Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with blad

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1 Key words: Female with bladder irritability, Subjective symptoms, Pyuria, Bacteriuria

2 Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with bladder irritability

3 Fig. 3 Distribution of bacteriuria, Pyuria and Subjective symptoms(1353 cases) : severe urinary symptoms except pain on urination : mnderatp urinary symptoms except pain on urination : mild urinary symptoms except pain on urination Fig. 4 The degree of bacteriuria in typical and atypical cystitis

urinary symptoms except pain on urination : mild urinary symptoms except

4 Fig. 5 The degree of pyuria in typical and atypical cystitis Fig. 6 The severity of subjective symptoms in typical and atypical cystitis

5 Fig. 7 Three-dimensional distribution of Bacteriuria, Pyuria and Subjective symptoms Fig. 8 Relationship between degrees of bacteriuria and pyuria in female patients with bladder irritability(1353 cases)

6 Fig. 9 Relationship between degree of pyuria and severity of subjective symptoms in female patients with bladder irritability(1353 cases) Fig. 10 Relationship between degree of bacteriuria and severity of subjective symptoms in female patients with bladder irritability(1353 cases)

8 8) Kass, E. H.: Bacteriuria and the diagnosis of infection of the urinary tract. Arch. Intern, Med., 100: , ) Kunin, C. M.: Pyuria. In: Detection, prevention and management of urinary tract infec- tions(kunin, C. M. ed) 4th ed. p.60-63, Lea & Febiger, Philadelphia, ) Brumfitt, W.: Urinary cell counts and their value. J. Clin. Path., 18: , ) Stansfeld, J. M.: The measurementand mean- ing of pyuria. Arch. Dis. Child., 37: , ) Stamm, W. E.: Measurement of pyuria and its relation to bacteriuria. Am. J. Med., 75(1B): 53

10) Brumfitt, W.: Urinary cell counts and their value. J. Clin. Path., 18: 550-555, 1965. 11) Stansfeld, J. M.

9 Clinical Study on Female Patients with Bladder Irritability Takaoki HIROSE & Yoshiaki KUMAMOTO Department of Urology, Sapporo Medical College We conducted a clinical study on the relationship between bacteriuria, pyuria and subjective symptoms in 1353 female patients without any underlying disease but complaining of bladder irritability. The results were as follows: 1) Two-thirds of these patients met the standard criteria of typical acute cystitis by the Japanese UTI committee, while those remaining were judged to have atypical acute cystitis. 2) The symptom of pain on urination, one of the requirements to meet the standard criteria, was found in fifty eight percent of those with atypical acute cystitis. 3) Sixty one percent of the patients with atypical acute cystitis had pyuria of more than 10 WBCs/hpf and fifty one percent bacteriuria of more than 104 cfu/ml. 4) The analysis of the correlation between the degree of bacteriuria, the degree of pyuria and the severity of subjective symptoms revealed a stronger correlation between bacteriuria and pyuria, and pyuria and subjective symptoms, followed by bacteriuria and subjective symptoms, in this order. When taking it into consideration that bacteria multiply in bladder urine, which elicits a local defense response representing the appearance of pyuria, resulting finally in subjective symptoms, the results described above are valid.

The results were as follows: 1) Two-thirds of these patients met the standard criteria of typical acute cystitis by the Japanese UTI committee, while those remaining were judged to have atypical

Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S.

Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S. Table 1. Clinical summary of acute uncomplicated cystitis patients treated with 7432-S UTI : Criteria by the