1
, / / / / / / / / / / / / / / / / / /,, / / / /// /// / / / / / / / // / CBT / / / / / / 2
/ / / / / /. / / / / / / / / POS / / / / / / / / /,,, CBT 3
/ / / / / / / / 4
5 ARDS
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CT MRI PET/CT 7
8
MESS MESS subspeciality EBM global standard 9
10
QOL Good Job 11
? 12
13
14
.. 15
16
C-Fos Regulation by the MAPK and PKC Pathways in Intervertebral Disc Cells 17
AP- c-fos Sprague Dawley-Rat n= PKC Phorbol -myristate -acetater PMA AP- PMA c-fos/c-jun c-fos c-fos Extracellular Matrix ECM PMA MAPK MAPK inhibitor c-fos PKC PKC- PKC- c-fos PMA AP- PMA c-fos c-jun c-fos c-fos ECM Aggrecan type collagen PMA MAPK MAPK inhibitor PMA c-fos PMA c-fos PD ERK / inhibitorpma PKC- PKC- expression plasmids c-fos c-fos PMA c-fos c-fos PMA MAPK PKC PMA c-fos PDMAPK ERK / PKC- PKC- PMA c-fos c-fos ECM c-fos ECM target ERK c-fos c-fos c-fos 18
CKD CKD-MBD CKD UTxIS PTH PCS UTx CKD-MBD PCS PCS.. mm PCS IS.. mm PCS.mM PTH camp PTH mrna BrdU-ELISA.mM PCS MTT PCS PCS.mM DNA fragmentation IS. mm PCS ROS IS. mm ROS PCS. mm ROS N- NAC NAC PCS. mm.mmpcs PCS.mM MAPK.mM PCS MAPK JNK p JNK p.mmpcs PCS IS CKD-MBD PCS JNK p MAPK IS 19
TEL FAX TEL e-mail, 20
DNA DNA 21
22
...cf. :. %. %... %. %,. %. %. %. %..... 23
.. % Part Par 24
25
m! 26
? 27
35
36
%?? - -, E-mail:shiina@is.icc.u-tokai.ac.jp 37
FAX TEL FAX TEL FAX E-mail
FAX TEL FAX e-mail