carglumic acid

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1

2 carglumic acid

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4 carglumic acid (rinn)

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23 JueI VC, Massey lr,l. Myasthenia gravis. Orphanet J Rare Dis Nov 6i2:44. Leonardi M, Raggi A, Antozzi C, Confalonieri P, Maggi L, et al. The relationship between health, disability and quality of life in Myasthenia Gravis: results from an Italian study. J Neurol Jani257: doi /s Epub 2009 Aug 8. Matsuda M, Dohi-lijima N, Nakamura A, et al. Increase in incidence of elderly onset patients with myasthenia gravis in Nagano Prefecture, Japan. Intern Medicine Jun, 44 (a):stz-1. Murai H, Yamashita N, Watanabe M, Nomura Y, et al. Characteristics of nyasthenia gravis according to onset-age: Japanese nationwide survey. J Neurol Sci. 20tl Jun 15; 305(l-2) i doi: /j. jns.20lt epub2ol1 Nlar 26. Okinaka S, Reese HH, Katsuki S, et al. The prevalence of multiple sclerosis and other neurological diseases in Japan. 1966,47 (Suppl l9): Romi F, Gilhus NE, AarIi Jn. Myasthenia gravis: clinical, immunological, and therapeutic advances. Acta Neurol Scand Feb; 111(2):134-4I.

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30 AUCo-e (ng'tu,/nn-)

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39 I lq!e+ti

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41 87

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48 ):, I -, *rjrjn-,

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51 9.7 a?/1r ) r1qlonl

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60 t24 'oe 1- I

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67 Co (nc/ml)

68 s(+)l+ifvu (mllmrn) X (nglml)

69 tttto 7) sc/i,!$fij (300rgl E tfl) *5$offiH*o

70 copies/ml- =too,ooo Sloo,ooo copies/ml-

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76 $mso 54 6mg 75 6mg D--? > = l--/v 36.0mg 2 Omg 27mg Q connoo"orr

77 028 mg'/ml 7Omg 0.28 mg,/ml ntg,/ ml ng,/ml 50mg /:4 7 tv 047 mg,/ml l4{ mg,/ml mg'/ml mg'/ml mg,/ml Q comomtrt

78 177ev >y 4C7Y> 7 -= l-y' 7+tt / t t> )l tv ts-v P e> Q Comornurt

79 C Codrd.tr{.1

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81 AUCuz+r fue'tr,/rl\ C tn. (!s,,/ rj.\ c2451 (rs./ml \ AUCou +n, (ub'tu/nj,\ Crr fus'/nl]. c2g1 (ro./mr \ ll lr ( ) 2.4r fl.8.3.4) (L t74.29\ l8.39ll /L ',1 1.90! i \ t45.99 (l s6.53\ (L3t.t \ 25.96s 17.17r ( \ fi5.80. I \ 2.41! ( ) ( \ ( ) I 5.88! (L0.2s.24.60\ 3.01{ fl ) Q Cortactrat

82 Q cornootrr

83 Q Cornornu*

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85 r: i? y 2 zl tv 0.75%

86 vt.y ) 7, )v0.75% 7 tv=-)v

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91 *77aiE:fiil 5pg azyv>y *7Aaid:fril 20rrg arrury *A7oEHil 60ug 72rU>Y

92 I 5ue

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98 t Elffi tt+tvz ito.lb ' il#tr, r\t tv2 No.2o t Elffi r\l.tvz No.2z o ilffi, tt+.tvz t{0.24

99 t'l ET tv=*tv N.N'-t 7 - =)V,t:, 7 - = V l,/ )7 :. >

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