Fig. 1 Chemical structure of DL-8280
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1 Fig. 1 Chemical structure of DL-8280
2 Fig. 2 Susceptibility of cl in ical isolates to DL4280 Fig. 5 Susceptibility of clinical isolates to DL-8280 Fig. 3 Susceptibility of clinical isolates to DL-8280 Fig. 4 Susceptibility of clinical isolates to DL-8280
3 Fig. 6 Susceptibility of clinical isolates to DL-8280 P. aeruginosa 50 strains (100 ~) Fig. 7 Susceptibility of clinical ieolates to DL-8280 S. marcescens 25 strains (100 ~) Table 1 Comparative antibacterial activity of DL-8280 and other agents against clinical isolated pathogens NFLX: norfloxacin, PPA: pipemidic acid, NA: nalidixic acid, CFS: cefsulodin, GM: gentamicin
4 Table 2 Serum levels of DL-8280 (200 mg, fasting) (healthy volunteers) Table 3 Urinary excretion of DL-8280 (200mg, fasting) (Healthy volunteers) L: Urinary levels, R: Urinary recovery Fig. 8 Serum and saliva levels of DL-8280 (200 mg, fasting) Fig. 9 Urinary excretion of DL-8280 (200 mg, fasting)
5 Table 4 Saliva levels of DL-8280 (200 mg, fasting) (Healthy volunteers) (Healthy volunteers) Table 5 Clinical results of DL-8280 on RTI Table 6 Clinical results of DL-8280 on UTI
6 Table 7 Clinical response to DL-8280 Table 8 Bacteriological response to DL-8280
7
8 Fig. 10 Case No. 22: acute pyelonephritis (male, 45y) 1) SATO, K.; Y. MATSUURA, M. INOUE, T. UNI, Y. OSADA, H. OGAWA & S. MITSUHASBI: In vitro and in vivo activity of DL-8280, a new ozazine derivative. Antimicr. Agents & Chemoth. 22: 548 `553, ) MATSUURA, Y.; K. SATO, M. INOUB & S. MITSU. HASHI DL-8280, a new synthetic antimicrobial agent: in vitro and in vivo antimicrobial potency against clinical isolates resistant to nalidizic acid, pipemidic acid and gentamicin. In Genetics, Biochemistry and Molecular Biology-Drug Resistance in Bacteria-(S. MITSUBASHI, Ed.), japan Scientific Societies Press, Tokyo, pp.401 `405, 1982
9 BACTERIOLOGICAL AND CLINICAL EVALUATION OF DL-8280 IN THE FIELD OF RESPIRATORY AND URINARY TRACT INFECTIONS FUMIO MATSUMOTO and TOSHIO HOJOH Department of Infectious Disease, Kanagawa Prefectural Nursing and Hygienic School Hospital TAKAYUKI TAKAHASHI, EIGORO SUGIURA and YUJI TAURA Central Laboratory, Kanagawa Prefectural Nursing and Hygienic School Hospital TETSURO HIRABAYASHI Pharmacy, Kanagawa Prefectural Nursing and Hygienic School Hospital The studies on antimicrobial activity, absorption, excretion and clinical evaluation of DL-8280 were performed, and following results were obtained. 1) Antibacterial activity : DL-8280 showed an excellent antibacterial activity against gram-negative rods and gram-positive cocci. In the case of S. aureus, DL-8280 completely inhibited the growth at the concentration of 1.56ƒÊg/ml and the growth of about 90% of clinically isolated strains of gram-negative rods such as E. coli, K. pneumoniae, P. mirabilis, P. aeruginosa, S. marcesens were inhibited at the concentration of 1.56ƒÊg/ml, lower than the MIC value. 2) Peak serum concentration of 2.21ƒÊg/ml of DL-8280 in healthy adult volunteer was attained at 2 hours after a single oral administration of 200mg. The half life of DL-8280 in serum was calculated to be 5.3 hours and serum concentration was still more than 0.77ƒÊg/ml at 10 hours after dosing. The peak urinary concentration of DL-8280 was 346.5ƒÊg/ml which was found in urine collected during 4 to 6 hours after administration and urinary recovery rate was 60.6% within 10 hours. 3) Clinical efficacy rate in 12 patients with respiratory tract infection was 91.7%, and all of 12 patients with urinary tract infection were responded successfully to DL-8280 therapy. As for the untoward reaction of DL-8280, vertigo was observed in one patient, and slight elevation of S-GOT, S-GPT and Al-Pase was observed in 1 patient out of 24 patients. It was concluded that DL-8280 was a useful synthetic oral antimicrobial agent for the treatment of not only UTI but also RTI.
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日本化学療法学会雑誌第53巻第S-3号
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VOL.27 S-5 CHEMOTHERAPY Table 1 Clinical evaluations of cefamandole on UTI (1) Benign prostatic hypertrophy (2) Transurethral resection of bladder tum
CHEMOTHERAPY JUNE 1972 Fig. 1 Chemical structure of cefamandole E. coil, Klebsiella Proteus vulgaris indole positive Proteus sp., Enterobacter, Citrobacter, Serratia marcescens Chemical name: 7-D-mandelamido-3-
VOL.32 S-9 CHEMOTHERAPY Table 1 Minimum inhibitory concentrations of AC-1370, CPZ and CAZ Table 2 Efficacy of AC-1370 and CPZ against systemic infections in mice *Inoculum size: 106 cells/ml * 95% confidence
CHEMOTHERAPY Methicillin-resistant S.aureus(MRSA) coccus epidermidis 105 Streptococcus pyogenes E.faecali senterococcus avium Enterococcus faecium Str
cefaclor(ccl),cefuroxime(cxm),cefixime (CFIX),cefteram(CFTM),cefdinir(CFDN) pneumoniae,streptococcus pyogenes Moraxella catarrhalis,haemophilus influenzae,escherichia coli, Klebsiella pneumoniae,proteus
Table 1. Concentration of ritipenem in plasma, gallbladder tissue and bile after ritipenem acoxil administration (200 mg t.i.d., 3 days) N.D.: not det
Table 1. Concentration of ritipenem in plasma, gallbladder tissue and bile after ritipenem acoxil administration (200 mg t.i.d., 3 days) N.D.: not detected *: time after last administration Table 2. Concentration
CHEMOTHERAPY
VOL.40 S-1 coagulase negative Staphylococcus sp, methicillin- resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Escherichia coli, Citrobacter freundii, Klebsiella pneumoniae, Enterobacter
VOL. 20 NO. 5 CHEMOTHERAPY Methoxy-4-sulfanilamidopyrimidine (OS-3376) Sulfadimethoxine (SDM) Table 1. In vitro antibacterial activities of OS-3
VOL. 20 NO. 5 CHEMOTHERAPY 653 2-Methoxy-4-sulfanilamidopyrimidine (OS-3376) Sulfadimethoxine (SDM) Table 1. In vitro antibacterial activities of OS-3376, SDM, SIZ and SMZ against Gram-positive and negative
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Escherichia coli Enterococcus faecalisstreptococcus agalactiae Klebsiella pneumoniae Staphylococcus epidermidis E. colie. faecalispseudomonas aeruginosa K. pneumoniae S. agalactiae E. coli E. coli μ p
CHEMOTHERAPY SEPT. 1991
CHEMOTHERAPY SEPT. 1991 VOL. 39 S-3 Table 1. Background of characteristics and allocation of 9 healthy male volunteers in a single-dose study on betamipron Table 2. Background of characteristics and allocation
semen quality or those without WBC in semen. In the patients with azoospermia and normal FSH levels (normogonadotropic azzospermia), the antibody (IgG
CLINICAL STUDIES OF UROGENITAL INFECTIONS WITH CHLAMYDIA TRACHOMA TIS Report 2. The Epidemiology of Chlamydial Infections in Okayama District in Japan and Detection of Antibodies to Chlamydiae in the Sera
日本化学療法学会雑誌第51巻第2号
piperacillin piperacillin PIPC. g Cmax CL PIPC CL CLR CLNR CL PIPC g g Cmax PIPC Key words: piperacillin Piperacillin PIPC PIPC g g PIPC Cmax g g ml g g ml g g ml T T T PIPC g g T Ccr ml min AUCCmax PIPC
CHEMOTHERAPY SEPT. 1970
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Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection
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VOL. 33 S-5 CHEMO THERAPY Fig. 1 Chemical structure of HAPA-B 1-N-[ (2 S)-3-Amino-2-hydroxypropiony1]-4- O-(6-amino-6 - deoxy-ƒ -D- glucopyranosyl) -6
VOL. 33 S-5 CHEMO THERAPY Fig. 1 Chemical structure of HAPA-B 1-N-[ (2 S)-3-Amino-2-hydroxypropiony1]-4- O-(6-amino-6 - deoxy-ƒ -D- glucopyranosyl) -6- O-[3-deoxy-4 -C-methyl-3 -(methylamino) -ƒà-l- arabinopyranosyl]-2
VOL.27 CHEMOT S-1 HERAPY 185 に感 性 を示 して い たが,臨 床 的 に は無 効 で あ った 本 症 る 細 菌学 的 に も検 討 した が,起 炎菌 と考 え られ る細 菌 を 例 で は 基礎 疾 患 と して縦 隔 洞腫 瘍 が あ り,既 に 副 腎
CHEMOTHERAPY Table 1 Clinical evaluation of Mezlocillin treatment against respiratory and other infectious diseases *: fever, eruption, granulocytopenia, thrombocytopenia, GOT, GPT elevation (See table
Feb THE JAPANESE JOURNAL OF ANTIBIOTICS Tebipenem pivoxil 1 1, Meiji Seika 2 Meiji Seika G 3 Meiji Seika Tebipen
Feb. 2016 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 1 53 53 Tebipenem pivoxil 1 1, 3 2 2 1 1 Meiji Seika 2 Meiji Seika G 3 Meiji Seika 2015 12 15 Tebipenem pivoxil 10% 2010 4 2013 3 3,547 3,540 3,540 3,331
Key words: bacterial meningitis, Haemophilus influenzae type b, Streptococcus pneumoniae, rapid diagnosis, childhood
Key words: bacterial meningitis, Haemophilus influenzae type b, Streptococcus pneumoniae, rapid diagnosis, childhood Fig.1 Distribution of the cases with bacterial meningitis by age and pathogens Chiba
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VOL.30 S-1 CHEMOTHERAPY Table 1 Dose of CTT and subjects i. v.: Intravenous bolus injection d. i. v.: Intravenous drip infusion i. m.: Intramuscular injection Fig. 1 Schedule for examination of CTT, 1.0g
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VOL. 21 NO. 2 CHEMOTHERAPY 395
394 CHEMOTHERAPY MAR. 1973 VOL. 21 NO. 2 CHEMOTHERAPY 395 396 CHEMOTHERAPY MAR. 1973 VOL. 21 NO. 2 CHEMOTHERAPY 397 398 CHEMOTHERAPY MAR. 1973 VOL. 2 1 NO. 2 CHEMOTHERAPY 399 400 CHEMOTHERAPY MAR. 1973
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β Moraxella catarrhalis Escherichia coli Citrobacter Klebsiella pneumoniae Enterobacter cloacae Serratia marcescens Proteus Pseudomonas aeruginosa Acinetobacter Bacteroides fragilis β Haemophilus influenzae
CHEMOTHERAPY OCT Fig. 1 Chemical structure of CVA-K
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