第124回日本医学会シンポジウム
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- ありあ あさま
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1 III γ γ γ α γ Molecular Mechanism of Insulin Resistance by Adipocytes TAKASHI KADOWAKI Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo Key words γ
2 TNFα FFA 1,2 TNFα FFA 1,2 FFA FA-CoA IRS-1 IRS-2 PPARγ α 111
3 γ α α γ α
4 PPARγ 4 DNA 4,5PPARγ TNFα Acrp 30 AdipoQ GBP 28 5,6 FFA Ad globular gad FFA γ α α 113
5 2 6 2 KKAy 6 6,7 in vitro PPARα 8PPARα CoA ACO β UCP 2 AMP β α
6 PPARγ PPARγ 5 6,10 10 FACS fluorescence-activated cell sorter γ γ γ γ γ γ α PPARγ 115
7 α α cdna small interfering si RNA Globular cdna
8 α 7 AdipoR 1 AdipoR AdipoR 2 AdipoR 1 AdipoR 2 AdipoR 1 R2 7 G GPCR N C topology GPCR AdipoR 1 R2 globular AMPK p38mapk PPARα AdipoR AMPK p38mapk AdipoR AMPK p38mapk sirna AdipoR 1 R2 globular PPARα 8 9 AdipoR 1 R2 globular AMPK p38mapk PPARα AdipoR 1 R
9 1 Okuno A, Tamemoto H, Tobe K, et al. :Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. JClinInvest1998 ; 101 : Yamauchi T, Kamon J, Waki H, et al. : The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma PPAR gamma deficiency and PPAR gamma agonist improve insulin resistance. JBiolChem2001 ; 276 : Kadowaki T : Insights into insulin resistance and type 2 diabetes from knockout mouse models. JClinInvest 2000 ; 106 : Kubota N, Terauchi Y, Miki H, et al. : PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999 ; 4 : Yamauchi T, Waki H, Kamon J, et al. : Inhibition of RXR and PPAR gamma ameliorates diet-induced obesity and type 2 diabetes. JClinInvest2001 ; 108 : Yamauchi T, Kamon J, Waki H, et al. : The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 2001 ; 7 : Hara K, Boutin P, Mori Y, et al. : Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002 ; 51 : Yamauchi T, Kamon J, Waki H, et al. : Globular adiponectin protected ob ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 2003 ; 278 : Yamauchi T, Kamon J, Minokoshi Y, et al. :Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine 2002 ; 8 : Yamauchi T, Kamon J, Ito Y, et al. : Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003 ; 423 : T3L1 3T3L1 TNF-α cis-acting element in vitro TNF-α NF-κB TNF-α TNF-α TNF-α
10 β β β Adipo R 1 Adipo R 2 β β SNP SNP 2 SNP Reitman 119
11 Reitman Reitman Reitman Reitman Diabetes Reitman G C N C N N reviewer C N G C N
12 7 Adipo R 1 121
第124回日本医学会シンポジウム
IV β Therapeutic approaches to obesity HIRONOBU YOSHIMATSU Department of Internal Medicine 1, Faculty of Medicine, Oita University Key words 124 124 1,2 BAT uncoupling protein 1UCP1 1,3 A 1 α-fluoromethylhistidinefmh
15K00827 研究成果報告書
(TG) TG sterol regulatory element- binding protein (SREBP)-1c (Diabetes 53:560-569, 2004) SREBP-1c (1) SREBP-1c SREBP-1c liver X receptor (LXR)LXR O-Glc NAc (O-linked -N-acetyl glucosamine) (J Biol Chem
一般演題（ポスター）
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平成１４年度 本態性多種化学物質過敏状態の調査研究 研究報告書
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研究成果報告書
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東洋医学雑誌
Vol.61 No.7 924-929, 2010 a b c d Naoki OKADA ad Masaru NATSUAKI b Takashi NISHIMOTO ac Nishimoto Clinic, 2-8-31 Koshienguchi, Nishinomiya, Hyogo 663-8113, Japan Department of Dermatology, Hyogo College
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第89回日本感染症学会学術講演会後抄録（I）
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日本脂質栄養学会第12回大会へ参加される皆様へ
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第85 回日本感染症学会総会学術集会後抄録（III）
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研修コーナー
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