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2008 108-8641 5-9-1 TEL 03-5791-6334FAX 03-5791-6335 e-mailgakufu@lisci.kitasato-u.ac.jp 228-8555 1-15-1 TEL 042-778-9760FAX 042-778-9761 e-mailnyushi@kitasato-u.ac.jp URL http://www.kitasato-u.ac.jp/lisci/index.html 2008. 07. 01

History 1914 1918 1962 1972 1991 1993 2000 3 2000 7 2001 4 2002 4 2002 9 2004 4 2007 3 2008 4 50 I 2 3-4 5 6 7-8 134 144 164 141821COE 9-10 11 12 13-15 17-18 16 1 2

, Kitasato University 18 4 2 1 2 24 3 4

1 2 3A 4 5 6MRSAVRE 7 8 3 1 2 3 4 5 Department of Infection Control and Immunology Laboratory of Viral Infection I Laboratory of Viral Infection II Laboratory of Molecular Virology and Biology Laboratory of Bacterial Infection Laboratory of Immunoregulation Laboratory of Molecular Epidemiology for Infectious Agents Laboratory of Infectious Diseases Kitasato Institute for Life Sciences, Kitasato University Department of Drug Discovery Sciences Laboratory of Microbial Engineering Laboratory of Bioorganic Chemistry Laboratory of Biochemical Pharmacology for Phytomedicines Laboratory of Biological Functions Laboratory of Microbial Functions 91 18 36 2 2002 14 4 * 30 4 12 3 2004 16 4 * 14 44 11 11 3 3 8 8 3 3 25 25 9 3 36 24 3,665.71m 2 Y1 948.92m 2 S 428.24m 2 * Y3 181.69m 2 5,224.56m 2 2,877 250,1519,837 950,000 Managing Committee Department of Research Project Studies 200,000650,000 100,000 * Drug Discovery project from natural products resources Clinical Evaluation Project on Appropriate Use of Antibiotics Committee Research Promotion Centers Tropical Disease Center Microbial Resource Center Experimental Animal Center Administrative Office 5 6

Course for Infection Control and Immunology 1 2 Course for Drug Discovery Sciences 1 2 3 potential risk 3 3 B C EB GTP N- WASPArp2/3 21 infection control 1MRSA234 7 8

10 9

21COE 145 3 1 2065 1 Guadinomine Bordetella 660 246 COE 1 21COE Graduate School of Pharmaceutical Sciences Research Organization of Infection Control Science, Kitasato University Kitasato Institute for Life Sciences Basic Research Group Drug Discovery Research Group Graduete School of Fundamental Life Sciences Discovery of Anti-infectious Drugs Group of Etiology and Disease Condition Analysis The Kitasato Institute Scripps Institute Research and Education at World's Highest Level International Contributions Education of Research Scientists Graduate School of Medical Sciences Nosokomycin Lariatin Guadinomine Cyslabdan 626 Citridone 514 Actinohivin Biflavonoide Borrelidin Verticilide Pyripyropene 513 MRSA MRSA Candida HIV 21COE 1318P.11 19 36017 1 2 WHO 7,000 WHO 2010 11 12

1. 2. RS 3. AIK-C 4. 5. 6. Reverse genetics 1. 2. 3. 4. 5. 1. 2. 3. 4. trafficking 5. RNA 1. 2. 3. 4. 5. 6. in vivo 1. 2. 3. 1. 2. 3. 1. 2. 3. 4. Worldwide 1. 2. in situ 1. MRSAMDRP 2. 3. 4. 5. 6. 1. 2. 3. 2 4. P450 5. 2 6. 1. 2. 3. 4. 13 14

1. 1) 2) 3) 2. 3. 4. 1. 2. 3. 4. 1. 2. 3. 4. 5. 6. 1. DNDi 2. 3. 4. 1. 2. 3. 1. 2. RAResearch Assistant) TATeaching Assistant) (TA) TA (RA) RA TARA 3 2 15 16

I 4F 3F 2F 8F 1F 1F BF BF JR JR JR JR 87 20 JR 87 10 JR 87 10 10 10 1 25 M A P M A P 5 9 1 JR JR 87 JR 1 15 1 16 17 18