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An overview of regular dialysis treatment in Japan as of Dec. 31, 2004 Japanese Society for Dialysis Therapy

An overview of regular dialysis treatment in Japan as of Dec. 31, 2004 Japanese Society for Dialysis Therapy

200431 1978 1986 19891990 2000 2001DOS/V CD-ROM2002 2003 2004 2004102004 3,93220033,7501824.85 1.8 72 11 20041,83246.59 FAX Key man 513 3,8823,71798.7399.0.39 15583 5033

1388795.22 96.80 2004248,16610,4564.4 9.4 2005 Web,CD- ROM 200431 Key man

1 2 1 3 2 4 3100 5 4 6 5 7 6 8 7 9 1 10 2 11 3 1 13 2 14 3 15 4 16 1 17 2 18 32004 19 4 20 1 21 2101520 22 v

1 25 2 26 3 27 4 HCO3 28 5 29 6 30 7 31 1 D 32 2 D 33 3 D 34 4 D 35 5D 36 6D 37 7PTH D 38 8PTH D 39 1PTX 40 2PEIT 41 vi

1 45 2 48 3 LDL- 50 4 HDL- 52 5 54 6 56 7 58 8 60 9 PTH 62 10 64 11 66 36 4 70 vii

2 3,8821654.4% 97,3664,6565.0% 96,5404,6155.0328,79816,7945.4% 19682004 3,9323,882(98.73%) 2004

3 248,16610,456 1001,943.580.8 198986 1968/ 04 215 1969/ 04 301 1970/ 949 1971/ 1,826 1972/ 3,631 1973/ 6,148 1974/ 9,245 1975/ 13,059 1976/ 18,010 1977/ 22,579 1978/ 27,048 1979/ 32,331 1980/ 36,397 1981/ 42,223 1982/ 47,978 1983/ 53,017 1984/ 59,811 1985/ 66,310 1986/ 73,537 1987/ 80,553 1988/ 88,534 1989/ 83,221 1990/ 103,296 1991/ 116,303 1992/ 3,926 1993/ 134,298 1994/ 143,709 1995/ 154,413 1996/ 167,192 1997/ 175,988 1998/ 185,322 1999/ 197,213 2000/ 206,134 2001/ 219,183 2002/ 229,538 2003/ 237,710 2004/ 248,166

300,000 250,000 200,000 150,000 100,000 50,000 0 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 53,017 11,348 4,538 59,811,606 5,000 66,310 13,416 5,770 73,537 14,175 6,296 80,553 14,699 6,581 88,534 16,470 7,765 83,221 14,174 6,766 103,296 18,411 8,939 116,303 20,877 9,722 3,926 22,475 11,621 1993 134,298 23,874,143 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 143,709 24,296 13,187 154,413 26,398 14,406 167,192 28,409 15,174 175,988 28,870 16,102 185,322 29,641 16,687 197,213 31,483 18,524 206,134 32,018 18,938 219,183 33,243 19,850 229,538 33,710 20,614 237,710 33,966 21,672 248,166 35,084 22,715 200435,08420031,118(3.3%) 22,7151,043(4.8%) 1 4

1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 443.7 497.5 547.8 604.4 658.8 721.1 790.0 835.7 937.6 995.8 1,076.4 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 1,149.4 1,229.7 1,328.4 1,394.9 1,472.5 1,556.7 1,624.1 1,721.9 1,801.2 1,862.7 1,943.5 1989 100 1001,943.580.8514.5 5

6 200497,3664,6565.0% 1966/ 1968/ 08 105 48 1970/ 606 1969/ 08 206 1972/ 3,022 1971/ 1,575 1973/ 4,986 1974/ 5,515 1975/ 7,246 1976/ 9,204 1977/ 10,545 1978/,569 1979/ 16,519 1980/ 18,963 1981/ 21,032 1982/ 22,939 1983/ 24,474 1984/ 26,558 1985/ 1986/ 30,846 28,715 1988/ 36,447 1987/ 33,527 1990/ 40,723 1989/ 34,099 1991/ 45,682 1992/ 49,650 1993/ 53,262 1994/ 58,561 1995/ 59,715 1996/ 63,742 1997/ 66,880 1998/ 69,733 1999/ 75,448 2000/ 79,709 2001/ 83,914 2002/ 89,070 2003/ 92,710 2004/ 97,366

7 200479.1%17.2% CAPD3.5%CAPD4% CAPD8,774295 114 4 10,255 2,304 1,997 2,941 1,566 1,486 3,085 4,508 3,728 3,444 9,613 8,0 18,606 11,193 3,164 1,607 1,821 1,143 1,566 3,259 2,779 6,378 9,559 2,557 1,392 211 381 778 141 266 503 823 722 741 2,096 2,041 4,830 2,770 1,036 329 315 200 198 573 600 1,289 3,288 710 3 0 0 0 0 0 0 1 1 0 5 0 3 3 1 0 0 0 0 1 0 2 34 3 418 6 148 1 81 161 210 144 65 92 360 216 645 516 130 101 82 79 41 164 167 335 430 100 19 0 5 10 0 22 29 0 5 32 56 5 2 1 4 0 0 2 16 11 6 5 1,597 3,644 14,541 8,219 2,243 2,132 875 960 2,925 4,721 2,304 1,683 1,863 2,347 1,500 8,569 1,357 2,584 4,180 2,624 2,517 3,716 2,665 196,337 468 1,201 3,165 1,642 225 248 143 165 621 755 394 271 230 428 297 2,352 264 472 884 352 514 586 690 42,600 2 0 43 1 2 1 0 0 0 0 0 0 4 0 1 0 0 2 0 0 0 1 0 114 42 157 721 342 90 38 8 92 273 393 140 191 181 134 46 256 24 107 144 4 66 94 68 8,774 4 2 8 20 0 2 9 7 9 7 2 4 0 9 1 1 0 4 1 4 0 3 1 352,085 2,641 2,529 3,840 1,788 1,935 3,827 5,488 4,516 4,289,079 10,302 24,136 14,490 4,333 2,038 2,221 1,422 1,805 4,000 3,562 8,015 13,315 3,375 2,113 5,004 18,477 10,223 2,560 2,421 1,155 1,224 3,828 5,876 2,840 2,150 2,276 2,918 1,845 11,178 1,645 3,169 5,209 3,103 3,097 4,400 3,424 248,166

8,085 2,641 2,529 3,840 1,788 1,935 3,827 5,488 4,516 4,289,079 10,302 24,136 14,490 4,333 2,038 2,221 1,422 1,805 4,000 3,562 8,015 13,315 3,375 2,113 5,004 18,477 10,223 2,560 2,421 1,155 1,224 3,828 5,876 2,840 2,150 2,276 2,918 1,845 11,178 1,645 3,169 5,209 3,103 3,097 4,400 3,424 248,166 0 5,000 10,000 15,000 20,000 25,000

5 510 1015 1520 2025 25 50.8%51024.7%1015 11.7%15206.1%20253.8%252.9%10 24.5256,865 373 9

6 6 7 21 83 161 303 422 563 972 1,830 (0.0) (0.0) (0.0) (0.4) (0.7) (1.4) (2.0) (2.6) (4.5) (8.5) 6 5 9 16 43 81 136 215 275 425 829 (0.0) (0.0) (0.3) (0.7) (1.1) (1.7) (2.2) (3.5) (6.7) 11 16 37 6 242 439 637 838 1,397 2,659 (0.0) (0.0) (0.0) (0.4) (0.7) (1.3) (1.9) (2.5) (4.1) (7.8) 2,433 2,773 3,2 3,388 2,909 1,648 679 134 15 21,565 61 21,626 64.84 13.17 (11.3) (.9) (14.9) (15.7) (13.5) (7.6) (3.1) (0.6) (100.0) 1,103 1,403 1,680 1,871 1,889 1,447 679 184 16,3 50,362 67.37 13.69 (9.0) (11.4) (13.6) (15.2) (15.3) (11.8) (5.5) (1.5) (100.0) 3,536 4,176 4,892 5,259 4,798 3,095 1,358 318 31 33,877 111 33,988 65.76 13.42 (10.4) (.3) (14.4) (15.5) (14.2) (9.1) (4.0) (0.9) (100.0) 200435,0841,118(3.3%) 33,87721,565,3 6075 65.7664.8467.37 10

11 41.3%28.1% 9.3%8.8% 64.5665.34 65.7673.17 9,466 305 385 57 4 909 2,978 236 13,920 268 140 110 22 (28.1) (0.9) (1.1) (0.2) (0.4) (2.7) (8.8) (0.7) (41.3) (0.8) (0.4) (0.3) 65.34 63.72 68.42 57.33 61.51 59.77 73.17 60.99 64.56 58.91 64.62 64.63 44.00 14.76 16.24.67 11.66 18.99.38 11.66 16.97 11.33 14.53 11.03 11.55 22.26 31 51 134 104 5 41 243 957 3,3 33,729 206 33,935 (0.2) (0.4) (0.3) (0.4) (0.7) (2.8) (9.3) (100.0) 67.13 67.82 69.81 66.67 69.42 44.07 54.62 66.13 69.01 65.75 66.90 65.76 11.73.37 10.84 18.85 10.54 28.03 16.77 15.66 13.38 13.41 14.58 13.42

1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 15.6 60.5 3.0 2.8 2.4 0.9 1.1 4.4 17.4 58.7 3.3 2.8 2.2 0.7 1.1 4.0 19.6 56.0 3.5 3.1 2.1 0.9 1.1 4.8 21.3 54.8 3.7 2.9 2.0 1.0 1.2 4.2 22.1 54.2 3.9 3.2 1.8 0.8 0.9 4.1 24.3 49.9 3.9 3.1 1.8 0.9 0.9 3.8 26.5 47.4 4.1 3.1 1.5 0.8 1.0 4.0 26.2 46.1 5.4 2.9 1.5 0.7 1.1 3.3 28.1 44.2 5.5 3.0 1.7 0.6 1.3 3.7 28.4 42.2 5.9 2.7 1.6 0.7 1.3 3.7 1993 29.9 41.4 6.2 2.6 1.1 0.8 1.2 3.3 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 30.7 40.5 6.1 2.5 1.4 0.8 1.2 3.9 31.9 39.4 6.3 2.4 1.2 0.8 1.1 4.5 33.1 38.9 6.4 2.5 1.1 0.8 1.3 5.0 33.9 36.6 6.8 2.4 1.2 1.1 1.0 5.5 35.7 35.0 6.7 2.4 1.1 0.9 1.1 5.6 36.2 33.6 7.0 2.2 1.1 0.9 1.2 6.1 36.6 32.5 7.6 2.4 1.0 1.0 0.9 7.6 38.1 32.4 7.6 2.3 1.1 1.0 1.0 9.0 39.1 31.9 7.9 2.4 0.9 1.1 0.9 8.4 41.0 29.1 8.5 2.3 1.0 1.2 0.7 8.8 41.3 28.1 8.8 2.7 0.9 1.1 0.8 9.3 1998200441.3% 28.1%2 20049.3% 8.8 SLE

13 18 28 104 358 964 2,132 3,510 5,052 7,919 14,253 20,331 21,911 21,525 19,850 14,481 7,321 2,786 761 72 (0.0) (0.0) (0.0) (0.2) (0.7) (1.5) (2.4) (3.5) (5.5) (9.9) (14.2) (15.3) (15.0) (13.8) (10.1) (5.1) (1.9) (0.5) 18 9 17 67 211 505 1,133 1,903 2,882 4,595 8,644,149 13,054 13,217,339 10,775 7,214 3,308 885 106 (0.0) (0.0) (0.0) (0.2) (0.5) (1.2) (2.0) (3.1) (4.9) (9.3) (13.1) (14.0) (14.2) (13.3) (11.6) (7.8) (3.6) (1.0) 31 27 45 171 569 1,469 3,265 5,413 7,934,514 22,897 32,480 34,965 34,742 32,189 25,256 14,535 6,094 1,646 178 (0.0) (0.0) (0.0) (0.2) (0.6) (1.4) (2.3) (3.4) (5.3) (9.7) (13.7) (14.8) (14.7) (13.6) (10.7) (6.1) (2.6) (0.7) 143,389 (100.0) 55 143,444 62.64.65 93,031 (100.0) 45 93,076 64.37 13. 236,420 (100.0) 100 236,520 63.32.86 63.3262.6464.37 75 13

106,458 (45.1) 61.80 13.01 2,977 1,437 1,760 1,076 7,933 13,485 1,785 (1.3) (0.6) (0.7) (0.5) (3.4) (5.7) (0.8) 61.44 63.64 57.77 55.33 61.84 72.23 61.39 14.46 14.22 9.70 17.29 10.83 11.98 13.81 71,394 (30.2) 64.78 10.87 2,117 450 1,258 236 (0.9) (0.2) (0.5) 54.69 63.91 64.02 46.22 13.43 11.25 11.53 17.56 458 477 543 646 188 491 1,596 4,050 15,219 (0.2) (0.2) (0.2) (0.3) (0.2) (0.7) (1.7) (6.4) 67.09 65.80 67.72 58.74 68.45 38.04 50.29 61.00 65.63 9.95 11.29 11.69 18.44 11.89 18.79.30 16.37 13.61 236,034 (100.0) 471 236,505 63.32 65.51 63.32.86 13.68.86 45.1% 30.2%1/3 72.2363.32 14

1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 7.4 74.5 1.5 2.7 3.1 0.5 0.8 2.2 8.4 72.1 1.7 2.9 3.3 0.4 0.8 2.3 9.4 72.3 1.9 3.0 2.6 0.5 0.9 2.3 10.5 70.6 2.0 3.1 2.4 0.5 0.9 2.5 11.7 69.4 2.1 3.1 2.4 0.5 0.9 2.6.8 67.9 2.1 3.2 2.3 0.5 0.9 2.5 14.0 65.9 2.3 3.2 2.2 0.5 0.9 2.6 14.9 64.1 2.6 3.3 2.2 0.5 1.0 2.6 16.4 61.7 2.9 3.3 2.1 0.5 1.1 2.9 17.1 60.4 3.1 3.3 2.0 0.5 1.1 2.9 18.2 58.8 3.4 3.3 1.9 0.5 1.1 2.9 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 19.2 57.7 3.6 3.2 1.8 0.5 1.1 3.1 20.4 56.6 3.8 3.2 1.7 0.5 1.1 3.2 21.6 55.4 4.0 3.2 1.6 0.5 1.1 3.6 22.7 54.1 4.2 3.2 1.6 0.6 1.1 3.9 24.0 52.5 4.4 3.2 1.5 0.6 1.1 4.2 25.1 51.1 4.5 3.2 1.5 0.6 1.1 4.4 26.0 49.7 4.8 3.2 1.4 0.6 1.0 5.0 27.2 49.6 5.0 3.3 1.4 0.6 1.0 5.6 28.1 48.3 5.1 3.3 1.3 0.6 1.0 5.9 29.2 46.6 5.3 3.3 1.3 0.6 0.9 6.3 30.2 45.1 5.7 3.4 1.3 0.6 0.9 6.4 ß 15

1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 51.9 53.2 54.4 55.1 55.9 56.9 57.4 58.1 58.1 59.5 59.8 48.3 49.2 50.3 51.1 52.1 52.9 53.8 54.5 55.3 56.0 56.6 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 60.4 61.0 61.5 62.2 62.7 63.4 63.8 64.2 64.7 65.4 65.8 57.3 58.0 58.6 59.2 59.9 60.6 61.2 61.6 62.2 62.8 63.3 200465.8 63.3105.3 16

17 2004 10ICD-10 (24.3%)(21.9%)(10.6%) (25.3%)(22.6%)(6.8%) 385 (21.9) 108 (6.2) 427 (24.3) 32 (1.8) 186 (10.6) 39 (2.2) 71 (4.0) 56 (3.2) 48 (2.7) 281 (25.3) 72 (6.5) 251 (22.6) 33 (3.0) 75 (6.8) 40 (3.6) 39 (3.5) 52 (4.7) 13 (1.2) 666 (23.2) 180 (6.3) 678 (23.7) 65 (2.3) 261 (9.1) 79 (2.8) 110 (3.8) 108 (3.8) 61 (2.1) 668 (23.3) 182 (6.3) 678 (23.6) 65 (2.3) 261 (9.1) 79 (2.8) 110 (3.8) 108 (3.8) 61 (2.1) 2 (50.0) 2 (50.0) 1 24 (1.4) 8 (0.5) 15 (0.9) 8 (0.5) 205 (11.7) 143 (8.1) 1,756 (100.0) 17 1,773 1 8 (0.7) 7 (0.6) 6 (0.5) 3 (0.3) 152 (13.7) 77 (6.9) 1,110 (100.0) 1,2 2 32 (1.1) 15 (0.5) 21 (0.7) 11 (0.4) 357 (.5) 220 (7.7) 2,866 (100.0) 29 2,895 4 (100.0) 1 5 2 32 (1.1) 15 (0.5) 21 (0.7) 11 (0.4) 357 (.4) 220 (7.7) 2,870 (100.0) 30 2,900

1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 32.3 14.1 10.8 8.6 3.8 6.1 33.4 15.7 9.5 7.4 4.6 5.2 32.6.6 8.8 7.5 4.5 5.7 32.3 14.2 8.9 7.5 3.7 5.3 30.0 14.5 8.6 8.4 5.6 5.2 26.9 16.6 9.5 7.8 5.5 7.2 22.6 18.7 8.2 9.1 5.2 7.5 23.4 17.8 9.2 9.0 6.0 8.8 24.4 18.3 7.4 6.4 5.1 8.5 23.3 19.8 7.1 8.3 5.1 9.8 22.8 19.7 7.3 9.2 4.8 9.3 26.0 19.4 8.2 9.3 5.2 9.9 24.6 21.1 7.4 9.3 5.3 10.6 23.9 23.8 7.6 9.5 4.2 10.3 23.3 23.6 6.3 9.1 3.8.4 23.6%23.3%9.1%6.3% 3.8%1 200220% 18

19 2004 2004 2,991 (23.4) 1,318 (10.3) 2,423 (18.9) 253 (2.0) 1,311 (10.3) 266 (2.1) 741 (5.8) 689 (5.4) 245 (1.9) 2,185 (27.7) 871 (11.1) 1,459 (18.5) 198 (2.5) 553 (7.0) 219 (2.8) 379 (4.8) 382 (4.9) 83 (1.1) 5,176 (25.0) 2,189 (10.6) 3,882 (18.8) 451 (2.2) 1,864 (9.0) 485 (2.3) 1,0 (5.4) 1,071 (5.2) 328 (1.6) 2 (50.0) 2 (50.0) 5,178 (25.1) 2,191 (10.6) 3,882 (18.8) 451 (2.2) 1,864 (9.0) 485 (2.3) 1,0 (5.4) 1,071 (5.2) 328 (1.6) 15 139 (1.1) 100 (0.8) 54 (0.4) 95 (0.7) 1,252 (9.8) 898 (7.0),790 (100.0) 158,948 7 58 (0.7) 90 (1.1) 30 (0.4) 25 (0.3) 887 (11.3) 450 (5.7) 7,876 (100.0) 106 7,982 22 197 (1.0) 190 (0.9) 84 (0.4) 0 (0.6) 2,139 (10.4) 1,348 (6.5) 20,666 (100.0) 264 20,930 4 (100.0) 2 6 22 197 (1.0) 190 (0.9) 84 (0.4) 0 (0.6) 2,139 (10.3) 1,348 (6.5) 20,670 (100.0) 266 20,936

1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 30.3 11.0 30.5 11.5 31.3 11.5 33.2.0 32.7.0 36.5.2 33.4 11.7 30.4 11.6 30.5.1 31.1 11.3 29.9.2 28.2.6 25.4 13.8 24.1 14.6 23.9 14.9 24.1 15.0 24.3 16.3 23.2 16.6 25.5 16.3 25.1 15.9 14.2 15.4 14.2 14.0 14.2.9 13.2 13.9 13.7 13.6 13.5 14.1 13.5.9.6.1 11.3 11.3 11.6 11.2 7.7 5.3 6.9 4.8 6.4 5.3 6.9 6.1 5.8 6.0 6.9 5.4 7.6 5.3 8.2 5.8 7.6 5.8 7.1 5.8 7.4 5.7 7.3 7.1 7.2 7.5 7.7 7.4 8.1 8.4 7.7 7.9 7.6 7.4 8.3 7.0 8.5 7.4 8.5 7.4 5.1 4.9 5.7 4.7 5.2 4.8 4.4 4.6 4.4 4.5 4.1 4.5 5.8 6.3 6.7 7.0 7.7 7.9 9.1 9.0 2003 25.0 18.5 10.7 8.5 6.2 9.7 2004 25.1 18.8 10.6 9.0 5.4 10.3 0002001 25%220032004 18.8% 10.6% 6.2%5.4% PTCACABG 20

1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 9.0 8.9 9.1 9.0 8.5 9.2 7.9 9.6 8.9 9.7 9.4 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 9.5 9.7 9.4 9.4 9.2 9.7 9.2 9.3 9.2 9.3 9.4 1983 19897.9%8.5%9.29.3% 20049.4% 21

22 1983 80%86.0% 62.3%60.2%1039.3%15 29.3%10 2025.6% 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 11,050,036,971 14,238 15,424 16,951 16,908 19,339 21,364 23,231 24,540 25,280 27,047 29,510 30,362 31,994 33,578 36,503 37,973 38,293 38,568 0.837 0.837 0.816 0.821 0.836 0.845 0.868 0.858 0.848 0.843 0.854 0.852 0.862 0.855 0.861 0.868 0.873 0.878 0.876 0.877 0.877 0.773 0.763 0.748 0.754 0.767 0.769 0.789 0.777 0.765 0.759 0.774 0.774 0.784 0.782 0.785 0.798 0.804 0.806 0.803 0.806 0.714 0.705 0.694 0.701 0.707 0.701 0.721 0.709 0.698 0.688 0.704 0.708 0.718 0.714 0.722 0.736 0.741 0.744 0.739 0.669 0.658 0.646 0.657 0.648 0.643 0.656 0.649 0.638 0.630 0.641 0.648 0.655 0.656 0.665 0.678 0.679 0.684 0.629 0.619 0.604 0.608 0.600 0.592 0.604 0.598 0.583 0.577 0.589 0.593 0.602 0.605 0.609 0.619 0.623 0.598 0.583 0.564 0.564 0.553 0.546 0.557 0.548 0.536 0.531 0.541 0.543 0.555 0.559 0.561 0.570 0.567 0.545 0.530 0.525 0.511 0.505 0.513 0.507 0.494 0.489 0.498 0.501 0.513 0.508 0.517 0.531 0.514 0.490 0.492 0.476 0.469 0.475 0.469 0.458 0.453 0.460 0.462 0.473 0.470 0.503 0.485 0.459 0.457 0.444 0.435 0.441 0.435 0.427 0.420 0.426 0.425 0.437 0.473 0.457 0.433 0.429 0.416 0.405 0.409 0.405 0.396 0.391 0.394 0.393 0.444 0.429 0.408 0.402 0.390 0.379 0.384 0.376 0.369 0.364 0.366 0.421 0.404 0.384 0.377 0.366 0.355 0.357 0.350 0.342 0.339 0.398 0.379 0.360 0.356 0.345 0.333 0.334 0.326 0.320 0.379 0.357 0.337 0.334 0.322 0.309 0.3 0.307 0.357 0.338 0.318 0.316 0.302 0.290 0.293 0.338 0.320 0.299 0.297 0.285 0.272 0.321 0.301 0.280 0.279 0.266 0.303 0.286 0.264 0.264 0.288 0.272 0.249 0.271 0.256 0.256

25 26.2%75.1% 119,532 (75.1) 8,442 (76.7) 29 (61.7) 251 (73.2) 69 (75.0) 2,878 (68.5) 118 (79.7) 35,503 (26.2) 3,460 (37.4) 10 (20.4) 118 (39.5) 32 (35.6) 1,060 (28.5) 38 (40.4) 1,432 (1.1) 160 (1.9) 6 (13.3) 1 (0.4) 79 (2.2) 3,213 (2.5) 587 (6.2) 1 (2.6) 35 (11.2) 2 (2.2) 90 (2.5) 3 (3.1) D HCO3PTXPEIT

26 1.5g3.0g3.0g6.0g 9g6.0g 731 (1.8) 4,993 (.4) 15,218 (37.9) 15,028 (37.4) 3,083 (7.7) 1,8 (2.8) 40 108,666 177

9.00 5.41 5.26 169.02 0.95 1.79 1.49 187.20 9.33 5.45 5.81 211.63 0.98 1.97 1.58 219.34 9.25 5.30 5.80 205.03 0.97 1.69 1.49 239.26 9.32 5.40 5.98 232.73 0.92 1.75 1.51 242.46 9.40 5.45 6.18 274.84 0.92 1.74 1.51 272.63 9.44 5.93 6.26 299.91 0.97 2.06 1.51 297.65 9.45 5.34 6.34 287.52 1.04 1.55 1.57 276.65 PTH mg/dlmeq/l PTH 27

20.76 3.28 21.29 3.46 20.75 3.19 20.00 3.25 19.20 3.04 18.39 2.96 19.42 3.52 HCO3 HCO3 28

29 1.5g3.0g 3.0g4.5g 8,264 (6.3) 47,819 (36.5) 50,223 (38.3) 13,944 (10.6) 7,338 (5.6) 1,947 (1.5) 1,531 (1.2) 253 43,689 208 (%)

8.96 5.27 5.41 220.77 1.05 1.72 1.63 239.02 9.11 5.22 5.16 181.65 0.90 1.64 1.36 190.60 9.09 5.36 5.26 169.34 0.90 1.76 1.42 185.95 9.16 5.45 5.50 169.95 0.92 1.77 1.49 190.01 9.17 5.51 5.74 174.20 0.92 1.85 1.50 197.17 9.13 5.66 5.92 190.21 0.95 1.92 1.58 211.78 9.08 4.99 5.79 2.07 1.03 1.27 1.64 259.91 9.10 0.98 4.76 1.32 5.74 1.63 178.01 210.63 PTH 24PTH PTHD 30

1,382 7,583 7,220 2,316 1,338 326 238 28 13,985 30 (21.6) (20.8) (19.1) (21.9) (24.6) (23.1) (21.2) (.0) (32.4) (42.9) 32.4% 6.0g9.0g 24.6% 31

32 D D D CAPDD CAPD 48,388 (29.2) 3,184 (27.1) (21.1) 87 (24.0) 22 (23.2) 1149 (25.1) 38 (25.5) 15,687 (9.5) 1,094 (9.3) 3 (5.3) 35 (9.7) 16 (16.8) 557 (.2) 33 (22.1) 3,904 (2.4) 425 (3.6) 13 (3.6) 13 (13.7) 296 (6.5) 5 (3.4) 1,032 (0.6) 78 (0.7) 2 (3.5) 35 (0.8) 95,917 (57.8) 6,911 (58.9) 40 (70.2) 226 (62.4) 44 (46.3) 2,463 (53.8) 72 (48.3) 947 (0.6) 39 (0.3) 1 (0.3) 75 (1.6) 1 (0.7)

6,822 (4.1) 671 (5.8) 1 (1.7) 27 (7.4) 19 (0.4) 18,359 (11.1) 2,030 (17.4) 7 (.1) 86 (23.7) 9 ( 9.5) 3 ( 2.7) 6 ( 4.1) 232 53 (0.5) 1 (0.3) 138,605 (84.1) 8,860 (76.1) 50 (86.2) 248 (68.3) 86 (90.5) 4,309 (94.9) 139 (95.2) 748 (0.5) 36 (0.3) 1 (0.3) 89 (2.0) 1 (0.7) D 15%D CAPD3%CAPDD 33

13,835 (31.7) 4,377 (10.0) 831 (1.9) 353 (0.8) 23,968 (54.9) 311 (0.7) 15,151 (31.5) 4,564 (9.5) 1,159 (2.4) 353 (0.7) 26,660 (55.4) 235 (0.5),492 (27.5) 4,041 (8.9) 1,231 (2.7) 264 (0.6) 27,136 (59.7) 263 (0.6) 5,430 (25.0) 1,927 (8.9) 705 (3.2) 90 (0.4) 13,436 (61.9) 106 (0.5) 2,705 (23.9) 1,136 (10.0) 348 (3.1) 37 (0.3) 7,017 (62.0) 82 (0.7) 1,746 (24.5) 768 (10.8) 224 (3.1) 27 (0.4) 4,324 (60.7) 35 (0.5) 1,521 (27.8) 6 (11.2) 158 (2.9) 23 (0.4) 3,132 (57.2) 31 (0.6) D D20 34

925 (2.1) 2,4 (4.9) 41 39,679 (92.1) 298 (0.7) 1,521 (3.2) 3,417 (7.2) 46 42,449 (89.1) 226 (0.5) 2,025 (4.5) 5,499 (.2) 89 (0.2) 37,402 (82.7) 204 (0.5) 1,327 (6.1) 4,276 (19.7) 42 (0.2) 15,973 (73.7) 69 (0.3) 860 (7.6) 2,625 (23.1) 24 (0.2) 7,813 (68.7) 43 (0.4) 494 (6.9) 1,613 (22.6) 26 (0.4) 4,992 (69.9) 18 (0.3) 388 (7.1) 1,066 (19.5) 18 (0.3) 3,989 (72.8) 17 (0.3) D D20 PTX 35

36 D 0.75g3.0 g 4,823 (9.2) 1,502 (8.7) 767 (16.6) 29,463 (56.2) 11,357 (65.6) 3,723 (80.7) 16,140 (30.8) 3,973 (23.0) 88 (1.9) 1,786 (3.4) 370 (2.1) 11 (0.2) 259 (0.5) 99 (0.6) 27 (0.6) 409 4 40 1,147 105,673 1,063

492 (6.5) 1,035 (13.8) 2,844 (37.8) 2,7 (28.3) 1,028 (13.7) 14 3,271 (16.0) 6,342 8,007 2,692 150 158 (31.0) (39.1) (13.2) (0.7) 286 152,297 875 D 1.5g3.0g3.0g4.5g 15.0g30.0g7.5g15.0g 37

4,501 4,832 4,010 3,615 3,314 3,050 2,896 2,390 2,319 2,028 8,698 2,516 462 159 163 (33.2) (33.6) (32.1) (31.1) (31.0) (31.8) (30.9) (28.7) (28.9) (28.1) (25.8) (18.7) (13.7) (10.8) (10.7) 1,731 1,472 1,215 1,107 1,014 920 866 802 725 672 3,169 1,026 207 87 89 (.8) (10.2) (9.7) (9.5) (9.5) (9.6) (9.2) (9.6) (9.0) (9.3) (9.4) (7.6) (6.2) (5.9) (5.9) 200 218 182 185 213 225 214 217 238 211 1,374 566 1 63 49 (1.5) (1.5) (1.5) (1.6) (2.0) (2.3) (2.3) (2.6) (3.0) (2.9) (4.1) (4.2) (3.6) (4.3) (3.2) 1 105 86 71 53 63 46 40 37 50 167 47 3 3 4 (0.8) (0.7) (0.7) (0.6) (0.5) (0.7) (0.5) (0.5) (0.5) (0.7) (0.5) (0.4) (0.2) (0.3) 6,976 7,687 6,935 6,578 6,058 5,305 5,319 4,844 4,674 4,231 20,170 9,182 2,548 1,152 1,209 (51.4) (53.5) (55.6) (56.6) (56.6) (55.2) (56.7) (58.1) (58.2) (58.5) (59.8) (68.4) (75.8) (78.2) (79.5) 42 65 56 60 45 43 46 44 35 36 162 83 22 10 7 (0.3) (0.5) (0.4) (0.5) (0.4) (0.4) (0.5) (0.5) (0.4) (0.5) (0.5) (0.6 (0.7) (0.7) (0.5) PTHD PTH200pg/mlD PTHDPTH PTHD D 38

86 96 2 156 175 222 266 291 367 381 2,482 1,660 483 206 230 (0.7) (0.7) (1.0) (1.4) (1.7) (2.3) (2.9) (3.5) (4.6) (5.3) (7.3) (.1) (13.9) (13.6) (14.8) 7 232 301 367 464 516 668 770 886 922 6,968 4,602 1,360 610 570 (1.0) (1.7) (2.5) (3.2) (4.4) (5.5) (7.2) (9.3) (11.1) (.8) (20.6) (33.7) (39.1) (40.3) (36.8) 9 5 9 6 8 6 10 14 13 11 88 67 23 5 1 (0.0) (0.2) (0.2) (0.2) (0.3) (0.5) (0.7) (0.3),934 13,656 11,757 10,849 9,866 8,649 8,286 7,113 6,676 5,843 24,173 7,302 1,597 682 743 (97.9) (97.3) (96.1) (95.0) (93.5) (91.6) (89.3) (86.3) (83.8) (81.3) (71.4) (53.4) (46.0) (45.1) (47.9) 41 51 48 46 38 54 49 50 22 33 142 41 11 10 7 (0.3) (0.3) (0.4) (0.4) (0.4) (0.6) (0.5) (0.6) (0.3) (0.5) (0.4) (0.3) (0.3) (0.7) (0.5) PTHD DPTHD PTH 600pg/ml 39

160,694 9,361 573 98 46 116 7 15 3,551 (92.1) (5.4) (0.3) (0.0) (0.0) (0.0) (2.0) PTX 6%PTX 40

167,952 1,576 317 146 85 48 63 20 226 3,243 (96.7) (0.9) (0.2) (0.0) (0.0) (0.0) (0.0) (1.9) PEIT PEIT2,4811,576 PEIT 41

2003 LDL HDL- PTH 2004 2003 end point PTH 2003171,933 end point 2004 2004 2004 censored case end point censored case 2003137,214 end point2004 2004 censored case 45

46 20038,715 end point2004 Lacunar Infarction 2004 censored case 2003140,474 end point2004 2004 censored case Cox

47

180mg/dl 240mg/dl 2001 3 260mg/dl 240260mg/dl 1.221.45 160mg/dl 48

160mg/dl 160mg/dl 160mg/dl 200mg/dl 220mg/dl 160mg/dl 49

80mg/dl LDL LDL 60mg/dl LDL LDL 50

100mg/dl LDL LDL100mg/dl LDL60mg/dl LDLp=0.06 60mg/dl LDL 51

52 HDL- HDL- HDL- HDL- HDL-

HDL-30mg/dl HDL- 53

50mg/dl 54

50mg/dl 200mg/dl 150175mg/dl 55

meq/l mg/dl 9mg/dl 11mg/dl 8mg/dl 11mg/dl 56

57

56mg/dl 4mg/dl 8mg/dl 6mg/dl 58

4mg/dl 59

4080 3080 70 60

70 61

60pg/ml 360pg/ml PTH 60pg/ml 720pg/ml PTH 3060pg/ml0360pg/ml PTH 30pg/ml 360pg/ml PTH 62

63

3.5mEq/L 2.52.75mEq/L 2.753.0mEq/L3.5mEq/L 2.753.0mEq/L 64

2.52.75mEq/L 2.5mEq/L 65

66

67

70

71

An overview of regular dialysis treatment in Japan as of Dec. 31, 2004