2 Key words 2 Type 2 diabetes Insulin resistance Impairement of insulin secretion Spontaneously diabetic model animal high-fat diet diabetogenic gene 1 2 2 2 2
2 1 2 2 SMXA-5
3 SM.A-T2dm2sa SMXA-5 SM/J A/J 2 HND Horio-Niki diabetic 4 HND 5 HND C57BL/6J(B6) 6 (A) 12 (B)
6 HND C57BL/6J(B6) 7
Diabetogenic factors of type 2 diabetes Studies in spontaneously diabetic animal models Type 2 diabetes, Insulin resistance, Impairement of insulin secretion, Spontaneously diabetic model animal, High-fat diet, Diabetogenic gene Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University Key words