化学物質の内分泌かく乱作用に関する環境省の今後の対応方針について
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- ゆみか ひろもり
- 7 years ago
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1 ExTEND
2 ExTEND2005 Enhanced Tack on Endocrine Disruption
3 10 (1998 )5 - SPEED'98-12 (2000 ) ( SPEED'98 ) 14 (2002 )8 (WHO)/ (ILO)/ (UNEP) Global Assessment of the State-of-the-Science of Endocrine Disruptors( WHO ) (OECD) 15 (2003 )5 15 (2003 ) 2 SPEED'98 ( )
4 1 3 SPEED 98 3 SPEED 98 4 (1) 4 (2) 5 (3) 8 (4) (1) 16 (2) 18 (3) 20 (4) 24 (5) 27 (6) 27 (7) WHO SPEED
5 SPEED (1998 ) ( )
6 SPEED (1998 ) SPEED 98 (1) ( ) ( ) POPs 1 ( ) 2 : : : ( ) - 4 -
7 SPEED 98 (in vitro ) ( ) ( )4-t- 23 (o,p -DDT p,p -DDE ) OECD ( )
8 (1421 ) (HSI) ( 70 ) (G SI) (H S I) (F 0 : 100 ) (F 1 : 70 ) (G SI) (HSI) (F 0 ) 2 (F 1 ) (180 )
9 t- ( ) cis- 2,4-4- trans- 4- ( ) ( ) A ( ) ( ) -2- -n- - ( ) p,p - p,p - ( ) o,p - ( ) p,p -
10 SPEED ( ) (Hershberger )
11 ( ) ( ) ( ) ( ) ( ) 4-t- ( ) cis- ( ) 2,4- ( ) 4- ( ) trans- ( ) 4- ( ) ( ) A ( ) ( ) -2- ( ) ( ) -n- ( ) ( ) ( ) ( ) ( ) - ( ) ( ) ( ) ( ) p,p - ( ) p,p - E ( ) o,p - ( ) p,p - ( )
12 (4-14-2) 4-1 (1) A ( ) PCB DDT (HCB) (HCH) PCB ( ) 80% Total PCB / PCB ( )
13 4-2 (2) 10 3 (20 60 ) (2000).,70:
14 (4) 10 (1998 ) OECD WHO ( ) H10 H11 H12 H13 H14 H15 H ( ( 16 ) (OECD) OECD ( enhanced TG211 enhanced TG206) OECD ( (WHO)WHO/ILO/UNEP 14 WHO WHO (
15 () - 13-
16 OECD - 14-
17 (1) (2) (3) (4) (5) (6) (7) WHO 11 WHO 12 IUPAC EC WHO (2002) Global assessment of the state-of-the-science of endocrine disruptors, WHO/IPCS/EDC/ WHO/UNEP/ILO (2004) Report of the joint IPCS-Japan workshop on Endocrine disruptors: Research needs and future directions, WHO/IPCS/EDC/01/ J. Miyamoto and J. Burger (2003) Implication of Endocrine Active Substances for Human and Wildlife, Scope/IUPAC. 14 EC (2001) Communication from the Commission to the Council and the European Parliament on the implementation of the Community Strategy for Endocrine Disrupters- A range of substances suspected of interfering with the hormone systems of humans and wildlife (COM(1999)706), COM(2001)262final
18 (1) ( ) (4 ) - 16-
19 ( )
20 (2) 10 (1998 ) SPEED 98 ( ) 49 (1973 ) ( ) ) ) ) ) ) - 18-
21 ( ) ( )
22 (3) 10 (1998 ) () OECD
23 ( ) (in vivo ) 15 ) ) (in vitro ) ( ) USEPA(1998)Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) Final Report - 21-
24 ) DNA DNA () ) ) / / ) ) in vivo - 22-
25 ) ) ) in vitro in vivo in vitro in vivo ) OECD - 23-
26 (4) (6) ( ) - 24-
27 - 25-
28 OECD OECD 20 OECD in vivo - 26-
29 (5) ( ) ( ) (6) - 27-
30 (7) 10 (1998 ) ( ) ) - 28-
31 ) 1) 2) - 29-
32 ) ( )
33
34 - 32-
35 LC/MS
36
/ 3 1 / 3 / 3 1 /
8-18-29 3 291415 297 1-11-4 3/31/ 3/31/ 29 8 22 29 1 17 24 8-1 29 [1] PCB [2] HCB [3] [4] [5] DDT [6-1] p,p'-ddt [6-2] p,p'-dde pg/l ( ) nd 2,4 (46/47) 2.9 18 (47/47) 84 12 pg/g-dry ( ) nd 61, (61/62)
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平成 25 年度調査結果概要 ( 媒体 : 気単位 : pg/m 3 ) 1 2 3 4 PCB 類 3-2 p,p -DDT p,p -DDE 3-3 p,p -DDD 3-4 3-4-1 cis- クロルデン 4-2 trans- クロルデン 4-3 オキシクロルデン 4-4 o,p -DDT 3-5 o,p -DDE o,p -DDD HCB( ヘキサクロロベンゼン ) 3-1 cis- ノナクロル
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