Core Ethics Vol. DMD.... DMD.. PGD.... DMD

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1 Core Ethics Vol. preimplantation genetic diagnosis PGD Franklin Franklin = : DMD a b

2 Core Ethics Vol. DMD.... DMD.. PGD.... DMD

3 PCR polymerase chain reaction FISH fluorescence in situ hybridization PCR FISH X Y FISH DNA PCR X PCR Handyside, et al. PCR Handyside, et al. X FISH Griffin, et al. FISH Munne FISH Munne et al. : PGD PGDpreimplantation genetic screening PGS FISH Sermon FISH

4 Core Ethics Vol. Takeuchi - DMD FISH % pending : DMD % : DMD % : : b

5 FISH : DMD FISH : Cell Recycling Cell Recycling PCR FISH FISH Thornhill de novo a: Cell Recycling PCR FISH b: :

6 Core Ethics Vol... FISH FISH Fertility and Sterility FISH % Tanaka et al. : - FISH FISH : X DMD Handyside --

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8 Core Ethics Vol. : : - PGD for aneuploidy screening PGD AS Mastenbroek S. IVF RNA Franklin, S.,, Better by design? Miller,P. and Wilsdon, J. eds., Better Humans? DEMOS collection 21, =, -. Griffin D. K., et al.,, Diagnosis of sex in preimplantation embryos by fluorescent in situ hybridization, British Medical Journal, :. Handyside A. H. et al.,, "Biopsy of Human Preimplantation Embryos and Sexing by DNA Amplification,"Lancet, ( ): -. Handyside A. H. et al.,, "Birth of a Normal Girl after IVF and Preimplantation Diagnostic Testing for Cystic Fibrosis," New England Journal of Medicine, ( ) : -.,, Duchenne -. NTT

9 ES. : -. : -.. a : - b. :- : - Mastenbroek, S., et al.,, In Vitro Fertilization with Preimplantation genetic Screening The New England Journal of Medicine, : -. : - Munne S et al,, "Diagnosis of Major Chromosome Aneuploidies in Human Preimplantation Embryos," Human Reproduction, : - : or.jp/kaiin/html/ofure_ jul.html. :-., : -. biopsy : - : ART : - Sermon K. et al.,, Preimplantation genetic diagnosis Lancet, : - - : : -. : - Gary, D.Hodgen,, Embryo Biopsy supplement :. Takeuchi K., et al.,, Preclinical models for human pre-embryo biopsy and genetic diagnosis.. Efficiency and normalcy of mouse pre-embryo development after different biopsy techniques. Fertility and Sterility, ( ) : -. Embryo Biopsy PCR supplement :. ; -. Tanaka Atsushi, et al.,, Preimplantation diagnosis of repeated miscarriage due to chromosomal translocations using metaphase chromosomes of a blastomere biopsied from - to -cell-stage embryos Fertility and Sterility, ( ) : - Thornhill,A., et al., Recycling the single cell to detect specific chromosomes and to investigate specific gene sequences Human Reproduction, ( ) : - a : -

10 Core Ethics Vol. b : - :. / siryou.pdf..

11 The Background to Changes in the Framework of Permission for Preimplantation Genetic Diagnosis in Japan TOSHIMITSU Keiko Abstract: This article investigates into the politics under which preimplantation genetic diagnosis (PGD) was introduced to Japan, particularly in the period from, when the Japan Society of Obstetrics and Gynecology provided the guideline, to, when the Society first permitted the practice. Despite strong criticism from women s and disabled people s organizations, the Japan Society of Obstetrics and Gynecology started PGD, hoping to reach a social consensus on this issue by restricting the use to only diagnosing for the disease genes of serious inherited diseases. However, some sterility clinics, without waiting for permission from the Society, started preimplantation genetic screening (PGS) in the diagnosis of chromosomal abnormality from around. Simultaneously, research institutions, like university hospitals, recognized that diagnosing for disease genes is not sufficient for choosing an embryo good enough for transplantation and, therefore, decided that PGS is necessary. Through such a process, the meaning of selecting a fertilized egg shifted from selecting life to selecting a suitable embryo for in vitro fertilization-embryo transfer (IVF-ET), and thus the social meaning of PGD also changed. Around, it shifted from a way to prevent giving birth to babies with an inherited disease to a way to cure sterility and even to the pursuit of happiness by women (and their husbands). Keywords: preimplantation genetic diagnosis (PGD), preimplantation genetic screening (PGS), prenatal diagnosis, recurrent spontaneous abortion, politics

1990 preimplantation genetic diagnosis: PGD ( )

1990 preimplantation genetic diagnosis: PGD ( ) Title Author(s) 日本における受精卵診断をめぐる論争 (1990 年代 ) - 争いの経過 - 利光, 恵子 Citation 医療生命と倫理社会. 7 P.67-P.85 Issue Date 2008-03-20 Text Version publisher URL https://doi.org/10.18910/12560 DOI 10.18910/12560 rights