..../....

H

6

7

ARDSDIC ARDS DIC 10

11

12

13

14

15

semi immune non immunesemi immune 16

17

20

m km km 21

DDT N,N diethyl m toluamide DEET DEET DEET 22

DEET mm impregnated bed net 23

Malarone 24

25

mg mg recreational drug 26

Nivaquine, Aralen, Resochin, Avloclor Paludrine Vibramycin Malarone *** mg mg mg mg mg mg kg mg mg kg mg kg mg mg kg kg kg kg g kg ml Nivaquinemg mg, Aralen mg mg 27

βca g mg 28

29

30

31

Non immune VFRs : visiting friends and relatives DEET DEET DEET 32

kg mg/kg kgkg kgkg kg ARDS 33

DEET DEET 34

35

MDPC, 2005

A Step Forward in Family Travel : Malaria Prophylaxis for All Ages, J Travel Med, 10(suppl 1), 2003 Balakrishnan I, Gillespie SH : Vector borne Parasitic Diseases. In : Principles and Practice of Travel Medicine, Zuckerman JN ed., John Wiley & Sons, Ltd, Chichester, p91 124, 2001 Bannister B, Hatz C, Toovey S, Price R, Zuckerman JN : The role of standby emergency medication for falciparum malaria : current opinion. Travel Med Infect Dis 2 : 119 126, 2004 CDC : Malaria. Health information for International Travel 2003 1004, Arguin P et al. CDC, NCID, p99 116, 2003 CDC : Travelers Health. Malaria (http://www.cdc.gov/travel/diseases.htm#malaria) Lobel HO, Kachur SP : Malaria. In : Textbook of Travel Medicine and Health, DuPont HL, Steffen R ed., BC Decker Inc, Hamilton, p184 205, 2001 Petersen E : Malaria chemoprophylaxis : when should we use it and what are the options? Expert Rev Anti infect Ther 2 : 89 102, 2004 Preventing Malaria in International Travelers, J Travel Med 8(suppl 3), 2001 Travelers Malaria, Schlagenhauf P ed., BC Decker Inc, Hamilton, 2001 Travel Medicine and Malaria A ReviewoftheCurrent Issues, Travel Med Infect Dis 2(3 4), 2004 UK Health Protection Agency : Malaria (http://www.hpa.org.uk/infections/topics _az/malaria/menu.htm) WHO: International Travel and Health : Situation as on 1 January 2003, Malaria, p130 148, 2003 WHO : International Travel and Health. Malaria (http://www.who.int/ith/chapter 07_01.html) 38

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http : //www.jomf.or.jp/ http : //www3.johac.rofuku.go.jp/ http : //www.mofa.go.jp/mofaj/toko/medi/ http : //www.forth.go.jp/ 40

Afghanistan C m DOX MEF A/P Bangladesh B Dhaka DOX MEF A/P Bhutan C Chirang, Samchi, Samdrupjongkhar, Sarpang, Shemgang DOX MEF A/P Burma Myanmar B Yangon Mandalay DOX MEF A/P DOX A/P Cambodia B Phnom Penh Tonle SapAngkor Wat DOX MEF A/P DOX A/P East Timor A DOX MEF A/P Hong Kong D India B Delhi Bombay m DOX MEF A/P Indonesia B Java Sumatra Irian Jaya Borobudu DOX MEF A/P Laos B Vientiane DOX MEF A/P Malaysia C DOX MEF A/P Nepal C Teraim Kathmandu DOX MEF A/P North Korea D Pakistan B m DOX MEF A/P Philippines C Bohol Catanduanes Sebu Subic DOX MEF A/P China C DOX MEF A/P CHL South Korea D Sri Lanka B Colombo Kalutara Nuwara Eliya DOX MEF A/P Thailand B DOX MEF A/P Viet Nam B DOX MEF A/P Angola A DOX MEF A/P Benin A DOX MEF A/P Botswana B DOX MEF A/P Brundi A DOX MEF A/P Burkina Faso A DOX MEF A/P Cameroon A DOX MEF A/P Cape Verde C Sao Tiago DOX MEF A/P Central African Republic A DOX MEF A/P Chad A DOX MEF A/P Comoros A DOX MEF A/P Congo A DOX MEF A/P DR Congo Zaire A DOX MEF A/P Côte d Ivoire A DOX MEF A/P Djibouti A DOX MEF A/P Egypt D Equatorial Guinea A DOX MEF A/P Eritrea B m Asmara DOX MEF A/P Ethiopia B m Addis Ababa DOX MEF A/P Gabon A DOX MEF A/P Gambia A DOX MEF A/P Ghana A DOX MEF A/P Guinea A DOX MEF A/P Guinea Bissau A DOX MEF A/P Kenya B m Nairobi DOX MEF A/P Liberia A DOX MEF A/P Madagascar A DOX MEF A/P Malawi A DOX MEF A/P Mali A DOX MEF A/P Mauritania A DOX MEF A/P Mauritius C Mayotte A DOX MEF A/P Morocco D Rabat Tangier Casablanca Mozambique A DOX MEF A/P Namibia C KavangoKunene DOX MEF A/P Nigeria A DOX MEF A/P Niger A DOX MEF A/P Rwanda A DOX MEF A/P Saõ Tome and Principe A DOX MEF A/P Senegal A DOX MEF A/P Sierra Leone A DOX MEF A/P Somalia A DOX MEF A/P 41

South Africa C MpumalangaKruger KwaZulu Natal DOX MEF A/P Sudan A DOX MEF A/P Swaziland B DOX MEF A/P Tanzania A m DOX MEF A/P Togo A DOX MEF A/P Uganda A DOX MEF A/P Western Sahara D Zambia A DOX MEF A/P Zimbabwe B Harare Bulawayo DOX MEF A/P Papua New Guinea B m DOX MEF A/P Solomon Islands A Rennnel Bellona Temotu Tikopia Anuta Fatutaka DOX MEF A/P Vanuatu A DOX MEF A/P Iran C Baluchestan DOX MEF A/P Iraq C Sulaimania Duhok Erbil Ninawa Tamim Basrah CHL Oman D Musandam Saudi Arabia C JizanJeddah Mecca Medina DOX MEF A/P Syria D CHL Turkey D CHL Yemen B Sanam DOX MEF A/P Dominican Republic C CHL Haiti A Labadee CHL Belize B Belize CHL Costa Rica D Alajuela, Limon LimonGuanacaste, Heredia CHL El Salvador C CHL Guatemala C m Antigua Atitlan CHL Honduras C CHL Mexico C ChipasQuintana RooTabasco CH Nicaragua C Managua CHL Panama B Panama DOX MEF A/P Argentina D CHL Bolivia C m La Paz DOX MEF A/P Brazil C DOX MEF A/P Colombia C mbogota DOX MEF A/P Equador C mquito DOX MEF A/P French Guiana C DOX MEF A/P Guyana C DOX MEF A/P Paraguay C Alto Parana Caaguazu Canendiyu CHL Peru B Lima Lima DOX MEF A/P Surinam B Paramaribo DOX MEF A/P Venezuela C DOX MEF A/P NIS Armenia D Azerbaijan D Agcabdi, Barda Georgia D Kyrgyz D Tajikistan D Dushanbe Gorno Badakhshan Leninabad Turkmenistan D Mary Uzbekistan D Uzynskiy 42

DOX MEF CHL A/P CDC : Traveler s Health http : //www.cdc.gov/travel/yb/outline.htm WHO : International Travel and Health http : //www.who.int/ith/countrylist01.html MARA/ARMA Project http : //www.mara.org.za/ 43