1 1 1 1.1 1.1.1 3 : 0: + : +0 : : } 40 40 40 = 3 35 35 (38 )? +0+7 30 35-0+0 38 38 +30 5 30 30 +20 16 16 1. [ ] 2. 3. 4. + = etc 1.1.2 Ru
1 2 1.2 1.2.1 =PAS.. =.. =.... 1% 01% ] 1.2.2 = = = = 4 (A/A 2 / /B ) 1 8 2n / 16 32 2n n 64 n 64 n ml /ml AI ml 50 5 10 0.5 0.25-0.5 30 1 30 1 0.2-0.5 100 80 2.5 10 20-25 400 250 2 50 50-70 7.5 10 0.5 2 1-3 0.6 0.04 17 ] ] 4
1 3 1.2.3-5 & + 1.3 5 = 6 = = = 7 8 9 = 1.3.1 @ :714 ;2026 ph ( ) K/Na = / = 10 5 : 7 : / 8 : 6 9 : 10 / & / / /
1 4 1.3.2...... +. for /K/.. +. rat/mouse with / : :... +. for (Ru & S ) ( S 11 ) 1.3.3 / : < < : < 1.3.4 (+) < < 13 11 : & V
2 5 2 2.1 ( = ) - / ( ) 1 (etc ) 2.1.1 2 14 2n at 3 2n ] / 4 n & 5 n ] 6 n+n 1 : 4 2 / 2 : 5 : Ru 3 : 6 :
2 6 2.1.2 1. / 2. 3. & & Ru: 2hour { } 1week [ ] 1week ( ( ) : ( )) [ ( ) ] [ ] / / 7 8 9 2.2 10 etc 2 Ru, 7 9 / 8 10 : A A A
3 7 3 { } F B1 3 F B2 4 F B3 2 1 1 1 5 1 5 FB: 3 3.1 GnRH h CRH ACTH h LH/FSH / ACTH 1 / 2 PIF PRL PRL / - OT 3.3.2 LH h FSH h / / ACTH h PRL / FB hcg ecg PL PG FSH FB / h LH h FSH 1 β GnRH 2
3 8 1. [ ] 2. [ ] 3. 4. 5. / 1. LHFSH 2. 3. FSH 3 3.2 - - 6 GnRHF SH RHLH RH 1 4 7 3 F SHLH 2 5 8 ( ) Estrogen/P rogesterone 1. FSH-RH FSH 2. FSH E 3. E LH-RH 4. LH-RH LH 5. LH FSH E P E 6. E 7. FSH-RH LH-RH 8. LH LH E P 9. P LH 3.2.1 1. FSH-RH FSH 2. FSH =FSH 3. 4. FSH 3 - -
3 9 3.3 3.3.1 gonadotropin GnRH LHFSH / / FSH/LH LHRH/FSHRH GnRH LH GnRH FB(-)= FB(+)= GnRH 4 GnRH-analogue LH/FSH LH/FSH 5 6 LHRH etc LH etc = 3.3.2-4 5? 6 GnRH LH?
3 10 3.4 3.4.1 FSH LH FSH LH 7 ( ) 8 / 9 / LH FSH / LH [LH ] GnRH & = LH LH/FSH / + LH 3.4.2 PIH TRHE / etc / = / = 7 FSH 9 LH 8 FSH FSH
3 11 3.5 3.5.1 LH ( ) / / / etc etc = BW GTHFSH/LH Androgen sterility etc 1 : 3065 : 2223 : 60 3.5.2 (E 1 ) (E 2 ) (E 3 E ) estriol LH F SH / 10 () + FSH/LH LH E/P E + 10 E+: / / /
3 12 3.5.3 LH FSH LH 11 12 + FSH/LH + LH +E 13 etc LH 19- P 6 3.5.4 // / /// 14 // 11 : / / // / 12 P : / / 13 14 :
3 13 3.5.5 FSH / FSH LH 15 GnRH 3.6 3.6.1 ecg PMSG MW:53k FSH LH PMSG = FSH LH hcg LH 3.6.2 / /Ru 15 GnRH GTH GnRH LH
3 14 3.6.3 local hormone or / / F 2α 16 17 etc? CCMCounter Current Mechanism PGF 2α CCM PGF 2α V V A V /// PGF 2α / / 3.7-18 ex 19 / 16 PGF 2α : & 17 PG etc GTH PGF 2α 18 : 19 etc LH /
4 15 4 / GnRH 1 etc etc 4.1 = P 4.2 2 / = / = [ ] 1 : : 2 :
4 16 4.3 + + + + = [ ] SM + [ ]= SM [ ] SM - + SM = [ ] + [ ] = GnRH = SM
4 17 4.3.1 delayed implantation 3 3 4
5 Q54 18 5 Q54 6 Q76 6.1 Ru / 7 Q80 8 Q97
9 19 9 9.1 / 1% 9.1.1 = / 9.1.2 1 / 1. 2. H-Y 3. XX/XY 4. 40 8% 1 1/80 1/200
9 20 9.1.3 XX XX/XY XY/XYY / ex. = & 9.1.4 Bruce effect & 9.1.5 2 2