7 1,315 213 KPA.1 IU/mL 21 9% 22 44 75%.1 IU/mL 1975 DPT 45 49 39.7% 5 22.1% Clostridium tetani 1 21 213 4 16 118 118 128 1948 1952 1959 1964 DPT 1968 1975 2 1 4 DPT 1981 DTaP212 DPT-IPV 7 7 1,315 1 2 213 7 1 KPA.2 IU/mL - 259 -
IU/mL.1 IU/mL A 5 1-19 11,315 581 44.2% 5 78.9% 6.% 7 B 1 3 29 96.7%.1 IU/mL 3 4 1 2.1 IU/mL 1 2 5 3 1 21 1 2 9% 22 38 85%.1 IU/mL 3 1 39 77.8% 7/9 4 43 9% 39 3 1 4 2.1 IU/mL 9% 3-34 8% 64.6%4-44 81.5% 4 2 1975 DPT 35 39 65 54 71% 61975 44 75.% 12/16.1 IU/mL 3 145 49 39.7% 25/635 22.1% 41/185 4 21968 DPT 1968 213 45 45 45 248 27 83.5% 6 C 7 5 3 5 2 7 D 1998 23 28 213 1998 5-26 -
4-1 213 1964-1968 28 23 4-44 4-1 E 2 3 4 5 94.9% 98.% 99.3% 1%1 24 47 79.2% 44.7% 8 6 45 1968 1 URL: http://www.nih.go.jp/niid/ja/survei/285-idwr/ydata/5195-report-ja213-3.html - 261 -
1 The number of examinees for tetanus susceptibility investigation by age group in each prefecture 213 Prefecture Age group years -4 1-19 2-29 3-39 4-49 5-1315 29 161 265 211 14 144 185 Hokkaido 139 2 19 2 2 2 2 2 Tokyo 358 91 51 72 47 21 28 48 Fukui 138 8 5 25 32 19 18 31 Aichi 14 13 19 28 2 2 2 2 Ehime 188 44 3 3 2 22 22 2 Kochi 22 9 2 68 47 16 15 27 Fukuoka 15 24 17 22 25 22 21 19-262 -
2 Age group distribution of tetanus antitoxin titer by prefecture 213 Prefecture Age group years Antitoxin titer IU/ml.1.1.32.1.32 1. 3.2 1. / / / / / / /.31.99.319.999 3.199 9.999 G.M.T. Hokkaido 139 21 6 9 1 21 38 34.9 2 1 1 1.8 18 1 2 2 2 7 4.8 19 1 1 2 4 11 2.1 1-14 9 1 1 1 2 3 1.4 11 1 4 5 1 1. 2-24 14 1 1 3 5 4 1. 6 1 3 2 1.6 3-34 6 2 1 1 2.9 14 2 1 2 1 3 5.9 4-44 8 1 1 2 2 2.8 12 5 2 2 2 1.2 5-2 12 1 1 1 4 1.8 Tokyo 358 41 12 43 56 54 11 36 15.6 8 1 1 2 3 1.7 83 1 5 12 13 34 13 5 1.1 51 1 1 7 4 8 16 1 4 1. 1-14 41 1 2 7 11 3 12 4 1.4 31 1 4 6 5 11 2 2.6 2-24 27 1 7 3 5 7 3 1.4 2 2 5 7 5 1.4 3-34 14 2 3 5 3 1.5 7 1 1 3 1 1.6 4-44 16 3 2 3 6 1 1.7 12 5 1 4 2.2 5-48 31 4 6 3 3 1.1 Fukui 138 35 6 11 11 45 26 4.4 3 1 1 1.1 5 2 1 1 1.2 5 1 1 2 1.9 1-14 5 1 1 1 2.1 2 1 9 9 1.8 2-24 16 1 2 11 2.4 16 3 1 3.5 3-34 9 1 1 1 5 1.8 1 1 2 3 2 2.2 4-44 1 1 1 2 4 2.3 8 3 1 3 1.3 5-31 27 1 2 1.1 Aichi 14 28 5 7 12 31 4 11 6.8 4 2 1 1 1.3 9 6 3 2.6 19 1 1 2 7 4 2 2.8 1-14 16 2 3 6 2 3 1.4 12 1 2 2 6 1.9 2-24 5 3 2 1.1 15 2 1 2 4 5 1.7 3-34 11 2 2 2 4 1.9 9 1 3 1 1 2 1.1 4-44 13 1 3 5 4.5 7 5 1 1 3.6 5-2 18 1 1.3 Ehime 188 32 3 6 17 46 62 12 1.9 7 1 5 1 1.8 37 1 1 2 14 1 9 3.6 3 2 1 4 9 13 1.5 1-14 3 1 4 3 13 9.5. 2-24 1 2 6 2.5 1 1 1 5 3.5 3-34 11 1 4 5 1 1. 11 1 2 2 6.8 4-44 13 2 3 3 5.6 9 8 1.6 5-2 18 1 1.1-263 -
2 Age group distribution of tetanus antitoxin titer by prefecture 213 Prefecture Age group years Antitoxin titer IU/ml.1.1.32.1.32 1. 3.2 1. / / / / / / /.31.99.319.999 3.199 9.999 G.M.T. Kochi 22 33 11 19 1 45 41 18 25.8 5 1 1 3.7 4 1 1 2 1.3 2 4 2 9 2 2 1.4 1-14 25 2 2 1 6 5 9 3.4 43 2 4 3 1 9 5 1 1.3 2-24 38 3 1 5 3 11 1 5.6 9 1 1 5 2.4 3-34 12 2 1 1 3 3 2.4 4 1 1 1 1.5 4-44 1 1 1 1 5 1 1 1.3 5 4 1.3 5-27 2 6 1. Fukuoka 15 32 2 11 9 35 36 13 12.9 1 1.3 23 6 11 1 5 2. 17 1 1 4 6 3 2 1.4 1-14 21 1 1 2 8 6 3 2.2 1 1.6 2-24 14 3 1 2 5 3.4 11 1 1 3 3 3.4 3-34 12 2 5 3 2.8 1 1 2 1 5 1.3 4-44 11 2 2 3 2 2.6 1 8 2.1 5-19 18 1.1-264 -
3 Age distribution of tetanus antitoxin titer 213 Age years Antitoxin titer IU/ml.1.1.32.1.32 1. 3.2 1. / / / / / / /.31.99.319.999 3.199 9.999 G.M.T. 1315 222 45 16 125 277 344 128 68.7 3 1 1 1 2 9 12 3 1.9 1 66 3 2 5 7 12 16 1 11 1.3 2 34 1 4 1 15 6 7 2.4 3 42 1 2 4 4 21 8 2 1.2 4 37 1 8 2 7 1 1.6 5 36 1 4 11 14 6 3.2 6 24 2 2 5 7 8 1.2 7 21 2 3 6 5 4 1.8 8 35 1 2 6 6 9 8 2 1.4 9 45 2 5 3 16 16 2 1.5 1 13 3 5 4 1.2 11 35 1 1 5 8 8 11 1.4 12 54 4 2 3 2 9 17 6 11 1.4 13 28 1 3 1 3 7 9 4 1.5 14 17 1 3 2 8 2 1.8 15 4 3 1 1.7 16 3 1 2 1.1 17 16 3 4 1 7 1.5 18 6 2 1 5 4 19 18 5 6.8 19 35 1 1 3 11 1 3 6 1.3 2 5 3 2 7 6 18 1 3 1.4 21 21 1 1 2 6 7 4.7 22 15 2 1 1 7 2 2.6 23 19 1 3 9 6.6 24 19 4 2 4 6 3.5 25 21 1 1 1 2 11 4 1.4 26 16 1 4 7 4.5 27 18 2 1 1 5 8 1.8 28 18 1 1 4 7 4 1.5 29 14 1 4 4 4 1.4 3 18 1 1 2 4 4 3 2 1.5 31 18 1 1 3 7 4 2.5 32 11 3 5 3 1.8 33 13 1 1 3 2 6.6 34 15 2 5 6 1 1.8 35 1 1 2 3 3 1.6 36 14 1 2 2 3 4 1 1.5 37 14 1 2 2 1 3 2 3.4 38 18 2 2 1 7 5 1.5 39 9 2 2 2 3.1 4 16 1 7 5 2 1.4 41 16 1 1 1 5 7 1.7 42 14 1 3 2 5 1 2.8 43 19 1 1 4 4 7 2.7 44 16 4 1 1 2 2 5 1.5 45 2 7 1 3 3 5 1.2 46 12 9 1 1 1.1 47 7 4 1 2.1 48 13 9 3 1.8 49 11 9 1 1 8.1 5 1 7 1 2 1.4 51 11 9 1 1. 52 8 7 1.5 53 1 5 1 1 2 1.4 54 2 15 2 2 1.1 55 13 12 1.1 56 12 1 1 1.6 57 5 3 1 1. 58 8 7 1. 59 11 1 1.3 6 7 4 2 1.1 61 13 1 1 1 1.1 62 7 6 1. 63 9 8 1. 64 7 5 1 1.2 65 6 3 1 1 1.1 66 5 5. 67 4 3 1. 68 2 2. 69 2 2. 7-15 11 3 1. - 265 -
4 Age group distribution of tetanus antitoxin titer 213 Age group years Antitoxin titer IU/ml.1.1.32.1.32 1. 3.2 1. / / / / / / /.31.99.319.999 3.199 9.999 G.M.T. 1315 222 45 16 125 277 344 128 68.7 3 1 1 1 2 9 12 3 1.9 179 4 3 8 15 25 72 31 21 1.5 161 1 4 16 14 4 47 3 9.9 1-14 147 6 4 17 16 26 44 18 16.8 118 3 1 9 12 31 4 1 12.9 2-24 124 6 3 15 12 44 31 12 1.5 87 4 2 4 15 34 24 4.5 3-34 75 2 2 6 1 21 24 8 2.7 65 7 8 8 5 16 14 6 1.4 4-44 81 6 2 7 14 18 26 4 4.6 63 38 2 4 6 8 3 1 1.3 5-185 144 13 11 4 5 7 1.1 Age months 5 Age distribution of tetanus antitoxin titer in infants Antitoxin titer IU/ml.1.1.32.1.32 1. 3.2 1. / / / / / / /.31.99.319.999 3.199 9.999 G.M.T. 3 1 1 1 2 9 12 3 1.9. 1. 2 1 1. 3. 4 1 1 1.3 5 1 1.3 6 3 2 1 2.6 7. 8 3 1 1 1 1.7 9 2 1 1 1.3 1 12 1 2 4 4 1.7 11 7 1 2 4.5-5 3 1 1 1.6 6-11 27 1 1 2 8 11 3 1.9-266 -
6 The number of examinees for tetanus susceptibility investigation by vaccination history and age group 213 Age group years 1-14 2-24 3-34 4-44 5- Vaccination history Vaccinee 1 1 dose 2 2 doses 3 3 doses 4 4 doses 5 5 doses Others A B C D E F G H Nonvaccinee Unknown Vaccinee % 1315 47 24 78 1 32 54 129 581 93.6 3 1 2 14 7 6 95.8 179 3 2 41 77 2 18 98.1 161 1 19 9 94 13 25 1. 147 3 2 8 1 5 29 17 28 97.5 118 4 4 9 8 32 12 2 29 95.5 124 4 7 4 5 24 7 14 59 93.8 87 1 6 2 8 5 9 56 1. 75 2 2 11 7 53 1. 65 2 1 2 3 3 6 48 88.2 81 6 2 2 2 1 5 63 66.7 63 5 1 1 1 5 5 61.5 185 19 6 5 3 6 146 51.3 Vaccinee % = B+C+D+E+F+G / A+B+C+D+E+F+G 1 Primary vaccination series : 4 doses DPT or DPT-IPV / Booster vaccination : 1 dose DT DPT : diphtheria-pertussis-tetanus combined vaccine / DPT-IPV : DPT-inactivated poliovirus combined vaccine DT : diphtheria-tetanus combined toxoid Prefecture Hokkaido Tokyo Fukui Aichi Ehime Kochi Fukuoka 7 The number of examinees for tetanus susceptibility investigation by vaccination history and prefecture Vaccination history Vaccinee Vaccinee Nonvaccinee 1 2 3 4 5 Unknown % 1 dose 2 doses 3 doses 4 doses 5 doses Others A B C D E F G H 1315 47 24 78 1 32 54 129 581 93.6 139 3 51 12 73 1. 358 7 5 5 53 151 32 36 69 97.6 138 3 5 4 8 28 2 9 52 65.1 14 14. 188 3 4 13 69 3 21 75 1. 22 7 13 14 22 1 39 97 1. 15 1 1 1 12 32 7 12 75 86.7 Vaccinee % = B+C+D+E+F+G / A+B+C+D+E+F+G 1 Primary vaccination series : 4 doses DPT or DPT-IPV / Booster vaccination : 1 dose DT DPT : diphtheria-pertussis-tetanus combined vaccine / DPT-IPV : DPT-inactivated poliovirus combined vaccine DT : diphtheria-tetanus combined toxoid - 267 -
8 Age group distribution of tetanus antitoxin titer by vaccination history 213 Vaccination history Age group years Antitoxin titer IU/ml.1.1.32.1.32 1. 3.2 1. / / / / / / /.31.99.319.999 3.199 9.999 Non-vaccinee 47 26 4 3 1 5 8.8 1 1. 3 2 1.6. 1-14 3 1 1 1.1 4 1 3 1.4 2-24 4 1 1 2.9. 3-34. 2 1 1 1.3 4-44 6 1 1 1 2 1.7 5 3 1 1.7 5-19 18 1. G.M.T. 1 2 3 Vaccinee : 1 dose 24 5 3 1 2 1 6 5 1 2.5.. 1 1.1 1-14 2 1 1. 4 1 2 1 3.7 2-24 7 1 1 3 2 2.6 1 1.2 3-34 2 2 4.8 1 1 5.1 4-44.. 5-6 3 2 1.7 Vaccinee : 2 doses 78 4 3 5 9 18 23 16 1.8 2 1 1 2.9 2 1 2 2 3 7 5 2. 19 1 2 3 5 8 2.7 1-14 8 1 1 1 2 2 1 1.3 9 2 2 2 2 1 1.2 2-24 4 3 1.7 6 1 2 3 1.2 3-34. 2 1 1.6 4-44 2 1 1 1.6 1 1 1.3 5-5 2 1 1 1 1. Vaccinee : 3 doses 1 2 5 12 17 25 24 6 9 2.1 14 1 2 4 6 1 1.4 41 1 6 8 7 11 4 4 2.3 9 1 1 2 2 2 1 1.7 1-14 1 2 2 4 2.7 8 1 1 2 1 1 2 3.5 2-24 5 2 2 1.7 2 2.5 3-34 2 1 1.3 3 1 1 1 7.1 4-44 2 1 1 6.1 1 1.3 5-3 1 1 1.3-268 -
8 Age group distribution of tetanus antitoxin titer by vaccination history 213 Vaccination history Age group years 4 Antitoxin titer IU/ml.1.1.32.1.32 1. 3.2 1. / / / / / / /.31.99.319.999 3.199 9.999 Vaccinee : 4 doses 32 2 2 28 33 78 99 38 22 3.1. 77 1 3 1 34 17 12 6.5 94 2 11 8 23 3 14 6 2.9 1-14 5 2 9 9 12 13 4 1 1.2 32 2 4 1 12 1 3 1.9 2-24 24 3 3 11 6 1.8 8 3 5.4 3-34 11 1 3 5 1 1.9 3 2 1.7 4-44 2 1 1 1.3 1 1 2. 5-. 5 Vaccinee : 5 doses 54 1 2 7 24 1 1 4.2... 1-14 29 1 2 12 6 8 4.8 12 3 6 2 1 3.2 2-24 7 1 3 2 1 6.5 5 1 2 2.6 3-34.. 4-44 1 1 1.. 5-. Primary vaccination series : 4 doses DPT or DPT-IPV / Booster vaccination : 1 dose DT DPT : diphtheria-pertussis-tetanus combined vaccine / DPT-IPV : DPT-inactivated poliovirus combined vaccine DT : diphtheria-tetanus combined toxoid G.M.T. - 269 -
1 213 Age distribution of tetanus antitoxin positives, 213 Antitoxin positives % 1 9 8 7 6 5 4 3 2 1 n = 1315 Antitoxin titer IU/ml.1.32.1.32 1 3.2 1 5 1 15 2 25 3 35 4 45 5 55 6 Age years 2213 Age group distribution of tetanus antitoxin positives, 213 Antitoxin positives % 1 9 8 7 6 5 4 3 2 1 n = 1315 Antitoxin titer IU/ml.1.32.1.32 1 3.2 1 1-14 2-24 3-34 4-44 5-54 55-59 6 Age group years - 27 -
3213 Age group distribution of tetanus antitoxin positives in infants, 213 Antitoxin positives % 1 9 8 7 6 5 4 3 Antitoxin titer IU/ml 1 1 9.9.1.9.1.9.1 2 1-2 n = 1 3-5 n = 2 6-8 n = 6 9-11 n = 21 Age group months No. of sample - 271 -
4-1 /.1 IU/ml Age/age group distribution of tetanus antitoxin positives (titer.1 IU/ml) in different years Antitoxin positives % 1 9 8 7 6 5 4 3 2 1 Year No. of sample 1998 n = 1426 23 n = 1448 28 n = 1288 213 n = 1315 age group in 1998 : result of 15 years 1 2 3 4 5 6 7 8 9 1-14 2-24 3-34 4-44 5-54 55-59 6 Age/age group years 4-2 /.1 IU/ml Age/age group distribution of tetanus antitoxin positives (titer.1 IU/ml) in different years Antitoxin positives % 1 9 8 7 6 5 4 3 2 1 Year No. of sample 1998 n = 1426 23 n = 1448 28 n = 1288 213 n = 1315 age group in 1998 : result of 15 years 1 2 3 4 5 6 7 8 9 1-14 2-24 3-34 4-44 5-54 55-59 6 Age/age group years - 272 -
5 213 Age group distribution of tetanus antitoxin positives in each prefecture, 213 Hokkaido Tokyo Fukui Antitoxin positives % 1 9 8 7 6 5 4 3 2 1 n = 139 n = 358 n = 138 Antitoxin titer IU/ml Aichi Ehime Kochi Antitoxin positives % 1 9 8 7 6 5 4 3 2 1 n = 14 n = 188 n = 22.1.32.1.32 1 3.2 1 1-14 2-24 3-34 4-44 5 1-14 2-24 3-34 4-44 5 1-14 2-24 3-34 4-44 5 Age group years Fukuoka 1 9 8 7 6 5 4 3 2 1 n = 15 1-14 2-24 3-34 4-44 5 1-14 2-24 3-34 4-44 5 1-14 2-24 3-34 4-44 5 1-14 2-24 3-34 4-44 5.1.32.1.32 1 3.2 1 Age group years Antitoxin positives %.1.32.1.32 1 3.2 1 Age group years - 273 -
6 ( 19 ) 213 Tetanus antitoxin positives by vaccination history with antitoxin titer (-19 years old), 213 Cumulative antitoxin positives % 1 9 8 7 6 5 4 3 2 1.1.32.1.32 1 3.2 1 Antitoxin titer IU/ml Vaccination history No. of sample Vaccinee : 5 doses n=41 Vaccinee : 4 doses n=253 Vaccinee : 3 doses n=82 Vaccinee : 2 doses n=58 Vaccinee : 1 dose n=7 Non-vaccinee n=11 Primary vaccination : 4 doses Booster vaccination : 1 dose - 274 -