ｨｺ02ｨｨ00ｨｪｨｦ apple09apple040ｸ903, 0ｹ ｹ ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ

Transcription

1 ｨｪ04ｨ ｨｦ07ｨｦ 0402ｨｬｨｮ04ｨｦ07ｨｦ ｨｪｨｺ02 ｨｺ0204 ｨｪ0703 5, 6ｧ8 1, 2009, 0603apple. 27ｨC35 ｨｦ03ｨ ｨｦｨｺ01 ｨｬ : : ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ00 ｨｨｨｦｨｺ ｨ 00 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨｨｺｨ ｨｺ ｨｨｨｺ000505ｨｪ02ｨｪ0000ｨｲ04ｨｦ ｨ apple6ｦ apple6ｦ apple6ｦ ｸ ｸ800 6ｦ ｸ8 08apple ｸ ｦ006036ｦ003090ｹ apple6ｦ fl ｦ0 08apple09 apple6ｦ apple ｦ ｸ8. 050ｸ ｸ apple076ｦ0006ｦ apple076 56ｦ0000ｸ8 006ｦ ｦ ｦ ｸ apple07060ｸ8, 036ｦ ｦ ｸ ｦ0fl 0ｹ06ｦ ｦ0 0601apple0ｸ8030ｸ apple apple6ｦ fl ｦ0, apple apple6ｦ apple ｦ ｷ300apple00 apple6ｦ ｸ apple6ｦ , 036ｦ ｦ apple09fl03000ｸ ｹ apple , ｦ0fl 0ｹ ｷ3096ｦ ｹ fl. ｨｨ ｸ ｸ806 6ｦ0006ｦ apple ｸ fl apple6ｦ009apple6ｦ ｹ ｸ ｦ ｹ fl 0ｹ fl ｦ ｦ00009fl ｸ90ｹ ｸ ｦ0: apple6ｦ001 08apple ｦ ｸ8, ｦ006036ｦ003090ｹ apple6ｦ ｦ ｨ 00 ｨｺ6ｦ001 08apple ｦ ｸ8 (ｨｺｨｨ05) apple6ｦ0006ｦ003 fl6 502fl000306fl ｦ ｹ06ｦ apple000ｹ06ｦ00ｸ90ｸ fl ｦ00ｹ ｸ apple6ｦ ｦ ｹ00900 [1ｨC3] ｸ ｹ06ｦ fl ｸ90ｹ ｸ80603apple0ｸ806 apple ｦ ｦ ｨｺｨｨ05, ｦ00ｸ90ｸ apple % 096ｦ , 0ｹ fl apple apple076 56ｦ ｹ ｦ0 apple apple09apple ｸ ｹ06ｦ [2, 4] apple ｦ ｹ ｦ fl ｹ ｸ ｦ006036ｦ003090ｹ apple036ｦ00309 ｨｺｨｨ05 [1, 2, 4]. ｨｦ - 006ｦ ｦ apple09 006ｦ002090ｹ ｹ ｦ ｦ ｸ ｦ006036ｦ apple apple6 76ｦ0006ｦ ｹ apple07fl fl ｦ00ｸ90306fl 096ｦ00ｹ06ｦ ｸ ｦ ｸ80309 [2, 3]. ｨｪ6ｦ apple6ｦ , ｹ ｸ apple0ｸ8030ｸ80309 ( ｹ ｦ apple076 56ｦ000000ｸ80309) 0207apple036ｦ ｦ006036ｦ003090ｹ ｨｺｨｨ ｦ00ｹ apple006 50ｸ8046ｦ ｹ ｸ ｦ apple076 56ｦ000000ｸ803 apple6ｦ ｦ006036ｦ003090ｹ apple6ｦ ｦ0 (02ｨｨ0702) ｦ ｨC50% ｸ ｦ ｷ30909apple fl ｦ apple09fl03000ｸ803 08apple ｹ fl ｹ ｦ ｦ00009fl [5ｨC9]. ｨｦ ｹ ｸ ｨｨ apple ｦ apple6ｦ0 036ｦ0apple6ｦ apple ｸ90306fl 03fl ｸ ｸ fl apple apple6ｦ fl 0600apple ｸ ｦ apple07000ｸ apple apple6 76ｦ , 036ｦ ｷ apple6ｦ apple ｸ ｦ0040ｹ0000ｸ806 0ｷ apple ｨｺ ｦ0016ｦ ｦ00401, , ｨｺ ｦ , ｨｮ ｦ0, 41; [email protected]. 030ｸ8 (090405), ｦ0096ｦ ｦ00ｹ ｦ , 096ｦ00ｹ06ｦ ｸ9 03apple00 040ｸ903 0ｹ apple ｦ ｦ00ｷ ｦ ｹ fl ｦ ｸ ｦ ｹ ｦ000000ｸ803, 08apple ｸ ｨｨ ｹ fl ｦ06 502fl0003 1ｨC fl0ｷ36ｦ0; 08apple apple6 5090ｹ apple % ｸ ｸ ｸ800, apple ｦ ｸ800 0ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ0090ｸ8 [8ｨC13]. 046ｦ002090ｹ ｹ ｦ apple076 56ｦ000000ｸ ｦ006036ｦ apple6ｦ0016ｦ ｦ00ｹ ｦ apple ｦ ｦ00009fl, 08apple09 0ｹ % ｸ ｦ00ｸ apple076 7apple apple076 56ｦ00009fl 0800apple6 5090ｹ apple070ｷ ｦ0, ｦ ｸ800 50% ｨC , 066 5fl096ｦ000000ｸ apple076 7apple apple ｦ ｷ300apple00 apple6ｦ ｦ006036ｦ003090ｹ [5ｨC9] applefl 006ｦ0 08apple ｹ ｦ apple09fl apple6ｦ ｦ006036ｦ003090ｹ ｷ300apple00 apple6ｦ apple6ｦ0016ｦ0, ｷ ｸ fl0ｸ ｦ003070ｹ ｦ00009fl 6ｦ apple , ｦ fl0ｸ apple0003fl 0000 apple6ｦ009apple6ｦ ｦ0006ｦ ｦ ｦ0fl 036ｦ ｦ ｹ ｦ ｹ apple0708apple09fl [14]. ｨｴｨｨｨ ｨ ｨｦ00ｨｦ07ｨ ｨｹ 0200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨ07 apple6ｦ ｹ0000ｸ803 6ｦ000000ｸ803, ｦ006036ｦ0090ｸ8 apple6ｦ0016ｦ ｦ06 502fl0ｸ903 20ｨC50% ｦ0 [5, 6, 8, 9, 15] ｸ apple ｦ ｦ00ｷ ｸ76ｦ ｸ ｦ00009fl 08apple09 6ｦ fl ｸ803 apple6ｦ0-

2 ｨｺ02ｨｨ00ｨｪｨｦ apple09apple040ｸ903, 0ｹ ｹ ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ ｦ00ｹ apple ｹ apple6 5090ｹ0000ｸ [5, 7ｨC9, 15]. ｨｨ07 0ｹ06ｦ apple6ｦ fl ｹ06ｦ ｦ ｸ ｦ006036ｦ ｦ0 096ｦ ｦ00ｸ903 03apple , ｦ0fl ｹ06ｦ0fl03 apple6ｦ fl ｦ006036ｦ ｹ ｸ8 [8, 9, 15ｨC17]. 02ｨｨ ｦ ｹ06ｦ apple000ｹ06ｦ fl ｸ apple6ｦ [8, 9, 15, 18]. ｨｬ 6 509apple ｸ ｸ apple6 50ｸ800 03apple ｦ ｹ06ｦ ｦ006036ｦ00909apple076 56ｦ00009fl ｦ ｦ00ｸ903 apple6ｦ , ｦ06 502flfl 40ｨC50%, 096ｦ apple6ｦ ｹ ｸ8 15ｨC25% ｦ ｦ ｨC15%; apple ｦ008000ｸ ｦ ｹ ｹ ｦ00000, ｹ06ｦ006030ｸ ｹ ｦ ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ fl6 502fl0ｸ90306fl apple6ｦ ｹ0-0109, 0ｸ ｸ8, ｦ0, 08apple ｦ ｸ ｹ ｸ8applefl, apple apple6ｦ ｸ ｦ ｦ00009fl 09 apple. [5, 8, 9, 15, 19ｨC21]. ｨｺｨｨ05 096ｦ ｦ apple apple00 09 apple ｦ006036ｦ00909apple076 56ｦ ｸ9 0ｸ800 07apple6 76ｦ0000ｸ8, applefl 006ｦ0 0ｹ ｨｨ apple09 ｨｺｨｨ ｦ00309apple fl apple ｨC 6 5 1ｨC6% ｹ06ｦ [1, 2, 4]. ｨｪ apple ｦ0030ｸ8 6ｦ ｦ0-090ｸ86 56ｦ00ｸ903, 0ｹ ｦ0fl 0ｹ06ｦ ｦ0 02ｨｨ apple09 ｨｺｨｨ ｸ ｨC10 apple6ｦ ｦ apple076 56ｦ [1, 2, 4]. ｨｨ02ｨｪｨｦ02ｨｦｨｺ06ｨｦ00ｨｦ07ｨ ｨｹ 0200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ ｦ006036ｦ00909apple076 56ｦ apple apple ｸ ｦ ｸ , 06 0ｹ fl096ｦ apple ｦ0 6ｦ ｸ ｦ006036ｦ ｦ ｸ ｦ006036ｦ0090ｸ apple ｦ06 502fl0ｸ ｦ06 502fl0ｸ90ｸ ｦ0-020ｸ apple ｦ006036ｦ ( %) 09 08apple090300apple ｹ06ｦ fl6 502fl0ｸ90306fl ｹ0-000ｸ80309, 0807apple6ｦ0086ｦ0fl 08apple ｸ apple6ｦ ｦ0apple0900, % ｹ06ｦ apple6ｦ ｦ06 76ｦ00ｸ90306fl apple ｦ , 006ｦ0 6 7apple6ｦ000090ｷ apple ｸ ｦ0 [5, 7, 22, 23]. ｨｺ6ｦ00608apple ｦ006036ｦ fl096ｦ ｸ ｦ0 01apple ｦ ｦ , ｹ % ｦ006036ｦ ｦ ｸ90306fl ｦ0- apple09fl03, 15% ｨC ｹ00100, 5% ｨC ｦ0, ｦ006036ｦ0090ｸ apple ｦ06 502fl0ｸ ｦ ｹ ｦ0 020ｸ fl [5, 7, 22, 23] ｦ006036ｦ00909apple076 56ｦ apple ｸ (0ｹ000apple ｦ apple000ｸ800 0ｸ ) 09 08apple07fl6 502fl000306fl ｸ ｦ0apple0ｷ ｦ ｹ ｦ0; ｦ06 502fl apple090300apple0007 5ｨC10% ｦ006036ｦ003090ｹ apple6ｦ apple000ｹ06ｦ fl ｦ ｸ apple6ｦ apple apple6ｦ ｦ00ｷ30909 apple6ｦ0016ｦ ｦ apple apple6ｦ ｸ ｦ ｦ00009fl03 [5, 7, 22, 23]. ｨｺｨｨ ｦ006036ｦ00909apple ｦ ｦ ｸ803, 036ｦ ｦ ｸ ; 07 80% ｦ006036ｦ ｨｺｨｨ fl6 502fl0ｸ90306fl apple ｸ80309 (016ｦ001 08apple6ｦ , ｦ0apple09fl ｦ0), % ｨC 04apple6ｦ ｸ80309 ( ｦ ｸ90306fl 6 5 0ｹ apple6ｦ apple070603apple6ｦ ｦ0) 09 4% 08apple ｦ06 502fl0ｸ ｸ ｦ0000ｷ300apple07036ｦ ｹ ( ｦ ｦ0fl ) [1, 4, 5, 18, 22]. ｨｨapple09 ｨｺｨｨ05 006ｦ ｹ06ｦ ｦ00ｸ ｹ0-000ｸ ｹ06ｦ apple6ｦ fl (86%), apple6ｦ ( ｹ06ｦ ) apple000ｹ06ｦ fl % ｹ06ｦ0006 5; 0807apple6ｦ ｦ ｦ00ｹ apple (76%) 006ｦ0 0807apple6ｦ ｦ ｦ ｹ000apple fl (21%), ｦ006036ｦ003090ｹ apple6ｦ ｦ apple000ｹ06ｦ fl 6 5 3% ｹ06ｦ0006 5; apple040ｸ90ｸ ｹ ｨｺｨｨ05 08apple09 02ｨｨ0702 fl6 502fl000306fl 6ｦ ｦ0apple0ｷ ｦ0 (91% ｹ06ｦ0006 5) [1, 4, 5, 18, 22]. ｨｦ ｸ ｦ006036ｦ003090ｹ apple070ｷ ｦ0 08apple09 ｨｺｨｨ05 fl6 502fl000306fl 0307, 0ｹ ｨｨ ｦ06 502fl0ｸ9-0ｸ ｹ06ｦ ｹ000036ｦ fl apple6ｦ apple apple6 76ｦ , 6 5 0ｹ06ｦ , 0807apple6ｦ apple000ｹ06ｦ fl 04 95% ｸ803, ｸ90ｸ ｦ ｦ0090ｸ ; 06070ｹ000036ｦ apple6ｦ ｨC % 006ｦ0 020ｸ ; , ｹ ｨC %; , ｦ0 ｨC 6 5 8%; , ｦ ｹ0000ｹ ｨC 6 5 5% [1, 4, 5, 18, 22]. 046ｦ002090ｹ ｹ000036ｦ000000ｸ ｷ300apple6ｦ ｸ ｦ006036ｦ ｨｺｨｨ05 08apple09 02ｨｨ apple6ｦ ｦ00003, 0ｹ00307 apple6ｦ ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ apple ｦ ｹ apple0007 apple6ｦ ｦ00ｸ90ｸ fl ｦ006036ｦ003090ｹ apple070ｷ ｦ apple apple6 76ｦ0006ｦ003. ｨｪ6ｦ ｦ0apple096ｦ ｨｨ ｹ ｦ ｦ apple090ｹ ｦ006036ｦ00909apple076 56ｦ00009fl, ｦ ｦ006036ｦ003090ｹ ｦ0 6ｦ0-0ｸ apple6ｦ apple6 5090ｹ , 6ｦ ｷ300apple6ｦ ｸ ｦ006036ｦ003090ｹ ｹ06ｦ ｦ0096ｦ apple08 6ｦ fl 000ｸ , 0ｹ ｦ0fl 03016ｦ00000 fl6 502fl000306fl apple apple09fl03090ｸ9 09 apple ｦ006036ｦ003090ｹ apple ｦ003090ｹ apple6ｦ ｸ ｹ ｦ00ｹ ｦ ｸ8 09 apple6ｦ0016ｦ [1, 4]. 05 0ｹ ｦ001020ｸ90ｹ06ｦ fl 086ｦ ｹ ｦ0fl ｨｨ apple09 ｨｺｨｨ05, apple6ｦ0fl apple0ｸ86 56ｦ ｸ800 08apple ｦ fl 6 5 apple6ｦ ｦ , 08apple apple076 56ｦ , 08apple ｦ ｹ ｷ300apple00- apple6ｦ ｸ ｦ006036ｦ apple09 apple6ｦ apple ｦ ｸ8.

3 130200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ00 ｨｨｨｦｨｺ ｨ 00 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨｨｺｨ ｨｺｨｨ ｨ 04ｨ ｨｮ ｨｹ 0102ｨｺｨｪｨ ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ ｦ ｦ000000ｸ apple6ｦ00304apple0ｸ ｸ ｦ0-020ｸ ｦ0090ｸ86 56ｦ00003, 0ｹ ｹ apple07fl fl 02ｨｨ apple09 ｨｺｨｨ05 6ｦ0006ｦ ｹ0000ｸ ｸ90ｸ apple ｦ0016ｦ003 08apple ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ0 apple apple6 76ｦ [8, 9] ｦ ｦ0apple6ｦ apple6ｦ ｦ apple6ｦ fl 096ｦ ｦ00009fl ｸ ｨｨ ｹ fl fl fl apple apple ｦ003 [10, 22]. ｨｨapple ｹ0000ｸ ｦ006036ｦ0096ｦ apple apple ｦ06 502fl fl0ｷ3006 5, ｦ0 07 1ｨC ｨｨapple ｸ ｦ006036ｦ0096ｦ003 0ｹ apple ｦ0090ｸ86 56ｦ fl 09006ｦ0-0ｹ apple070ｹ000 ｨC fl0ｷ3006 5, fl0ｷ ｹ % ｹ06ｦ apple , 6 50ｸ ｦ ｨｨ0702, 04 apple6ｦ ｹ ｸ ｹ ｸ ｦ06 502fl fl0ｷ ｸ8 0002fl0ｸ ｸ90ｸ apple ｦ ｹ ｹ fl 09 08apple07fl ｨｨ0702: 1) ｦ ｦ00ｹ06ｦ0-0207, 006ｦ ｦ00ｸ90ｸ appleapple6ｦ ｹ ｹ ｹ apple0700 apple6ｦ apple6 50ｸ ｹ ｹ06ｦ apple ｹ ( ｸ806, ｸ ); 2) apple0700 apple6ｦ ｦ ｦ00009fl ｹ , 006ｦ ｦ00ｸ90ｸ apple076 7apple apple040ｸ90ｸ ｹ1000ｷ300026ｦ ｷ300apple00 - apple6ｦ ｸ806 6ｦ0apple6ｦ ( ｦ ｸ ); 3) apple076 7apple apple6ｦ , 006ｦ ｦ00ｸ90ｸ apple6 5090ｹ000040ｸ ｦ00ｹ ｸ ｦ0 ( 026ｦ ｦ ｸ ) [22, 24, 25]. ｨｦ ｸ ｨｨ0702 fl6 5-02fl000306fl apple , apple0ｸ ｨBfl , 0ｹ ｹ apple ｹ ｦ apple076 5, ｦ00ｸ90ｸ ｹ ｸ9 016ｦ0apple , ｸ apple6 5090ｹ0000ｸ fl ｦ0, 08apple fl 040ｹ009030ｸ86 56ｦ apple0ｸ apple apple ｹ ｦ00ｹ ｦ0 apple6ｦ ｸ ｦ006036ｦ [5, 10, 18, 20, 22, 24, 25] ｦ fl ｦ0 02ｨｨ ｦ06 76ｦ fl ｸ ｸ803, 070ｹ06ｦ ｸ ｸ ｦ003090ｹ ｨｦ 006ｦ applefl 006ｦ ｹ ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ apple ｹ0000ｸ ｦ00ｹ ｸ fl ｦ0, ｦ fl ｦ ｦ ｦ003090ｹ apple6ｦ0016ｦ ｦ ｸ903 applefl , 09006ｦ apple0ｸ applefl ｹ06ｦ fl apple00000ｷ309apple076 56ｦ apple6 5090ｹ0000ｸ ｦ0. 046ｦ ｸ ｦ0apple6ｦ apple fl ｸ ｦ006036ｦ apple6ｦ0016ｦ ｸ9 fl6 502fl000306fl apple apple ｦ00ｹ06ｦ ｦ ｦ00009fl 06 apple6ｦ fl ｸ , 0ｹ06ｦ apple , ｦ ｦ008000ｸ ｦ fl fl 07 ｨB ｸ803 08apple ｦ ｸ fl apple090ｹ000apple ｦ fl ｹ06ｦ ｸ803 0ｷ300apple00 apple6ｦ ｸ ; 07 apple6ｦ00ｸ76ｦ ｦ fl ｦ ｦ apple6ｦ fl ｦ0fl 6 50ｸ8apple6ｦ apple ｹ apple6ｦ apple ｹ0000ｹ0000ｸ apple6ｦ ｸ apple ｹ0000ｸ fl ｦ0 [5, 10, 18, 20, 22, 24ｨC27]. 046ｦ007 07apple0703, 036ｦ ｦ0apple6ｦ apple000ｸ apple ｸ ｸ8, 016ｦ ｦ ｸ apple ｸ apple , apple6ｦ ｦ0apple 09fl, 07 0ｸ apple ｸ800 (0ｹ ｹ ) 08apple09086ｦ0 0109, apple ｸ800, apple ｹ fl fl03 0ｹ000apple00086ｦ0, apple000ｷ ｦ0, 09 apple , apple000ｹ06ｦ00ｸ90306fl 08apple09 0ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ0096ｦ ｦ0-0ｹ apple apple6ｦ ｸ apple6 5090ｹ0000ｸ fl ｦ0 [5, 10, 18, 20, 22, 24ｨC27] ｸ fl6 502fl0ｸ90306fl 006ｦ apple6ｦ ｦ006036ｦ apple6ｦ0016ｦ ｨｦ apple000ｹ06ｦ00ｸ90306fl ｹ06ｦ00ｸ700 (94ｨC97%), ｸ8apple6ｦ ｸ , 0ｹ apple apple6 5090ｹ0000ｸ fl ｦ apple090ｹ apple6ｦ fl apple6ｦ ｦ00ｷ ｦ ｦ ｹ00001 [18]. 016ｦ001 08apple apple6 5090ｹ0000ｸ fl ｦ0, 036ｦ apple ｦ006036ｦ0096ｦ apple fl03 apple6ｦ apple6ｦ00ｸ90ｸ ｦ0apple6ｦ apple ｦ00ｸ903 08apple apple6ｦ , ｦ0fl 006ｦ ｹ0000ｸ apple07. ｨｺ ｦ0 08apple09 0ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ0, 016ｦ apple apple6 5090ｹ0000ｸ fl ｦ0, fl6 5-02fl000306fl 0ｹ06ｦ006030ｸ apple ｸ apple , 07 0ｸ80ｹ ｦ0 6 50ｸ apple6ｦ fl, fl 006ｦ0 020ｸ9 6ｦ fl apple ｨC ｨC60% ｹ06ｦ [5, 10, 18]. 016ｦ001 08apple6ｦ , apple ｦ apple ｸ ｦ0apple6ｦ apple, 0ｹ06ｦ00ｸ ｦ apple ｹ06ｦ0060ｸ8, 006ｦ0 6 50ｸ apple ｸ ｹ ｨｨ07 08apple090ｹ apple ｦ003090ｹ ｦ0apple apple ｦ0 006ｦ ｹ06ｦ ｦ0 020ｸ9 6ｦ fl 08apple ｦ006036ｦ0096ｦ ｦ ｹ000apple fl030100, ｦ0fl 08apple fl apple apple ｸ8 ( apple apple ｦ0) [5, 10, 18]. ｨ 6ｦ ｸ apple ｸ apple (ｨ 05ｨ 04), ｦ ｦ008000ｸ ｨB ｸ803 08apple ｦ apple6ｦ ｦ ｦ0, 006ｦ0 020ｸ9 6ｦ0-0ｸ90306fl 08apple ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ ｹ06ｦ ｨC68% ｹ06ｦ0006 5, apple0003fl 016ｦ001 08apple apple6 5090ｹ0000ｸ803 0ｷ300apple00 apple6ｦ ｸ fl ｹ06ｦ ｦ ｦ06 502fl % ｸ80400 [5, 10, 18, 20, 22, 23, 28] , 0ｹ ｹ apple6 5090ｹ0000ｸ , apple07016ｦ00ｹ ｸ803, 08apple apple0ｸ803 ｨ 05ｨ ｦ ｸ ｸ ｦ ｦ00009fl, 08apple09 0ｷ300apple00 apple6ｦ00200-

4 ｨｺ02ｨｨ00ｨｪｨｦ05 000ｸ ｦ006036ｦ0096ｦ003 fl fl 096ｦ fl ｦ ｹ000036ｦ00ｸ903-06fl 06 apple ｸ ｸ ｦ00309: ｸ9, apple , [5, 10, 18, 20, 22, 23, 28]. ｨｺ6ｦ apple ｦ apple09 02ｨｨ ｦ0 020ｸ9 6ｦ00ｸ903-06fl 06 0ｹ06ｦ ｨC95% [18, 22, 23, 29]. ｨ fl ｹ apple6 50ｸ ｦ ｦ00009fl 076 7apple6ｦ000090ｹ ｦ00ｸ90306fl 0ｹ103070ｷ ｦ ｹ ｸ9, 6ｦ apple ｦ00307apple ｸ9, 6 5 6ｦ ｸ803 apple6ｦ ｦ fl 6ｦ0086ｦ00309fl, , , 096ｦ06 7apple ｨｨapple09 0ｹ fl6 502fl000306fl 006ｦ fl00-000ｸ ｨｨ apple ｦ0apple6ｦ006036ｦ00009fl ｸ ｦ fl0306fl fl020ｸ80309, 086ｦ ｸ80309, ｷ3096ｦ ｸ80309, 00fl ｸ ｸ80309, 08apple076 7apple applefl0ｸ ｦ003fl0300, apple apple04086ｦ00ｸ90ｸ , ｹ ｦ ｦ0apple6ｦ006036ｦ00ｸ90ｸ fl apple6ｦ ｦ fl 036ｦ ｦ0090ｸ86 56ｦ000030ｸ806 6ｦ0086ｦ ｦ ｦ003090ｹ apple ｹ000036ｦ ｹ ｦ ｹ apple ｦ ｹ fl ｹ ｦ ｦ ｸ ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ0096ｦ ｸ76ｦ ｸ9 0107apple ｸ803 08apple07-0ｷ ｨｨ ｹ apple6ｦ apple ｦ ｦ002020ｸ9-0ｷ309006ｦ00ｷ30906, apple ｸ apple , fl 09 apple ｦ0apple6ｦ apple000ｸ8 02fl ｸ ｦ006036ｦ003090ｹ apple6ｦ ｦ apple000ｹ06ｦ00ｸ903-06fl apple [18, 22, 23, 29]. ｨｦ0ｹ06ｦ ｸ ｸ8 08apple09 0ｷ300apple00 apple6ｦ ｸ ｦ ｦ0096ｦ ｸ8apple6ｦ ｸ8, 016ｦ001 08apple apple6 5090ｹ0000ｸ fl ｦ ｦ apple ｦ ｦ ｦ00ｷ ｦ ｸ ｦ006036ｦ apple6ｦ0016ｦ0 070ｹ06ｦ ｸ ｸ ｦ0 0ｸ86 56ｦ00ｸ90306fl 07 0ｸ80ｹ apple ｸ ｦ ｸ ｹ ｸ apple , 06apple6ｦ apple ｹ009036ｦ00ｸ90306fl 0107apple ｸ ｸ8 apple6ｦ009 apple6ｦ fl apple ｸ803 08apple09-086ｦ , 086ｦ0apple ｦ002020ｸ90ｷ309006ｦ00ｷ30906 [5, 10, 18, 20, 22, 24ｨC27]. ｨｦ0ｹ06ｦ ｸ ｸ ｸ ｹ0000ｸ ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ0096ｦ00309 apple6ｦ0016ｦ0 apple ｸ86 56ｦ00ｸ apple6 50ｸ apple ｦ0016ｦ ｦ ｦ00009fl (0800apple6 5090ｹ ｹ06ｦ ｸ ｸ8), 07 0ｸ80ｹ ｦ06 502fl0ｸ90306fl apple00 apple6ｦ fl 096ｦ ｦ00009fl ｸ ｸ ｦ0apple fl03. ｨｨapple09 apple6ｦ ｹ0000ｸ ｦ006036ｦ fl03 ( ｦ ｹ ｦ0006ｦ ｦ00307apple076 5) apple040ｸ apple6 5090ｹ ｹ06ｦ ｸ ｸ8, ｦ0 016ｦ001 08apple ｦ ｦ00ｷ ｸ ｹ0000ｸ ｦ0030ｸ802070ｹ0000ｸ ｦ ｦ apple ｹ ｦ0fl ｦ ｦ0 07 0ｸ80ｹ ｸ86 56ｦ apple ｦ ｦ apple090ｹ ｹ06ｦ ｸ ｦ0apple fl0309 [5, 10, 18, 20, 22, 24ｨC27]. ｨｦ ｹ0000ｹ0000ｸ ｸ8 08apple apple6ｦ001apple6ｦ000096ｦ ｸ ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ apple000ｹ06ｦ00ｸ90306fl 09006ｦ00ｹ ｹ06ｦ00ｸ700 (42%), 0ｹ apple apple6 5090ｹ0000ｸ fl ｦ0 (19%); 08apple09 0ｹ ｦ ｹ06ｦ ｦ0apple ｦ00ｸ90306fl 08apple09 016ｦ0apple0ｷ ｦ ｸ ｹ00001 (77%), 096ｦ apple ｸ ｦ006036ｦ0096ｦ (49%) 09 apple ｦ0 020ｸ9 6ｦ0-0ｸ90306fl 08apple ｹ0000ｸ ｦ006036ｦ0096ｦ003 (33%), ｦ0-0ｸ ｹ06ｦ ｦ0 09fl ｸ8apple6ｦ0086ｦ00ｸ90306fl 6 5 apple ｸ8040ｷ3 096ｦ0-030ｸ802016ｦ0, ｦ apple ｦ0, 03apple , ｦ0066ｦ ｸ apple ｦ ｸ803 apple ｹ apple6 5090ｹ0000ｸ ｦ0 08apple ｦ006036ｦ003090ｹ ｷ300apple00 apple6ｦ apple6ｦ ｹ06ｦ ｦ ｸ8apple6ｦ ｹ0000ｹ0000ｸ ｦ fl ｦ ｦ00ｷ ｦ006036ｦ0096ｦ0, ｦ00ｸ ｸ fl apple090ｹ000apple ｦ fl, ｦ0 060ｹ00003 apple6ｦ ｦ00ｷ ｹ ｦ ｸ ｹ00001 [5, 10, 18, 20, 22, 24ｨC27]. ｨｦ 0ｸ ｦ003090ｹ ( ｸ800) ｸ8 08apple09 0ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ0 036ｦ0apple6ｦ apple ｸ90306fl 09006ｦ00ｹ ｹ06ｦ , apple6ｦ ｦ ｸ8apple6ｦ ｸ9. ｨｨ07fl ｦ ｸ ｸ ｸ ( apple0300apple0309fl, applefl ｦ0, ｦ0apple03apple07-086ｦ00309fl, 0ｹ apple ｸ800 apple6ｦ apple ｦ0, 6ｦ fl, ｸ ｨｦｨｴ, apple01076ｦ fl0ｷ309fl 09 08apple.) 0703apple6ｦ0086ｦ ｦ0apple6ｦ ｦ ｹ ｦ0apple6ｦ apple apple apple apple6 76ｦ ｦ0 [30, 31]. ｨｬ ｸ ｦ006036ｦ0096ｦ00309 apple6ｦ0016ｦ ｦ fl 006ｦ0 020ｸ9 6ｦ fl ｹ % ｹ06ｦ0006 5, 08apple09 0ｹ ｦ ｹ06ｦ ｦ apple09 apple6ｦ , 08070ｹ00109, ｹ ｹ apple6ｦ ｦ ｦ , apple ｦ0 020ｸ9 6ｦ fl 08apple09 apple6ｦ ｹ ｸ8. ｨｨapple ｸ ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ ｦ006036ｦ0096ｦ fl ｸ ｹ ｦ fl apple000ｹ06ｦ fl 6 707apple6ｦ ｹ06ｦ00ｸ700, 0ｹ apple ｹ0000ｸ ｸ ｦ006036ｦ0096ｦ003. ｨ 0405ｨｪｨｺｨｬ020004ｨｪ0200ｨｲ0402ｨｹ 05ｨ ｨｦ05ｨｪｨ ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨ07 006ｦ fl0ｸ apple0003fl apple ｸ ｦ ｦ ｦ0 fl6 502fl000306fl ｹ (06 07apple 086ｦ , 6ｦ0006ｦ ｦ0, , 0207apple0309apple076 56ｦ ｹ ｸ8). ｨｦ 006ｦ apple ｸ apple ｦ ｸ ｦ apple ｦ06 502fl000306fl ｸ apple ｦ001040ｸ ｦ ｦ ｸ ｹ ｦ ｹ ｸ9 036ｦ apple apple ｸ8fl ｨｨ ｦ apple6ｦ00304apple000ｸ803 6ｦ000000ｸ ｸ ｦ0 020ｸ ｦ0090ｸ86 56ｦ00003, 0ｹ ｦ006036ｦ0090ｸ8 ｨｺｨｨ ｸ ｦ ｹ

5 ｨｦｨｺ02ｨｪｨｦｨｺ0402ｨｹ 05ｨ ｨｦ05ｨｪｨ ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨ ｦ applefl 6ｦ ｸ apple ｸ ｨｨ ｸ ｦ00ｹ ｦ , apple apple076 56ｦ ｹ ｹ fl , apple070ｷ ｹ fl. ｨｨ07016ｦ0096ｦ ｦ apple ｹ ｦ00ｹ ｹ apple apple086ｦ00009fl 6 50ｸ flapple apple6ｦ0 08apple ｦ009 6ｦ ｦ ｦ001apple ｦ0: ｸ ｦ00ｹ appleapple000209apple ｸ ｦ00ｹ apple6ｦ00ｷ300apple00 apple6ｦ , 6ｦ ｹ apple fl apple086ｦ00009fl apple070ｷ ｹ fl 036ｦ0apple6ｦ apple fl 08apple ｦ00ｸ90ｸ fl apple ｦ [33, 34]. ｨ ｦ apple ｹ apple6ｦ0 026ｦ001036ｦ apple ｦ0090ｸ8 (000507) apple ｸ ｦ006036ｦ003090ｹ apple6ｦ ｦ ｹ00001, ｹ apple6 5090ｹ0000ｸ803 0ｷ300apple00 apple6ｦ ｸ , 04016ｦ0090ｸ86 56ｦ00ｸ ｦ0 08apple ｹ ｦ00ｹ ｸ apple apple [35, 36]. 05 0ｹ06ｦ , ｦ0096ｦ00007, 0ｹ / ｷ30ｸ ｦ ｹ ｦ00ｹ appleapple000209apple ｦ002090ｹ apple090ｹ ｦ006036ｦ ｹ apple6ｦ fl , ｦ0apple0ｷ ｦ ｦ0 [36]. ｨ 09040ｹ apple086ｦ00009fl apple apple ｹ ｸ ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ00 ｨｨｨｦｨｺ ｨ 00 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨｨｺｨ ｨｺｨｨ ｸ , 6 50ｸ8fl6 502fl00030ｸ803 08apple09 6ｦ0006ｦ apple ｦ ｦ00ｷ ｦ0apple ｸ apple6ｦ ｸ9 06 0ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ0096ｦ apple apple6 76ｦ [5, 8, 9]. ｨｺ ｸ90300apple006ｦ0fl apple6ｦ00209fl (ｨｺ01ｨｪ) ｦ fl 066ｦ0030ｸ apple ｦ000000ｸ ｦ apple ｦ0 ｨｺ apple6ｦ003036ｦ ｦ006036ｦ ｸ ｸ , ｦ apple09 006ｦ002090ｹ ｹ06ｦ appleapple6ｦ , 016ｦ002000ｷ ｷ309apple076 56ｦ000000ｸ ｸ apple ｸ ｸ90ｹ ｦ006036ｦ ｸ ｸ ; 0000apple ｦ006036ｦ apple09 ｨｺ01ｨｪ apple6ｦ ｦ ｦ ｦ0, apple ｸ8fl6 502fl0ｸ90306fl 006ｦ apple04-086ｦ00ｸ90ｸ ｦ0 [5, 10, 19, 24]. ｨｨ apple fl apple6ｦ apple040ｸ90ｸ ｸ ｦ0 006ｦ ｸ90300apple000ｸ apple6ｦ003036ｦ ｦ006036ｦ ｷ36ｦ0 (0107apple07006ｦ0-0ｹ ) ｸ apple apple ｸ9, 0ｹ ｨBfl0600fl000306fl 006ｦ002090ｹ apple07096ｦ0 (apple ｸ8) 6 5 0ｷ apple ｦ flapple09096ｦ00ｷ apple090200apple0909 [5, 10, 19, 24]. 026ｦ apple ｦ ｦ0fl apple6ｦ00209fl (02ｨｺｨｪ) apple6ｦ ｸ fl6 502fl000306fl 02040ｹ ｸ ｹ ｸ ｦ ｨｨ0702, ｦ ｸ apple6ｦ apple6ｦ apple ,5 0603, ｸ apple ｹ ｹ ｦ0 070ｹ06ｦ apple6ｦ fl, 0ｹ00307 fl6 502fl fl, 016ｦ , 08apple ｹ ｦ00ｹ009030ｸ803 [5, 10, 19, 24, 32]. ｨｨ apple ｦ0fl 0ｹ ｦ0fl apple6ｦ00209fl (ｨｨｨｴｨｪ) ｨC , ｦ000000ｸ ｦ ｦ apple ｹ06ｦ00ｸ90ｸ70903 apple6ｦ ｸ ｸ , 036ｦ ｦ ｨｺ apple ｸ ｸ F-L-05O06A, 0ｹ fl ｦ0apple0309apple076 56ｦ ｹ ｹ apple070ｷ ｸ ｦ ｸ8fl6 502fl ｷ ｦ ｸ ｦ0apple fl fl fl 070ｹ ｸ apple apple000ｸ [5, 10, 19, 24, 26, 32] fl ｦ ｦ ｦ fl0ｸ apple0003fl ｦ fl 076 7apple6ｦ000090ｹ , ｨｨｨｴｨｪ ｦ0 6 56ｦ ｦ ｹ ｦ00ｹ apple ｦ0090ｸ86 56ｦ fl ｸ803, 6 5 0ｹ06ｦ , 02fl apple6ｦ ｦ apple ｦ006036ｦ , ｷ ｦ00ｹ ｷ300apple00 apple6ｦ , 02fl 096ｦ apple6 5090ｹ apple090ｹ apple6ｦ fl ｦ0, apple000ｷ apple ｷ300apple00 - apple6ｦ ｸ ｦ006036ｦ apple070ｷ ｹ fl, 08apple apple076 56ｦ00009fl apple ｹ ｹ fl 0ｷ300apple00 apple6ｦ ｸ ｦ00ｹ ｸ [5, 10, 19, 24, 26, 32]. ｨｬ0ｹ009030ｸ86 56ｦ0fl 04016ｦ0096ｦ000000ｸ ｸ ｦ006036ｦ003090ｹ ｨｺｨｨ05, ｨｨｨｴｨｪ fl6 502fl000306fl ｦ ｸ803 02fl 08026ｦ00009apple076 56ｦ00009fl 6ｦ ｦ ｦ apple6ｦ ｨｺｨｨ05. ｨｦ ｦ0fl 0ｹ ｦ0fl ｸ90300apple006ｦ0fl apple6ｦ00209fl (ｨｦ06ｨｴ01ｨｪ) ｸ90ｹ06ｦ apple ｦ002fl0ｷ apple6ｦ ｸ803 08apple00086ｦ0apple6ｦ , ｹ06ｦ00ｸ90ｸ ｹ0000ｸ ｸ8, 0ｹ fl ｹ06ｦ apple6ｦ fl ｦ apple ｨｦ06ｨｴ01ｨｪ 036ｦ fl 06 0ｷ ｸ9 apple6ｦ ｦ ｷ300apple00 apple6ｦ ｸ apple ｦ006036ｦ apple apple076 56ｦ00009fl 0ｹ ｹ fl 0ｷ300apple00 apple6ｦ ｸ ｦ00ｹ ｸ [5, 10, 19, 24, 26, 32]. ｨｴ apple070ｹ1000ｷ300026ｦ apple6ｦ00209fl (ｨｴｨｴ07), fl6 502flfl ｦ ｸ ｦ , ｨB apple6ｦ0086ｦ fl fl0009fl ｸ803, ｦ ｹ ｦ fl apple070209apple076 56ｦ apple ｦ003090ｹ apple070ｷ ｸ8. ｨｨapple09 ｨｴｨｴ ｦ ｸ ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ0096ｦ00309 apple6ｦ0016ｦ0 6 50ｸ8fl6 502fl0ｸ90306fl 07-0ｸ ｸ fl ｷ3096ｦ , 06 08apple ｦ0 6ｦ fl apple02000ｸ ｸ , apple036ｦ00ｷ ｦ ｦ0-apple ｦ applefl 006ｦ0 apple6ｦ00608apple070603apple6ｦ ｹ ｸ ｸ apple ｹ0000ｸ803 0ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ0096ｦ ｦ fl 08apple apple6ｦ000090ｹ ｸ ｸ ｸ ｹ ｸ ｸ ｦ ｸ , ｸ90ｸ70903 apple6ｦ ｸ [5, 10, 19, 24, 26, 32].

6 ｨｺ02ｨｨ00ｨｪｨｦ ｹ ｦ ｦ apple6ｦ0 apple ｦ0 (VEGF) ｦ0-096ｦ00207, 0ｹ ｸ apple apple086ｦ00009fl 6ｦ ｦ0 6ｦ ｷ30909apple fl ｦ ｸ apple6ｦ ｦ ｦ003090ｹ apple6ｦ ｦ ｹ ｨｨapple09 0ｹ ｸ8fl ｸ ｹ apple apple fl VEGF ｦ ｹ apple ｹ fl [37]. ｨ ｦ apple086ｦ00009fl 036ｦ003apple ｸ ｦ apple ｦ ｸ ｦ0096ｦ00207, 0ｹ ｦ002090ｹ apple076ｦ apple ｦ000000ｸ ｦ ｸ apple ｦ ｦ0090ｸ fl6 502fl000306fl apple000ｸ803 08apple apple ｦ002090ｹ009fl ｦ00ｹ apple6ｦ00ｷ300apple00 apple6ｦ ｸ8fl ｦ , 0ｹ apple apple086ｦ00009fl apple ｦ ｦ0090ｸ fl6 502fl000306fl 006ｦ ｸ apple apple076 56ｦ00009fl apple000ｷ ｦ ｦ00ｷ ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ [38]. ｨ ｹ (ｨ 0707), ｦ000000ｸ ｦ ｹ ｦ ｹ apple apple6ｦ ｹ0000ｸ flapple000ｸ ｦ0apple0100apple076 5, apple6ｦ ｸ ｸ ｦ ｹ apple6ｦ ｦ00ｹ ｹ ｹ00000 [39ｨC41]. ｨｦ ｦ00ｹ009030ｸ8 02fl ｦ00ｷ apple6ｦ ｦ apple6ｦ ｹ apple09apple07 0ｸ8 6ｦ ｦ0 01 0ｹ ｦ ｦ ( ｦ006036ｦ0090ｸ8 apple6ｦ0016ｦ0), apple0902flapple ( ｦ ｦ0) ｸ ｷ309036ｦ0apple ｦ ( ｦ0) ｦ006036ｦ003090ｹ ｦ ｦ0apple0ｷ ｸ ｸ apple apple04, ｸ ｦ00ｹ ｸ ｦ flapple000ｸ ｹ ｦ00309, 0307apple ｦ ｦ ｦ flapple000ｸ ｦ00309, apple0ｸ803, ｦ00107, apple006ｦ ｹ ｦ ｦ ｦ0 0500r 00ｨｺ ｦ ｦ ｸ apple6ｦ0090ｷ36ｦ ｷ300apple6ｦ ｸ ｦ006036ｦ apple6ｦ0016ｦ0 08apple ｦ0030ｸ8, ｹ ｷ300apple00 apple6ｦ ｸ803, ｹ000006ｦ ｦ0fl 0ｹ apple fl 08apple ｦ ｷ ｹ ｦ ｦ apple ｦ ｷ ｹ ｦ0036ｦ0090ｸ8, 0ｹ apple fl ｦ0apple0100apple apple ｦ0 P501S ｹ06ｦ fl % ｹ06ｦ [42]. ｨｨapple6ｦ ｹ apple ｦ ｹ ｨ ｦ apple ｸ803 6ｦ (01 0ｷ apple6ｦ ｦ003, , 08apple S-100, 0309apple apple6ｦ apple09080ｷ ｦ apple04-1, , ) fl apple fl apple09006ｦ ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ apple6 5090ｹ apple6ｦ ｹ06ｦ06 76ｦ ,5% ｹ06ｦ0fl03 [39ｨC41]. 0000ｨｮ0004ｨ ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ ｹ ｨｨ apple09 ｨｺｨｨ05 fl6 502fl000306fl ｦ0 6ｦ00ｹ00006, 6 5 apple apple ｹ ｦ ｸ ｨC ｦ ｹ000036ｦ apple6ｦ ｹ0000ｸ apple6ｦ ｹ apple6ｦ003016ｦ ｹ apple6ｦ [8, 9, 14] ｦ ｦ000000ｸ apple6ｦ00304apple0ｸ ｸ ｦ0 020ｸ fl03, 0800apple000ｹ ｸ ｸ ｹ fl 02ｨｨ0702 6ｦ0006ｦ ｹ0000ｸ ｦ003, 08apple fl00030ｸ803 08apple09 apple6ｦ apple ｦ ｸ apple6ｦ ｦ0 [8, 9]. 0709apple04apple6 7090ｹ ｹ ｸ ｨｨ ｹ009036ｦ fl ｦ ｸ ｦ apple0703, 0708apple fl0ｸ90ｸ apple ｦ00ｹ , fl 08apple ｹ ｨC20% 086ｦ00ｷ ｦ ｦ0090ｸ86 56ｦ fl 006ｦ ｹ ｸ ｸ ｦ006036ｦ0096ｦ , ｦ ｸ apple6ｦ , 08apple ｹ0000ｸ apple6ｦ fl03 [5, 6, 10, 18, 20, 43]. ｨｨapple apple04apple6 7090ｹ ｹ ｹ06ｦ fl 066ｦ0036ｦ0fl 6 50ｸ ｦ0fl 6 50ｸ ｦ ｸ803, ｦ0006ｦ0 6 50ｸ ｦ ｦ06 502fl0003 8ｨC fl0ｷ3006 5, 6ｦ ｹ0006ｦ0fl 6 50ｸ ｦ ｨC25% [5, 6, 10, 18, 20, 43] ｦ0096ｦ ｦ ｦ apple ｦ006036ｦ003090ｹ ｨｺｨｨ05, fl ｦ0apple6ｦ apple006ｦ0 6 50ｸ ｦ0fl 0ｹ06ｦ ｦ0 0807fl fl ｹ0000ｸ803 0ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ ｹ ｦ0fl 0300apple6ｦ00809fl (00ｨｪ) 006ｦ ｦ0, apple fl000306fl 08apple ｦ006036ｦ0096ｦ ｦ0 036ｦ ｨB00036ｦ0; 07 0ｸ70008apple ｦ000000ｸ ｹ009036ｦ fl ｦ ｹ ｦ0 [5, 21, 44, 45]. ｨｮ6ｦ ｦ ｦ0 08apple09 08apple ｨｪ ｦ06 502fl ｨC80%, ｦ0006ｦ0 6 50ｸ ｦ fl000306fl fl0ｷ3006 5, ｹ0006ｦ0fl 07 0ｸ76ｦ0fl 6 50ｸ ｦ ｦ0 020ｸ9 6ｦ fl 04 5ｨC15% ｸ ｦ apple fl 00ｨｪ 04 6ｦ fl ｹ ｦ ｹ ｸ ｹ06ｦ ｸ8 apple apple0702fl apple ｦ ｦ006036ｦ , ｦ fl ｹ apple000ｷ ｸ ｸ7040ｸ9 6 50ｸ ｦ [5, 21, 44, 45] ｸ8 006ｦ ｸ apple04apple ｹ apple6ｦ apple ｸ ｹ ｦ008apple6ｦ ｨC apple6ｦ apple04apple6 709fl, apple6ｦ0fl 08apple ｦ06 502fl ｹ0000ｹ ｦ ｦ apple6ｦ ｹ ｦ ｸ ｦ apple000009fl apple ｦ ｹ apple6ｦ apple04apple (05ｨｪｨｺ07) 06036ｦ00207 apple006ｦ ｸ9 0ｹ apple04apple6 7090ｹ ｹ ｸ803 0ｷ300apple00 - apple6ｦ ｸ ｦ006036ｦ apple6ｦ0016ｦ0 c apple6ｦ apple ｦ00ｹ ｦ ｸ apple6ｦ00ｷ ｦ ｸ9. ｨｦ ｸ ｸ803 08apple ｸ ｨｪｨｺ07 fl6 502fl000306fl 0307, 0ｹ ｹ ｦ ｹ fl ｦ ｦ ｹ ｦ ｦ ｸ apple apple ｦ0 0ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ , ｹ apple , apple apple6 5090ｹ00007 apple6ｦ0 0907apple ｸ ｹ0000ｸ ｸ apple6ｦ fl03; 05ｨｪｨｺ apple fl000306fl ｹ ｹ0000ｸ ｸ ｦ0apple ｦ ｸ803 0ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ ｨｺｨｨ05 [5, 46ｨC50].

7 130200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ00 ｨｨｨｦｨｺ ｨ 00 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨｨｺｨ ｨｺｨｨ apple apple ｸ ｦ003036ｦ ｦ ｦ ｦ00207 apple6ｦ ｸ9 0800apple , ｷ ｦ ｸ76ｦ0 fl0ｸ apple- 6 76ｦ apple6ｦ000fl0ｸ90ｸ ｦ008apple6ｦ fl apple6ｦ apple04apple ｨC 6 76ｦ003036ｦ apple6ｦ apple6ｦ (0704ｨｺｨｪ) apple ｦ0fl ｸ90300apple006ｦ0fl 09 apple ｦ0, 03070ｹ00007 apple6ｦ006060ｹ009030ｸ86 56ｦ00ｸ90ｸ76ｦ0fl 08apple ｷ3090ｸ ｦ ｸ ｸ apple090ｸ9, fl ｦ0000ｷ apple apple ｷ apple09apple076 56ｦ apple ｦ ｹ06ｦ ( apple fl 0701apple04086ｦ00ｸ90ｸ apple076 50ｸ ｦ ) 030ｸ806fl0ｹ ｹ ｸ ｹ10000apple ｹ ｹ fl [51ｨC54] ｹ ｦ ｹ fl ｦ0 0704ｨｺｨｪ fl apple070209apple076 56ｦ00300 apple ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ % ｹ ｦ0096ｦ ｦ0000ｸ8 6 50ｸ ｦ ｨｹ6 502flfl ｷ ｦ ｸ76ｦ0 fl0ｸ ｹ fl, 0704ｨｺｨｪ apple fl030006fl 08apple09 apple000ｷ ｦ003 0ｷ300apple00 - apple6ｦ ｸ ｦ006036ｦ apple fl ｦ ｦ ｹ fl ｦ apple07090ｸ8 apple6ｦ fl 0600apple ｸ ｹ0000ｸ803 0ｹ [51ｨC54]. ｨｴ apple6ｦ apple09 02ｨｨ ｦ0fl ｦ00ｹ ｦ ｹ ｹ fl ｸ ｦ006036ｦ0096ｦ00309 apple6ｦ0016ｦ0 apple ｦ ｦ00ｷ30909, 08070ｹ ｦ apple fl000306fl ｹ ｹ ｸ ｦ006036ｦ003090ｹ [5, 11, 55, 56]. 0503apple6ｦ fl 08apple fl apple6ｦ ｨｨ fl096ｦ0006ｦ ｸ apple ｦ00009fl 08apple076 7apple apple076 56ｦ00009fl apple070ｷ ｦ apple ｦ apple6ｦ fl [8, 9]. ｨ , 0ｹ ｦ006036ｦ003090ｹ ｨｺｨｨ05 08apple07fl6 502fl ｸ9 0ｹ ｷ ｦ ｦ003, ｦ0 016ｦ apple apple6ｦ00809fl (096ｦ001020ｸ90ｹ06ｦ00ｸ90ｸ76ｦ0fl06fl apple04apple6 7090ｹ ｦ ｦ00603apple6ｦ00ｷ30909) ｦ ｸ apple070ｷ ｸ ｦ ｹ ｦ apple07000ｸ8 0800apple6 5090ｹ , 036ｦ ｷ300apple6ｦ ｸ ｦ006036ｦ , ｹ ｷ300apple00 - apple6ｦ ｸ ｦ006036ｦ [5, 11, 55, 56]. ｨ ｨｮ0004ｨ fl ｸ803 apple ｦ ｦ apple6ｦ001 08apple ｦ ｸ ｦ006036ｦ003090ｹ apple6ｦ ｦ0 08apple ｦ fl ｦ ｦ ｸ9 08apple apple ｸ ｦ0fl 0ｹ06ｦ ｦ0 0601apple0ｸ8030ｸ apple03 02ｨｨ0702, apple6ｦ ｦ006036ｦ ｦ ｸ apple apple076 7apple apple040ｸ90ｸ ｹ fl ｦ006036ｦ003090ｹ apple070ｷ ｦ0, apple apple6ｦ apple ｦ apple090ｹ apple6ｦ fl ｦ0, 036ｦ ｦ apple09fl03000ｸ ｹ apple , ｦ0fl 0ｹ ｷ3096ｦ ｹ fl ｨC ｦ ｦ ｸ apple07060ｸ8, apple0ｸ800 03apple00 040ｸ ｦ ｦ0006ｦ ｦ0 09 apple6ｦ009apple6ｦ ｦ ｸ fl 0903 apple fl. 05ｨｨｨ 05ｨｦ01 00ｨ ｨｪ00ｨｺ02ｨｪｨｬｨｺ01 1.Ruijter E., van De Kaa C., Miller G. et al. Molecular genetics and epidemiology of prostate carcinoma // Endocrin. Rev Vol. 20. P. 22ｨC ｦ ｨｨ., ｨ 03fl ｨｴ fl fl apple6ｦ0016ｦ0 08apple ｦ ｸ8 // ｨｨapple6ｦ ｹ ｦ0fl fl ｧ ｨC apple apple ｦ fl, 06036ｦ000 6ｦ0apple ｦ ｦ00ｷ , 01026ｦ ｦ00ｷ309fl apple6ｦ0016ｦ0 08apple ｦ ｸ8 // ｨｨapple6ｦ ｹ ｦ0fl fl ｧ ｨC16. 4.Boyle P., Maisonneuve P., Napalkov P. Incidence of prostate cancer will double by the year 2030: arguments // Europ. J. Urol Vol. 29 (suppl. 2). P. 3ｨC ｦ0apple030ｸ , 076ｦ006 6ｦ0apple , , ｨｪapple04-026ｦ ｦ006036ｦ003090ｹ ｦ0 // ｨｨapple6ｦ ｹ ｦ0fl apple070309apple04apple6 709fl (apple fl 6 5apple6ｦ00ｹ00006). 05ｨｨ, ｨC Gandola L., Navarria P., Lombardi F. Treatment of single brain metastases // Forum (Genova) Vol. 11. N 1. P. 38ｨC58. 7.Taillibert S., Delattre J. Metastatic tumors of the nervous system // J. Neurooncol Vol ｧ8 10. P. 1ｨC apple ｦ006036ｦ003090ｹ ｦ0fl 0ｷ300apple00 apple6ｦ ｦ0fl : ｸ ｸ apple ｦ ｹ ｨｺ /05, apple6ｦ ｸ ｸ ｦ , 08apple ｦ ｹ ｦ006036ｦ003090ｹ apple6ｦ fl ｦ ｹ ｸ803: apple ｭ -apple6ｦ ｦ ｨｺ /05, , ｦ ｨｰ ｦ ｦ ｦ ｦ006036ｦ ｦ00ｹ ｸ // apple6ｦ ｹ apple ｧ ｨC ｸ80ｹ , 0707apple ｦ , ｨｦapple apple ｦ0apple ｦ0fl 0300apple6ｦ00809fl 08apple ｦ006036ｦ0096ｦ // ｹ ｸ ｦ ｧ ｨC Black P. Brain metastases: current status and recommended guidelines for management // Neurosurgery Vol. 5. 6ｧ8 5. P. 617ｨC Wen P.Y., Loeffler J.S. Brain metastases // Curr Treat Options Oncol Vol. 1. 6ｧ8 5. P. 447ｨC apple , 0206apple6ｦ ｦ ｸ800 08apple ｸ8 apple006ｦ ｦ00ｷ ｷ3096ｦ apple076 56ｦ ｹ ｦ ｹ ｸ ｹ ｸ ｦ006036ｦ003090ｹ apple6ｦ ｦ0 // ｨ fl 6 50ｸ ｹ ｸ ｦ apple07-016ｦ ｦ apple ( ｦ ) ｧ ｨC apple , ｨｰ0002fl ｦ0 ｨｪ.05., 0109apple090ｹ , 0206apple6ｦ apple ｦ ｹ ｦ0fl 070ｷ ｦ

8 ｨｺ02ｨｨ00ｨｪｨｦ05 036ｦ006036ｦ003090ｹ apple6ｦ fl ( 0006fl apple ｦ0 020ｸ fl) // apple07060ｸ ｧ ｨC ｨｨ ｦ006036ｦ003090ｹ , ｨｨ apple0ｸ800 6ｦ ｸ , 096ｦ ｦ ｦ ｹ fl ｸ ｦ ｦ003090ｹ apple6ｦ ｦ0 // ｨｨ6ｦ ｦ ｦ0fl ｷ309006ｦ0 09 apple006ｦ ｦ00ｷ309fl ｧ ｨC ｨｺ ｦ ｨｨ., ｨ fl , ｦ ｦ003090ｹ ｦ , apple6ｦ ｨｦ ｦ00ｷ309fl 096ｦ ｦ ｦ ｹ ｸ803: apple ｭ 016ｦ ｦ ｨｬ026ｦ0, ｦ0apple6ｦ0036ｦ , ｦ , 03apple0ｸ ｷ apple. ｨｨapple ｸ8 096ｦ apple04apple ｦ006036ｦ003090ｹ ｦ0 // ｹ ｸ ｦ ｧ ｨC ｦ0 ｨ.ｨｨ., 04apple ｦ0 ｨｪ.05., 046ｦ ｦ ｨｺ., ｦ0 02.ｨ., 0109apple ｹ ｦ0fl 0300apple6ｦ00809fl ｦ ｦ apple6ｦ ｹ ｦ ｦ00ｷ30909 // 026ｦ ｸ8 VI apple ｹ apple00000ｷ30909 (02., 26ｨC fl applefl ). 02., ｨC ｦ0 0ｹ00900 ｨ.05., 036ｦ0 0ｹ009006ｦ0 ｨ.ｨｨ., 016ｦ ｨｺ ｦ006036ｦ ｹ apple6ｦ ｦ0. 00., apple060006fl000ｷ3 05.ｨ ｦ apple fl ｦ006036ｦ ｹ apple6ｦ0016ｦ ｦ0: ｭ 016ｦ ｦ , ｦ0026ｦ0apple ｨ ｦ006036ｦ0090ｸ : apple ｭ 016ｦ ｦ ｨｨ, Kaal E.C.A., Taphoorn M.J.B., Vecht C.J. Symptomatic management and imaging of brain metastases // J. Neurooncol Vol ｧ8 10. P. 15ｨC ｦ0apple ｹ0 02.ｨｦ., ｦ0 ｨ.ｨｨ., 016ｦ apple ｦ ｦ ｹ ｦ006036ｦ003090ｹ apple6ｦ fl 0000apple ｸ ｹ ｸ803 // ｨｺ ｹ apple006ｦ ｧ ｨC ｦ0apple ｹ0 02.ｨｦ ｹ apple07fl fl ｦ ｦ ｦ0 // ｹ ｸ ｦ ｧ ｨC , apple096ｦ ｨ., flapple076 56ｦ0 05.ｨｨ. ｨｨapple6ｦ ｹ ｦ0fl apple ｦ fl apple07, ｦ ｦ ｨｨ ｦ fl 08apple fl ｦ0. 02., ｦ , ｨｺ6ｦ ｨｨ6ｦ0apple6ｦ ｦ ｹ ｦ ｦ00009fl. 02., , 076ｦ0000ｷ ｨｰ.07., ｨｺ apple ｸ ｦ00ｷ ｹ ｦ00ｹ ｦ ｸ apple6ｦ00608apple070603apple6ｦ ｸ apple036ｦ ｦ00ｹ ｸ apple6ｦ ｦ // ｨｨapple ｸ8 086ｦ ｦ ｸ (6ｦ fl 006ｦ0040ｹ0000ｸ ｦ00ｷ30906). ｨｪ. IｨCII. 02., ｨC ｦ0000ｷ ｨｰ.07., 0104apple6ｦ , 016ｦ008apple6ｦ , ｹ06ｦ0apple076 56ｦ0 ｨｦ apple ｸ ｸ ｦ ｦ006036ｦ // ｨｦ fl: apple09fl 09 08apple6ｦ ｦ ｧ ｨC apple apple06016ｦ0fl , 04apple ｦ0 05.ｨｨ ｦ ｦ001apple ｸ803 08apple apple ｹ ｦ ｦ00009fl03 // ｦ ｸ apple07060ｸ apple apple070309apple04apple : ｦ0040ｹ0. 03apple. ｨｺ /05, ｦ0apple0ｹ ｦ apple : ｸ apple ｸ8 02fl ｹ apple070309apple04apple apple07apple006ｦ ｦ // ｹ ｦ0fl apple fl 0309apple04apple6 7090ｹ ｦ ｦ ｦ0. ｨｮ ｨｨ, ｨC ｦ ｦ apple fl , Lampl Y., Paniri Y., Eshel Y. LDH isoenzymes in cerebrospinal fluid in various brain tumours // J. of Neurology, Neurosurgery, and Psychiatry Vol. 53. P. 697ｨC Stockhammer G., Obwegeser A., Kostron H., Schumacher P. et al. Vascular endothelial growth factor (VEGF) is elevated in brain tumor cysts and correlates with tumor progression. // Acta Neuropathol (Berl) Vol ｧ8 1. P. 101ｨC Friedberg M.H., Glantz M.J., Klempner M.S., Cole B.F., Perides G. Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis // Cancer Vol ｧ8 5. P. 923ｨC apple , 006ｦ ｦ ｨ ｹ ｹ ｹ apple ｹ ｦ ｦ ｦ0 BER EP4 09 apple ｦ ｷ ｹ ｦ apple6 5090ｹ0000ｸ ｦ006036ｦ003090ｹ fl ｦ0 // 02apple ｦ ｧ ｨC ｨｨ0003apple , ｨｺ6ｦ ｨｪ. 09 apple. ｨｺ ｹ ｦ ｹ ｦ0. 016ｦ0096ｦ00000, Kleihues P., Cavenee W.K. Pathology and Genetics of Tumors of the Nervous System. Metastatic Tumors of the CNS // WHO Classification of Tumors. Lyon: IARC Press, P. 249ｨC Sheridan T., Herawi M., Epstein L., Illei P.B. The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate // Am. J. Surg. Pathol. 2007, Sep. Vol ｧ8 9. ｨｺ. 1351ｨC Nussbaum E.S., Djalilian H.R., Cho K.H., Hall W.A. Brain metastases. Histology, multiplicity, surgery, and survival // Cancer Vol. 78. N 8. P. 1781ｨC Lutterbach J., Bartelt S., Ostertag C. Long-term survival in patients with brain metastases // J. Cancer Res. Clin. Oncol Vol ｧ8 8. P. 417ｨC Bonerandi J.J., Hesse S. Treatment of brain metastases of malignant melanoma: value of fotemustine // Drugs Today Vol. 32 (Suppl. E). P. 29ｨC Brown P.D., Brown C.A., Pollock B.E., Gorman D.A., Foote R.L. Stereotactic radiosurgery for patients with ｰradioresistant ｱ brain metastases // Neurosurgery Vol ｧ8 3. ｨｺ. 656ｨC Kim S.H., Chao S.T., Toms S.A., Vogelbaum M.A., Barnett G.H., Suh J.H., Weil R.J. Stereotactic radiosur-

9 130200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ00 ｨｨｨｦｨｺ ｨ 00 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨｨｺｨ ｨｺｨｨ05 35 gical treatment of parenchymal brain metastases from prostate adenocarcinoma // Surg. Neurol Jun. Vol ｧ8 6. ｨｺ. 641ｨC Modha A., Shepard S.R., Gutin P.H. Surgery of brain metastases ｨC Is there still a place for it? // J. Neurooncol Vol ｧ8 10. P. 21ｨC Chang S.D., Lee E., Sakamoto G.T., Brown N.P., Adler J.R. Stereotactic radiosurgery in patient with multiple brain metastases // Neurosurg. Focus Vol. 9. 6ｧ8 2. ｨｺ. 6ｨC Chang E.L., Selek U., Hassenbusch S.J. et al. Outcome variation among ｰradioresistant ｱ brain metastases treated with stereotactic radiosurgery // Neurosurgery Vol ｧ8 5. ｨｺ. 936ｨC Yamamoto M., Ide M., Nishio S., Urakawa Y. Gamma Knife radiosurgery for numerous brain metastases: is this a safe treatment? // Int. J. Radiat. Oncol. Biol. Phys Vol ｧ8 5. P. 1279ｨC Vesagas T.S., Aguilar J.A., Mercado E.R., Mariano M.M. Gamma knife radiosurgery and brain metastases: local control, survival, and quality of life // J. Neurosurg Vol. 97 (5 Suppl). P. 507ｨC Pan H.C., Sheehan J., Stroila M., Steiner M., Steiner L. Gamma knife surgery for brain metastases from lung cancer // J. Neurosurg Vol. 102 (Suppl). P. 128ｨC Nam T.K., Lee J.I., Jung Y.J., Im Y.S. et al. Gamma knife surgery for brain metastases in patients harboring four or more lesions: survival and prognostic factors // J. Neurosurg Vol. 102 (Suppl). P. 147ｨC ｨｨ ｦ0fl ｨ ｸ ｨC ｸ apple6ｦ : ｦ ｹ ｦ00ｹ ｸ // apple ｦ0fl fl ｨｪ. 4. 6ｧ ｨC ｦ ｦ apple fl apple ｸ apple6ｦ ｦ00ｹ ｸ ｦ0 // apple ｦ0fl fl ｨｪ. 4. 6ｧ ｨC149. METASTATIC BRAIN LESION IN PROSTATE CANCER K.G. Airapetov In the paper main aspects of the problem of metastatic brain lesion in prostate cancer are considered. The most urgent questions, such as high frequency of latent forms of brain lesion, narrow spectrum of the methods of early and timely diagnostics of cerebral lesions, unfavourable clinical prognosis, and low efficacy of special treatment, were accentuated and analyzed. Similar complex analysis of the problem is necessary for the elaboration of effective methods of diagnostics and treatment of this severe disease. Key words: prostate cancer, metastatic brain lesion. 3*

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