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1 Bisphosphonate related osteonecrosis of jaw; BRONJ BRONJ BP α-streptococcus 0 BRONJ BRONJ BP I Paget Bisphosphonate related osteonecrosis of jaw; BRONJ 2002 Marx RE, Stern DS Oral and Maxillofacial pathology 2,3 BRONJ 4,5 BRONJ BP

2 32 1 BRONJ BRONJ II BRONJ BRONJ 4 BP BRONJ 6 1 III BP BRONJ BP BP

3 BRONJ α-streptcoccus Neisseria species

4 BP BP 4 15 IV BP BRONJ BRONJ 13 BRONJ 14 BP BRONJ 15 BRONJ BRONJ BRONJ 19 4

5 BRONJ 35 5 A 10 mg 0.5 mg B 1.8 mg mg 2 mg

6 α-streptcoccus Neisseria species 15 Bacteroides 2 Prebotella 2

7 BRONJ g S 600 mg 100 mg 2 g MS 100 mg Meiji Seika 200 mg 500 mg 250 mg 1 g 500 mg 9...

8 38 16 QOL 5 BP BP P-C-P R1 17 BP BP BRONJ BRONJ BRONJ 19 BRONJ BRONJ BP BP BP 20 RANKL receptor activator of nuclear factor-kb ligand BP Actinomyces, Veillonella, Eikenella, Moraxella, Fusobacterium, Bacillus, Staphylococcus, Streptococcus, and Selenomonas 24,25

9 BRONJ BRONJ BP BRONJ BP 1 Coleman RE: Future directions in the treatment and prevention of bone metastates. Am J Clin Oncol 25: S32 S38, Wang, J., Gooder, N.M.: Osteonecrosis of the jaws associated with cancer chemotherapy. J Oral Maxillofac Surg 61: , Marx, R.E.: Pamidronate (Aredia) and Zoledronate (Zometa) induced avascular necrosis of the jaws. J oral Maxillofac Surg 61: , : , : 28 32, Bianchi ML, Limonta C, et al. Comment on: bisphosphonates and osteonecrosis of the jaw. J Rheumatol 47: 383, Boonyapakorn T, Schirmer I, et al. Bisphosphonate-induced osteonecrosis of the jaws: prospective study of 80 patients with multiple myeloma and other malignancies. Oral Oncol 44: , Mavrokokki T, Cheng A, et al. Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia. J Oral Maxillofac Surg 65: , Murad OM, Arora S, et al. Bisphosphonates and osteonecrosis of the jaw: a retrospective study. Endocr pract 13: , Christodoulou C, Pervena A, et al. Combination of the jaw more frequently than bisphosphonates alone. Oncology 76: , Sedghizadeh PP, Stanley K, et al. Oral bisphosphonates use and the prevalence of osteonecrosis of the jaw: an institutional inquiry. J Am Dent Assoc 140: 61 66, : , Yoneda T, et al. Bisphosphonate-Related Osteonecrosis of the Jaw: Position Paper from the Allied Task Force. Committee of Japanese Society for Bone and Mineral Research, Osteoporosis Society Japan, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology and Japanese Society of Oral and Maxillofacial Surgeons, J Bone Miner Metab (in press) 15 Urade M, et al. Nationwide Survey for Bisphosphonate-Related Osteonecrosis of the Jaws in Japan. J Oral Maxillofac Surg 69: e364 e371 (2011) Bartl R, Frisch B , Philipp S, Moritz B, et al. The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw result of a clinical case series with an average follow-up of 20 months. Clin Oral Invest DOI /s American Dental Association Council on Scientific Affairss: Dental management of patients receiv-

10 40 ing oral bisphosphonate therapy Expert panel recommendations. JADA 137: , World of Bisphosphonate; illustrated mechanism of action and clinical use Henry DH, et al.: J Clin Oncol. 2011; 29(9): Stopeck AT, et al.: J Clin Oncol. 2010; 28(35): Fizazi K, et al.: Lancet. 2011; 377(9768): Bisphosphonate-related osteonecrosis of the jaw in patients with osteoporosis. Am Fam Physician Jun 15; 85(12): Bisphosphonate-related osteonecrosis of the jaw. Rev Bras Reumatol Mar-Apr; 52(2): Bisphosphonate osteonecrosis of the jaw: a literature review of UK policies versus international policies on the management of bisphosphonate osteonecrosis of the jaw. Br J Oral Maxillofac Surg Jul; 49(5): Clinical experience with spiramycin in bisphosphonate-associated osteonecrosis of the jaw. Int J Immunopathol Pharmacol Apr-Jun; 23(2): Page

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