どのようなものが強化になるのか

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1 Sensory reinforcement experimental yoked experimental yoked (Berlyne,199) 1 Social reinforcement (Thompson,19) Mirror as reinforcer Fighting cock Key1:mirror Key:food Key3:water (Watanabe,) 3 1

2 Play as reinforcement 1 TIME (SEC) 1 =.1 =. =.9 =. =.17 Mirror vs. f r ost ed mi r r or (N=7) Mirror vs. l i vebi r d (N=) Mirror vs. f r ost ed bi r d (N=) Moni t or vs. TV pr ogr am (N=7) Moni t or vs. r ever sed moni t er (N=) (Humphreys & Einon,191) 5 (Losey & Margules,197) 7

3 (Gray et al.,1) 9 1 French suite#5 philharmonic suite#3 Violin orchestra Piano suite#5 Five philharmonic suite#11 Variation for orchestra 11 STAYING TI ME ( M I N) STAYING TI ME ( M I N) BIRD BIRD3 BACH VS. SCHOENBERG BACH SI LENT SCHOENBERG ** BACH SI LENT SCHOENBERG STAYING TI ME ( M I N) BACH SI LENT SCHOENBERG BACH VS. SCHOENBERG STAYING TI ME ( M I N) BACH SI LENT SCHOENBERG 1 3

4 (Yamazaki,Suzuki & Watanabe,submitted) STAYING TI ME ( M I N) VI VALDI CARTER SI LENT VIVALDI VS. CARTER STAYING TI ME ( M I N) VI VALDI CARTER SI LENT Bach Tocatta and fuga F major VI3 food FI 7 VI3 FI 7 food Stravinsky The rite of spring 13 1 Bach vs Stravinsky Stravinsky vs white noise 1. (N=) (N=) 1. Choice to Bach sessions Choice to Stravinsky sessions

5 Bach vs white noise 1. Choice to Bach (N=) Proportion of choice sessions ! 1 VI3 (Yanagi & Watanabe, in preparation) VI3 Choice to Bach Music preference in rats Bach vs Stravinsky (N=7) Noise vs scream Bach vs Stravinsky 1 sessions.7 Bach Tocatta and fuga F major food FI 7 FI 7 food Stravinsky The rite of spring Choice to noise

6 (Shinozuka, in preparation) X X 1 1 X X X 3

7 5 7 7

8 ICS (sensory reinforcement) (social reinforcement) (intracranial self-stimulation) 9 (Carlson,199,p) (Rozenzweig et al.,199,p51) 3 (elasiticity) (Carlson,199,p15) 31 (Hursh & Netelson,191) 3

9 ICS in hamsters stimulator dominant male (sensory reinforcement) (social reinforcement) (intracranial self-stimulation) (self administration) subordinate male (Kureta & Watanabe,1995) 33 3 Self-administration (Schuster et al.,197) 35 (Deneau et al.,199) 3 9

10 CPP(Conditioned Place Preference) Pre-test metamphetamine saline (Carlson,1997,p577) 37 3 systemic CPP n.a. microinjection Conditioned pleasure in humans Orbitfrontal cortex N.Accumbens VTA 39 (Hermuth,1) 1

11 Behavioral addiction food social sex drug ICS information (Holden,1) 1 cortex DA stimulants dopamine Food,social etc ICS VTA DA N.Accumbens ethanol opiate morphine 3 (Garris et al,1999) 11

12 Role of dopamine in operant conditioning (Self,3) 5 7 1

13 (Schlteis et al.,) Morpnine-dependent rats (Carlson,199,p57) 9 FR schedule CS->naloxone CS 5 methamphetamine Origin of dopaminergic reward -phylogenetic study

14 (Kusayama & (Tuazon,D.) Watanabe,1999) Procedure of drug administ rat ion Filter paper Plain paper Subject 53 (Kusayama & Watanabe,) 5 Post -Pre (sec) n= 11 ** n= 1 n= 1 n= (mg/ kg).15 Methamphetamine P<. 5 P<

15 oper ant condit ioning of single neur on dopamine act ion pot ent ial hippocampus (St ein & Belluzzi, 199) 57 5 OPERA NT CONDI TI ONI NG BY DOPA MI NE I NJ ECTI ON reinforcement r ei nf or cement ANTAGONISM D1 anat goni st D ant agoni st 59 15

16 1 1

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