?
Circadian Rhythm Circa-dian Rhythm (suprachisamatic nucleus; SCN) 24 24
Rat)
Circadian Rhythm (suprachiamatic nucleus; SCN)?
(SCN) SCN
Suprachiasmatic Nucleus
SCN
1. 2. 3. 4. Time lag
1 2 3
Delayed sleep phase syndrome; DSPS Advanced sleep phase syndrome;asps
Seasonal affective disorder (SAD) (
1. 2. 3.
(Phase response curve:prc)
1. 2.
1. 2. 3. 1. 2. 1. 2. 1. 2.
1. 2. B12
Per1 Tei et al. 1997 Nature
INPUT OUTPUT ADJUST THE CENTRAL CLOCK
(Phase response curve:prc)
JET LAG SYNDROME Jet lag syndrome is caused by transient dissociation between the environmental and internal times after abrupt shift of lightdark (LD) cycle. In other words, internal clocks fail to catch up immediately with new environmental light-dark pattern.
CT4 CT16 LIGHT( ) CT16 LIGHT(-) 夜間の光照射では 腹外側部にのみPER1が発現した
DMSCN VLSCN INTERACTION CIRCADIAN RHYTHM LOCOMOTIVE BEHAVIOR HORMONE TEMPERATURE SLEEP etc.
Per
1. 2. 3. 1. 2. 1. 2. 1. 2.
?