Title 歯性病巣の関連する皮膚疾患におけるビオチンの効用 Author(s) 高橋, 愼一 ; 川島, 淳子 ; 森本, 光明 ; 山根, 源之 Journal, (): - URL http://hdl.handle.net/10130/526 Right Posted at the Institutional Resources for Unique Colle Available from http://ir.tdc.ac.jp/
18592202 90197145 18 19 C 20 3
30:381-384, 2008. () 27:795-800, 2007. 196-202, 2007. () 56:226-233, 2007. () HEMA 3 17 2006 7
3 17 2006 7 Oral pemphigus 1 1 2007 12 282 2007 11 (MDS) 16 2006 7 60 2006 5 Kawashima. J., Takahashi. S., et al Hemifacial trial of VitaminC sonopheresis in melasma 1st Congress of the international dermoscopy society2006 4
(competitive enzyme-linked assay) 0998 9mg 100 9 12 9 TNF IL-6CD4/ 18 7 10 CD4/8 TNF- 4 IL-6 4 3 1 IL-6 IL-6 78% IL-6 IL-6 9mg 3/4
We investigated 18patients with pustular palmoplantaris (PPP) on the existence of osteoarthritis, periodontitis and the efficacy of biotin by scoring the severity of eruption with PPPASI (palmoplantar Pustular Psoriasis Area Severity Index). We also analyzed CD4/8 and plasma concentration of TNF-, IL-6 and biotin before and after biotin treatment. Serum concentration of biotin was measured by competitive enzyme-linked assay. We found osteoarthritis (39%), periodontitis (56%) very frequently in these patients. However, these complications did not correlate with severity of eruptions. Elevations of plasma concentrations of IL-6 was detected in 4 of our patients, although there was no significant changes of CD4/8 and TNF-. In these 4 cases three patients had severe periodontitis and one had pyelonephritis Serum concentration of biotin was about 100 times higher in the patients with administration of 9 or 12mg of biotin daily than those without biotin treatment. There was no significant difference of serum biotin concentration between patients with 9mg daily and those with 12mg daily. This result means 9mg of biotin per day is enough for the treatment of the patients with PPP. Biotin was very effective for 14(78%) patients investigated. PPPASI of the patients was significantly lowered after biotin treatment (p<0.01). Biotin was also effective for the osteoarthritis. Serum IL-6 concentration was significantly decreased after biotin treatment (p<0.01). Furthermore, we confirmed synergic effect of dental treatment on eruptions and osteoarthritis of the patients with PPP. These results indicate IL-6 may be a useful marker for severe periodontitis in the patients with PPP. We also suggest biotin (9mg daily) together with dental treatment for periodontitis is quite effective for PPP.
Actinobacillus actinomycetemcomitans PSORS1 20 CD4 TNF- IL-6
, 111:426, 2001. Takahashi S, Kawashima J, Morimoto M, Yamane G, Ishihara K, Okuda K : Remission of palmoplantar pustulosis after periodontal treatment : Role of oral bacterial heat shock proteins Annales de Dermatologie et de Venereologie, 129(1S):768, 2002. MooK No2.. 237-244, 1985. Maebashi M, Makino Y, Furukawa Y, Ohinata K, Kimura S, Sato T: Effect of biotin treatment on metabolic abnormalities occurring in patients with sternocostoclavicular hyperostosis J. Clin. Biochem. Nutr. 15:65-76, 1993.
CD4/8 TNF- 18 4 IL-6 4 3 1 IL-6 IL-6 p<0.06