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7 Circadian Rhythm Circa-dian Rhythm (suprachisamatic nucleus; SCN) 24 24

8 Rat)

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10 Circadian Rhythm (suprachiamatic nucleus; SCN)?

11 (SCN) SCN

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13 Suprachiasmatic Nucleus

14 SCN

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19 Time lag

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25 1 2 3

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29 Delayed sleep phase syndrome; DSPS Advanced sleep phase syndrome;asps

30 Seasonal affective disorder (SAD) (

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35 (Phase response curve:prc)

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37 1. 2.

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44 1. 2. B12

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46 Per1 Tei et al Nature

47 INPUT OUTPUT ADJUST THE CENTRAL CLOCK

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51 (Phase response curve:prc)

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56 JET LAG SYNDROME Jet lag syndrome is caused by transient dissociation between the environmental and internal times after abrupt shift of lightdark (LD) cycle. In other words, internal clocks fail to catch up immediately with new environmental light-dark pattern.

57 CT4 CT16 LIGHT( ) CT16 LIGHT(-) 夜間の光照射では 腹外側部にのみPER1が発現した

58 DMSCN VLSCN INTERACTION CIRCADIAN RHYTHM LOCOMOTIVE BEHAVIOR HORMONE TEMPERATURE SLEEP etc.

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63 Per

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2 1,384,000 2,000,000 1,296,211 1,793,925 38,000 54,500 27,804 43,187 41,000 60,000 31,776 49,017 8,781 18,663 25,000 35,300 3 4 5 6 1,296,211 1,793,925 27,804 43,187 1,275,648 1,753,306 29,387 43,025

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