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1 7 1, KPA.1 IU/mL 21 9% %.1 IU/mL 1975 DPT % % Clostridium tetani DPT DPT 1981 DTaP212 DPT-IPV 7 7 1, KPA.2 IU/mL

2 IU/mL.1 IU/mL A , % % 6.% 7 B %.1 IU/mL IU/mL % %.1 IU/mL % 7/ % IU/mL 9% % 64.6% % DPT % % 12/16.1 IU/mL % 25/ % 41/ DPT % 6 C D

3 E % 98.% 99.3% 1% % 44.7% URL:

4 1 The number of examinees for tetanus susceptibility investigation by age group in each prefecture 213 Prefecture Age group years Hokkaido Tokyo Fukui Aichi Ehime Kochi Fukuoka

5 2 Age group distribution of tetanus antitoxin titer by prefecture 213 Prefecture Age group years Antitoxin titer IU/ml / / / / / / / G.M.T. Hokkaido Tokyo Fukui Aichi Ehime

6 2 Age group distribution of tetanus antitoxin titer by prefecture 213 Prefecture Age group years Antitoxin titer IU/ml / / / / / / / G.M.T. Kochi Fukuoka

7 3 Age distribution of tetanus antitoxin titer 213 Age years Antitoxin titer IU/ml / / / / / / / G.M.T

8 4 Age group distribution of tetanus antitoxin titer 213 Age group years Antitoxin titer IU/ml / / / / / / / G.M.T Age months 5 Age distribution of tetanus antitoxin titer in infants Antitoxin titer IU/ml / / / / / / / G.M.T

9 6 The number of examinees for tetanus susceptibility investigation by vaccination history and age group 213 Age group years Vaccination history Vaccinee 1 1 dose 2 2 doses 3 3 doses 4 4 doses 5 5 doses Others A B C D E F G H Nonvaccinee Unknown Vaccinee % Vaccinee % = B+C+D+E+F+G / A+B+C+D+E+F+G 1 Primary vaccination series : 4 doses DPT or DPT-IPV / Booster vaccination : 1 dose DT DPT : diphtheria-pertussis-tetanus combined vaccine / DPT-IPV : DPT-inactivated poliovirus combined vaccine DT : diphtheria-tetanus combined toxoid Prefecture Hokkaido Tokyo Fukui Aichi Ehime Kochi Fukuoka 7 The number of examinees for tetanus susceptibility investigation by vaccination history and prefecture Vaccination history Vaccinee Vaccinee Nonvaccinee Unknown % 1 dose 2 doses 3 doses 4 doses 5 doses Others A B C D E F G H Vaccinee % = B+C+D+E+F+G / A+B+C+D+E+F+G 1 Primary vaccination series : 4 doses DPT or DPT-IPV / Booster vaccination : 1 dose DT DPT : diphtheria-pertussis-tetanus combined vaccine / DPT-IPV : DPT-inactivated poliovirus combined vaccine DT : diphtheria-tetanus combined toxoid

10 8 Age group distribution of tetanus antitoxin titer by vaccination history 213 Vaccination history Age group years Antitoxin titer IU/ml / / / / / / / Non-vaccinee G.M.T Vaccinee : 1 dose Vaccinee : 2 doses Vaccinee : 3 doses

11 8 Age group distribution of tetanus antitoxin titer by vaccination history 213 Vaccination history Age group years 4 Antitoxin titer IU/ml / / / / / / / Vaccinee : 4 doses Vaccinee : 5 doses Primary vaccination series : 4 doses DPT or DPT-IPV / Booster vaccination : 1 dose DT DPT : diphtheria-pertussis-tetanus combined vaccine / DPT-IPV : DPT-inactivated poliovirus combined vaccine DT : diphtheria-tetanus combined toxoid G.M.T

12 1 213 Age distribution of tetanus antitoxin positives, 213 Antitoxin positives % n = 1315 Antitoxin titer IU/ml Age years 2213 Age group distribution of tetanus antitoxin positives, 213 Antitoxin positives % n = 1315 Antitoxin titer IU/ml Age group years

13 3213 Age group distribution of tetanus antitoxin positives in infants, 213 Antitoxin positives % Antitoxin titer IU/ml n = n = n = n = 21 Age group months No. of sample

14 4-1 /.1 IU/ml Age/age group distribution of tetanus antitoxin positives (titer.1 IU/ml) in different years Antitoxin positives % Year No. of sample 1998 n = n = n = n = 1315 age group in 1998 : result of 15 years Age/age group years 4-2 /.1 IU/ml Age/age group distribution of tetanus antitoxin positives (titer.1 IU/ml) in different years Antitoxin positives % Year No. of sample 1998 n = n = n = n = 1315 age group in 1998 : result of 15 years Age/age group years

15 5 213 Age group distribution of tetanus antitoxin positives in each prefecture, 213 Hokkaido Tokyo Fukui Antitoxin positives % n = 139 n = 358 n = 138 Antitoxin titer IU/ml Aichi Ehime Kochi Antitoxin positives % n = 14 n = 188 n = Age group years Fukuoka n = Age group years Antitoxin positives % Age group years

16 6 ( 19 ) 213 Tetanus antitoxin positives by vaccination history with antitoxin titer (-19 years old), 213 Cumulative antitoxin positives % Antitoxin titer IU/ml Vaccination history No. of sample Vaccinee : 5 doses n=41 Vaccinee : 4 doses n=253 Vaccinee : 3 doses n=82 Vaccinee : 2 doses n=58 Vaccinee : 1 dose n=7 Non-vaccinee n=11 Primary vaccination : 4 doses Booster vaccination : 1 dose

VERO IU/mL.1 IU/mL A , % % 6.% 7 B %.1 IU/mL IU/mL %.1 IU/mL 1

VERO IU/mL.1 IU/mL A , % % 6.% 7 B %.1 IU/mL IU/mL %.1 IU/mL 1 7 1,348 213 VERO.1 IU/mL 1 82.8% 1 5 9%.1 IU/mL 1 6 9 58.7% 1 46.2% 12 15 8%.1 IU/mL 2 3-34 7% 36.9%1975 DPT 4 54 5% 55 1958 12.9%.1 IU/mL Corynebacterium diphtheriae 1999 1948 1958 DP 1964 DPT 1968 1975

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