2 (2007 ) 9:25 10:55 akio@sfc.keio.ac.jp knakahig@sfc.keio.ac.jp ktsuge@ttck.keio.ac.jp TTCK SFC
1 2 DNA RNA
mrna mrna RNA 3 2007
( ) Part 1 DNA Part 2 PCR DNA ( ) Part 3 RNA Part 4
Chapter 8 (p.243-260) 9 26 Chapter 9 (p.263-298) 10 3 Chapter 10 mrna (p.300-342) 10 10,17 RNA Chapter 11 Chapter 12
Fig.
RNA 8.1 8.1.1 8-1 HeLa
8-1
8.1 fluorescence recovery after photobleaching; FRAP
8.1.2 DNA HU 2-1 40 100 DNA 8-2 30nm
(functional domain) DN I 8-3 30nm
RNA Fig.4-37 Fig.4-36
1024 22 Fig.4-39 Fig.4-41
8.1.2 (heterochromatin; ) euchromatin;
DNA DNA Y 2.8
8.4 insulator
(positional effect) 8.5
8.5
8.6
(locus control region; LCR) DN I
8.2 8.2.1 8.8
Fig.4-23 30nm 30nm
8.9 N DNA Fig.4-32 30nm N
Fig.4-24 Fig.4-26 4 Fig.4-27
N P Ac Me u Fig.4-35
N N K DNA HAT HDAC Fig.4-35
DNA ATP DNA 8-10 DNA DNA DNA DNA DN
8.2.2 histone descetylase; HDAC (Sin3,NuRD DNA 5 -CG-3 5 -CNG-3 DNA Fig.7-80
DNA DNA DNA Dnmt1 Dnmt3 Dnmt3b 8.11
DNA DNA Fig.7-81
X genomic imprinting X X chromosome inactivation
8.12 DNA CpG MeCP CpG CpG Methyl-CpG-binding protein HDAC DNA MeCP HDAC DNA
DNA Fig.7-83
X (X inactivation) H2A H2A1 DNA Xic Xist 25kb RNA H4 Fig.7-78
Fig.7-77 Wikipedia X 1000 1000 X X 1 X X