=7y/> *-z r f -t V)t /ttv 2mg t-z rf,t Y)t/ttv 5mg t-7 rf -t Y)t7ttv l}mg
NTBC2mg NTBC5mg NTBClOmg
Cmax (uelml) rt,z
Boehringer Ingelheim
5ng n=6 ttzz s rhl
CLn ezl ImLlnin]
,l5ue(n=70)
Page 1
Page2
Page 3 AUCsasp (oo. hrlml-) tttz ftr) Xn-4 lvz (hr)
Page 4 x:u:6il
Page 5
A:.attt @nzrs
Trz (h)
p<0 000f' -2 3Yol 4. 743?q o. rz4okl'
(mean*sd. n=12)
34.5 mg
CL (ml,/midkg) trn (min)
l6 1ms ll I nrq )--< 2 ::- l. - 1y o 17 ilrq
itif fllf f
tb NovARr I s
trfl4^/l^7
Cmax (uglml)
300m9 I 50mg I 5omg 75nC tlogisticelb (60t181fl\ 3E/62$l 15mg 300mg 75mg 300ng I 5Omg 15mg
3inaruho vltrfifft=ta?t
tlr NovnRr I s
trb+^/l^7,
Cmar (ug/ml)
l5omg 75mE 300m9 300mg I 5omg l5omg 75mg 75mg t289/3t2lf'l\
tlttl: E-*9:(xFl7:3() (frbeuetriern<) w\,\rw. novartis.co.jp 0120-003-293 3inaruho vlt,fi#frrte?t
PtviFTzffiz+omg
Grade 4
c.- Lti2 I pg/nl) (h)
- <^,'r=^ ------ rrtu,1tta -flrffi I 16@ll frll\t>r M 2S l9 137 98 fl 39 20 9 I I ^Laa'=1* M 3n 26 ua t62 lll & $ 14 6 I A4Fffi H (OS) O Kaplan-Meierffi fr (2010+I2E30E h v lt7)