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1 δ!!!

2

3

4 μ μ μ γ UBE3A Ube3a Ube3a δ

5 !!!! α α α α α α α α α α

6 μ μ α β α β β

7 !!!!!!!! μ!

8 Suncus murinus μ Ω! π μ Ω

9 in vivo! μ μ μ!!!

10

11 !

12 in situ! in vivo δ δ

13 !!!!!!!!!!

14 ! in vivo Orexin-Arch Orexin-Arch

15 !! μ μ μ μ!! α α

16

17

18

19 ! μ! μ!μ

20 ! δ! μ!!

21 !!! β!!! in vivo!

22 !

23

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