50 2 Vol. 2 No. 999
0 Vol. 2 No. 999
5 00 4 Vol. 2 No. 999
5 Vol. 2 No. 999 0 00 0 60 2 27 2
6 Vol. 2 No. 999 0 2 00 4 5
7 Vol. 2 No. 999 2 00 0800 0,500 0 0
9 Vol. 2 No. 999 2 60 02 04 4 6,88 R
() CCU 0DNA (2) () () (2) 0 Vol. 2 No. 999
Vol. 2 No. 999 DIDI () (4) GCP GCP 00 0
600500,000 Evidence-Based Medicine POS 72,000,000 0-862-957/FAX 0-862-466 /22 /2 /7,0000,0005,0000 0426-76-6706/FAX 0426-75-8964 2 Vol. 2 No. 999
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Michaelis-Menten VmaxS V kms VS Vmax kmvmax Michaelis-MentenV SFDose/ Michaelis-Menten VmaxCss.ave SFDose/ kmcss.ave Css.aver SFDose/Css.aveCr Vol. 2 No. 999 5
Css.ave Css.avekm Crphenytoin Vmax/kmVmaxkm Css.avekm Crphenytoin MichaelisMenten 9 CrVdKelKel0.69/t/2 t/2 t/26. VmaxCss.ave Css.aveCr kmcss.ave Vmax Crphenytoin kmcss.ave CrVd0.69/t/2 Vd0.69 t/2 Cr 6. Vd0.69 t/2phenytoin Vmax kmcss.ave Vd0.69 kmcss.ave 6.2 Vmax 60kg 2mg/L20mg/L 0.65L/kgVmax mg/kg/daykmmg/l 60kgVd9L Vmax7.5mg/h 2mg/L Vd0.69 t/2phenytoinkmcss.ave Vmax 9L0.69 mg/l2mg/l 7.5mg/h 24.7 20mg/L 9L0.69 t/2mg/l20mg/l 7.5mg/h 7. 24 20mg/L7 90 6 Vol. 2 No. 999
7 Vol. 2 No. 999 Cfree Cbound Cpat Cadjust Alb.pat Alb.normal Cadjust 4.4mg/dl Cpat Cadjust Alb.pat Alb.normal 6. Cpat Cadjust Alb.pat Alb.normal Cfree CfreeCbound 5mg/L.0mg/dl 5mg/L 0. 2.mg/L 020mg/L 24 Cmax Cpat Cadjust 2.mg/L Alb.pat Alb.normal 5mg/L.0 4.4 0. 0.
LDphenytoin VdCmax LDphenytoin SF LD Vd Cmax F S 58kg 0mg/L 0.920.65L/kg 0.65L/kg58kg0mg/L LDphenytoin.00.92 409.8mg Michaelis-Menten VmaxCss.ave SFDose/ kmcss.ave Vmaxkm Vmaxkm VmaxCss.ave Dose kmcss.avefs 6.4 6.5 205cm 50kg 2mg/L F.0S.0 Vmaxmg/kg/daykmmg/L VmaxCss.ave Dose kmcss.avefs mg/kg50kg2mg/lday mg/l2mg/l.0.0 262.5mg/day F S.0 Vmaxkm VmaxCss.ave Dose kmcss.ave Dose DosekmVmax Css.ave Dose Vmax km Vmax/ Css.ave Dose/Css.aveDose y ax b x Dose/Css.avexDosey DoseCss.ave kmy Vmax Ludden 20 260mg/day mg/l 8 Vol. 2 No. 999
9 Vol. 2 No. 999 00mg/day 0mg/L 2mg/L 260mgmg/L 00mg0mg/L Ludden Vmax476mg/daykmmg/L 2mg/L 7mg mg2mg/l 00mg/day 50mg/day 6.5 VmaxCss.ave Dose kmcss.ave 476mg2mg/Lday mg/l2mg/l 7.mg/day 6.7mg/L Population pharmacokinetics kmdose/ Css.ave VmaxDose/ mg/l50mg/day 476mg/day50mg/day 6.7mg/L
The rd Edition of Michael E. Winter's BASIC CLINICAL PHARMACOKINETICSApplied Therapiutics,Inc. Drug Information 996.2 998.0 0 2 Vol.20No.0 0.50.2ng/ml0.52.0ng/ml Vol.2No.422.7L/kg0.5L/kg Vd=.7L/kg55kg=9.5LVd=0.5L/kg55kg=27.5L 9.5L.0mg/L2.mg/L 27.5L.0mg/L2.mg/L.00.87.00.87 96.7mg28.5mg 20 Vol. 2 No. 999
ddddddddddddddddddddddddddddddddddddddddddddd ddddddddddddddddddddddddddddddddddddddddddddd first impression Secord,P.E.,etal,964 979 Asch,S.E.,946 Vol. 2 No. 999 2
24 Vol. 2 No. 999 PO X
25 Vol. 2 No. 999 Lederer,952
26 Vol. 2 No. 999 Kubler-Ross969 5 ü
27 Vol. 2 No. 999 98 99 997 No.79, 982 99 987 979 FAX FAX 0-294-759
R R 28 Vol. 2 No. 999
29 Vol. 2 No. 999 0. R R R
Vol. 2 No. 999 44
2 Vol. 2 No. 999 80 40 OUTPUT OUTPUT TIP 8 DI
Vol. 2 No. 999 20056 5 2005 455 2,000 2,000 20056
4 Vol. 2 No. 999
5 Vol. 2 No. 999 500 495406 2000 985 NARCISSINON 05 67 0 0 2 4 79 67 Publius Ovidius Naso47 Narkissos
Narcissus narcissist Narcissism Daffodil Persephone Hãdẽs 0 PolyanthusnarcissusTazette narcisse à bouguets, Narcissus tazetta L 045cm 2.5 cmmm 2 Chinense sacred lily, Ntazetta Lvarchinensis Roem. 40cm jonquiljonquille jonquille Njonquilla L 045cm cm poet's narcissus Dichternarzisse jeannette Npoeticus L 045cm0.60.8cm 0cm 4.5cm.6cm daffodillentlilytrumpet narcissus OsterglockeTrompetenndrzisse 6 Vol. 2 No. 999
aiaultcoucoufaux narcisse Npseudonarcissus L 5cm0.5.cm cm 920 campernelle jonquil campernellegrande jonquille N odorus L 5cm 8cm.2cm 0 0cm cm m 2 0g25g 25g 0 5cm 2cm 5cm LicorineTazettine Glucomannane27 EugenolBenzaldehyde Benzoic acidester NarcissinLinalool Benzylacetate BenzylalcoholTerpineol cineol Vol. 2 No. 999 7
90942 95025 96944 2 95429,000 200 8 Vol. 2 No. 999
4 Vol. 2 No. 999 0 0 896 4897 5898 99 994 995 996 997,970,20,095 550 80 699,27,960 8,44 6,82 7,02 25,702 5,75 26,25 46,27 9,989 64 9 0 2 5 5 8 9.5 0.7.8 46.7 4. 7.7 8. 20.4 9.9.9.0 20.6 28.6 2.2 6.8.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0. 0.0 0.0 0.0 0.0 0.0 0.0
42 Vol. 2 No. 999 7 20 550 85 4 6 2 0 7 9 6 4 2 2 76 4 5 87.0 70.0 26.0. 0.4 20.0 6.7.6. 2.5 0.4 0.2 0.4.8 7.5 6.4 5.8 80 605 205 72 224 6 9 0 4 0 8 20 2.0 72.9 24.7 8.7 27.0 4.0.9 2. 0..7 0.5 0.4 2.2 9.8 2.4 4.6 699 56 79 60 245 20 20 20 6 28 5 72.0 80. 25.6 8.6 0.4 5. 2.9 2.9.6 2.9 0.4 0.4 9.0 4.0 5.0 0.,27 969 50 44 292 79 27 5 65 4 7 46 27 7.0 79.6 28.8.6 0. 24.0 4.7 2.2 0.4 5. 0.2 0.2 0. 6.0.8 2.2 4.,960,60 52 5 2 568 76 2 0 257 6 5 88 56 2 27.0 8.2 26.6 2.6 0. 29.0 9.0.2 0.5 0.2. 0.2 0.8 0. 4.5 2.9.6 2.
0.00.5 2 0.0.2 978 982 57 HUS 9,49242 2HUS.4 6.Salmonella spp. 2.Vibrio parahaemolyticus.escharichia coli 4.Staphylococcus aureus 5.Clostridium perfringens 6.Bacillus cereus 7.Campylobacter jejuni 8.Campylobacter coli 9.Clostridium botulinum 0.Yersinia enterocolitica.vibrio choleras non-ol 2.Vibrio fluvaialis.vibrio mimicus 4.Aeromonas hydrophila 5.Aeromonas sobria 6. Plesiomonasshigelloides.Shigella spp. 2.Vibrio cholerae Ol.Salmonella serovar Typhi 4.Listeria monocytogenes 5.Yersinia pseudotuberculosis 6.Streptococcus spp. 7.Vibrio vulnificus.small Round Structured Virus 2. Vol. 2 No. 999 4
44 Vol. 2 No. 999 550 90 2 28 4 5 4 2 2 4 2 5 6 6 45 72 25.0 6.4.8 5. 7.5 0.9 0.2 0.7.8 2.2 5.6 7.8 0.4 6.4.. 8.2. 22.7 80 07 42 6 49 6 2 4 7 9 2 2 88 75 2 7 68 267 207.0 2.9 5..9 5.9 0.7 00.2 0.5 2.0 2. 0.2.9 0.6 0. 9.0.4 2.0 8.2 2.2 24.9 699 08 27 0 5 7 7 22 8 7 8 8 7 7 69 258 55.0 5.5.9 4. 7..0.0. 2.6 2.4 5.4 0.4 2.6 2.4.0 9.9 6.9 22.2,27 44 4 2 80 8 8 2 5 2 8 59 5 2 6 8 506 2.0.8.5.7 6.6 0.7 0.7.9 2.9 0.2.5 4.8 0. 2.9.9. 6.8 4.6 26.5,960 74 52 28 94 9 9 0 7 2 8 78 46 6 0 8,57.0 8.9 2.7.4 4.8 0.5 0.5.5.9 0. 0.9 4.0 0. 2..6 0.8 5.2 7.2 59.0
45 Vol. 2 No. 999 982 From Farm To Table 550 96 2 22 6 75 8 8 5 6 7 55.0 7.5.8 4.0..6 2.9.5 0.9.5 0.2. 0.0 80 55 42 2 5 08 280 9 5 67 2 7 98.0 8.7 5..9 0.6.0.7..8 8. 0.2 2.0.8 699 95 0 2 72 25 8 66 9.0.6 4..0.9 0. 6.2..6 9.4 2.7 5.9,27 8 59 4 5 04 57 4 20 74 2 6 0.0 5.0 4.8.5.2 8.5 29..2.6 6. 0.2. 27.,960 426 62 2 46 4 7 2 8 725.0 2.7.2.7. 7.4 2. 0.4 0.6 4. 0..7 7.0
HACCP 54 7 55 2 2,697 84 26 665 27 72 54 776 6 56 7,85 25 79,529 999,8 50 967 0,004 06 559 020 595 8,26 54 2 850 7 825 26 67 0 57 06 790 02 780 4,989 26 689 5,59 29 90 559 5 70 24,8 025 644 0,922 7 527 0 602 2,758,044 26 744 222 66 8,29 46 Vol. 2 No. 999
47 Vol. 2 No. 999 NASA From Farm To Table 05 05 75 65 0 O57520 75
48 Vol. 2 No. 999 0 // 0
Preventive Medicine 99726607 Preventive Medicine 9972662 80 nocebo effect placebo effect, 47 nocebo effect placebo effect.7 962 2, 50 Vol. 2 No. 999
Bri Med J 996624 Drug Development Research 9920 Lancet 958i08 J Clin Psychopharmacology 98224245 50 67 55 bioequivalence Drug Development Research 9920 J Clin Psychopharmacology 98224245 Bri J Psychiat 97220507 Bri J Med 996569 PTP PTPpress through packing PTP press through packing MEDLINB PTPpress through packing PTPblister packblister pak blister wrappedtablet or capusule, blister PTP PTP PTP PTP PL lancet 9964728 Otolaryngology Head and Neck Surgery 99526747 Vol. 2 No. 999 5
0 500 6 0-004 -29-5F TEL 0-69-9842 FAX 0-69-9777 009007040
5 Vol. 2 No. 999 950 5060 70 90GDP5 HMOMGO MGO HMO OBRA 90
54 Vol. 2 No. 999 QOL SOAP SO A P HMO 65
55 Vol. 2 No. 999 6 945 6 92 82 98 97 80 0 7 5000 9927,600 6,6005,000 7,500 9,0000 9995
997 90 050 97080 0 970 56 Vol. 2 No. 999
200 OK Vol. 2 No. 999 57
DI REPORT 58 Vol. 2 No. 999 DI NSG-L SG-L NSG SG-L SG N SG-L -L -N UHBKGApHNSL UHAGKBNSpH UHAGKBSpH UHAGKBNpH UHAGKSpH UHAGKBpH UHAGSpH UHAGKpH UHAGpH UAGpH HAGpH AGpH ApH GpH B H K U G'' '' '' BM0 BM9 BM9-RL BM8- BM6L BM5L BM6 BM6-0 9 9 8 8 8 7 7 7 6 5 5 4 4 2 2 0 9 8 8 7 7 6 6 5 4 4 2 2 0 9 9 8 7 6 6 6 0 9S 8S 8 7S 7 6S 6 5 4U 4 A G B H K U 50,0,0,0,0,0,0,0,0,0,0,0,0 50 9500 9000 9000 700 8400 8000 6200 7000 700 6600 5700 5700 4700 4000 600 2800 2000 000 600 2500 2800 000 500 000 2500 500 400 9500,85500 8600,77400 6800,6200 7600,68400 6200,55800 5800,52200 5500,49500 5200,46800 4500,40500 2800,26600 200,28800 400,2600 900 900 2000 2400 2000 2000 200 7500 4500 700 0 0 00 9000 8400 7200 8000
DI REPORT 59 Vol. 2 No. 999 BM4- BM- BMGPS- BMPGU- BMBU BMLN BM5000 BMS BM BMMAU 0s 0 9a 9s 8a 8s 7a 7s 6a 5a 5b 5 4a 4b a b h k -MN -M -Tf -Te -Tc -Kc -Pc -Tb -Db -Ga 8 7 6 5 4B 4U B K U 2 G P B 0EA 9EA 8EA 7EA 6EA 5EA 4EA L U GPB GPU 8 6 5 B K U U-7 U-5 BIO-Gen8 BIO-Hemo GP/ ph-u-- 4 2 2 0 0 0 9 9 8 8 7 7 6 5 5 5 4 4 2 2 8 7 6 5 2 2 8 7 6 5 4 4 2 0 9 8 7 6 5 4 0 6 4 4 2 8 6 5 7 5 8 50, 50 50 50 2,0,0,0,0,0,0 50 50 50 50 25 0 6400 2000,4000 600 4200 2600 200 000 2000 500 7800,9000 8000 8500 8000 7600 6800 5800 6200 5200 5500 4500 500 200 4400 2900 200 2000 2000 2400 2000 7500 6500 6000 5,4000 200 800,26000 2400 700 2600 500 7600 5800 5200 4200,500 200,24000 2800 2400 2500 2400 400,200 50 200 200 400 9500 9000 8000 700 6600 5700 4700 9000 2800 2000 500 750 2650 4500 4500 4000 000 000 000 700 5700 7400 400 800 60-97
50 9 56 72 600 662 6465 6567 6770 024 8 67 69 60 Vol. 2 No. 999
6 Vol. 2 No. 999 74 0 88
6 Vol. 2 No. 999 028 29 5 4 6 20 2 2 24 25 27 28 2.2 29.0 29.0 6. 6.5 25.8 22.6 6. 29.0 2.9 25.8 45.2 67.7 0 2.9 87. 47.4 25. 8.9 0.5 7.4 24.2 20.0 8.4 26..5 5.8 64.2 64.2.2 6. 90.5 7.7 2. 57.5 6.6 0. 8. 8.9 9.8 2.9.7. 79.4 59..2 2.0 96.8 7. 62.9 9.8 27.8 8. 7.2 57.7 2.6 56.0.4. 57.7 49.5 2.4 5.2 82.4 92. 78.8 96.2 7. 80.8 88.5 84.6 75.0 84.6 26.9.8 40. 5.8 40.4.5 48. 27.6.0 20.7.0 0 0. 0..8 0.4 24. 4.4 48..4 6.9 89.7 8.8 8.4 4.8. 6..2 4..2 9.4 6. 0.2 5.0 5. 0 2.0 98.0 70.4 7.0 74.8 27.4 7.8 27.8 55.7 22.2.7 6. 7.0 60.9 49.6 0.8. 97.9 7. 5.5 90. 42.6 42.6 7.6 45.5 8.8 67. 5.8.9 40.6 59.4 5.0.0 92.0 97.9 80.9.0 6.7 80.9 66.0 6.8 66.0 9.5 25.5 0 6.7 42.6 7.0 6.4 76.6 65 554 B D E A B C D E A
64 Vol. 2 No. 999 2 70 75 X 5 2 20 2 22 2YMCA 27 28
65 Vol. 2 No. 999 0 2000 2000 0 0 2 0 50409 4 584 2728 60 20 4,8074,70 60540 7 8 8 927,92 0 0 2 20 20
0-294-027 20 7955 26 22 5 278 00 0-0054 2 294027 66 Vol. 2 No. 999