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3 Special IssueManagement principles in the critically ill - Review Case reports
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8 et al et al et al et al
9 Nutritional management in critically ill patients Akiko Mano, Emiko Nakataki, Harutaka Yamaguchi, Daisuke Inui, Jun Oto, Hideaki Imanaka, and Masaji Nishimura Emergency and Critical Care Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan
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12 et al et al et al et al et al et al
13 et al et al et al et al et al et al et al et al et al et al et al et al
14 Blood glucose control in critically Ill patients Moritoki Egi Department of Intensive Care, Okayama University Hospital, Okayama, Japan
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22 Oral health care for severe human cases encountered in Intensive Care Unit -professional oral care at Tokushima University Hospital Intensive Care Unit- Masami Yoshioka, Masaaki Yokoyama, and Tetsuo Ichikawa Department of Oral Health Care Education, Institute of Health Biosciences, the University of Tokushima Graduate School, and Oral Health Management Center, Tokushima University Medical and Dental Hospital, Tokushima, Japan
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25 ２ ２ 近 藤 和 也 a a b b 図２ 胸腺における未分化な T リンパ球と樹状細胞の分布 胸腺組織において CD１a 抗体を使用し 未分化な T リンパ球 を染色している ２ a S １ ０ ０ beta 抗体を使用し 樹状細胞を染 めている ２ b c 癌抑制遺伝子 p５ ３の蛋白発現の程度を免疫染色にて検 討すると 非浸潤型胸腺腫は８例の内１例も p５ ３の発現 を認めなかった 浸潤型胸腺腫は１/９例 １ １ に発 現を認め 胸腺癌は１ ４/１ ９例 ７ ４ に発現を認め う ち５例は強発現であった 図４ p５ ３の発現の高い胸 腺癌に対して PCR-SSCP 法および sequencing 法にて 点突然変異を検索すると１例にexon６のcodon２２２に C-T の塩基置換を認めた 胸腺腫では癌遺伝子 p５ ３蛋白の発 図３ type B１胸腺腫における未分化な T リンパ球と樹状細胞の 分布 type B１胸腺腫の medullary differentiation の領域である ３ a CD１a 抗体を使用し 未分化な T リンパ球を染色している ３ b S １ ００beta 抗体を使用し 樹状細胞を染めている ３ c 現はまれであるが 胸腺癌は高頻度であるが p５ ３の点 突然変異はまれである１０ 胸腺癌では 癌関連遺伝子の DNA のメチル化が高頻 度に認められるのに対して胸腺腫では頻度が少ない 癌 non-invasive thymoma n=8 positive case 関連遺伝子 DAP-K p-１ ６ MGMT HPP１ の DNA メチル化を検討すると その頻度は胸腺腫では２ ９ に対 して 胸腺癌では８ ６ と高頻度に認めた 図５ 胸腺 highly positive case invasive Thymoma n=9 癌の６ ０ が複数の癌関連遺伝子のメチル化を認めた１１ 腫瘍の機能的な見地 genetic および epigenetic な見 11% 26% thymic ca n=19 74% 地からみると 胸腺腫と胸腺癌には 生物学的な違いが あり 異なる疾患単位とみるべきである 図４ 胸腺腫と胸腺癌における癌抑制遺伝子 p５ ３蛋白の発現
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27 et al et al. β et al. et al. et al
28 Therapeutic strategy for mediastinal tumors Kazuya Kondo Department of Oncological Medical Services, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan
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32 A case of descending colon cancer complicated with a left psoas abscess Mitsutoshi Fukuyama, Sadahiro Yoshida, Takeshi Kuroda, Michiaki Imatomi, and Tsuneo Saitoh Department of Surgery, Oe Kyodo Hospital, Tokushima, Japan
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36 Six cases of splenic artery aneurysms Mitsutoshi Fukuyama, Sadahiro Yoshida, Takeshi Kuroda, Michiaki Imatomi, and Tsuneo Saitoh Department of Surgery, Oe Kyodo Hospital, Tokushima, Japan
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41 Two cases of abdominal emergencies in patients of advanced age over ninety Mitsutoshi Fukuyama, Takeshi Kuroda, Takafumi Kinoshita, Masahiro Iuchi, Yoh Fukuda Yoshinori Aoki, and Kunio Ogasahara Department of Surgery, Takamatsu Municipal Hospital, Kagawa, Japan
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Special IssueDiagnoses and therapeutic agents for age-related diseases Reviews Original Case reports β Medicinal drugs affecting on clinical laboratory blood test results and adverse effects of them
第６４巻１・２号（４月号）／特集・Ａはじめに Ｐ１
Special IssueHow can we promote basic medical research? Review Case reports How can we reenergize basic research at medical schools in Japan? -basic research situation in the US as a comparison to
Special IssueOncology Nutrition Reviews Proceeding DNA β Nutrition and physical activity and the prevention of cancer Yutaka Taketani Department of Clinical Nutrition, Institute of Health Biosciences,
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Special IssuePhysiology, psychology and treatment of eating disorders Reviews Originals Proceeding Case Report ob α α et al. et al et al Control of food intake Kyoichi Kishi, Kazuhito Rokutan, Takeshi
Special IssueMedical Care and Education in Tokushima : Their Present and Future Reviews Original Case report スポーツと腰痛 １ ３ 図１ ２ 腰椎分離症の病期分類 図１ ５ 成人発症新鮮腰椎分離症 陸上 五輪選手 断に難渋する謎の腰痛となることもある 図１ ６は CT
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Special Issue 1Sudden cardiac death symposium in Tokushima Special Issue 2How to do for your health? Reviews Original Epidemiologic problems of sudden death of school children in Tokushima Prefecture
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Special Issue 1Recent advances in radiation diagnosis and radiation therapy Special Issue 2The way and the power for overcoming diabetes mellitus Review Originals Current topics on radiation exposure
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χ χ χ χ χ χ χ χ β The Health Administration Center, Tohoku University ; Department of Gastroenterology, Tohoku University Hospital Department of Endoscopic Diagnostics and Therapeutics, Chiba University
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γ Present status of anti-hiv therapy Akio Adachi Department of Virology, The University of Tokushima School of Medicine, Tokushima, Japan Epidemiological survey of sexually transmitted disease
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Feature articlespsychiatric and psychosomatic symptoms in daily clinical practice Originals Mild depressive disorder and panic disorder Kazuomi Inoue Department of Human Development, Naruto University
Special IssueCardiovascular therapeutics -Up-to-Date techniques and managements- Reviews Report Case reports Early treatment of acute myocardial infarction -chain of survival- Masataka Sata Department
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Feature articlesdiet in a society with a growing elderly population and a low birth rate Original The problems of breastfeeding Kazuhisa Maeda, Ryuji Mitani, Satoko Endo, Yoshika Saijo, and Toshihiro
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Special Issue 1Health foods from the aspect of medicien and pharmacy Special Issue 2New trend in pediatrics Reviews Health food and natural products Yoshihisa Takaishi Department of Natural Medicines,
Special IssueTo save our life from myocardial infarction -what can we do before and after heart attack- Reviews Originals Case reports et al et al et al et al et al et al et al et al et al et al et
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Feature articlesthe Front of Stroke Management Originals α Imaging protocol for apoplexy of acute phase Masafumi Harada, Kazuhide Yoneda, Naomi Morita, Mayumi Takeuchi, Sonoka Hisaoka, Toshiko Okada,
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Feature articlessafety Management for the patient in IT (Information Technology) era Reviews The systematic safety management at Tokushima Municipal Hospital (large-scale hospital) Shigetoshi
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2008 Vol.50 No.2 Jpn J School Health Jpn J School Health Graduate School of International Studies, J.F. Oberlin University Research Fellow of the Japan Society for the Promotion of Science College of
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Feature articles 1Why is it that allergic diseases have been increasing? Feature articles 2Space medicine and medicine for the future Review γ ε γ γ γγ α αβ et al et al et al et al et al et al Is nutritional
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26 1 : Self - reported Practices of Cancer Pain Management among Nurses in Tohoku University Hospital Hideyuki Hira
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2010 Vol.52 No.2! ! Jpn J School Health Jpn J School Health Jpn J School Health! Jpn J School Health Aichi University of Education Nagoya University "! Jpn J School Health! Graduate School of Public Health
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Professor, Department of Cardiovascular Medicine Graduate School of Medicine and Faculty of Medicine, The University of Tokyo Ryozo Nagai Former Senior Clinical Advisor, Centers for Medicare & Medicaid
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Feature articlescommon skin diseases of the aged Originals patched PTCH PTCH PTCH PTCH p53 p53 ras p16 INK4a ras Rb/p16 INK4a CDK4 p16 INK4a PTCH p16 INK4a PTEN p16 INK4a BCL2 patched PTCH INK4a PTEN/MMAC1
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上原記念生命科学財団研究報告集, 24(2010) 164. 消化器癌におけるエピジェネティックな microrna 異常の解析 鈴木拓 Key words: 胃癌, 大腸癌,microRNA, DNA メチル化, 癌抑制遺伝子 札幌医科大学医学部内科学第一講座 緒言 microrna( 以下 mirna) は 18 ~ 22 塩基程度の短い non-coding RNA であり, 分化 増殖 アポトーシスなど細胞内の様々なプロセスに重要な役割を担っている
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A consideration of the relationship between Advance Care Planning and Advance Directives, Based on evidence from the U.S.A. Advance Directives AD AD 1 1990 2 AD 2012 2001 3 AD Advance Care Planning ACP
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