Suzuki K. (2016). Breeding for disease resistance to Mycoplasma pneumonia of swine All about SWINE 48, 2-12 PRDC ARMPS PRRS 18 1 21 24 32 40 MPS EU 2006 2011 SPF 2 3 MPS 5 MPS 4 MPS MPS MPS 2
MPS MPS MPS MPS Kadowaki 4 14 35 50 110 MPS 120 5 1 70kg 1 SRBC 1 Goodwin 5 MPS BLUP 4 2 3 5 MPS 2 2 4 5 30kg 8 105kg 9 10 200 50 120 200 110 60 50 3 SD 1 2 DGg/day 886.7127.1 957 70 0.0612 0.0253 BFmm 23.93.97 19-5 -2.71-9 MPS% 2.372.80 0-2.4 -.2-0.462 CORmg/dl 1.521.27 1 SD -1.3-1.07-50 DGBFMPSCOR 1 DG, BF, MPS, COR 4 3 5 4 2 1DG, BF, MPSCOR 50 110 13 50 3
1 2 3 4 5 35 50 50 49 48 58 1 1 110 110 47 40 32 36 34 20 12 10 11 37 52 45 49 46 232 508 189 68 229 161 82 287 81 248 740 647 25 42 34 31 29 14 13 10 35 51 49 53 51 48 13 13 10 33 49 40 40 38 48 4 MPS 0.07 MPS 0.43 MPS SRBC IgG 5 IgG 26 IL-17 IFN- TNF- 37MPS IL-17IFN- -0.86-0.45 MPS MPS TNF- 0.69 TNF- DGBFMPSMPS COR 4
DG BF MPS COR DG (G5) 0.60 (0.03) 0.24 (0.06) -0.01 (0.12) 0.31 (0.09) BF (G5) 0.12 0.65 (0.04) -0.02 (0.19) 0.06 (0.10) MPS (G5) 0.02 0.05 0.07 (0.04) 0.43 (0.26) COR (G5) 0.05 0.09-0.04 0.20 (0.04) DGBFMPS COR MPS 5 MPS MPS MPS MPS Shimazu Borjigin 8,9,10 MPS 0-702714 5-7 0 MPS 14 ELISA Real-time PCR SAS MPS 5
12 17 74kg MPS MPS 4a MPS B 5a 6abMPS GH 0 5c IFN- MPS 7aMPS MPS MPS 2 MPS 6 16 66kg 1 1 MPS 4bMPS MPS B 5b MPS IgG 7c GH 1 MPS 5d NK IFN- IgA MPS 6c 7bdMPS MPS MPS IFN- IgA B IgG 6
GH LW D MPS F1 1/21/4 MPS F1 F1 MPS F1 Borjigin 11 MPS La LaWa LaWb Wa Wb Lb LbWb 4 65kg 661010 SRBC MPS LbWb La LaWa LaWb La MPS 8aSRBC LaWb LaWa La SRBC IgG 8b LbWb 7
8
IgA La SRBC LaWbLaWaLbWb 8c SRBC LaWb LaWa La 9aB T 9b amps La MPS La MPS LaWaD MPS La11 28kgMPS LaWaDLaWa D12 44kg LbWbD11 28kg 12 36 MPS F1 La MPS LaWaD La LbWbD IgG LaWaD La LbWbD -70 2 14 La LaWaD La LbWbD IgA LaWaD La LbWbD T 9
B LaWaD LbWbD LaWaD IFN- IL-6 mrna La LbWbD IL-4 TGF- La LbWbD MPS LaWaD LbWbD MPS MPS CT IgG IFN- IgA MPS IL-17 MPS 10
MPS 1 Mallard BA, Wilkie BN: Phenotypic, genetic and epigenetic variation of immune response and disease resistance traits of pigs, Advances in Pork Production, 48, 139-146 (2007) 2 Nishida A, Ogawa T, Kikuchi Y, Wakoh K, Suzuki K. Shibata T, Kadowaki H: A hopeful prospect for genetic improvement of chronic disease resistance in swine. Asian-Aust. J. Anim. Sci 14, Special Issue: 106-110 (2001) 3 Wilkie BN, Mallard BA: Breeding for Disease Resistance in Farm Animals 2nd edn. p379-396. CABI Publishing, New York (2000) 4 Kadowaki H, Suzuki E, Kojima-Shibata C, Suzuki K, Okamura T, Onodera W, Shibata T, and Kano H: Selection for resistance to swine mycoplasamal pneumonia over 5 generations in Landrace pigs, Livestock Science, 147, 20-26 (2012). 5 Goodwin RF, Whittlestone P: Enzootic pneumonia of pigs: immunization attempts inoculating Mycoplasma suipneumoniae antigen by various routes and with different adjuvants, Br. Vet. J. 129, 456-464 (1973) 6 Okamura T, Maeda K, Onodera W, Kadowaki H, Kojima-Shibata C, Suzuki E, Uenishi H, Satoh M and Suzuki K: Correlated responses of respiratory disease and immune capacity traits of Landrace pigs selected for Mycoplasmal pneumonia of swine (MPS) lesion, Animal Science Journal, DOI: 10.1111/asj.12560 (20) 7 Sato T, Okamura T, Kojima-Shibata C, Kadowaki H, Suzuki E, Uenishi H, Suzuki K: Correlated response of peripheral blood cytokines with selection for reduced Mycoplasma pneumonia of swine lesions in Landrace pigs, Animal Science Journal, Early View online : DOI: 10.1111/asj.12462 (20) 8 Shimazu T, Borjigin L, Katayama Y, LiM, Satoh T, Watanabe K, Kitazawa H, Roh S, Aso H, Kazuo K, Suda Y, Sakuma A, Nakajoh M, Suzuki K: Immunological characterization of peripheral blood leukocytes using vaccine for mycoplasmal pneumonia of swine (MPS) 11
in swine line selected for resistance to MPS, Animal Science Journal, 84, 683-692 (2013) 9 Shimazu T, Borjigin L, Katayama Y, LiM, Satoh T, Watanabe K, Kitazawa H, Roh s, Aso H, Kazuo K, Suda Y, Sakuma A, Nakajoh M, Suzuki K: Genetic selection for resistance to mycoplasmal pneumonia of swine (MPS) in the Landrace line influences the expression of soluble factors in blood after MPS vaccine sensitization, Animal Science Journal, 85, 365-373 (2014) 10 Borjigin L, Shimazu T, Katayama Y, Li M, Satoh T, Watanabe K, Kitazawa H, Roh S, Aso H, Katoh, Uchida T, Suda Y, Sakuma A, Nakajo M and Suzuki K. Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine, Animal Science Journal, Article first published online : 11 AUG 20, DOI: 10.1111/asj.12440 (20) 11 Borjigin L, Shimazu T, Katayama Y, Satoh T, Watanabe K, Kitazawa H, Roh S, Aso H, Katoh, Uchida T, Suda Y, Sakuma A, Nakajo M and Suzuki K: Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line. Animal Science Journal, In press (20) 12