200mg 2005 3 876179 2002 3 3 200mg VFEND for Intravenous Use (1) (2) [4.1 ] (3) [4.2 ] (1) [1] (2) (3) [1] 3
More information1 MR 63 2 IF 10 3 IF 2 IF IF IF 3 IF A4 9 IF IF IF 11 1 IF IF 4 IF IF MR IF IF MR Drug Safety Update IF
2003 7 3 872189 873919 IF 1998 9 PROBEAN CAP. 1 250mg Polyenephosphatidylcholine 1998 9 16 1999 7 9 1999 7 FAX IF 2003 7 1 MR 63 2 IF 10 3 IF 2 IF IF IF 3 IF A4 9 IF IF IF 11 1 IF IF 4 IF IF MR IF IF MR
More informationMV X 5 6 Common Terminology Criteria for Adverse Events Grade 1 Grade Gy 16 QOL QOL 5 6 7, 8 9, VOL.3 NO
乳がん患者の放射線皮膚炎に対するスキンケアの指導の実際 がん放射線療法看護認定看護師とがん放射線治療に携わる看護師との比較 Educating practice of skin care for radiodermatitis of breast cancer patients: Comparison of the nurses with certified nurse in radiation therapy
More information1) 1) 1 R 2 3 4 5 6 3) 4) 5) Punch 7 10g/mL(63.6mol/L) 20mg/kg 78 5 23 Cmax 250mg 3.9g/ml 500mg 6.0g/ml1000mg 8g/ml2000mg 15g/ml 33.4 110-116mL/min 1,8) 8 95 9 10 ( ) 11 desa 12 13 12) 2.5 5 19 Rec assayames
More informationVENTANA ALK D5F3 Rabbit Monoclonal Antibody OptiView ALK D5F3
VENTANA ALK D5F3 Rabbit Monoclonal Antibody OptiView ALK D5F3 2 OptiView ALK D5F3 11 10 79.3%31% 18% 80 85NSCLC 40% 1,2 1 1018 ALK ALK 2 ALK 3 5% ALK EML4 EML4-ALK Coild-Coil ALK ALK 3,4,5 2 6 EGFR 50%
More information1) University Group Diabetes Program: A study of hypoglycemic agents on vascular complica- in patients with adult-onset tions diabetes. I. Design, methods and baseline results. Diabetes 19 (suppl. 2):
More informationComplex sleep apnea syndrome and sleep disordered breathing in patients with cardiovascular disease V o l. 4 1 N o. 3 ( 2 0 0 9 ) V o l. 4 1 N o. 3 ( 2 0 0 9 ) V o l. 4 1 N o. 3 ( 2 0 0 9 ) Sleep J Clin
More information研究成果報告書
様式 C-19 科学研究費補助金研究成果報告書 平成 21 年 5 月 18 日現在 研究種目 : 基盤研究 (C) 研究期間 :2007~2008 課題番号 :19590726 研究課題名 ( 和文 ) 腫瘍間質を標的とした胃癌に対する新しい治療法の開発 研究課題名 ( 英文 ) Development of new therapeutic strategy for gastric cancer
More information400 46 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 LVFX 100 mg 3 / 7 150 mg 2 / 7 2 2006 2008 9 LVFX PK PD 2009 7 100 mg 1 3 500 mg 1 1 AUC/MIC
Dec. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 399 45 2012 11 5 LVFX 500 mg 1 1 20 Chlamydia trachomatis C. trachomatismycoplasma genitalium M. genitalium LVFX 1 500 mg 1 1 7 22 22 C. trachomatis 17
More information