Enterovirus Infection in Children Fukushima Medical University School of Medicine

CA1 CA19 CA4 CA3 PV3 CA13 CA18 CA17 CA24v CA11 CA15 CA20 CA24 CA21 CA22 E16 PV1 PV2 E31 E5 E15 E24 E6 E27 E18 E17 E13 CB1 E14 E32 E19 CB5 E7 E12 CB2 E11 E29 CB4 E1 E21 E9 E3 CB6 E26 E4 CA9 E30 EV69 E20 E25 CB3 E33 CA10 CA6 CA12 CA5 CA7 CA8 EV68 EV70 CA16 CA14 CA2 E2 EV71 C B D A 0.30 0.20 Genetic distances 0.10 0.00 Cluster

RS

C-1 C-4 C-2 C-2 C-3 C-1 C-1 B-1 B-3 B-4 B-5 Isolation number in Fukushima Isolation number in Japan

0.20 0.10 0.00 CV-A16 EV71(BrCr) India/R13223-IND-01 USA/2228-NY72/72 USA/6910-OK87/87 75 USA/2235-NY77/77 74 Kanagawa/V-3478/82 Kanagawa/V-4879/84 Bulgaria/258/75 Ehime/2118/78 95 Aichi/70 Nagoya-73 Nagoya/70 USA/1011-ND79/79 Aichi/3059/73 USA/2229-NY76/76 Ehime/209/78 USA/10181-MN78/78 USA/2231-NY77/77 Hungary-78 Kanagawa/V-4110/83 Kanagawa/V-4014/83 Kanagawa/V-4185/83 Fukushima/29/83 Fukushima/419/85 Fukushima/135/84 Aichi/3359/83 Taiwan/80/73 Taiwan/244/86 88 Taiwan/240/86 Taiwan/T86236a/86 Epsom/10620/99 97 Fukushima/10350/03 Kanagawa/HO793f/03 Kanagawa/HO793ts/03 Kanagawa/P-2265/03 Fukushima/10013/03 Fukushima/10100/03 Singapore/4915/99 Australia/4F/AUS/4/99 Malaysia/SK026/97 Malaysia/SK036/97 Kanagawa/V-14457/97 Singapore/3526/98 Malaysia/SK-EV006/97 SAR/MY104-9/97 Singapore/13/98 Fukushima/3302/93 Fukushima/1448/96 74132/85 Kanagawa/V-4083/83 71 Ehime/0445/90 Fukushima/1478/89 Aichi/1/89 Kanagawa/V-9281/90 Kanagawa/V-7949/98 USA/7633-PA87/87 USA//7673-CT87/87 USA/8102-WA87/87 77 USA/1413-CA87/87 USA/MS/7423/87 Singapore/5511/00 Fukushima/10104/03 Kanagawa/HC29F/00 79 Kanagawa/P-530/00 Hyogo/1610/00 Fukushima/8269/00 Kanagawa/P-739/00 Kanagawa/P-583/00 Kanagawa/P-499/00 Fukushima/8272/00 Hyogo/1580/00 SAR/CN9502/00 93 SAR/S21082/00 Singapore/5536/00 SAR/CN0942/00 Singapore/2027/01 Singapore/5926/00 Singapore/5859/00 Taiwan/7008/98 Singapore/18/97 Osaka/C7/97 Kanagawa/V-14429/97 Taiwan/J1263P4/98 Taiwan/5929/98 Taiwan/1394/98 B-1 B-5 B-3 B-2 B-4 Group B

63 50 56 43 37 100 88 AY208117 (97/20062-33/99) Sweden (1999) AF401357 (Berlin/8134/65) 79 AF401359 (Potsdam/0412/76) Germany (1974,1976) AF401360 (Halle/0352/74) E13-VP1 (Del Carmen) AF401358 (Potsdam/0529/79) Germany AJ537605 (CF957-95) AJ537604 (CF1083-91) France (1995) AF295467 (42/99)Sweden AJ30925 (/pe/roma96) Italy (1996) 100 33 AF538285 (Dresden/420/01) AY131288 (Kassel/310/01) AF401355 (Krefeld/679/00) Germany (2001) AB109382 (02-204SFH2) AB109384 (02-206NPH3) 25 28 AB109386 (02-216SFR1) 52 AB109378 (02-182NPR2) 36 66 AB109380 (02-185SFC2) Fukuoka (2002) 37 454 AB109379 (02-184SFC2) AB109383 (02-205SFH2) AB109381 (02-201FCC1) 19 44 AB092984 (ONO2-2R) Hiroshima (2002) AB109377 (02-131SFR1) Fukuoka (2002) 25 46 Fukushima AJ537606 (CF1393-00) France (2000) AF401354 (Stuttgart/435/00) 38 AF538284 (Magdeburg/377/01) 24 AF401353 (Ulm/573/00) Germany (2000-01) 2 33 AF401356 (Chemniz/501/00) 2 24 AY007223 (Weissenfels/2000/DEU) 20 74 AJ537607 (CF1504-01) AJ537609 (CF1925-01) France (2001) 0 1 AB086858 (19/Fukushima/01) AY268569 (KOR-E13-02-19) Fukushima (2001) 47 AY268561 (KOR-E13-02-01) AY268563 (KOR-E13-02-07) 13 AY268568(KOR-E13-02-18) 15 55 AY268574 (KOR-E13-02-33) AY268576 (KOR-E13-02-36) 5 AY268571 (KOR-E13-02-24) 28 AY268564 (KOR-E13-02-08) AY268577 (KOR-E13-02-48) Korea (2002) 2 AY268567 (KOR-E13-02-17) 30 AY268565 (KOR-E13-02-11) AY268573 (KOR-E13-02-28) 0 AY268572 (KOR-E13-02-26) 0 AY268578(KOR-E13-02-49) 0 AY268566 (KOR-E13-02-12 3 AY268562 (KOR-E13-02-06) 67 AY268570 (KOR-E13-02-20) 0.10 Nucleotide distance 0.00 Virus () in CSF Virus () in CSF

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et al et al Enterovirus Infection in Children Fukushima Medical University School of Medicine