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(1) 種類 程度 肥満細胞数の測定と組織でのサ RT-PCR FACS ()

(1) NMU-/- IgE NMU IgE -/-NMU -/-B IgE NMU -/-B6 IgE NMU NMU CTLMC BMMC IgE NMU CTLMC

13 1. Hayakawa J, Mizukawa Y, Kurata M, Shiohara T: A syringotropic variant of cutaneous sarcoidosis -Presentation of three cases exhibiting defective sweating responses- J Am Acad Dermatol 68: 1016-1021, 2013. doi: 10.1016/j.jaad.2012.11.039. 2. Shiohara T and Mizukawa Y: Fixed drug eruption: the dark side of activation of intraepidermal CD8+ T cells uniquely specialized to mediated protective immunity. Chem Immunol Allergy 97:106-121, 2012. doi: 10.1159/000335623. 3. Shiohara T, Kano Y, Takahashi R, Ishida T and Mizukawa Y: Drug-induced hypersensitivity syndrome: recent advances in the diagnosis, pathogenesis and management. Chem Immunol Allergy 97:122-138, 2012 doi: 10.1159/000335624. 4. Mizukawa Y, Horie C, Yamazaki Y and Shiohara T: Detection of varicella-zoster virus antigens in lesional skin of zosterifrom lichen planus but not in that of linear lichen planus. Dermatology 225(1); 22-26, 2012. doi: 10.1159/000339771. 5. Kano Y, Horie C, Inaoka M, Ishida T, Mizukawa Y, Shiohara T: Herpes zoster in patients with drug-induced hypersensitivity syndrome/dress. Acta Derm Venereol 92(2); 2060207, 2012. doi: 10.2340/00015555-1317 6. : 1. 65: 478-481, 2011 http://top.islib.jp/bcs/ct/medicalfinder/fixed ViewPdf.do?isid=1412102966 7. :. 238: 775-778, 2011. 8.. 121: 1869-1874, 2011. 9. : :. 9: 219-221, 2011. 10. Horie C, Mizukawa Y, Yamazaki Y, Shiohara T: Varicella-zoster virus antigen expression of eccrine gland and duct epithelium in herpes zoster lesions. Br J Dermaaaatol 165:802-807, 2011 doi: 10.1111/j.1365-2133.2011.10462.x. 11. : IgE 121:2923-2924 2011. 12. Shiohara T, Sato Y, Takahashi R, Kurata M, Mizukawa Y: Increased susceptibility of cutaneous viral infections in atopic dermatitis: the role of regulatory T cells and innate immuni defects. Curr Probl Dermatol 41: 125-135, 2011. doi: 10.1159/000323306. 13. Narita YM, Hirahara K, Mizukawa Y, Kano Y, Shiohara T: Efficacy of plasumapheresis for the treatment of severe toxic epidermal necrolysis: Is cytokine expression analysis useful in predicting its therapeutic efficacy? J Dermatol 38 (3);236-245. doi: 10.1111/j.1346-8138.2010.01154.x.

15 1. (HZ)HSV. 77 26 2 16. 2. :. 25 12. 9 TAP,, 3. ¹(¹): GVHD 1. 43, 1., 25 12 4. Mizukawa Y, Shiohara T: Mechanisms insuring regulatory T cell recruitment in fixed drug eruption lesions. 8th International Congress on Cutaneous Adverse Drug Reactions. Taoyuan, Taiwan, Nov 17 th, 2013. 5. :... 112,, 25 14. 6. Mizukawa Y, Komatsu Y, Yamazaki Y, Shiohara T: IgE has different effects on mast cell subtypes. The 37 th Annual Meeting of the Japanese Society for Investigative Dermatology. Nago, Dec 8th, 2012. 7. Komatsu Y, Sato Y, Ushigome Y, Doi T, Mizukawa Y, Shiohara T: Involvement of sweating disturbance in the pathogenesis of lichen planus and atopic dermatitis. The 37 th Annual Meeting of the Japanese Society for Investigative Dermatology. Nago, Dec 8th, 2012. 8. Mizukawa Y, Doi T, Komatsu Y, Ushigome Y, Shiohara T: Sweating disturbance as a trigger for lichen planus. 10th Meeting of the German-Japanese Society of Dermatology. Tokyo, Nov 18 th, 2012. 9. Sato Y, Mizukawa Y, Doi T, Komatsu Y, Ushigome Y, Shiohara T: Impression mold techniques (IMT): A useful methods for the analysis of sweating responses. 10 th Meeting of the German-Japanese Society of Dermatology. Tokyo, Nov 18 th, 2012. 10. Bell 1. 75 24 2 18. 11. Mizukawa Y, Shiohara T: Multiple fixed drug eruption as a possible abortive variant of toxic epidermal necrolysis. The 22 th World Congress of Dermatology. Korea, May 29th, 2011 12. Mizukawa Y, Shiohara T: A dual role of the degranulation of different mast cell subtypes The 36 th Annual Meeting of the Japanese Society for Investigative Dermatology. Kyoto, Dec 9th, 2011 14. : Langerhans. HSV 18,, 23 8 19.

15. :. 36,, 23 6 9. 1. 杏林大学 医学部 准教授