ACTIVE FOCUS

ACTIVE FOCUS

Am ACTIVE FOCUS 100% ACTIVE FOCUS 1, m x 4 10-3* 0-4 -4 -.5 x 10-3* 4 0 - - -1.5-1 ACTIVEFOCUS -0.5 0 0.5 mm 1 1.5.5 69.4 1 40.5 100 1, -4 -.5 - -1.5-1 -0.5 0 0.5 mm 1 1.5.5

CPD AcyrSof IQ 1,3 4 6 *,3 ACTIVEFOCUS 4.50.5.00 1.75 1.50 1.5 1.00 Log 0.75 Units 0.50 0.5 0 1.5 cpd n=17/130 3 cpd n=19/13 6 cpd n=116/18 1 cpd n=103/117 AcrySof IQ ACTIVE FOCUS IOL AcrySof IQ IOL AcrySof IQ Monofocal ACTIVEFOCUS A.75D 3mm 4.5mm ACTIVE FOCUS AcyrSof IQ 1,3 * 3

AcrySof IQ ACTIVEFOCUS AcrySof IQ ACTIVEFOCUS 5 6 67cm (6 in) 50cm (0 in) 40cm (16 in) 33cm (13 in) 100 80 0/0 1.0 0.0 0/5 0.8 0.1 LogMAR 0/3 0.63 0. 60 40 0 0/40 0.5 0.3 0 1 1.5.5 3 3.5 4 4.5 5 5.5 6 mm 0/50 0.4 0.4 +0.00-0.50-1.00-1.50 -.00 -.50-3.00-3.50-4.00 D AcrySof IQ ACTIVEFOCUS IOL n=130 AcrySof IQ IOL n=133 AcrySof IQ ACTIVEFOCUS IOL AcrySof IQ ACTIVEFOCUS IOL AcrySof IQ ReSTOR +3.0 D IOL AcrySof IQ ReSTOR +3.0 D IOL 4

6 AcrySof IQ ACTIVEFOCUS ReSTOR 3.0 A A 50 m 5mm 1.0D 5

AcrySof IQ 7 AcrySof IQTORIC AcrySof IQ TORIC 10 3% 9 6

AcrySof A 10,11 AcrySof BioMaterial A YAG 1,13 10,11 6.00 10 5.00 4.00 3.00 ug.00 SEM 1.00 n=1 n=11 n=1 n=11 0.00 P<0.001 AcrySof BioMechanics 17,18 IOL 17,18 14-18 7

ACTIVEFOCUS AcrySof IQ 1,3,4 8,9,15 018 SV5T0 SV5T3 SV5T4 SV5T5 SV5T6 IOL - 1.5 D.5 D 3.00 D 3.75 D - 1.03 D 1.55 D.06 D.57 D IOL +.5 D +.0 D 7 6.0 30.0D 6.0mm 13.0mm A 119.1 * / 119.3 ** 1.55 *** B C 6.0 30.0D D 6.0 7.0D 0 STABLEFORCE B C 6.0 30.0D D 6.0 5.0D * A ** 14 94 A *** IOL 000BZX01096000 600BZX00179000 IQ +.5D 700BZX00006000 IQ +.5D 1. Alcon Data on File. (April 11, 016).. Alcon Data on File. (Oct 17, 016). 3. AcrySof IQ ReSTOR +.5 D IOL Directions for Use. 4. Vega F,Alba-Bueno F, Millán MS, et al. Halo and through-focus performance of four diffractive multifocal and intraocular lenses. Invest OphthalmolVis Sci. 015;56;3967-3975. 5. SV5T0 6. Alcon Internal Bench Data 7. Hayashi K, Manabe S, Yoshida M, Hayashi H. Effect of astigmatism on visual acuity in eyes with a diffractive multifocal intraocular lens. J Cataract Refract Surg. 010;36(8):133-139. 8. Potvin R, et al. Toric intraocular lens orientation and residual refractive astigmatism: an analysis. Clin Ophthalmol. 016;10:189-1836. 9. Visser N, Bauer NJ, Nuijts RM. Toric intraocular lenses: historical overview, patient selection, IOL calculation, surgical techniques, clinical outcomes, and complications. J Cataract Refract Surg. 013;39(4):64-637. 10. Ong M, Wang L, Karakelle M. Fibronectin adhesive properties of various intraocular lens materials. Alcon Laboratories, Fort Worth, TX, USA. ARVO 013. 11. Linnola RJ, Sund M, Ylonen R, et al. Adhesion of soluble fibronectin, laminin, collagen type IV to intraocular lens materials. J Cataract Refract Surg. 1999;5(11):1486-1491. 1. Boureau C, et al. Incidence of Nd:YAG laser capsulotomies after cataract surgery: comparison of 3 square edge lenses of different composition. Can J Ophthalmol. 009;44:165-170. 13. Apple DJ, Peng Q, Visessook N, et al. Eradication of posterior capsule opacification: documentation of a marked decrease in Nd:YAG laser posterior capsulotomy rates noted in an analysis of 5,416 pseudophakic human eyes obtained postmortem. Ophthalmology. 001;108(3):505-518. 14. Nejima R, et al. Prospective intrapatient comparison of 6.0-millimeter optic single-piece and 3-piece hydrophobic acrylic foldable intraocular lenses. Ophthalmology. 006;113(4):585-590. 15. Wirtitsch MG, et al. Effect of haptic design on change in axial lens position after cataract surgery. J Cataract Refract Surg. 004;30(1):45-51. 16. AcrySof IQ Toric IOL Directions for Use. 17. Lane SS, Ernest P, Miller KM, Hileman KS, Harris B, Waycaster CR. Comparison of clinical and patientreported outcomes with bilateral AcrySof Toric or spherical control intraocular lenses. J Refract Surg. 009;5(10):899-901. 18. Lane SS, Burgi P, Milios GS, Orchowski MW, Vaughan M, 010-85-66 SMB316-1 01803 1803IPA