3 3.1 世界的なポリオ根絶 67 3, 7 8 1789 19 19 198 55. 8. HTTP://WWW. POLIOERADICATION.ORG/ POLIOANDPREVENTION. ASPX 1931 19511233 1949 3 55 7. HTTP://UPLOAD.WIKIMEDIA.ORG/WIKIPEDIA/ COMMONS/5/5C/POLIO_EGYPTIAN_STELE.JPG. 2 1988 127 35 WHO WHA2 67 R W, O M, S L.. pp 632. 5, P,,, 28 66 212
1955 9 1963 1 3 3 1955 1957 1962 1956 196 1955 1961 95% 68 56 69 9. HTTP://EN.WIKIPEDIA. ORG/WIKI/FILE:SALKWS.JPG 1. HTTP://UPLOAD.WIKIMEDIA. ORG/WIKIPEDIA/COMMONS/B/B9/ALBERT_ SABIN.JPG 68 S A, E.. pp 62 623. 5, S, W, P,,, 28. 69. MMWR,, 1993. http://www.cdc.gov/mmwr/preview/mmwrhtml/35381.htm 212 67
1994222 7 21 4 71 2 2 13 2113 72 211 59 6 73 1 74 1988 2354 5 75 8, 6, 4, 2, 1944 1947 195 1953 1956 1959 1962 1965 1968 1971 1974 1977 198 1983 1986 1989 1992 56. 7.. http://www.polioeradication.org/polioandprevention/historyofpolio.aspx 71.. http://www.polioeradication.org/infectedcountries.aspx 72.. http://www.polioeradication.org/dataandmonitoring.aspx 73... http://www.polioeradication.org/dataandmonitoring/poliothisweek.aspx 68 212
3 WHO 57. 1988 125 WHO 58. 21 4 1 8 6 4 2 1 3 59. 211 1 3 26 4 6. 211 74 R W, O M, S L.. pp 643. 5, S, W, P,,, 28. 75 R J, M A, S L.. Vaccine 21; 29: 334-343 212 69
3.2 インフルエンザ菌 b 型 (Hib) bhib 5 11 6 95% b b61 76, 77, 78 Hib 34 5 1 2 882 51 491 1 1 2 4% 62 5 Hib 198 2 1987 Hib 3 Hib PRP 11. b CDC 61. b CDC 76 A, J P, M.. pp 162. 5, S, W, P,,, 28. 77 Hib.. http://www.hibaction.org/research.php#disease_burden 78 M. b. Jpn J Infect Dis 29; 62: 87-92. 7 212
3 B11 C7 CRM197 Hib DTP DTaP 9%Hib Hib Hib 99% 79 1 1 2 1 8 3 Hib 63 81 199 124 3 121 12 Hib Hib 1 b 8 /1 5 6 4 2 62. 5B 25 2 15 1 5 1991 1992 1993 1994 1995 1996 1997 1998 1999 2 21 22 23 /1 5 5Hib 63. 5HibHib 79. Hib. http://en.wikipedia.org/wiki/hib_vaccine#impact 8 R A, O, G. bhib Hib. Lancet. 25;366(948):144-5. 81 J, C L, M P E. b. BMJ 24; 329: 655-658. 212 71
3.3 流行性耳下腺炎 ( おたふくかぜ ) 82 5 1934 12 64 37% 31% 1.5 5. 11 83 25 84 198732165 15 12. CDC HTTP://PHIL.CDC.GOV/PHIL/DETAILS. ASP?PID=13 64. CDC HTTP://PHIL.CDC.GOV/PHIL/DETAILS.ASP?PID=8757 82 S A, S A.. pp 435 465. 5, S, W, P,,, 28. 83 H, M, H.. Pediatr Infect Dis J 29; 28: 173-5. 84 Y. K, M.. Auris Nasus Larynx 25; 32: 125-128. 72 212
3 195 196 13 1 MMMMR MMRV 1 5 9 98% 65 92 96%78 91% 1 1% 251 87 37% 31% 1.5 5. 15. 1 8 6 4 2 1977-1979 1993-1995 65. 2 85 S A, S A.. pp 435 465. 5, S, W, P,,, 28. 86 S A, S A.. pp 44 442. 5, S, W, P,,, 28. 87 S A, S A.. pp 451 452. 5, S, W, P,,, 28. 212 73
3.4 世界的な麻疹の根絶 88 13 17 2 66 1954 1963 89 1, 1 3 15% 4 2 77 7, 5 5 9 95% 1 2 112 15 2 4 6 1 13. CDC 66. CDC HTTP://PHIL.CDC.GOV/PHIL/DETAILS.ASP?PID=8429 88 P, M J, G H.. pp 353 398. 5, S, W, P,,, 28. 89 P, M J, G H.. pp 358 359. 5, S, W, P,,, 28. 74 212
3 MMR MMRV 5 15% MMR MMRV 5 27 9 196 67 91,92 2198 199 21 14.2 26. 93 91 85 94 6 5 2 21 212 22 199 99% WHO23 25 2 5%68 95 6, 4, 2, 196 1963 1966 1969 1972 1975 1978 1981 1984 1987 199 1993 1996 1999 22 25 45, 4, 35, 3, 25, 2, 15, 1, 5, 2 27 67. 68. 9. http://www.aap.org/advocacy/releases/whyimmunize.htm 91.,, 1994. MMWR 1995; 43:1.. http://www.cdc.gov/mmwr/preview/mmwrhtml/39679.htm 92.,, 25. MMWR 27; 54: 2-92. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5453a1.htm 93 P, M J, G H.. pp 359. 5, S, W, P,,, 28. 94. Hib. http://www.appliedeconomics.com.au/pubs/reports/health/ph5.htm 95., 2 27. MMWR 28; 57: 133-136. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5748a3.htm?s_cid=mm5748a3_e 212 75
3.5 ロタウイルス 69 14 A B C D E 5 A 14G P G G1 G2 G3 G4 G9G12 6 G P P P[8]G1 P[4]G2 P[8]G3 P[8]G4 P[8]G9 P[6]G9 96 69 27 1 97 5 25% 7 98 5 4% 1 2 3 17 1 5191,35 71 99 14. D HTTP://WWW.VACCINEINFORMATION.ORG/ROTAVIRUS/ PHOTOS.ASP 69. CDC HTTP://PHIL.CDC.GOV/PHIL/DETAILS.ASP?PID=197 96.. ACIP MMWR 29; 58: 1-25. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr582a1.htm 97 H F, P A, U D.. pp 715 734. 5, S, W, P,,, 28. 98 J E, M M, A D.. Expert Rev Vaccines 21; 9: 395-47 99 L J, L, E.. J Infect Dis 25; 192: s133-145. 76 212
3 7. 5 23 2,3 1 1,4 17 1 19 1,35 1 5 12425 323 1 15 2 16 17 71. 1 n = 34,837 n = 34,788 n = 1,1 n = 1,1 13 15 4 14 16. 212 77
2 85 98% 1 42 63% 12 72 13 15 16 17 18 18 73 14 3% 8% 8% 6 5% 3% 3% 18% 18% 28% 34% 17. 37, 11 28 % 1 75 5 25 16 27 28 72. 26 5 2628 25 2 15 1 5 2-26 27 28-2 3-5 6-11 12-17 18-23 24-35 36-47 48-59 73. 1. Rota Teq. 211 7. http://www.merck.com/product/usa/pi_circulars/r/rotateq/rotateq_pi.pdf 11 GSK.. 211 2. https://www.gsksource.com/gskprm/en/us/adirect/gskprm?cmd=productdetailpage&product_id=124417358525&featurekey=6594#nlmhighlights 12 C, B.. Micobiowiki. 29 1 9. http://microbiowiki.wetpaint.com/page/rotavirus%3a+interesting+facts+about+a+virus+on+the+rise 13 Y, J E, L H. 5. Pediatr Infect Dis J 211; 3: s16-s2. 14 A T, C A, M. 18. JID 21; 21(11):1617-1624. 15 L H, C, N J. 4. Pediatr Infect Dis J 211; 3: s61-s66. 16 T, K V, M.. Pediatr Infect Dis J 211; 3: s21-s24. 17 J P, S B, K.. Pediatr Infect Dis J 211; 3: s25-s29. 18 J E, M M, D C.,, 3. Pediatr Infect Dis J 211; 3: s56-s6. 78 212
3 2745% 2843% 28 29 75% 85% 89.3% 74% 61 98% 27 2865% 28 2983% 28 29 5% 75% 42% 27 11% 29 4% 79% 285 81% 28 48% 29 35% 295 69% 74% 88% 23% 52 63% 73 86% 275 22% 1 637% 285 37% 1 658% 9, 18, 11, 16, 111, 17, 112, 113 18. 19 J E, M M, A D.. Expert Rev Vaccines 21; 9: 395-47. 11 J E, J D, C A. 26. Pediatr Infect Dis J 211; 3: s3-s34. 111 Y, J E, L H. 5. Pediatr Infect Dis J 211; 3: s16-s2. 112 M, C, V. 5. Pediatr Infect Dis J 211; 3: s11-s15. 113 C, J A, P.. Pediatr Infect Dis J 211; 3: s6-s1. 212 79
2114 114 6 81% 115 15. 25 6 4,56 116 26 3 26 1 27 15 117 77% 118 5% 119 1 88% 12 114 L H, C, N J. 4. Pediatr Infect Dis J 211; 3: s61-s66. 115 M W, H J, A.. Pediatr Infect Dis J 211; 3: e13-18. http://www.ncbi.nlm.nih.gov/pubmed/21378594 116.. http://www.merck.com/responsibility/access/access-feature-nicaraguan.html 117 PATH. http://www.rotavirusvaccine.org/files/rvp_summaryreport_final.pdf 118 View Change.Org.. http://www.viewchange.org/videos/living-proof-nicaragua-a-vaccines-remarkable-impact 119 PATH.... http://www.path.org/news/pr185-rotavirus-vaccines-asia.php 12 T C, F, L. 5. European Society for Pediatric Infectious Diseases28. 21 5 421 5 8. http://www.kenes.com/espid21/posters/abstract596.htm 8 212
3 3.6 ヒトパピローマウイルス (HPV) HPV 198 HPV L1 L1 HPV 52L1 L2 74 L1 L2 8% 5 1 HPV HPV2 4 16187% 75611 9% 76 HPV 1 E6 E7 L1 74. 5 1 725 L1 HPV4 19 121 HPV 1 2 5 8 19. HPV 5 6 11 16 18 33 45 121T, I H, D R.. pp 246. 5, S, W, P,,, 28. 212 81
75. HPV CDC 76. HPV NIH 122 2 3 27 3,27 123 AIDS 7% 51 HPV 52 58% HPV16 2% HPV18 31 33 35 45 52 58 77 124 4 44 78 125 211 1 2,714,29 126 % 6 5 4 3 2 1 HPV 16 HPV HPV 18 HPV 31 HPV 77. 33 HPV 35 HPV 45 HPV 52 HPV 58 122 J T, I H, D R.. pp 243 257. 5, S, W, P,,, 28. 123. HPV.. 27. http://whqlibdoc.who.int/hq/27/who_ivb_7.5_eng.pdf 124. HPV.. 27. http://whqlibdoc.who.int/hq/27/who_ivb_7.5_eng.pdf 125.. Surveillance Epidemiology and End Results. SEER 24 28. http://seer.cancer.gov/csr/1975_28/browse_csr.php?section=5&page=sect_5_table.7.html 126.. http://www.cancer.gov/cancertopics/types/cervical 82 212
3 127 L1 74 L15 VLP L1 L1 HPV ACIP11 12 26 4 9 26 2 216 18 46 11 16 18 63 2 15 1 5 15-19 2-24 25-29 3-34 35-39 1 4-44 45-49 5-54 55-59 6-64 65-69 7-74 75-79 8-84 85+ 78. 127 J T, I H, D R.. pp 243-257. 5, S, W, P,,, 28. 212 83
HPV 94 96% CIN 1% 128 HPV 2 HPV 1 HPV 3 18 38% 13 59% 131 HPV HPV 27 2 12 26 12 13 27 11 14 27 27 28 114 23 7 12 26 199 8 12 29 12 13 21 1 12 28 27 12 13 18 11 12 13 26 9 26 21 2. 129 128 J T, I H, D R.. pp 243 257. 5, S, W, P,,, 28. 129. HPV. http://en.wikipedia.org/wiki/hpv_vaccine 13 J M L, M, C L. HPV. Lancet 211; 377: 285-292. 131 B, N, R. 4. Lancet Infect Dis 21; 11:39-44. 84 212
3 HPV 27HPV27 29 14 15 72% 16 17 66% 3 132 12 13 9 15 HPV National HPV Vaccination Program Register 21HPV16 56% 25 HPV1692% 133, 134 18 3 38% 135 59% 136 3HPV 8 % 6 4 2 132.. HPV. http://www.health.gov.au/internet/immunise/publishing.nsf/content/immunise-hpv 133. Q&A HPVHPV 21. http://www.cancer.org.au/file/newsmedia/mediareleases28/ceruresearchhpvq&a.pdf 134 M A, K, J M L.. Intl J Cancer 28; 123: 1854-1863. 135 J M L, M, C L. HPV. Lancet 211; 377: 285-292. 136 B, N, R. 4. Lancet Infect Dis 21; 11:39-44. 212 85
3.7 肺炎球菌感染症 Streptococcus pneumoniae 79 IPD IPD 1881 16 9 2 1 137 2 1 5 138 5 5 137 6 3, IPD 139 1 7,5 14 6,1IPD5 72 21 16. X HTTP://EN.WIKIPEDIA.ORG/WIKI/FILE:PNEUMONISWEDGE9.JPG 79. CDCHTTP://EN.WIKIPEDIA.ORG/ WIKI/FILE:PNEUMOCOCCUS_CDC_PHIL_ID13.JPG 137 National Foundation for Infectious Diseases.. http://www.nfid.org/factsheets/pneumofacts.shtml 138 S, J, C.. pp 531 567. 5, S, W, P,,, 28. 139.. http://www.cdc.gov/vaccines/vac-gen/whatifstop.htm#pneumo 14.. ACIP MMWR 2; 49 (RR-9): 1 35. 86 212
3 IPD22 IPD 23 IPD 1998 1999 51 4.85 641 61.5651 61.5 1,3 7 2 5,, 21. 5 141 2 5 23 26 19.5 23.8 12.6 13.8 2 21 79.2 43.1 198 1999 37.8 2 1988 21 93.5 55.3 58.8 21 23 416 1998 167 1 42, 143, 144, 145, 146 22. IPD 1 1 < 2 167 2,396 2 4 36 227 2 5 5 9 6 54 1 19 3 35 23. IPD1998 47 141.. 29 5. www.cdc.gov/vaccines/pubs/pinkbook/downloads/slides/pneumo11.ppt 142.. 29 5. www.cdc.gov/vaccines/pubs/pinkbook/downloads/slides/pneumo11.ppt 143 H. 7 22 21. J Infect Chemother 211; DOI: 1.17/s1156-11-264-8 144 E, J, M. 5. An Esp Pediatr 22; 57: 31-39. 145 A, B, L I. 5. Trop Med Intl Health 26; 11: 1422-1431. 146 P, R, F. 2. Arch Dis Child 24; 89: 757-762. 147 N, T, I. 23 26. J Infect 28; 57: 455-458. 212 87
IPD7 28%11 44% 148 4% 3 5% HIV 1,5 5 55% 1977 14 198323 23 2423 IPD 85% PD 75% 75 95% 8 149 81 15 23 IPD 3 2 151 2 IPD7 25 IPD9% 291 71 5 7F 3 23 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 1A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 2, 22F, 23F, 33F 24. 23 21 13 1 3 6A19A 7 4, 6B, 9V, 14, 18C, 19F, 23F 25 7 148 S, J, C.. pp 531 567. 5, S, W, P,,, 28. 149.. 29 5. www.cdc.gov/vaccines/pubs/pinkbook/downloads/slides/pneumo11.ppt 15 L, R J, Y.,,. mbio 211; 2(1):e39-1. 151.. http://www.cdc.gov/vaccines/vac-gen/whatifstop.htm#pneumo 88 212
3 99 1%2 1 7,8 5 1 8 1 5 6 4 2 1998 1999 2 21 22 23 24 25 26 IPD 8. 5 6 5 4 3 2 1 1998 1999 2 21 22 23 24 25 26 1 >8 65-79 5-64 18-49 81. 212 89
3.8 水痘帯状疱疹ウイルス (VZV) 152 VZV2 17. 1767 1 1892 2 153 82 1 4 1 1,5 1,626 4 1 1, 1 3,5 A 1 2.62 5HIV 1 4. 4.5 18 99% 4 1 12 486 1 72 1,18 154 1 18. FISLEHTTP://EN.WIKIPEDIA.ORG/WIKI/FILE:HERPES_ZOSTER _CHEST.PNG 17. CDC HTTP://PHIL.CDC.GOV/PHIL/ DETAILS.ASP 82. E CDC HTTP://PHIL.CDC.GOV/PHIL/DETAILS.ASP 152 A A, M, J F.. pp 915 958. 5, S, W, P,,, 28. 153 A A, M, J F.. pp 915 958. 5, S, W, P,,, 28. 154 M J.. pp 157 168. 5, S, W, P,,, 28. 9 212
3 VZV VZV 19881995 1 4MMRV25 VZV 26 VZV1 2 5% 19% 2 98% 1% 155 1995 1 27 ACIPMMR 2 9% 9% 83 156 2574% 1 24 88 48 79 1, 1,35 1,5 1,6 26. 152 27. 2 % 1 8 6 4 2 1 1 4 5 9 1 14 15 19 2 83. 2 155 A A, M, J F.. pp 915 958. 5, S, W, P,,, 28. 156 A A, M, J F.. pp 915 958. 5, S, W, P,,, 28. 212 91
3.9 B 型肝炎 157 B 6 9 4%.5 1% 33% BHBsAg6 B 19. B 84 2 4, B 5% 15% B 6% 3 5% 1981B B B 1986 B B3 415 BB 3 29% 1 6% 2 3 5, B6 85 158 B 25% B 2 3 125 B 4, 5, 159 19. B CT HTTP://UPLOAD.WIKIMEDIA.ORG/ WIKIPEDIA/COMMONS/F/FE/SE.JPG 84. B E CDC HTTP://PHIL.CDC.GOV/PHIL/DETAILS.ASP 157 E E, J W. B. pp 25 241. 5, S, W, P,,, 28. 158.. B. No24. 28 8. http://www.who.int/mediacentre/factsheets/fs24/en/index.html 159 E E, J W. B. pp 25 241. 5, S, W, P,,, 28. 92 212
3 B 12 B8 1% 7 95% 16 B B 1991B B B 87 B B B86 85. B B 6 B 3 5 B 2 35, 3, 25, 2, 15, 1, 5, B B 198 1982 1984 1986 1988 199 1992 1994 1996 1998 2 22 24 26 28 86. B 161 B B 1 % 8 6 4 2 87. B B 162 16 E E, J W. B. pp 25 241. 5, S, W, P,,, 28.. 161.. A, B, Chttp://www.cdc.gov/hepatitis/Statistics/index.htm 162 E E, J W. B. pp 25 241. 5, S, W, P,,, 28 212 93