HCV 150 HCV 13 3 13 4 13 8 14 2
14 2 14 8 15 3 15 8 17 3 7 8 18 3
----- i Q1 1 Q2 1 Q3 1 Q4 2 Q5 3 Q6 3 Q7 3 Q8 4 Q9 4 Q10 : 5 6 Q1 6 Q2 7 Q3 7 8 Q4 8 Q5HCV 8 Q6HCV 9 Q7HCV 9 Q8NAT 10 Q9 10 Q10 11 Q11 11 Q12 11 Q13NAT 11 Q14 12 Q15 12 Q16 13
Q17 13 Q18 13 Q19? 14 Q20 14 15 Q21 15 Q22 15 Q23 15 Q24 16 Q25 16 Q26 16 Q27 17 Q28 18 Q29NAT 18 Q30 19 Q31 19 21 Q32 21 Q33 21 Q34 21 Q35 21 22 Q36 22 Q37 22 Q38 23 Q3923 Q40 24 Q41 24 Q42 25 Q43 25 Q44 _25 27 Q45 27 Q46 27 Q47 28
Q48 28 Q49 29 Q50 29 Q51 29 Q52 29 Q53 30 31 Q54 31 Q55 31 Q56 _31 32 Q57 32 Q58 32 34 Q59 34
Q1 Q2 70 Q3
Q4 (1989 )11 (HCV)HCV C100-3 (1992 )2 HCV (1999 )10 NAT HCV RNA 4 (1992 ) 6 (1994 ) 63 (1988 ) http://www.mhlw.go.jp/houdou/0105/h0518-2a.html#betu1
Q5 () () Q6 HCV HCV HCV HCV HCV NATHCV RNA 3 HCV HCV HCV Q7 2
Q8 Q9 70% 40 100 6570 HCV 100
70 1016 2025 Q10 14 173 8
Q1 (HCV HCV HCV 70HCV HCV HCV HCV 70 HCV HCV 6570% 40 HCV 70 1016%2025% HCV
50 60 Q2 (HCV HCV 1988 (HCV HCV Q3(HCV) HCV HCV 70% HCV 6570% HCV
Q4(HCV) HCV HCV HCV HCV HCV HCV Nucleic acid Amplification Test: NAT HCV (RNA) 1 HCV HCV HCV HCV HCV HCV HCV HCV 3 HCV HCV HCV HCV HCV HCV Q5HCV HCV 5557nm RNA RNA HCV HCV (HCV ) E2/NS-1 HCV NS C100-3 C-33c NS5 HCV HCV ( HCV HCV HCV HCV HCV HCV
HCV HCV HCV HCV HCV HCV HCV HCV HCV HCV HCV HCV HCV HCV HCV HCV Q6HCV 2 13 HCV PHA 2 12 HCV PA 2 5 HCV PHA 2 4 HCV PA HCV HCV 98 HCV RNA HCV HCV HCV RNA HCV Q7HCV HCV HCV HCV HCV HCV HCV HCV HCV HCV HCV HCV HCV
HCV EIA HCV HCV HCV HCV (NAT) (NAT) HCV Q8NAT Nucleic acid Amplification TestNAT 1 PCR(Polymerase chain reaction) HCV HCV (HCV RNA)HCV HCV HCV HCV HCV HCV HCV NAT HCV RNA HCV Q9(HCV) HCV HCV HCV HCV HCV HCV HCV HCV HCV
HCV RNA HCV HCV HCV HCV HCV HCV HCV HCV NAT HCV RNA 3 Q10(HCV) HCV HCV HCV HCV HCV HCV HCV HCV HCV Q11 HCV 6 1b 70 2a 20 2b 10 Q12(HCV) HCV 3 HCV Q13NAT (HCV) HCV 2
10 10 1.5 HCV 12 NAT HCV RNA Q14(HCV) HCV a. 4 (1992 ) b. c. d. c e. f. g. h. i. j. http://www.mhlw.go.jp/houdou/0105/h0518-2a.html#betu1 Q15(HCV) HCV HCV
Q16: Q17 Q18
HIV HBs HCV HBs HCV Q19(HCV) HCV RNA HCV Q20 HCV HCV HCV ASTGOTALTGPT CTMRI
Q21(HCV) HCV HCV HCV HCV HCV HCV HCV Q22(HCV) HCV Q23(HCV) 150 21 14 HCV HCV 50 12 HCV HCV
HCV HCV Q24(HCV) HCV Q25(HCV) HCV 3,079 3 HCV 703 4 HCV 703 25 HCV HCV HCV HCV Q26(HCV) HCV
Q27(HCV) (1989 )11 HCV HCV C100-3 4 (1992 )2 HCV HCV 11 (1999 )10 NAT HCV RNA HCV NAT HCV NAT HIVHBVHCV 4 1992 HCV 6 1994 63 1988 HCV HCV HCV HCV HCV http://www.mhlw.go.jp/houdou/0105/h0518-2a.html#betu1 NAT HCV RNA 6 HCV
Q28 6 HCV 1989 11 HCV C100-3 8.7 21992 2 HCV 1999 10 NAT HCV RNA NAT HCV RNA 10 2 /ml HCV HCV RNA 10 HCV NAT NAT HCV B (HBVHIV Q29NAT 500 1 NAT 500 NAT 1999 7 2000 1 2,140,207 19 HBV 8 HCV NAT 500 50 (50 NAT)2000 2 2004 7 24,702,784 HBVHCVHIV 473 72 8 2004 8 20 NAT
2005 12 6,994,084 HBVHCVHIV 133 13 4 (HBVHCVHIV) (HBs HBc HCV HIV )NAT NAT NAT HBVHCVHIV Q30(HCV) HCV HCV HCV (E2/NS-1 )HCV E2/NS-1 E2/NS-1 HCV HCV HCV Q31(HCV) HCV HCV E2/NS-1 HCV
HCV HCV HCV HCV HCV RNA HCV
Q32(HCV) HCV HCV Q14 HCV HCV Q33HCV HCV 84 87 3 1 2 2.3% HCV HCV HCV 2 HCV Q34HCV HCV HCV Q35HCV HCV HCV 12 12 HCV 12 2 3 NAT HCV RNA HCV HCV
HCV Q36 HCV HCV HCV E2/NS-1 HCV HCV HCV HCV Q37HCV HCV HCV 1 1 23 1 2 3. 4.
5. 6. HCV HCV Q38HCV HCV 70 HCV 40 100 6570 HCV 1,428 HCV HCV 100 70 1016 2025 Q39HCV? ALT(GPT)AST(GOT) 1 1,020 HCV 43.5 530 52.0 5 0.5 1 0.2 ASTALT 483 47.4 ALT HCV
2 1 2 40 20 ALT ALTAST Q40HCV HCV 23 Q41HCV HCV HCV
2 3 http://www.jsh.or.jp/ Q42HCV HCV HCV Q43HCV (HCV) HCV HCV Q44HCV 1995 2000 6 348.6 2000 HCV 1619 0.1%2029 0.2% 3039 0.8%4049 1.3%5059 1.8%6069 3.4%
HCV 70% HCV RNA (HCV 30 HCV RNA HCV HCV 2000 15 69 9,200 88.5 (72.5104.5 ) HCV 70 HCV 3 HCV 150 HCV 15 HCV 0.020.05 116-0033 3-6-21-201 TEL03-5982-2150 10:0016:00 FAX03-5982-2151 URLhttp://members.at.infoseek.co.jp/sin594/ E-mails-nisimu@sannet.ne.jp 156-0043 1-12-3-102 TEL03-3323-2260 13:0017:00 FAX03-3323-2287 URLhttp://www.geocities.co.jp/Colosseum-Acropolis/9112/ E-mailzenkanren@geocities.co.jp
Q45 1. (HCV) 2. 3. CT -FPPIVKA- HCV HCV 1 1 2 3 Q46 (HCV) HCV HCV 1b 202a 602b 40 HCV 1b HCV
HCV HCV HCV HCV HCV Q47 30 4050 Q48 HCV Q46 HCV
Q49 Q50 Q51 Q52(HCV) HCV
Q53
Q54(HCV) HCV 1.8% HCV HCV Q55(HCV) HCV HCV HCV HCV RNA 1 2 2 HCV RNA Q56(HCV) HCV HCV HCV
Q57(HCV) HCV (HBV) Q58(HCV) HCV 15 1,000ppm 1 1,000ppm 56 5060
2
Q59:
1 2002 3 2003 3 2004 3 2005 3 2 21 2001 12 2002 3 3 2005 3 4 2003 3 2004 3 2005 3 52000 6 2 2002 3 7HCV 3 2003 4 8. Katayama K et al., Titration of Hepatitis C virus in Chimpanzees for determining the copy number required for transmission (Intervirology, 47; 57-64, 2004) 9. Tanaka J et al., Early dynamics of hepatitis C virus in the circulation of Chimpanzees with experimental infection (Intervirology, 48; 120-123, 2005) 10. Tanaka J et al., Sex- and age-specific carriers of hepatitis B and C viruses in Japan estimated by the prevalence in the 3,485,648 first-time blood donors during 1995-2000 (Intervirilogy, 47; 32-40, 2004) 11. Consensus Statements on the Prevention and Management of Hepatitis B and Hepatitis C in the Asia-Pacific RegionJournal of Gastroenterology and Hepatology, Volume 15 Number 8 August 2000 12. Recommendation for Prevention and Control of Hepatitis C virus (HCV) Infection and HCV-Related Chronic DiseaseCenters for Disease Control and Prevention, October 1998 13. Hepatitis C, question & answer manualcanadian Liver Foundation, April 2000
100-8916 1-2-2 03-5253-1111 URLhttp://www.mhlw.go.jp/ 113-0033 3-2-15 7F 03-3813-4077 URLhttp://www.vhfj.or.jp/ 113-8621 2-28-16 03-39426485 URLhttp://www.med.or.jp/kansen/