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研究成果報告書

THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec LVFX 100 mg 3 / mg 2 / LVFX PK PD mg mg 1 1 AUC/MIC

Transcription:

Molecular Targeted Therapy for Lung Cancer from a Pharmaceutical Point of Viewe Naho SASAKI epidermal growth factor receptor tyrosine kinase inhibitor :EGFR-TKI vascular endothelial growth factor:vegf mg ph ph phauc mg Cmax. AUC Key words

mg mg CYP A CYP A CYP A AUC CYP A AUC CYP A CYP A ph H ph INR PT-INR CYP A CYP A CYP A AUC CYP A CYP A AUC Cmax CYP AAUC in vitrougt A UGT A

H.. EGFR SPF..

.... PS PS..

mg/kg + +

. JO VEGFNO NONa / mmhg mmhg Common Terminology Critetia for Adverse Events Ver.. VEGF VEGF /..L

/. /. G-CSF.. EGFR-mutation.... Wacker B, Nagrani T, Weinberg J, et al:correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase studies. Clin Cancer Ras,:-,... Sane DC, Brosnihan KB. Angiogenic growth factors and hypertension. Angiogegesis.: -,. Saif MW, Mehra R. Incidence and management of bevacizumabrelated toxicities in colorectal cancer. Expert Opin Drug Saf. : -,.