HIV1 IAS-USA
1 HIV
1 Amino Acid, Wild-Type Primary Mutation Amino Acid Substitution M I 54 Secondary Mutation Codon Mutation Selected In Vitro MUTATIONS IN THE PROTEASE GENE SELECTED BY PROTEASE INHIBITORS Protease Inhibitors Indinavir Ritonavir Saquinavir Nelfinavir Amprenavir 1 L K L V M M I AG V V I L 71 82 10 24 20 32 36 46 54 73 77 84 90 IRV MR I I I I SA V VT IAFTS V M L 32 82 20 36 33 46 54 71 77 84 90 F IL VL G 71 82 10 48 54 90 73 77 84 D V S A N 82 88 10 30 36 46 77 71 84 90 FI N IL AFTS D I I 46 10 32 47 50 54 84 FIRV IV V V MUTATIONS IN THE REVERSE TRANSCRIPTASE (RT) GENE SELECTED BY RT INHIBITORS Nucleoside RT Inhibitors Zidovudine 1 Didanosine Zalcitabine Lamivudine M DK LT K 67 210 41 70 215 219 L NR W YF Q K L M E V 44 118 184 D I V Stavudine 75 T Y Abacavir 41 65 67 70 74 115 210 184 215 FV A F F Q Multinucleoside Resistance A 62 75 77 116 151 V IL Y M Multinucleoside 67 70 Resistance B 41 62 69 ^ R Insert Nonnucleoside RT Inhibitors Efavirenz 65 74 184 R V VI T 65 69 74 184 D 100 103 108 188 190 210 215 219 LKVV Y YG Nevirapine ll 100 106 188 103 108 181 190 I NA I CI CLH A P Delavirdine ll 103 181 C 236 225 LSA L P H 219 99 560
2