( 報告様式 4) 16ck h0002 平成 29 年 5 月 31 日 平 28 年度委託研究開発成果報告書 I. 基本情報 事業名 : ( 日本語 ) 革新的がん医療実用化研究事業 ( 英語 )Practical Research for Innovative Cancer Con
|
|
|
- あつみね かわらい
- 5 years ago
- Views:
Transcription
1 ( 報告様式 4) 16ck h0002 平成 29 年 5 月 31 日 平 28 年度委託研究開発成果報告書 I. 基本情報 事業名 : ( 日本語 ) 革新的がん医療実用化研究事業 ( 英語 )Practical Research for Innovative Cancer Control 研究 ( 日本語 ) がん診断から治療への効率的ワークフロー構築のための核医学分子イメージング法を用いる高度画像診断システムの確立 ( 英語 )Development of advanced diagnostic system using nuclear molecular imaging for establishment of effective workflow from cancer diagnosis to cancer therapy. 研究開発担当者 ( 日本語 ) 京都大学大学院薬学研究科教授佐治英郎所属役職氏名 : ( 英語 )Graduate School of Pharmaceutical Sciences, Kyoto University, Professor, Hideo Saji 実施期間 : 平成 28 年 4 月 1 日 ~ 平成 29 年 3 月 31 日 ( 日本語 ) 院内臨床研究の準備と実施 ( 英語 )Preparation and performance of clinical study 研究開発分担者 ( 日本語 ) 京都大学大学院医学研究科教授富樫かおり所属役職氏名 : ( 英語 )Graduate School of Medicine, Kyoto University, Professor, Kaori Togashi ( 日本語 ) 院内臨床研究の準備と実施 ( 英語 )Preparation and performance of clinical study 研究開発分担者 ( 日本語 ) 京都大学大学院医学研究科教授佐賀恒夫所属役職氏名 : ( 英語 )Graduate School of Medicine, Kyoto University, Professor, Tsuneo Saga 1
2 ( 日本語 ) 院内臨床研究の準備と実施 ( 英語 )Preparation and performance of clinical study 研究開発分担者 ( 日本語 ) 京都大学大学院医学研究科教授稲垣暢也所属役職氏名 : ( 英語 )Graduate School of Medicine, Kyoto University, Professor, Nobuya Inagaki ( 日本語 ) 非臨床 POC の取得 ( 英語 )Establishment of pre-clinical POC 研究開発分担者 ( 日本語 ) 京都大学放射線生物研究センター教授原田浩所属役職氏名 : ( 英語 )Radiation Biology Center, Kyoto University, Professor, Hiroshi Harada ( 日本語 ) 分子プローブの開発 ( 英語 )Development of molecular probes 研究開発分担者 ( 日本語 ) 京都大学大学院薬学研究科准教授小野正博所属役職氏名 : ( 英語 )Graduate School of Pharmaceutical Sciences, Kyoto University, Associate Professor, Masahiro Ono ( 日本語 ) 院内臨床研究の準備と実施 画像解析 ( 英語 )Preparation and performance of clinical study, Image analysis 研究開発分担者 ( 日本語 ) 京都大学大学院医学研究科准教授中本裕士所属役職氏名 : ( 英語 )Graduate School of Medicine, Kyoto University, Associate Professor, Yuji Nakamoto ( 日本語 ) 分子プローブの開発 院内臨床合成法の構築 ( 英語 )Development of molecular probes, Establishment of probe synthesis method for clinical study 研究開発分担者 ( 日本語 ) 京都大学大学院医学研究科助教佐野紘平所属役職氏名 : ( 英語 )Graduate School of Medicine, Kyoto University, Assistant Professor, Kohei Sano 2
3 ( 日本語 ) 分子プローブの開発 院内臨床合成法の構築 ( 英語 )Development of molecular probes, Establishment of probe synthesis method for clinical study 研究開発分担者 ( 日本語 ) 京都大学大学院医学研究科助教志水陽一所属役職氏名 : ( 英語 )Graduate School of Medicine, Kyoto University, Assistant Professor, Yoichi Shimizu ( 日本語 ) 分子プローブの開発 ( 英語 )Development of molecular probes 研究開発分担者 ( 日本語 ) 京都大学大学院薬学研究科助教渡邊裕之所属役職氏名 : ( 英語 )Graduate School of Pharmaceutical Sciences, Kyoto University, Assistant Professor, Hiroyuki Watanabe ( 日本語 ) 院内臨床研究の準備と実施 画像解析 ( 英語 )Preparation and performance of clinical study, Image analysis 研究開発分担者 ( 日本語 ) 京都大学大学院医学研究科講師石守崇好所属役職氏名 : ( 英語 )Graduate School of Medicine, Kyoto University, Lecture, Takayoshi Ishimori ( 日本語 ) 院内臨床研究の準備と実施 ( 英語 )Preparation and performance of clinical study 研究開発分担者 ( 日本語 ) 京都大学大学院医学研究科助教吉村通央所属役職氏名 : ( 英語 )Graduate School of Medicine, Kyoto University, Assistant Professor, Michio Yoshimura ( 日本語 ) 院内臨床研究の準備 ( 英語 )Preparation for clinical study 研究開発分担者 ( 日本語 ) 株式会社島津製作所基盤技術研究所放射線技術ユニットユニット長北村圭司所属役職氏名 : ( 英語 )Shimadzu Corporation, Technology Research Laboratory, Radiation Technology Unit, General Manager, Keishi Kitamura 3
4 ( 日本語 ) 分子プローブの薬効評価 事業化可能性の評価 ( 英語 )Drug evaluation of molecular probes, Evaluation of potential for industrialization 研究開発分担者 ( 日本語 ) 日本メジフィジックス株式会社創薬研究所創薬研究所長松本博樹所属役職氏名 : ( 英語 )Nihon Medi-Physics Co., Ltd., Research Center, General Manager, Hiroki Matsumoto ( 日本語 ) 薬効評価系の確立 安全性の評価 ( 英語 )Establishment of drug evaluation system, Evaluation of drug safety 研究開発分担者 ( 日本語 ) 日本メジフィジックス株式会社研究 事業開発部アシスタントマネージャー阿部務所属役職氏名 : ( 英語 )Nihon Medi-Physics Co., Ltd., Research and Business Development, Assistant Manager, Tsutomu Abe ( 日本語 ) 分子プローブおよび自動合成装置の開発 ( 英語 )Development of molecular probes and automated synthesizer 研究開発分担者 ( 日本語 ) アークレイ株式会社研究開発部分子診断研究ユニット責任者平井光春所属役職氏名 : ( 英語 )Arkray Inc., Research and Development Division, Head of Molecular Diagnostics Research Unit, Mitsuharu Hirai 4
5 II. 成果の概要 ( 総括研究報告 ) 研究開発代表者 : 京都大学大学院薬学研究科 佐治英郎総括研究報告を参照 和文平成 28 年度は研究計画調書に従い 膵がん ( インスリノーマ ) 肺がん 前立腺がん 固形がん低酸素領域を対象としたがん特性識別型分子プローブの開発研究および臨床研究の準備を進めた インスリノーマを標的とする 18 F-exendin4 誘導体については 新規化合物の FIH 試験という位置づけで 化合物の安全性評価を目的とした院内臨床試験を実施することとした 薬剤については 3 ロット製造試験を実施し 臨床試験に使用可能な品質の最終製剤を得た また 最終製剤について毒性試験を実施し 毒性に問題がないことを示した 臨床プロトコルにこれらの内容を追記し 医の倫理委員会への申請を行った 68 Ga-exendin4 誘導体については デフェロキサミンをキレート剤として利用した標識法を確立し GLP-1 受容体に対して高い親和性を有していることを示した さらにインスリノーマ細胞を移植した担がんマウスを用いた体内分布評価実験において GLP-1 受容体特異的な高い腫瘍集積を認め 小動物用 PET を用いたイメージング実験においても インスリノーマを明瞭に描出することに成功した 肺がんについては 肺がんに高発現する EGFR-TK の 1 次変異 (L858R) を特異的に検出可能な PET プローブの候補として 前年度までに絞込みに成功した HO-J について 18 F 標識体を合成し がん細胞への取り込みを評価した結果 2 次変異 (L858R/T790M) を持つがん細胞と比べて 1 次変異を持つがん細胞に高く取り込まれた また 両細胞を担がんしたマウスにおいて 投与 3 時間後に L858R 変異腫瘍と正常肺との比は 3 以上となり 小動物用 PET を用いた 1 次変異の特異的なイメージングに成功した また 肺がんプローブを用いたフレキシブル PET の画質シミュレーションを行い 至適撮像時間および画像再構成条件が予測された また全身用 PET/CT の CT 画像を利用した吸収補正ソフトやデッドタイム補正ソフト および薬物動態を調べるためのダイナミック収集ソフトの開発を行い ファントムデータでその動作を確認した 前立腺がんについては PSMA に対して特異的な結合性を示す 18 F-FSU880 について 自動合成システムの構築を進めた すなわち 自動合成システムは その前半部で 18 F-SFB を合成し 後半部で FSU880 の標識前駆体とのカップリング反応を実施するシステムとし 前半部の 18 F-SFB については合成時間約 40 分で 放射化学的収率約 50% で 18 F-SFB の合成に成功した また 後半部については 装置の改良を行い その性能を確認するため 現在 3 ロット製造試験を実施している また 院内での臨床研究検討会議をスタートし 臨床プロトコルの作成を開始した 低酸素領域検出用 PET プローブについては 腫瘍内低酸素領域を認識可能な 18 F-FMISO に代わる PET プローブ開発を目的とし FMISO のニトロイミダゾール骨格に FMISO よりも細胞内に滞留する化合物へと変換しやすいようにアゾ基を導入した化合物を設計 合成した これらの化合物群の中で 特に電子供与基で修飾した 2 種類の化合物が 通常酸素条件と比較して低酸素条件下で有意に高い取込みを示すことを見出したことから 担がんマウスを用いた体内分布評価実験を実施した その結果 投与後初期に腫瘍への集積を認めたものの その集積は経時的に減少した また 正常組織比も十分ではなかったことから 他の誘導体の評価を進める必要があると考えられた 5
6 英文 In the 2016 fiscal year, we developed molecular imaging probes targeting pancreatic cancer (insulinoma), lung cancer, prostate cancer, and solid tumors (hypoxic region) and prepared for a clinical study according to our research plan. Pancreatic cancer (insulinoma): We planned a clinical study to evaluate drug safety due to FIH study using the 18 F-labeled exendin4 derivative. A final high-quality product applicable for clinical study was obtained in three lots synthetic test. No toxicity was observed in mice on a toxicity test. Thereafter, we submitted a clinical protocol to our ethics committee. For the 68 Ga-labeled exendin4 derivative, a 68 Ga-labeling method was established using deferoxamine as a chelating agent, and the high affinity of this probe for the GLP-1 receptor was determined. Furthermore, an in vivo biodistribution study using insulinoma-bearing mice indicated the GLP-1 receptor-specific tumor accumulation of the probe. Finally, insulinoma was clearly visualized in mice using a small animal PET scanner. Lung cancer: We successfully labeled HO-J with 18 F as a candidate probe detecting the primary mutation (L858R) of EGFR-TK in lung cancer, and the cellular uptake was evaluated. The cellular uptake of 18 F-HO-J in cancer cells with L858R mutation was significantly higher than that in cells with secondary mutation (L858R/T790M). In tumor-bearing mice, tumors with L858R mutation were clearly visualized (tumor-to-lung ratio was more than three at 3 h after probe injection) using a small animal PET scanner. We performed imaging simulation of a lung cancer probe for flexible PET scanner, and the optimal acquisition time and image reconstruction parameters were predicted. We also developed an attenuation correction software that uses CT images of whole body PET/CT, a dead time correction software and a dynamic acquisition software to investigate pharmacokinetics, and confirmed their effects through phantom studies. Prostate cancer: We established an automatic synthesis system for 18 F-FSU880 specifically bound to PSMA in prostate cancer. 18 F-SFB was synthesized in the first phase, and 18 F-SFB was coupled with a precursor in the second phase. 18 F-SFB was successfully synthesized within 40 minutes with a radiochemical yield of approximately 50%. We are currently performing three lots synthetic test to evaluate the machine performance, and are preparing a clinical protocol. Solid cancer (hypoxic region): In order to develop an alternative PET probe to 18 F-FMISO for detecting hypoxic regions in the tumor, we designed and synthesized a series of probes where an azo group was introduced into the FMISO structure. In a cellular uptake study, two probes modified with electron donating groups were more significantly taken up by the cancer cells under hypoxia than under normoxia; thus, in vivo biodistribution studies using these probes were conducted. At an early time-point, the accumulation of radioactivity in the tumor was observed, but the accumulation level decreased over time. Due to a relatively low tumor-to-normal tissue ratio, the evaluation of other derivatives needs to be performed. 6
7 III. 成果の外部への発表 (1) 学会誌 雑誌等における論文一覧 ( 国内誌 0 件 国際誌 3 件 ) 1. Kimura H, Matsuda H, Ogawa Y, Fujimoto H, Toyoda K, Fujita N, Arimitsu K, Hamamatsu K, Yagi Y, Ono M, Inagaki N, Saji H. Development of 111 In-labeled Exendin(9-39) Derivatives for Single-Photon Emission Computed Tomography Imaging of Insulinoma. Bioorganic & Medicinal Chemistry. 2017, 25(4), Harada N, Kimura H, Onoe S, Watanabe H, Matsuoka D, Arimitsu K, Ono M, Saji H. Synthesis and Biological Evaluation of Novel 18F-Labeled Probes Targeting Prostate-Specific Membrane Antigen for Positron Emission Tomography of Prostate Cancer. Journal of Nuclear Medicine. 2016, 57(12) Kimura H, Sampei S, Matsuoka D, Harada N, Watanabe H, Arimitsu K, Ono M, Saj H. Development of 99m Tc-labeled Asymmetric Urea Derivatives that Target Prostate-Specific Membrane Antigen for Single-photon Emission Computed Tomography Imaging. Bioorganic & Medicinal Chemistry. 2016, 24(10) (2) 学会 シンポジウム等における口頭 ポスター発表 1. Development of a PET Imaging Probe for Discrimination of Secondary Mutation in the Epidermal Growth Factor Receptor, Hiroyuki Kimura, Haruka Okuda, Kenji Arimitsu, Akira Makino, Ryuichi Nishii,Anna Miyazaki, Hiroyuki Watanabe, Masahiro Ono, Hideo Saji, ポスター,Society of Nuclear Medicine and Molecular Imaging 2016 Annual Meeting, 2016/6/11~15, 国外 2. インスリノーマの局在診断を目指したPET 分子イメージングプローブの開発研究, ポスター, 西田なつき, 木村寛之, 有光健治, 桶谷亮, 宮本佳美, 河嶋秀和, 藤本裕之, 渡邊裕之, 小野正博, 稲垣暢也, 佐治英郎, 安井裕之, 日本薬学会第 137 年会,2017/3/25 27, 国内 3. 移植膵島量の定量評価を目的とした分子イメージング法の開発, ポスター, 桶谷亮, 木村寛之, 有光健治, 宮本佳美, 河嶋秀和, 藤本裕之, 渡邊裕之, 小野正博, 稲垣暢也, 佐治英郎, 安井裕之, 日本薬学会第 137 年会,2017/3/25 27, 国内 4. EGFR チロシンキナーゼを標的とした 18 F 標識 pyrido[3,4-d]pyrimidine 誘導体の合成と評価, ポスター, 石黒真澄, 奥田悠, 有光健治, 木村寛之, 髙瀨里紗, 牧野顕, 内本ひとみ, 繁田尭, 小野正博, 佐治英郎, 川崎郁勇, 第 66 回日本薬学会近畿支部総会 大会,2016/10/15, 国内 5. 上皮成長因子受容体 (EGFR) の遺伝子変異の識別を目的とした 18 F 標識分子イメージングプローブの開発, ポスター, 石黒真澄, 奥田悠, 有光健治, 木村寛之, 髙瀨里紗, 牧野顕, 内本ひとみ, 繁田尭, 小野正博, 佐治英郎, 川崎郁勇, 第 34 回メディシナルケミストリーシンポジウム,2016/11/30~12/2, 国内 6. Development of 99m Tc-labeled asymmetric urea derivatives targeting prostate specific membrane antigen for prostate cancer imaging. ポスター, 松岡大航, 木村寛之, 原田直弥, 7
8 三平崇太郎, 渡邊裕之, 小野正博, 佐治英郎, 第 26 回金属の関与する生体関連反応シンポジウ ム, 2016/6/16~17, 国内 (3) 国民との科学 技術対話社会 に対する取り組み 1. 薬のサイエンス 佐治英郎 高大連携特別講義 ( 膳所サイエンスプロジェクト ) 2017/2/11 大 津 国内 (4) 特許出願 該当なし 8
レントゲン X線
PET ( TIAN Mei ) PET 100 PET PET PET PET PET Positron Emission Tomography (PET) PET Positron Emission Tomography CT PET FDG Glucose and 18 F-FDG 18 F-FDGFDG CH3OH O CH3OH O OH OH OH OH OH OH OH 18 F *FDG
udc-2.dvi
13 0.5 2 0.5 2 1 15 2001 16 2009 12 18 14 No.39, 2010 8 2009b 2009a Web Web Q&A 2006 2007a20082009 2007b200720082009 20072008 2009 2009 15 1 2 2 2.1 18 21 1 4 2 3 1(a) 1(b) 1(c) 1(d) 1) 18 16 17 21 10
Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究 第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date URL
Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究 第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date 1958-01 URL http://hdl.handle.net/2433/111559 Right Type Departmental Bulletin
1_2.eps
第32回 日本頭頸部癌学会ランチョンセミナー6 Pre-Meeting Abstract FDG-PET の頭頸部癌における臨床的有用性 司会 長 放射線治療センター長 講演 1 耳鼻咽喉科 部長 講演 2 PETセンター長 岡村 光英 先生 日時 2008年6月13日 金 12:00 13:00 会場 ハイアットリージェンシー東京 共催 第32回 日本頭頸部癌学会 日本メジフィジックス株式会社 136-0075
総 説 6 6 PIMs P S J 7
2018 10 1-6 総 説 2018 P S J 1 2018 10 7-13 総 説 6 6 PIMs P S J 7 2018 10 19-29 誌上シンポジウム JASDS DSM 1997 2012 15 DSM DSSP JASDS DSM DSSP P S J 19 2018 10 30-34 誌上シンポジウム ADME 30 Pharmacy Society of Japan 2018
06_学術_関節単純X線画像における_1c_梅木様.indd
Arts and Sciences X The formulation of femoral heard measurement corrected enlargement ratio using hip joints X-ray Imaging 1 2 1 1 1 2 Key words: Bipolar Hip Arthroplasty (BHA) Preoperative planning Enlargement
<93C195CA D834F E696E6464>
45 I I Diabetes and Heart: Insight by Imaging Juhani Knuuti Turku PET Centre, Turku University Central Hospital II I Development and Application of Beta-Amyloid Imaging Agents Chet A. Mathis Department
Isotope News 2017年10月号 No.753
Ishioka Noriko ₁ はじめに RI RI RI RI ₂ 悪性褐色細胞腫と治療の現状 3,000 90 I meta- Iiodo-benzylguanidine I-MIBG 1 ₃ α 線の標的アイソトープ治療 2016 6 223 RaCl2 223 Ra 223 Ra 14 表 1 α 線と β 線の違い -decay (42%) Eα = 5.9 MeV At 7.2 h EC
CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation
CHEMOTHERAPY CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation CHEMOTHERAPY Table 1 Preliminaly test of AM- 715 1): Mean } SD *: Significant difference
日本消化器外科学会雑誌第29巻第9号
Table 1 Oligonucleotide primers used for RT-PCR and internal probes used for Southern blot hybridization Cytokine Primer Sequence (5'-3') 5' 3' Internal probe s' 3' Internal probe 5' 3' Internal probe
.N..
Examination of the lecture by the questionnaire of class evaluation -Analysis and proposal of result at the first term of fiscal year - Kazuo MORI, Tukasa FUKUSHIMA, Michio TAKEUCHI, Norihiro UMEDA, Katuya
技術研究報告第２６号
1) 2) 3) 250Hz 500Hz RESEARCH ON THE PHYSICAL VOLUME OF THE DYNAMIC VIBRATION RESPONSE AND THE REDUCTION OF THE FLOOR IMPACT SOUND LEVEL IN FLOORS OF RESIDENTIAL HOUSING Hideo WATANABE *1 This study was
Ⅱ. 用語の操作的定義 Ⅲ. 対象と方法 1. 対象 WAM NET 2. 調査期間 : 3. 調査方法 4. 調査内容 5. 分析方法 FisherMann-Whitney U Kruskal-Wallis SPSS. for Windows 6. 倫理的配慮 Vol. No.
研究報告 The Relation Between the Manager s Administrative Abilities Including Business Activities in Visiting Nursing Stations and the Station s Financial Profits Chisato Fujii Akiko Akama Mariko Ohtake Ikuko
The Journal of the Japan Academy of Nursing Administration and Policies Vol 7, No 2, pp 19 _ 30, 2004 Survey on Counseling Services Performed by Nursi
The Journal of the Japan Academy of Nursing Administration and Policies Vol 7, No 2, pp 19 _ 30, 2004 Survey on Counseling Services Performed by Nursing Professionals for Diabetic Outpatients Not Using
再生医科学研究所年報 Annual Report of the Institute for Frontier Medical Sciences Kyoto University Institute for Frontier Medical Sciences 1 2 3 4 5 6 Institute for Frontier Medical Sciences 1 Annual Report 2011
The Phase Behavior of Monooleoylglycerol-Water Systems Mivoshi Oil & Fat Co.. Ltd. Faculty of Science and Technology, Science University of Tokyo Inst
The Phase Behavior of Monooleoylglycerol-Water Systems Mivoshi Oil & Fat Co.. Ltd. Faculty of Science and Technology, Science University of Tokyo Institute of Colloid and Interface Science, Science University
Changes in Electrodermal Activity Associated with Candies and Chewing Gum Chewing Satoshi Beppu, Takeshi Morita*, Susumu Igarashi **, Kanichi Seto* an
Changes in Electrodermal Activity Associated with Candies and Chewing Gum Chewing Satoshi Beppu, Takeshi Morita*, Susumu Igarashi **, Kanichi Seto* and Yosihiro Amemiya Abstract: This study was designed
JOURNAL OF THE JAPANESE ASSOCIATION FOR PETROLEUM TECHNOLOGY VOL. 66, NO. 6 (Nov., 2001) (Received August 10, 2001; accepted November 9, 2001) Alterna
JOURNAL OF THE JAPANESE ASSOCIATION FOR PETROLEUM TECHNOLOGY VOL. 66, NO. 6 (Nov., 2001) (Received August 10, 2001; accepted November 9, 2001) Alternative approach using the Monte Carlo simulation to evaluate
０７０１０７３‐立命‐社会システム１５号／１５‐９－招待－横井
E-mailxiangzhijp@yahoo.co.jp p p Understanding of Asia by Students of Commercial College under the Old System ACaseStudyofTaihoku Commercial College Kaori Yokoi Abstract Using the Taihoku
udc-3.dvi
49 UDC 371.279.1 3 4 753 1 2 2 1 2 47 6 2005 11 14 50 No.35, 2006 1 1.1 AO 2003 2004 2005 2005 1 1 2005 1998 1999 2002 12 11 2000 SAT ACT Law School Admission Test LSAT Medical College Admission Test MCAT
OJT Planned Happenstance
OJT Planned Happenstance G H J K L M N O P Q R . %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. %. .... Q ......... . Planned Happenstance.. pp.- VOL.,NO. pp., Current Status of Ritsumeikan Employees
The Journal of the Japan Academy of Nursing Administration and Policies Vol 12, No 1, pp 49 59, 2008 資料 看護師におけるメンタリングとキャリア結果の関連 Relationship between M
The Journal of the Japan Academy of Nursing Administration and Policies Vol 12, No 1, pp 49 59, 2008 資料 看護師におけるメンタリングとキャリア結果の関連 Relationship between Mentoring and Career Outcomes of Nurses 今堀陽子 1) 作田裕美
EVALUATION OF MAGNETIC RESONANCE IMAGING (MRI) IN DIAGNOSIS OF ACOUSTIC NEUROMA-COMPARATIVE STUDY WITH PLAIN X-RAY AND CTS- KIMIHISA NOMURA, M.D., MAK
EVALUATION OF MAGNETIC RESONANCE IMAGING (MRI) IN DIAGNOSIS OF ACOUSTIC NEUROMA-COMPARATIVE STUDY WITH PLAIN X-RAY AND CTS- KIMIHISA NOMURA, M.D., MAKOTO SAKAI, M.D., ATSUSHI SHINKAWA, M.D. and HIROSATO
<95DB8C9288E397C389C88A E696E6462>
2011 Vol.60 No.2 p.138 147 Performance of the Japanese long-term care benefit: An International comparison based on OECD health data Mie MORIKAWA[1] Takako TSUTSUI[2] [1]National Institute of Public Health,
2 10 The Bulletin of Meiji University of Integrative Medicine 1,2 II 1 Web PubMed elbow pain baseball elbow little leaguer s elbow acupun
10 1-14 2014 1 2 3 4 2 1 2 3 4 Web PubMed elbow pain baseball elbow little leaguer s elbow acupuncture electric acupuncture 2003 2012 10 39 32 Web PubMed Key words growth stage elbow pain baseball elbow
1) University Group Diabetes Program: A study of hypoglycemic agents on vascular complica- in patients with adult-onset tions diabetes. I. Design, methods and baseline results. Diabetes 19 (suppl. 2):
Unknown
Journal of Breast and Thyroid Sonology Journal of Breast and Thyroid Sonology Vol.2, No.3 July 2013 Report The 30 th Meeting of Japan Association of Breast and Thyroid Sonology... 1 Department of Organ
86 Development of a Course Classification Support System for the Awarding of Degrees using Syllabus Data MIYAZAKI Kazuteru, IDA Masaaki, YOSHIKANE Fuyuki, NOZAWA Takayuki and KITA Hajime Research in Academic
A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, Sc
A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, School of Medicine, Tokushima University, Tokushima Fetal
ABSTRACT The movement to increase the adult literacy rate in Nepal has been growing since democratization in 1990. In recent years, about 300,000 peop
Case Study Adult Literacy Education as an Entry Point for Community Empowerment The Evolution of Self-Help Group Activities in Rural Nepal Chizu SATO Masamine JIMBA, MD, PhD, MPH Izumi MURAKAMI, MPH Massachusetts
1) Tatelman M: The angiographic evaluation of cerebral arteriosclerosis. Radiology 70: 801-810, 1958. 2) Elkeles A: A comparative study of calcified 8) Limpert JD, Vogelzang RL, Yao JST: Computed tomography
process of understanding everyday language is similar, finally as far as word production is concerned, individual variations seem to be greater at an
Understanding of Language in Early Development ( ) Research by Visiting Home (3) Center of developmenta1 education and research Center of developmenta1 education and research Center of developmenta1 education
2014 6 7 12 原 著 S 1, 2 1 1 1 1 2 1 2 2012 6 1 2013 8 26 S S S 148 4 72 49 6 / 60 7 / 12 20 7 / S S OTC 7
2014 6 1 6 Review Article Proposal for Outcome Verification of Iyakubungyo and Future Directions Miwako Kamei 1, Mitsuko Onda 2, Kazuko Akagi 3, Tomohide Akase 4, Noriko Fukushima 5, Noriko Miyamoto 6
日本消化器外科学会雑誌第25巻第11号
Key words: intestinal nerve plexus, hypoxic perfusion, immunohistochemistry, 5-100 protein Table I (A) Sroo staining reactivity of nerve tissue normal partly mildly declined all mildly declined partly
Fig. 1 Chemical structure of DL-8280
Fig. 1 Chemical structure of DL-8280 Fig. 2 Susceptibility of cl in ical isolates to DL4280 Fig. 5 Susceptibility of clinical isolates to DL-8280 Fig. 3 Susceptibility of clinical isolates to DL-8280 Fig.
生体ナノテク第4回_穴なし
!!!!!!!!!!!! TEM! SEM, AFM! 参考文献 最先端材料システム One Point! イメージング (共立出版) 実験がうまくいく 蛍光 発光試薬の 選び方と使い方! (羊土社) 非侵襲 可視化 技術ハンドブック (NTS) 講義と実習 生細胞蛍光 イメージング (共立出版) よくわかる生物電子 顕微鏡技術 (共立出版) (in vivo) - /! - MRI! - X! in
振動充填燃料の粒子焼結試験実施計画書
C JNCTJ8410 2004-006 2004 3 ( ) UPRISE Nd 250mL 0.2 mol Nd Nd (FP)DF DOBA DOiBA NN'-2--1.6 mol/l NN'- -1.7 mol/l NN'-1.5 mol/l DOBA 1mol/L 3.5mol/L 2 NN'--1.7 mol/l NN' -1.5 mol/l ZrRu Ce DF 150 100 Sr
History I COE
2008 108-8641 5-9-1 TEL 03-5791-6334FAX 03-5791-6335 e-mailgakufu@lisci.kitasato-u.ac.jp 228-8555 1-15-1 TEL 042-778-9760FAX 042-778-9761 e-mailnyushi@kitasato-u.ac.jp URL http://www.kitasato-u.ac.jp/lisci/index.html
05_藤田先生_責
This report shows innovation of competency of our faculty of social welfare. The aim of evaluation competency is improvement in the Social welfare education effects, by understanding of studentʼs development
8 The Bulletin of Meiji University of Integrative Medicine API II 61 ASO X 11 7 X-4 6 X m 5 X-2 4 X 3 9 X 11 7 API 0.84 ASO X 1 1 MR-angio
7-14 2010 1 1 1 2 1 1 1 2 Fontaine II ASO61 3 API ASO ASO ASO API API KKKKKKKKKK ASO Fontaine II API Received April 14, 2009; Accepted July 16, 2009 I arteriosclerosis obliterans: ASO ASO 50 70 1,2 Fontaine
VOL.39 S-3
VOL.39 S-3 CHEMOTHERAPY SEPT.1991 Table 1. Background of characteristics and allocation of 5 healthy male volunteers in a multiple-dose study on panipenem/betamipron Day 1 Fig. 1. Schedule of multiple-dose
untitled
11-19 2012 1 2 3 30 2 Key words acupuncture insulated needle cervical sympathetick trunk thermography blood flow of the nasal skin Received September 12, 2011; Accepted November 1, 2011 I 1 2 1954 3 564-0034
52-2.indb
Jpn. J. Health Phys., 52 (2) 55 60 (2017) DOI: 10.5453/jhps.52.55 * 1 * 2 * 2 * 3 * 3 2016 10 28 2017 3 8 Enhancement of Knowledge on Radiation Risk Yukihiko KASAI,* 1 Hiromi KUDO,* 2 Masahiro HOSODA,*
Jan THE JAPANESE JOURNAL OF ANTIBIOTICS XL-1 Table 1. Outline of administering doses, routes and sampling times *: 4 ml/hr/kg Bacillus subtilis
THE JAPANESE JOURNAL OF ANTIBIOTICS XL-1 Jan. 1987 Jan. 1987 THE JAPANESE JOURNAL OF ANTIBIOTICS XL-1 Table 1. Outline of administering doses, routes and sampling times *: 4 ml/hr/kg Bacillus subtilis
VOL. 34 S-2 CHEMOTH8RAPY 913
VOL. 34 S-2 CHEMOTH8RAPY 913 914 CHEMOTHERAPY APR. 1986 Fig. 1 Chemical structure of T-2588 and T-2525 T- 2588 pivaloyloxymethyl (+ )- (6 R, 7 R)-7-[(Z)-2- (2-amino- 4-thiazolyl)-2-methox yiminoacetamido]-3-[(
Journal of Geography 116 (6) Configuration of Rapid Digital Mapping System Using Tablet PC and its Application to Obtaining Ground Truth
Journal of Geography 116 (6) 749-758 2007 Configuration of Rapid Digital Mapping System Using Tablet PC and its Application to Obtaining Ground Truth Data: A Case Study of a Snow Survey in Chuetsu District,
CHEMOTHERAPY AUG. 1982 VOL. 30 NO. 8 CHEMOTHERAPY Fig.1 Relation between various-closis of cefazolin and detection rate of organisms in heart blood of dying mice with E. coli and P. aeruginosa infection
06_学術.indd
Arts and Sciences Development and usefulness evaluation of a remote control pressured pillow for prone position 1 36057 2 45258 2 29275 3 3 4 1 2 3 4 Key words: pressured pillow prone position, stomach
The nursing practices nurses consider important in the tertiary emergency rooms Kanako Honda'', Chizuko Miyake'', Midori Yao", Mikiko Kurushima", Kumiko Toyoda4 "The University of Shiga Prefecture, "Osaka
Visual Evaluation of Polka-dot Patterns Yoojin LEE and Nobuko NARUSE * Granduate School of Bunka Women's University, and * Faculty of Fashion Science,
Visual Evaluation of Polka-dot Patterns Yoojin LEE and Nobuko NARUSE * Granduate School of Bunka Women's University, and * Faculty of Fashion Science, Bunka Women's University, Shibuya-ku, Tokyo 151-8523
) 5 Lawton QOL 4 4 QOL Lawton 4) Philadelphia Geriatric Center Affect Rating ScaleARS ARS QOL 5) HDS R
Vol. 12 No. 2 2002 389 397 Λ1 Λ2 16 10 30 1 2 Lawton Philadelphia Geriatric Center Affect Rating ScaleARS Lawton ARS + ARS 6 2 ARS 2 12:00 15:0017:00 11:30 16:00 1 2 ARS 1 2 ARS QOL QOL QOL 1) QOL QOL
16_.....E...._.I.v2006
55 1 18 Bull. Nara Univ. Educ., Vol. 55, No.1 (Cult. & Soc.), 2006 165 2002 * 18 Collaboration Between a School Athletic Club and a Community Sports Club A Case Study of SOLESTRELLA NARA 2002 Rie TAKAMURA
揃 24 1681 0 20 40 60 80 100 0 21 42 63 84 Lag [hour] Lag [day] 35
![揃 24 1681 0 20 40 60 80 100 0 21 42 63 84 Lag [hour] Lag [day] 35](/thumbs/40/20539367.jpg "揃 24 1681 0 20 40 60 80 100 0 21 42 63 84 Lag [hour] Lag [day] 35")
Forecasting Model for Electricity Consumption in Residential House Based on Time Series Analysis * ** *** Shuhei Kondo Nobayasi Masamori Shuichi Hokoi ( 2015 7 3 2015 12 11 ) After the experience of electric
Effects of Diet Class on Overweight Middle-aged Women Analysis of Nutritional Intake Pattern YAMAGUCHI Shizue*, MATSUMOTO Tomoko**, MIMURA Kan-ichi***, ASAI Hitoshi****, OKUDA Toyoko***** * O saka Shin-ai
(1 ) (2 ) Table 1. Details of each bar group sheared simultaneously (major shearing unit). 208
2463 UDC 621.771.251.09 : 621.791.94: 669.012.5 Improvement in Cold Shear Yield of Bar Mill by Computer Control System Koji INAZAKI, Takashi WASEDA, Michiaki TAKAHASHI, and Toshihiro OKA Synopsis: The
2002 31 3 4 5 6 10 12 15 1 18 19 20 1
2002 31 3 4 5 6 10 12 15 1 18 19 20 1 2002 31 2 21 NATO 22 NATO 23 1 24 25 26 27 2 Soviet Industrial Location: A Reexamination 28 29 Department of History and Classics, University of Alberta 30 31 2 2002
1. Caov-3 細胞株 A2780 細胞株においてシスプラチン単剤 シスプラチンとトポテカン併用添加での殺細胞効果を MTS assay を用い検討した 2. Caov-3 細胞株においてシスプラチンによって誘導される Akt の活性化に対し トポテカンが影響するか否かを調べるために シスプラチ
( 様式甲 5) 学位論文内容の要旨 論文提出者氏名 論文審査担当者 主査 朝日通雄 恒遠啓示 副査副査 瀧内比呂也谷川允彦 副査 勝岡洋治 主論文題名 Topotecan as a molecular targeting agent which blocks the Akt and VEGF cascade in platinum-resistant ovarian cancers ( 白金製剤耐性卵巣癌における
100 SDAM SDAM Windows2000/XP 4) SDAM TIN ESDA K G G GWR SDAM GUI
30 99 112 2006 SDAM SDAM SDAM SDAM 1950 1960 1970 SPSS SAS Microsoft Excel ArcView GIS 2002 ArcExplorer 1) MANDARA 2) GIS 2000 TNTLite 3) GIS 100 SDAM SDAM Windows2000/XP 4) SDAM TIN ESDA K G G GWR SDAM
K06_アウトライン前.indd
CT 画 像 を 用 いた 肺 の 呼 吸 機 能 の 定 量 化 * ** * Quantification of the Respiratory Activity of the Lung using CT Images Takayuki HASHIMOTO* Caihua WANG**,and Jun MASUMOTO* Abstract We have developed a system to
アミヴィッド静注 CTD 第 2 部 2.1 第 2 部から第 5 部の目次 富士フイルム RI ファーマ株式会社
CTD 第 2 部 富士フイルム RI ファーマ株式会社 ( 空白ページ ) 2 第 2 部 ( モジュール 2): CTD の概要 ( サマリー ) ---------------------------------------------- 第 2 巻 2.2 緒言 2.3 品質に関する概括資料緒言 2.3.S 原薬 (AV-105, ) 2.3.S 原薬 ( フロルベタピル ( 18 F),
Huawei G6-L22 QSG-V100R001_02
G6 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 1 2 3 17 4 5 18 UI 100% 8:08 19 100% 8:08 20 100% 8:08 21 100% 8:08 22 100% 8:08 ********** 23 100% 8:08 Happy birthday! 24 S S 25 100% 8:08 26 http://consumer.huawei.com/jp/
[2] 1. 2. 2 2. 1, [3] 2. 2 [4] 2. 3 BABOK BABOK(Business Analysis Body of Knowledge) BABOK IIBA(International Institute of Business Analysis) BABOK 7
![[2] 1. 2. 2 2. 1, [3] 2. 2 [4] 2. 3 BABOK BABOK(Business Analysis Body of Knowledge) BABOK IIBA(International Institute of Business Analysis) BABOK 7](/thumbs/40/22240274.jpg "[2] 1. 2. 2 2. 1, [3] 2. 2 [4] 2. 3 BABOK BABOK(Business Analysis Body of Knowledge) BABOK IIBA(International Institute of Business Analysis) BABOK 7")
32 (2015 ) [2] Projects of the short term increase at present. In order to let projects complete without rework and delays, it is important that request for proposals (RFP) are written by reflecting precisely
Therapy for Asthenopia in Cases of Convergence Insufficiency Hiroko TAKASAKI, C.O.J., Nobuko INAGAMI, C.O.J., and Kayoko TAKENAWA, C.O.J.. Orthoptic c
Therapy for Asthenopia in Cases of Convergence Insufficiency Hiroko TAKASAKI, C.O.J., Nobuko INAGAMI, C.O.J., and Kayoko TAKENAWA, C.O.J.. Orthoptic clinic, Department of Ophthalmology, (Director: Prof
07_特集6_再校_0516.indd
158 MEDICAL IMAGING TECHNOLOGY Vol. 35 No. 3 May 2017 * * PET/CT 1 1 2 2 3 2 4 PET/CT PET/CT CT PET CT 10 PET/CT FROC 1 3.9 76 PET/CT Med Imag Tech 35 3 : 158 166, 2017 1. 1 magnetic resonance imaging
Title 外傷性脊髄損傷患者の泌尿器科学的研究第 3 報 : 上部尿路のレ線学的研究並びに腎機能について Author(s) 伊藤, 順勉 Citation 泌尿器科紀要 (1965), 11(4): Issue Date URL
Title 外傷性脊髄損傷患者の泌尿器科学的研究第 3 報 : 上部尿路のレ線学的研究並びに腎機能について Author(s) 伊藤, 順勉 Citation 泌尿器科紀要 (1965), 11(4): 278-291 Issue Date 1965-04 URL http://hdl.handle.net/2433/112732 Right Type Departmental Bulletin Paper
The Japanese Journal of Experimental Social Psychology. 2003, Vol. 42, No. 2, 146-165 Discoursive Strategy for the Commitment to Adoption with Infants Who Had Been Reared at Residential
46
The Journal of the Japan Academy of Nursing Administration and Policies Vol. 16, No. 1, PP 45-56, 2012 Factors Related to Career Continuation among Nurses Raising Children Mayumi Iwashita 1) Masayo Takada
Fig. 3 Flow diagram of image processing. Black rectangle in the photo indicates the processing area (128 x 32 pixels).
Fig. 1 The scheme of glottal area as a function of time Fig. 3 Flow diagram of image processing. Black rectangle in the photo indicates the processing area (128 x 32 pixels). Fig, 4 Parametric representation
新製品開発プロジェクトの評価手法
CIRJE-J-60 2001 8 A note on new product project selection model: Empirical analysis in chemical industry Kenichi KuwashimaUniversity of Tokyo Junichi TomitaUniversity of Tokyo August, 2001 Abstract By
Appropriate Disaster Preparedness Education in Classrooms According to Students Grade, from Kindergarten through High School Contrivance of an Educati
Appropriate Disaster Preparedness Education in Classrooms According to Students Grade, from Kindergarten through High School Contrivance of an Education of Disaster Preparedness System and Class Practice
The Japanese Journal of Health Psychology, 29(S): (2017)
Journal of Health Psychology Research 2017, Vol. 29, Special issue, 139 149Journal of Health Psychology Research 2016, J-STAGE Vol. Advance 29, Special publication issue, 139 149 date : 5 December, 2016
B5 H1 H5 H2 H1 H1 H2 H4 H1 H2 H5 H1 H2 H4 S6 S1 S14 S5 S8 S4 S4 S2 S7 S7 S9 S11 S1 S14 S1 PC S9 S1 S2 S3 S4 S5 S5 S9 PC PC PC PC PC PC S6 S6 S7 S8 S9 S9 S5 S9 S9 PC PC PC S9 S10 S12 S13 S14 S11 S1 S2
A comparison of abdominal versus vaginal hysterectomy for leiomyoma and adenomyosis Kenji ARAHORI, Hisasi KATAYAMA, Suminori NIOKA Department of Obstetrics and Gnecology, National Maizuru Hospital,Kyoto,
Vol. 42 No MUC-6 6) 90% 2) MUC-6 MET-1 7),8) 7 90% 1 MUC IREX-NE 9) 10),11) 1) MUCMET 12) IREX-NE 13) ARPA 1987 MUC 1992 TREC IREX-N
Vol. 42 No. 6 June 2001 IREX-NE F 83.86 A Japanese Named Entity Extraction System Based on Building a Large-scale and High-quality Dictionary and Pattern-matching Rules Yoshikazu Takemoto, Toshikazu Fukushima
03_学術.indd
Arts and Sciences CT Approach to the incidental discovery of early-stage breast cancer on a chest CT 33393 Key words: Breast cancer. CT. Mammography Abstract Recently, we have treated two patients in our
Core Ethics Vol.
Core Ethics Vol. < > Core Ethics Vol. ( ) ( ) < > < > < > < > < > < > ( ) < > ( ) < > - ( ) < > < > < > < > < > < > < > < > ( ) Core Ethics Vol. ( ) ( ) ( ) < > ( ) < > ( ) < > ( ) < >
% 95% 2002, 2004, Dunkel 1986, p.100 1
Blended Learning 要 旨 / Moodle Blended Learning Moodle キーワード:Blended Learning Moodle 1 2008 Moodle e Blended Learning 2009.. 1994 2005 1 2 93% 95% 2002, 2004, 2011 2011 1 Dunkel 1986, p.100 1 Blended Learning
29 28 39 1936 Acquiring technique and forming character in physical education after 1936 Analysis of articles of Kenji Shinozaki FUJIKAWA Kazutoshi The United Graduate School of Education Tokyo Gakugei
untitled
Bull. Shiga. Pref. Agric.Tech.Promo.Cent. 4645 55 2007 Improvement in Quality and Profitability in Tea Cultivation with Direct Covering Koji CHUTANI 10a 17 10 13 5 17 13 5 10a 10 5 3 5 1,2,3,8,12 1 6 39t
1) Michaelis L. Biochem Z., 59, 78, 1914. 2) Ferris H. C. Dent. Cosmos Phila., 63, 10, 93, 1921. 3) Bloomfield A. L. Bull Johns Hopk. Hosp. Bait., 31, 118, 1920. 4) Starr H. C. J. Biol. Chem. Bait., 54,
一次サンプル採取マニュアル PM 共通 0001 Department of Clinical Laboratory, Kyoto University Hospital その他の検体検査 >> 8C. 遺伝子関連検査受託終了項目 23th May EGFR 遺伝子変異検
Department of Clinical Laboratory, Kyoto University Hospital 6459 8. その他の検体検査 >> 8C. 遺伝子関連検査受託終了項目 23th May. 2017 EGFR 遺伝子変異検査 ( 院内測定 ) c-erbb/egfr [tissues] 基本情報 8C051 c-erbb/egfr JLAC10 診療報酬 分析物 識別材料測定法
40B: 43-54 2010 43 2010 1 27 Satoshi Shimai 1 and Shigehiro Fujimoto 2 1 Center for Liberal Arts and Education, Minami-Kyushu University, Miyakonojo,
40B: 43-54 2010 2010 1 27 Satoshi Shimai 1 and Shigehiro Fujimoto 2 1 Center for Liberal Arts and Education, Minami-Kyushu University, Miyakonojo, Miyazaki 885-0035, Japan; 2 Miyakonojo Public Health Institute,
ñ{ï 01-65
191252005.2 19 *1 *2 *3 19562000 45 10 10 Abstract A review of annual change in leading rice varieties for the 45 years between 1956 and 2000 in Japan yielded 10 leading varieties of non-glutinous lowland
Journal of Breast and Thyroid Sonology Journal of Breast and Thyroid Sonology Vol.2, No.1 January 2013 Overview History of JABTSJapan Association of Breast and Thyroid Sonology : Dawn of a JABTS Age; The
988 CHEMOTHERAPY NOV. 1971
988 CHEMOTHERAPY NOV. 1971 VOL. 19 NO. 8 CHEMOTHERAPY 989 Effect of medium-ph and inoculum size on activity of SB-PC heart infusion agar, mcg/ml Sensitivity distribution of Staphylococci to SB-PC in surgical
49148
Research in Higher Education - Daigaku Ronshu No.24 (March 1995) 77 A Study of the Process of Establishing the Student Stipend System in the Early Years of the PRC Yutaka Otsuka* This paper aims at explicating
b) Gram-negative bacteria Fig. 2 Sensitivity distribution of clinical isolates : E. coli Fig. 3 Sensitivity distribution of clinical isolates : Pseudomonas Fig. 1 Sensitivity distribution of clinical isolates
Bull. of Nippon Sport Sci. Univ. 47 (1) Devising musical expression in teaching methods for elementary music An attempt at shared teaching
Bull. of Nippon Sport Sci. Univ. 47 (1) 45 70 2017 Devising musical expression in teaching methods for elementary music An attempt at shared teaching materials for singing and arrangements for piano accompaniment
CHEMOTHERAPY aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Prote
aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Proteus mirabilis 3.13, Proteus vulgaris 1.56, Citrobacter freundii 0.39,
EVALUATION OF NOCTURNAL PENILE TUMESCENCE (NPT) IN THE DIFFERENTIAL DIAGNOSIS OF IMPOTENCE Masaharu Aoki, Yoshiaki Kumamoto, Kazutomi Mohri and Kazunori Ohno Department of Urology, Sapporo Medical College
Development of Analysis Equipment for the Reprocessing Plant using Microchips Microchip, Analysis, Reprocessing, Thermal Lens, Uranium, Plutonium Development of Analysis Equipment for the Reprocessing
Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (45)
Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 2305(45) 2306(46) THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Dec. Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 2307(47) 2308(48) THE JAPANESE
26 1 : Self - reported Practices of Cancer Pain Management among Nurses in Tohoku University Hospital Hideyuki Hira
26 1 : 35 45 2017 1 2 2 2 2 2 2 2 2 1 1 2 Self - reported Practices of Cancer Pain Management among Nurses in Tohoku University Hospital Hideyuki Hirayama 1, Yoko Nakajo 2, Akemi Saito 2, Rie Hatakeyama
Web Stamps 96 KJ Stamps Web Vol 8, No 1, 2004
The Journal of the Japan Academy of Nursing Administration and Policies Vol 8, No 1, pp 43 _ 57, 2004 The Literature Review of the Japanese Nurses Job Satisfaction Research Which the Stamps-Ozaki Scale
A Study on Throw Simulation for Baseball Pitching Machine with Rollers and Its Optimization Shinobu SAKAI*5, Yuichiro KITAGAWA, Ryo KANAI and Juhachi
A Study on Throw Simulation for Baseball Pitching Machine with Rollers and Its Optimization Shinobu SAKAI*5, Yuichiro KITAGAWA, Ryo KANAI and Juhachi ODA Department of Human and Mechanical Systems Engineering,
STUDIES ON THE RELATION BETWEEN LATE DUMPING SYNDROME AND GLUCAGON RESPONCES TO GLUCOSE Taisuke MATSUI The First Department of Surgery, Nara Medical U
STUDIES ON THE RELATION BETWEEN LATE DUMPING SYNDROME AND GLUCAGON RESPONCES TO GLUCOSE Taisuke MATSUI The First Department of Surgery, Nara Medical University, Kashihara (Director: Prof. H. Nakano) This
(1) 2
- - 1 2 34 5 1192-0397 1-1 E-mail:oda-yoshiya@c.metro-u.ac.jp 2270-1194 1646 E-mail:y-aoyagi@criepi.denken.or.jp 2270-1194 1646 E-mail: higashi@criepi.denken.or.jp 4270-1194 1646 E-mail: shintaro@criepi.denken.or.jp
Size Effect of Biomass on Carbonization Rate Treated in Superheated Steam Combined with Far Infrared Heating Akiko ISA Yoshio HAGURA and Kanichi Kit Graduate School of Biosphere Science, Hiroshima University,
10-渡部芳栄.indd
COE GCOE GP ) b a b ) () ) () () ) ) .. () ) ) ) ) () ........... / / /.... 交付税額 / 経常費 : 右軸交付税額 /( 経常費 授業料 ): 右軸 . ) ()... /.. 自治体負担額 / 交付税額 : 右軸 ()......... / 自治体負担額 / 経常費 : 右軸 - No. - Vol. No. - IDE
渡辺(2309)_渡辺(2309)
[ 29 p. 241-247 (2011)] ** *** ** ** Development of a nickel-based filler metal containing a small amount of silicon by WATANABE Takehiko, WAKATSUKI Ken, YANAGISAWA Atsusi and SASAKI Tomohiro Authors tried