抗アレルギー効果のあるKW乳酸菌の発見と活用
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- うたろう うみのなか
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1 KW Strachan BCG Lactobacillus Lactococcus Streptococcus Lactobacillus casei brevis johnsonii
2 Th2 Th2 IL 4 B IgE IgE IgE IL-12 IL-12 Th1 Th1 Th2 Th2 Th1 Th2 KW 101 Th1/Th2 BALB/c
3 OVA 2 Th2 OVA OVA Th2 OVA Th2 Th1 Th1 IL-12 Th2 IL-4 IL-12 IL-12 IL-12 Lactobacillus paracasei KW3110 IL-4 IL-4 IL-4 L. paracasei KW3110 L. paracasei L. paracasei
4 LPS LTA IL-12 NF-κB KW3110 LTA NF-κB LTA LTA data not shown LTA CpG DNA KW3110 KW3110 BALB/c 2 1 AIN mg KW OVA IgE OVA IL-12 IL-4 KW3110 Th1/Th2 IgE OVA IgE OVA IgE OVA KW3110
5 IgE 98 IgE OVA IL-12 KW3110 IL-4 KW3110 KW3110 CD40 B7-1 data not shown KW3110 Th1 Th2 IgE 1mg/mouse/day KW3110 KW L. paracasei KW Th1/Th2 5 L. delbrueckii B 200ml cfu IgE IgE Th1/Th2 ECP
6 Th1/Th2 B 1 4 Th1/Th2 p= Th1 Th2 data not shown KW3110 Th1/Th2 B 3 KW ECP B 1 4 ECP p= KW3110 ECP B 3 KW3110 8
7 IgE KW3110 B data not shown KW3110 data not shown KW3110 KW3110 KW3110 IgE NC/Nga 2 1 AIN mg KW IgE KW3110 KW3110 KW3110 data not shown IgE KW3110
8 KW3110 KW3110 KW KW
9 Th1/Th2 KW 8 8 Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299: Shirakawa T, Enomoto T, Shimazu S, Hopkin JM. The inverse association between tuberculin responses and atopic disorder. Science 1997; 275:77-9. Aaby P, Shaheen SO, Heyes CB, Goudiaby A, Hall, Shiell AJ AW, Jensen H, Marchant A. Early BCG vaccination and reduction in atopy in Guinea-Bissau. Clin Exp Allergy. 2000; 30: The anti-allergic effects of lactic acid bacteria are strain dependent and mediated by effects on both Th1/Th2 cytokine expression and balance. Daisuke Fujiwara, Sayo Inoue, Hideyuki Wakabayashi and Toshio Fujii A double-blind trial of Lactobacillus paracasei KW3110 strain administration for immunomodulation in patients with pollen allergy. Daisuke Fujiwara, Hideyuki Wakabayashi, Hiroyuki Watanabe, Satoshi Nishida and Hisakazu Iino
10 IL-12 IL-4 IL-12 IL-4 IL-12 (% of KW3110) IL-4 (% of control) KW3110 L. paracasei 100 KW3110 L. paracasei 26.4 KW4510 L. lindneri 95.8 KW3119 L. casei 27.5 KW4110 L plantarum 93.9 KW3917 L. paracasei 29.8 KW3210 S. salivarius 77.7 KW3911 L. paracasei 29.8 KW3925 L. paracasei 77.1 KW3926 L. paracasei 30.2 KW3811 L. brevis 76.1 KW3914 L. paracasei 35.7 KW3926 L. paracasei 70.1 KW3913 L. paracasei 36.3 KW3213 S. salivarius 65.3 KW3111 L. casei 36.3 KW4310 L. mesenteroides 57.4 KW4010 L. gasseri 36.7 KW3119 L. casei 56.0 KW4110 L plantarum 36.7 KW3927 L. paracasei 53.7 KW3317 L. delbrueckii 42.6 KW4010 L. gasseri 53.2 KW3929 L. paracasei 43.0 KW4610 L. rhamnosus 52.6 KW4310 L. mesenteroides 43.4 KW3118 L. casei 48.8 KW3120 L. casei 43.9 KW3824 L. brevis 46.7 KW4610 L. rhamnosus 45 KW3411 L. acidophilus 44.2 KW3925 L. paracasei 45.2 KW3112 L. casei 43.6 KW3927 L. paracasei 45.3 KW3920 L. paracasei 43.2 KW3118 L. casei 45.7 KW3111 L. casei 42.1 KW3114 L. casei 46.2 KW3813 L. brevis 41.5 KW3923 L. paracasei 47.7 KW3914 L. paracasei 39.5 KW3934 L. paracasei 48.7 KW3928 L. paracasei 39.2 KW3112 L. casei 48.8 KW3120 L. casei 38.8 KW3931 L. paracasei 49.0 KW3410 L. acidophilus 38.7 KW3410 L. acidophilus 49.2 KW3911 L. paracasei 38.5 KW3214 S. salivarius 49.5 KW3917 L. paracasei 38.4 KW3210 S. salivarius 49.9 KW3113 L. casei 38.3 KW3933 L. paracasei 50.1 KW3941 L. paracasei 38.3 KW3941 L. paracasei 50.3 KW3816 L. brevis 37.7 KW3936 L. paracasei 54 KW3828 L. brevis 37.2 KW3113 L. casei 54.8 KW3214 S. salivarius 37.2 KW3213 S. salivarius 54.8 KW3923 L. paracasei 37.2 KW3915 L. paracasei 54.9 KW3211 S. salivarius 37.1 KW4611 L. rhamnosus 55.4 KW3924 L. paracasei 35.1 KW3211 S. salivarius 56.8
11 KW3826 L. brevis 34.3 KW3932 L. paracasei 57.0 KW3822 L. brevis 33.8 KW3924 L. paracasei 57.0 KW3821 L. brevis 33.0 KW3939 L. paracasei 59.1 KW3820 L. brevis 30.8 KW3930 L. paracasei 59.7 KW3929 L. paracasei 30.7 KW3928 L. paracasei 59.8 KW3825 L. brevis 29.5 KW3912 L. paracasei 61.1 KW3823 L. brevis 28.8 KW3922 L. paracasei 61.6 KW3913 L. paracasei 28.2 KW3413 L. acidophilus 63.6 KW4211 L. johnsonii 26.7 KW3935 L. paracasei 63.7 KW3114 L. casei 26.2 KW3920 L. paracasei 63.7 KW3413 L. acidophilus 25.6 KW3411 L. acidophilus 66.7 KW3317 L. delbrueckii 21.9 KW3311 L. delbrueckii 66.9 KW4511 L. lindneri 21.4 KW3212 S. salivarius 67.1 KW3930 L. paracasei 19.5 KW3919 L. paracasei 67.4 KW3311 L. delbrueckii 19.4 KW3116 L. casei 68.3 KW3931 L. paracasei 19.3 KW3921 L. paracasei 68.7 KW3919 L. paracasei 19.1 KW4510 L. lindneri 69.0 KW3212 S. salivarius 19 KW3938 L. paracasei 69.8 KW3814 L. brevis 18.7 KW3712 L. helbeticus 70.7 KW3817 L. brevis 18.1 KW3115 L. casei 72.4 KW3712 L. helbeticus 18 KW3117 L. casei 73.4 KW3932 L. paracasei 17.9 KW3810 L. brevis 74.6 KW3412 L. acidophilus 17.1 KW3414 L. acidophilus 74.6 KW3933 L. paracasei 17.1 KW3513 B. breve 74.7 KW3810 L. brevis 16.4 KW3711 L. helbeticus 75.0 KW3912 L. paracasei 14.4 KW3822 L. brevis 76.7 KW3812 L. brevis 13.9 KW3412 L. acidophilus 78.0 KW3414 L. acidophilus 11.7 KW3811 L. brevis 78.5 KW3316 L. delbrueckii 10.7 KW3515 B. longum 79.3 KW3613 L. lactis 10.6 KW3511 B. longum 80.0 KW3915 L. paracasei 10.5 KW3825 L. brevis 80.9 KW3116 L. casei 10.3 KW3824 L. brevis 81.3 KW3922 L. paracasei 10.0 KW4211 L. johnsonii 82.8 KW3910 L. paracasei 9.0 KW3910 L. paracasei 83.0 KW3934 L. paracasei 8.1 KW3826 L. brevis 87.2 KW3921 L. paracasei 7.9 KW3823 L. brevis 87.9 KW3513 B. breve 7.5 KW3916 L. paracasei 89.7 KW3315 L. delbrueckii 7.4 KW3315 L. delbrueckii 90.4
12 KW3827 L. brevis 7.4 KW3918 L. paracasei 93.2 KW3815 L. brevis 5.9 KW4704 L. kefiri 94.3 KW3935 L. paracasei 5.5 KW4702 L. kefiri 96.5 KW3611 L. lactis 5.3 KW3828 L. brevis 98.4 KW3936 L. paracasei 5.1 control KW3710 L. helbeticus 5.1 KW3821 L. brevis KW3818 L. brevis 4.7 KW3820 L. brevis KW3115 L. casei 4.5 KW4703 L. kefiri KW3117 L. casei 4.5 KW3610 L. lactis KW3916 L. paracasei 4.3 KW3510 B. lactis KW3310 L. delbrueckii 3.6 KW3612 L. lactis KW4700 L. kefiri 3.6 KW4700 L. kefiri KW4701 L. kefiri 2.6 KW3813 L. brevis KW3939 L. paracasei 2.3 KW3310 L. delbrueckii KW4704 L. kefiri 2.3 KW3827 L. brevis KW4702 L. kefiri 2.1 KW3817 L. brevis KW3918 L. paracasei 2.0 KW3818 L. brevis KW4210 L. johnsonii 1.8 KW3816 L. brevis KW3819 L. brevis 1.8 KW3611 L. lactis KW3711 L. helbeticus 1.5 KW4511 L. lindneri KW4611 L. rhamnosus 1.3 KW4701 L. kefiri KW3938 L. paracasei 1.2 KW3819 L. brevis KW3514 B. infantis 1.2 KW3514 B. infantis KW3610 L. lactis 1.0 KW3815 L. brevis KW3510 B. lactis 0.5 KW3710 L. helbeticus control 0.2 KW3316 L. delbrueckii KW3511 B. longum 0.0 KW3814 L. brevis KW3515 B. longum 0.0 KW3812 L. brevis KW3612 L. lactis 0.0 KW4210 L. johnsonii KW4703 L. kefiri 0.0 KW3613 L. lactis 187.8
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