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17 RI 16 H16.3 H12.10 H8.4 S54.4 H15.4 H12.4 H17.5 H12.12 H16.9 H17.4 H17.4 H17.5 H17.10 H18.2 DNA PCRDNA MALDI-TOF/TOF 50 300-44 -
DNA - 45 -
http:/www.gifu-u.ac.jp/~lsrc 2 (2005 ) - 46 -
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2005 4 21 17 RI 2005 6 4 2 2005 7 22 4 Jr. 19 15 2005 8 10-54 -
2005 12 15 5-55 -
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; 600 ; DNA Zeiss Beckman Beckman TOMY Beckman BIORAD GenePulser CCD Zeiss CCD Zeiss Zeiss Lumat BIORAD PDS-1000DNA ABI373AABI310ABI3100 Procise clc GE Typhoon Affimetrix Becton DickinsonHPLC 290 146 95 28 5 16 67 56 2 2 1 6-57 -
1 FACS FACS 1FACS Calibur 2 3 2RI RI 16-58 -
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1. 2. - 60 -
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RI RI - 74 -
RNA in vitro RNA I sirna CYP3A H The Replication Fork Protection Complex Drexel University College of Medicine H H H Vibrio furnissii Vibrio cholerae Rochester - 75 -
Gateway DNA l ND1000 Miniscope TM1000 DNA BZ8000 ZOOM IPG SSH 17 17-76 -
DNA 1 I - 77 -
DNA 1,753 m 2 RI RI P1 P2 P3 DNA 233 DNA RI 123 17 4 21 178 17 5 20 MRC DNA Dr. David Loakes (MRC, Laboratory of Molecular Biology, Cambridge, UK) - 78 -
DNA 17 7 10 DNA DNA SSP 40 in vitro DNA II III MATE DNA - 79 -
15 4 4 5 5 12 16 10 15 RI 16 14 DNA 15 DNA 2 DNA DNA 22 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. - 80 -
13. 14. 15. 16. 17. 18. 19. 20. 21. CCD 18 3 31 13 57 3 1 1 49 38 2 ( )15 50 230 86 425 519 830 831 922 111 123 ( ) - 81 -
GeneChip technology 20 12 16 ( ) DNA DNA 1. 2. 3.PCR 4.RNA 5.RT-PCR 6. 7.DNA 14 7 7 81 8 5 ( ) (1) (2) DNA (3) DNA (1) (2) DNA (3) - 82 -
6 13 73031 ( ) D Jr. 1 2 DNA 3RFLP 4PCR 5 DNA 6RT-PCR 7 25 1223 12 25 ( ) 17 4 26 5 10 17 6 27-83 -
DNA 527 4568 1568 3030-84 -
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Hara, K., Okamoto, M., Aki, T., Yagita, H., Tanaka, H., Mizukami, Y., Nakamura, H., Tomoda, A., Hamasaki, N., Kang, D., Synergistic enhancement of TRIL- and tumor necrosis factor a-induced cell death by a phenoxazine derivative, Mol. Cancer Ther.4 (7), 1121-1127 (2005) Aki, T., and Mizukami, Y., Regulation of Cardiomyocyte functions by distinct phosphoinositide 3-kinase, Molecular Mechanisms of Heart diseases, (Edits Mizukami, Y. and Ohkusa, T.) Publisher Research Signport, 85-99 (2005) Kimura, Y, and Mizukami, Y.,and Matsuzaki, M., Orphan G protein-coupled receptor and ischemia, Molecular Mechanisms of Heart diseases, (Edits Mizukami, Y. and Ohkusa, T.) Publisher Research Signport, 99-113 (2005) - 86 -
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RI DNA P2 P3 DNA DNA DNA DNA C TOF-MS 3130 Avant - 94 -
in DNA type III - 95 -
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IV100-104 -
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17 4 2 3 FSRC 2 ( ) 30 30 RNA P3 DNA 4 1 RI -80 CCD TOF PCR [450 ] 17 17 13 1 1/4 6 5 17 2 4 1 30 3-111 -
DNA 17 1 1 17 3 30 DNA 4648 250 /1 758 1000 /1 370 PCR46 TOF 925 26 DNA 101 20 88 345 2 2 L5 FL 3 20 3 24 () 8 4 DNA 8 6 30 11 6 4 8 9 2 4 (3 ) (9 ) 2 17 9 11 19 12 17 11 6-112 -
500-113 -
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68 1 6 15 36 1 4 130-115 -
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