1) Delbet P: Retrocissement du choledoque. Cholecysto-duodenostomie. Bull Mem Soc Nat Chir 50: 1144-1146, 1924 2) Wiesner RH, LaRusso NF: Clinicopathologic Features of the Syndrome of Primary Sclerosing Cholangitis. Gastroenterology 79: 200-206, 1980 3) Helzherg JH, Petersen JIVI, Boyer JL: Improved Survival with Primary Sclerosing Cholangitis. A Review of Symptomatic and Asymptomatic Patients. Gastroenetrology 92: 1869-1875, 1987 4) Thompson HH, Pitt HA, Tompkins RK, et al: Primary sclerosing cholangitis, a heterogenous disease. Ann Surg 196: 127-136, 1982 5) Chapman RING, Marborgh BA, Rhodes JIVE et al: Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology. Gut 21: 870-877, 1980 6) Wiesner RH, Ludwig J, LaRusso NF, et al: Diagnosis and treatment of primary sclerosing cholangitis. Sem Liv Dis 5: 241-253, 1985 8) Wiesner RH, Grambsch PM, Dickson ER et al: Primary sclerosing cholangitis: natural history, prognostic factors and survival analysis. Hepatology 10: 430-436, 1989 9) Gross JB, Ludwig J, Wiesner RH et al: Abnormalities in tests of copper metabolism in primary sclerosing cholangitis. Gastroenterology 89: 272-278, 1985 troenterological Endoscopy 25: 1091-1099, 1983 12) Wiesner RH, LaRusso NF, Ludwig J et al:

Comparison of the clinicopathologic features of primary sclerosing cholangitis and primary biliary cirrhosis. Gastroenterology 88: 108-114, 1985 14) Danzi JT, Mskipour H, Farmer RG: Primary screlosing cholangitis. A report of nine cases and clinical revidw. Am J Gastroenterol 65: 109-116, 1976 15) Dobbins WO: Dysplasia and malignancy in inflammatory bowel disease. Ann Rev Med 35: 33, 1984 16) Bartholomew LG, Cain JC, Woolner LB et al: Sclerosing cholangitis. Its possible association with riedel struma and fibrous retroperitonitis. Report of 2 cases. N Engl J Med 269: 8-12, 1963 Three cases of Primary Screlosing Cholangitis Hiroyuki HIRANO,Masaru KOIZUMI,Takayoshi MEGURO, Naoaki TANNO,Yutaka MIYAZAKI,HIROSHI,SUZUKI, Nobuo HIWATASHI,Tooru SHIMOSEGAWA,Takayoshi TOYOTA This report describes 3 cases of primary sclerosing cholangitis (PSC). Case 1, a 52 yearold woman, developed an elevation of serum alkaline phophatase, and was diagnosed as PSC by endoscopic retrograde cholangiography (ERC). In this patient, ulcertive colitis was accompanied and died of colon cancer, with peritonitis carcinomatosa, 5 years after the diagnosis of PSC. Case 2, a 22 year-old woman, visited our hospital because of jaundice and disorder of liver function. The diagnosis of PSC and eosinophilic colitis was made during her admission in our hospital. In spite of occasional development of eosinophilia which is unrelated to her symptoms or other laboratory data, she is still following-up and treated at our outpatient clinics. The onset of symptom, case 3, a 29 year-old woman, was progressive jaundice. The diagnosis of PSC was made by percutaneous transhepatic cholangiography (FTC), and the drainage failed to improved her repeating cholangitis. She died of liver failure 15 months after the diagnosis. * The Third Department of internal Medicine, Tohoku University of Medicine (Sendai)