MBL CD8 CD4
8.1
8.2
5.20
8.3
8.4 8.5
8.6 8.7
8.8 8.9
8.10
8.18 B7 CD28 CD28 B7 CD28
8.13 2.22 NK
Toll(TLR) LBP! LPS dsrna ssrna TLR1/2/6! TLR4 TLR5 TLR3 TLR7/9 CD14! JNK/p38! MyD88! IRAK! TRAF! NFκB! TNF-α +
Toll(TLR) LPS dsrna ssrna LBP! TLR1/2/6! TLR4 TLR5 TLR3 TLR7/9 CD14!
MHC分子へのペプチド抗原の結合過程 図5.20
8.11
8.17
IFN-γ IL-12 IFN-γ CD4 TGF-β IL-4 IL-6 TGF-β Th1 Th2 Th17 IL-4, IL-5 IL-17, IL-21 TGF-β, IL-10 Treg Treg Treg
APC: antigen presenting cell)
8.4 CD62L 8.7
24 weeks old! Molano, et al, clinical immunol, 2003
68.2 " 6 " 12 " 24 " 8.1" 61.9" 4.8" 37.7 " 7.6" CD62L 6.0" 32.1" 17.7" 22.0" 17.8" 29.1" 15.7" 18.8" 22.8" 1.0 " 31.9 " 4.7" 2.9" 43.0" 1.4" 50.7" 3.8" 90.5 " CD44
LT LT LT: GM-CSF:- CXCL2:
B7 CD28 CD28 B7 CD28
IgM Hyper-IgM Syndrome (HIGM) B CSR SHM IgM " HIGM Type 1~6 " " IgG IgA " " /3 4 "
Type" HIGM Type 1!!!! HIGM Type 2!!! HIGM Type 3!!! HIGM Type 4!!! HIGM Type 5!!! HIGM Type 6!! IgM Hyper-IgM Syndrome (HIGM) Mutation (genetic inheritance)" CD40-L " (X-linked R)" " " AID (AR)! " " CD40 (AR)" " " Unknown (AR?)" " " UNG (AR)" " " NEMO " (X-linked R)" NFκB " A co-stimulatory molecule on T cells. Altered T cell-b cell interaction. " " An essential factor for SHM and CSR. C 5." " A co-stimulatory on B cells. Altered T cell-b cell interaction.." " Intact SHM but altered CSR; It is supposed that." " R C." " Mutated NEMO is u "
IgM " T " HIGM Type 1! HIGM Type 3! HIGM Type 6! κ κ B " HIGM Type 2! HIGM Type 5! HIGM Type 4! "
CD8 CD4 0 6 12 8 10 12 14 16
CD8 CD4 0 6 12 8 10 12 14 16
CD8 0 6 12 8 10 12 14 16
CD8 0 6 12 8 10 12 14 16
CD8 0 6 12 8 10 12 14 16
CD8 0 6 12 8 10 12 14 16
Vol.2 No.12
b(haemophilus influenzae: Hi ) 19 1933 Hi a~f 6 b (Hib) 500 Hib (Streptococcus pneumoniae: ) (H22 013
IgG 11
class II Th2 IgG Th2
+ IgM IgM IgM IgG MHC class II Th2 MHC class II Th2 IgG
+ IgM IgM IgM IgG MHC class II Th2 MHC class II Th2 IgG
Vol.2 No.12