ｨｺ02ｨｨ00ｨｪｨｦ apple09apple040ｸ903, 0ｹ ｹ ｷ300apple00 apple6ｦ ｸ ｦ006036ｦ

13050005ｨｪ04ｨ 01 040504ｨｦ07ｨｦ 0402ｨｬｨｮ04ｨｦ07ｨｦ 090004ｨｪｨｺ02 ｨｺ0204 ｨｪ0703 5, 6ｧ8 1, 2009, 0603apple. 27ｨC35 ｨｦ03ｨ ｨｦｨｺ01 ｨｬ0501 611.81:616-033.2:611.637 0200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ00 ｨｨｨｦｨｺ02050004ｨ 00 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨｨｺｨ ｨｺ020100 ｨｨｨｺ000505ｨｪ02ｨｪ0000ｨｲ04ｨｦ09 05000000ｨ 01 08 2009 6 7. 01.07. 0206apple6ｦ0080003076 5 1 05 apple6ｦ0 070300 0703apple6ｦ00800000ｸ8 070600076 5000ｸ800 6ｦ006080001030ｸ8 08apple07 0200030ｸ8 0300036ｦ006036ｦ003090ｹ0000601076 707 0807apple6ｦ008000009fl 6 70702076 500076 707 0307096 76ｦ0 08apple09 apple6ｦ00100 08apple00 06036ｦ003000200000706 08000200090ｸ8. 050ｸ8 000200000ｸ8 09 08apple076ｦ0006ｦ002090909apple076 56ｦ0000ｸ8 006ｦ009 07020000 6ｦ00103046ｦ00200000ｸ800 6 50708apple07060ｸ8, 036ｦ0010900 016ｦ001 6 50ｸ80607016ｦ0fl 0ｹ06ｦ0060307036ｦ0 0601apple0ｸ8030ｸ803 0207apple03 0807apple6ｦ008000009fl 0307096 76ｦ0, 0409010906 0608000103apple 03000307 076 5 apple6ｦ000-000006 09 066 507006 5apple00030000000706 096ｦ06 700070603090109 0ｷ300apple00 apple6ｦ00200000ｸ803 0807apple6ｦ00800000906, 036ｦ00207 026ｦ06 70708apple09fl03000ｸ806 01020900090ｹ00006010906 08apple076 7000709, 000909016ｦ0fl 0ｹ10202000103096 50007060300 0608000ｷ3096ｦ0020000076 707 02000ｹ0000009fl. ｨｨ07 07 000ｸ806 0107030802000106000ｸ806 6ｦ0006ｦ0020909 08apple07 0200-030ｸ8 000007 0307 0903 02fl apple6ｦ009apple6ｦ0 07030109 0ｹ10202000103096 5000ｸ803 03000307 076 5 096ｦ06 700070603090109 09 02000ｹ0000009fl 0ｹ103076 707 03fl080002076 707 096ｦ0-0702006 56ｦ00009fl. 01020ｸ90ｹ0006 50ｸ800 0602076 56ｦ0: apple6ｦ001 08apple00 06036ｦ003000200000706 08000200090ｸ8, 0300036ｦ006036ｦ003090ｹ00006010700 0807apple6ｦ00800000900 6 70702076 500076 707 0307096 76ｦ0. 050500050004ｨ 00 ｨｺ6ｦ001 08apple00 06036ｦ003000200000706 08000200090ｸ8 (ｨｺｨｨ05) 6 507 0300076 70903 0603apple6ｦ0006ｦ003 fl6 502fl000306fl 07 000903 0909 006ｦ009 07020000 0ｹ06ｦ0060307 6 50603apple000ｹ06ｦ00ｸ90ｸ7090306fl 090207016ｦ00ｹ00006036 50000000ｸ803 00076 50707 apple6ｦ009076 56ｦ0000906 04 0304080ｹ00900 [1ｨC3]. 05 0807060200 000900 6 707 0ｸ8 070303000ｹ06ｦ0000306fl 0906-01020ｸ90ｹ009030002000007 0ｸ80603apple0ｸ806 apple070603 096ｦ0 0702006 56ｦ0000307060309 ｨｺｨｨ05, 070603096 76ｦ00ｸ90ｸ70906 6 5 06apple00 000003 3% 096ｦ0 6 707, 0ｹ00307 0807096 50702fl0003 08apple076 700070909apple076 56ｦ00300 04 6 50700000900 0ｹ00906026ｦ0 apple006 7090603apple09apple0400030ｸ803 0602040ｹ06ｦ0006 5 01 2030 6 7. [2, 4]. 040004010207000007 08apple07 0702086ｦ00003 046 50002090ｹ0096 56ｦ0030006fl 010702090ｹ00006036 507 070200000ｸ803 06 0300036ｦ006036ｦ003090ｹ0000601090309 0207apple036ｦ00309 ｨｺｨｨ05 [1, 2, 4]. ｨｦ - 006ｦ00107 6ｦ00800 08apple09 006ｦ002090ｹ00909 07020004076 707 010702090ｹ00006036 56ｦ0 0703-6ｦ0020000000ｸ803 0300036ｦ006036ｦ009076 5 6 507 6 5000403apple0000000903 07apple6 76ｦ0006ｦ003 0903 01020900090ｹ00006010900 08apple07fl6 502000009fl 0706036ｦ00ｸ90306fl 096ｦ00ｹ06ｦ00603040ｸ9 0309-0009036ｦ00200000ｸ80309 [2, 3]. ｨｪ6ｦ0010903 07 apple6ｦ0090703, 010702090ｹ00006036 507 070200000ｸ803 0607 0601apple0ｸ8030ｸ80309 (01020900090ｹ000060109 0000036ｦ000090200-060309apple076 56ｦ000000ｸ80309) 0207apple036ｦ00309 0300036ｦ006036ｦ003090ｹ0000601076 707 ｨｺｨｨ05 09006ｦ00ｹ009030002000007 08apple006 50ｸ8046ｦ00003 010702090ｹ00006036 507 070200-000ｸ803 06 036ｦ000090200060309apple076 56ｦ000000ｸ803 apple6ｦ0010703. 0200036ｦ006036ｦ003090ｹ00006010700 0807apple6ｦ00800000900 6 70702076 500076 707 030709-6 76ｦ0 (02ｨｨ0702) 6 507090009016ｦ00003 04 25ｨC50% 6 5060003 07000107 070200-000ｸ803 09 6ｦ00606070ｷ30909apple04000306fl 06 0000 026ｦ06 70708apple09fl03000ｸ803 08apple07-6 70007090703 03000ｹ0000009fl 0700010702076 7090ｹ0000601076 707 096ｦ0 0702006 56ｦ00009fl [5ｨC9]. ｨｦ00010702076 7090ｹ00006010900 070200000ｸ800 06 02ｨｨ0702 0000apple00-0107 006ｦ0 030703000003 0706030703apple6ｦ0 036ｦ0apple6ｦ0010300apple0909040ｸ90306fl 03fl0800-020ｸ803 07 0ｸ70903 0607060307fl00090003 06 046 7apple07090706 apple6ｦ0096 5090309fl 0600apple000009000ｸ803 07060207080000000906 016ｦ001 0607 060307apple07000ｸ8 6 5000403apple0000-000903 07apple6 76ｦ000076 5, 036ｦ001 09 0ｷ3000003apple6ｦ00200000706 0000apple6 5000706 0609060300-1 0408000ｸ806 006ｦ0040ｹ0000ｸ806 0ｷ3000003apple ｨｺ070606090606010706 6ｦ0016ｦ0 00030909 006ｦ00401, 344006, ｨｺ070603076 5-006ｦ0-05070004, 0402. ｨｮ0003076 56ｦ0, 41; e-mail: airapetov@aaanet.ru. 030ｸ8 (090405), 000909010903 0807016ｦ0096ｦ00300020003 016ｦ00ｹ00006036 56ｦ0 0809090009, 096ｦ00ｹ06ｦ00603040ｸ9 03apple00 040ｸ903 0ｹ1010603apple0000000706 6 707060809036ｦ0-0209096ｦ00ｷ30909 09 0000096ｦ00300 02090300020000076 707 02000ｹ0000009fl. 05076 7026ｦ006-0007 07 0ｸ70006036ｦ003090603090ｹ00006010903 6ｦ000000ｸ803, 08apple07 07020809-030002000007060300 0809090009 070200000ｸ803 06 02ｨｨ0702 0009 02000ｹ0000009fl 060706036ｦ06 502fl0003 1ｨC2 030006fl0ｷ36ｦ0; 08apple09 0800apple6 5090ｹ0000703 0706030703apple00 0701070207 50% 070200000ｸ803 0903000ｸ903 0209 07 030007080006036 50000-000ｸ800, 0209 07 0000apple00090001036ｦ0 000200000ｸ800 0ｷ300apple00 apple6ｦ00200000ｸ800 0300-036ｦ006036ｦ0090ｸ8 [8ｨC13]. 046ｦ002090ｹ00900 01020900090ｹ000060109 036ｦ000090200060309apple076 56ｦ000000ｸ803 0300-036ｦ006036ｦ009076 5 apple6ｦ0016ｦ0 6 5 6 70702076 5000706 0307096 7 09006ｦ00ｹ009030002000007 040304-046ｦ00003 08apple076 7000709 070600076 500076 707 096ｦ0 0702006 56ｦ00009fl, 08apple09 0ｹ1030703 50% 070200000ｸ803 08076 709 6ｦ00ｸ903 0703 08apple076 7apple00060609apple076 56ｦ00009fl 0800apple6 5090ｹ000076 707 070804030702006 5076 707 08apple070ｷ30006066ｦ0, 0706036ｦ00200000ｸ800 50% ｨC 0703 07060207080000000906, 066 5fl096ｦ000000ｸ803 06 08apple076 7apple00060609apple07-6 56ｦ000090003 0ｷ300apple00 apple6ｦ00200000706 0300036ｦ006036ｦ003090ｹ00006010706 070200090009 [5ｨC9]. 040006030703applefl 006ｦ0 08apple076 700070603090ｹ000060109 0000 026ｦ06 70708apple09fl03-000700 apple6ｦ0096 509030900 0300036ｦ006036ｦ003090ｹ0000601076 707 0ｷ300apple00 apple6ｦ0020000076 707 apple6ｦ0016ｦ0, 01020900090ｷ30906030ｸ8 0000 04 0002fl0ｸ903 0706036ｦ003070ｹ000076 707 6 50009-036ｦ00009fl 6ｦ000000706 08apple07 02000300, 0807 006ｦ0060307fl0ｸ70000 6 5apple0003fl 0000 apple6ｦ009apple6ｦ0 07036ｦ0006ｦ0 07080309036ｦ00200006ｦ0fl 036ｦ0010309016ｦ0 02000ｹ000 0007-096ｦ06 7-00070603090ｹ00006010903 0300apple0708apple09fl030906 [14]. ｨｴｨｨｨ 050002ｨ ｨｦ00ｨｦ07ｨ ｨｹ 0200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ02050004ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨ07 apple6ｦ00902090ｹ0000ｸ803 6ｦ000000ｸ803, 0300036ｦ006036ｦ0090ｸ8 apple6ｦ0016ｦ0 6 5 6 707-02076 5000706 0307096 7 060706036ｦ06 502fl0ｸ903 20ｨC50% 0703 6 5060003 0708040307-020006 6 70702076 500076 707 0307096 76ｦ0 [5, 6, 8, 9, 15]. 04076 50006040900 03000307 0ｸ8 000006apple076 50909046ｦ00209096ｦ00ｷ30909 09 07020000 030ｸ76ｦ003000200-000ｸ800 0906060200 076 56ｦ00009fl 08apple09 6ｦ0040307080609fl03 070200000ｸ803 apple6ｦ0-

1328 01.07. 0209ｨｺ02ｨｨ00ｨｪｨｦ05 010703 000307000603apple09apple040ｸ903, 0ｹ00307 0ｹ009060207 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 09006ｦ00ｹ009030002000007 08apple006 507060307 0903 0ｹ009060207 0800apple6 5090ｹ0000ｸ803 0708040307020006 [5, 7ｨC9, 15]. ｨｨ07 0ｹ06ｦ00603070300 apple6ｦ0096 5090309fl 0602040ｹ06ｦ009 0703 6ｦ0020000000ｸ803 0300036ｦ006036ｦ009076 5 0307096 76ｦ0 096ｦ00009036ｦ00ｸ903 03apple00030000 0300060307, 04060304086ｦ0fl 02090400 0602040ｹ06ｦ0fl03 apple6ｦ0096 5090309fl 0300036ｦ006036ｦ009076 5 08000ｹ0000009 09 01070603000706 0609060300030ｸ8 [8, 9, 15ｨC17]. 02ｨｨ0702 006ｦ009 07020000 0ｹ06ｦ0060307 6 50603apple000ｹ06ｦ00003-06fl 04 070200000ｸ803 6 5 6 50709apple6ｦ0060300 0703 40 07 60 020003 [8, 9, 15, 18]. ｨｬ 6 509apple0706020ｸ803 070200000ｸ803 0800apple6 50ｸ800 03apple09 030006036ｦ0 0807 0ｹ06ｦ0-0603070300 0300036ｦ006036ｦ00909apple076 56ｦ00009fl 6 5 6 70702076 5000706 0307096 7 096ｦ00009-036ｦ00ｸ903 apple6ｦ001 02006 701076 707, 060706036ｦ06 502flfl 40ｨC50%, 096ｦ0030003 apple6ｦ001 030702070ｹ0000706 08000200090ｸ8 15ｨC25% 09 0300026ｦ00007036ｦ0 01070809 12ｨC15%; apple046 7090309 6 56ｦ008000ｸ80309 6 5 096ｦ06 700070603090ｹ00006010703 09 02000ｹ000 000703 08026ｦ00000, 0007 0300000000 0ｹ06ｦ006030ｸ80309 090603070ｹ00009016ｦ0-0309 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 fl6 502fl0ｸ90306fl apple6ｦ001 08070ｹ0-0109, 0ｸ70903076 509 000706 08000200090ｸ8, 08000204 016ｦ0, 08apple00 06036ｦ003000200-000706 08000200090ｸ8 09 03070ｹ0006 5076 707 0804090ｸ8applefl, 020903020708apple070209-0200apple6ｦ003096 5000ｸ800 096ｦ0 0702006 56ｦ00009fl 09 apple. [5, 8, 9, 15, 19ｨC21]. ｨｺｨｨ05 096ｦ00009036ｦ00003 0800apple6 50700 0300060307 06apple00 09 apple046 70903 0708040307020006 0807 0608070607 0007060309 0300036ｦ006036ｦ00909apple076 56ｦ00300 6 5 020ｸ9 0ｸ800 07apple6 76ｦ0000ｸ8, 000006030703applefl 006ｦ0 0ｹ10307 02ｨｨ0702 08apple09 ｨｺｨｨ05 01070006036ｦ00309apple04000306fl apple00 0107 ｨC 6 5 1ｨC6% 0602040ｹ06ｦ0006 5 [1, 2, 4]. ｨｪ0003 0000 0300000000 apple0009040200036ｦ0030ｸ8 6ｦ004030708060906 0807016ｦ0-090ｸ86 56ｦ00ｸ903, 0ｹ00307 0906030900006ｦ0fl 0ｹ06ｦ0060307036ｦ0 02ｨｨ0702 08apple09 ｨｺｨｨ05 0307080003 0ｸ80300 6 5 2ｨC10 apple6ｦ009 0702000400 096ｦ06 70007060309apple076 56ｦ000-000706 [1, 2, 4]. ｨｨ02ｨｪｨｦ02ｨｦｨｺ06ｨｦ00ｨｦ07ｨ ｨｹ 0200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ02050004ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 0200036ｦ006036ｦ00909apple076 56ｦ0000900 6 5 6 70702076 5000706 0307096 7 08apple0709060307-0903 08apple000903040ｸ70006036 500000007 6 700036ｦ003076 70000000ｸ803 0804030003, 06 0ｹ00003 066 5fl096ｦ00007 08apple0007 026ｦ0 6ｦ0000900 040902076 50ｸ803 0300036ｦ006036ｦ009076 5 006ｦ0 0902020409000ｸ80309. 0200036ｦ006036ｦ0090ｸ8 6 5 6 70702076 5000703 0307096 700 08apple00 06036ｦ06 502fl0ｸ903 0807 6ｦ06 502fl0ｸ90ｸ70000 07020004090006036 507 006ｦ0-020ｸ9 00000906 06apple00 09 6 5060003 0300036ｦ006036ｦ009076 5 6 5 090405 ( 07020000 90%) 09 08apple090300apple0007 6 5 2 3 0602040ｹ06ｦ0006 5 fl6 502fl0ｸ90306fl 07 0900070ｹ0-000ｸ80309, 0807apple6ｦ0086ｦ0fl 08apple000903040ｸ70006036 500000007 08apple6ｦ06 50700 08070204-046ｦ0apple0900, 6 5 90% 0602040ｹ06ｦ0006 5 070009 apple6ｦ0060807026ｦ06 76ｦ00ｸ90306fl 0604-0107apple0309016ｦ002000007, 006ｦ0 6 7apple6ｦ000090ｷ300 0600apple076 707 09 0002076 707 6 5000ｸ700-06036 56ｦ0 [5, 7, 22, 23]. ｨｺ6ｦ00608apple00 000200000900 0300036ｦ006036ｦ009076 5 6 5 6 70702076 5000703 0307096 700 066 5fl096ｦ00007 06 090003000006096 500070603000ｸ9 0807-0307016ｦ0 01apple076 509 6 5 016ｦ008 0706 07 026ｦ0060309, 6 56 509 04 0ｹ0006 707 80% 0300036ｦ006036ｦ009076 5 0207016ｦ0020909040ｸ90306fl 6 5 070200040903 08070204046ｦ0- apple09fl03, 15% ｨC 6 5 03070908000ｹ00100, 5% ｨC 6 5 06036 5070200 6 70702076 50007-6 707 0307096 76ｦ0, 0300036ｦ006036ｦ0090ｸ8 6 5 06080900000703 0307096 700 08apple00-06036ｦ06 502fl0ｸ903 0607 0706 016ｦ00904090603090ｹ00006010900 006ｦ0 020ｸ9 000009fl [5, 7, 22, 23]. 050902020409000700 0300036ｦ006036ｦ00909apple076 56ｦ0000900 08apple0709060307 0903 02090302076 70000000ｸ803 0804030003 (0ｹ000apple0009 020903026ｦ0-03090107-0209016 507apple000ｸ800 0ｸ7000209) 09 08apple07fl6 502fl000306fl 0902-020409000ｸ803 016ｦ0apple0ｷ3090007036ｦ00307090703 07 0702070ｹ00001 0307096 76ｦ0; 0607-06036ｦ06 502fl0003 08apple090300apple0007 5ｨC10% 0703 6 5060003 0300036ｦ006036ｦ003090ｹ000-06010903 0807apple6ｦ00800000906 090405 09 6 50603apple000ｹ06ｦ0000306fl 6 7026ｦ06 5000ｸ803 07 apple6ｦ0090703 08apple09 6 7000000apple6ｦ00209096ｦ00ｷ30909 apple6ｦ0016ｦ0 08000204 016ｦ0 09 020903020708apple0702090200apple6ｦ003096 5000ｸ803 096ｦ0 0702006 56ｦ00009fl03 [5, 7, 22, 23]. ｨｺｨｨ05 0300036ｦ006036ｦ00909apple040003 6 5 090405 016ｦ001 6 700036ｦ003076 70000-000ｸ803, 036ｦ001 09 0209030207-6 700036ｦ003076 70000000ｸ803 0804030003; 07 80% 6 5060003 0300036ｦ006036ｦ009076 5 ｨｺｨｨ05 6 5 090405 fl6 502fl0ｸ90306fl 6 5000403apple09-0307096 7076 50ｸ80309 (016ｦ001 08apple6ｦ06 5090207, 6 5 070200040903 08070204046ｦ0apple09fl03 0307096 76ｦ0), 0701070207 16% ｨC 04apple6ｦ00200000ｸ80309 (0207016ｦ0020909040ｸ90306fl 6 5 0ｹ10809-09 0604 04apple6ｦ00200000703 08apple070603apple6ｦ00006036 500 0608090000076 707 0307096 76ｦ0) 09 4% 08apple00 06036ｦ06 502fl0ｸ903 0607 0706 0902020409000ｸ806 016ｦ0000ｷ300apple07036ｦ0030709 07 0702070ｹ00001 090405 (020008030703000009006 700-6ｦ00200006ｦ0fl 070200090000) [1, 4, 5, 18, 22]. ｨｨapple09 ｨｺｨｨ05 006ｦ009 07020000 0ｹ06ｦ0060307 6 507090009016ｦ00ｸ903 07 0900070ｹ0-000ｸ800 070ｹ06ｦ06 709 0807apple6ｦ008000009fl 6 5 6 70702076 5000703 0307096 700 (86%), 030007080006036 50000000700 0807apple6ｦ00800000900 ( 07020000 4 070ｹ06ｦ06 7076 5) 6 50603apple000ｹ06ｦ0000306fl 6 5 14% 0602040ｹ06ｦ0006 5; 0807apple6ｦ00800000900 07020004076 707 0307096 76ｦ0 09006ｦ00ｹ009030002000007 0703090009apple040003 (76%) 006ｦ0 0807apple6ｦ0-080000090003 6 5 07 026ｦ0060309 096ｦ0 000006 0ｹ000apple0008000706 fl030109 (21%), 0300036ｦ006036ｦ003090ｹ00006010700 0807apple6ｦ00800000900 07 070903 0703 0002076 5 6 707-02076 500076 707 0307096 76ｦ0 6 50603apple000ｹ06ｦ0000306fl 6 5 3% 0602040ｹ06ｦ0006 5; 070309-0009apple040ｸ90ｸ70903 6 70906030702076 7090ｹ00006010903 0309080703 ｨｺｨｨ05 08apple09 02ｨｨ0702 fl6 502fl000306fl 6ｦ0 000007016ｦ0apple0ｷ3090007036ｦ0 (91% 0602040ｹ06ｦ0006 5) [1, 4, 5, 18, 22]. ｨｦ0607 000000070603000ｸ9 0300036ｦ006036ｦ003090ｹ0000601076 707 08apple070ｷ30006066ｦ0 08apple09 ｨｺｨｨ05 fl6 502fl000306fl 0307, 0ｹ00307 02ｨｨ0702 6 5 0807 6ｦ06 502fl0ｸ9-0ｸ70003 07020004090006036 500 0602040ｹ06ｦ0006 5 06070ｹ000036ｦ0000306fl 06 0807apple6ｦ00800-00090003 apple046 70903 07apple6 76ｦ000076 5, 6 5 0ｹ06ｦ006030007060309, 0807apple6ｦ00800000900 0107-06030006 6 50603apple000ｹ06ｦ0000306fl 04 95% 070200000ｸ803, 0903000ｸ90ｸ70903 0300036ｦ0-06036ｦ0090ｸ8 6 5 0307096 700; 06070ｹ000036ｦ000000700 0807apple6ｦ00800000900 010706030006 09 02006 7010903ｨC 6 5 31% 006ｦ0 020ｸ9 00000906; 010706030006, 02006 701090309 08000ｹ0000009 ｨC 6 5 19%; 010706030006, 02006 7010903 09 0107060300076 707 0307096 76ｦ0 ｨC 6 5 8%; 010706030006, 02006 7010903 09 006ｦ0 08070ｹ0000ｹ0000901076 5 ｨC 6 5 5% [1, 4, 5, 18, 22]. 046ｦ002090ｹ00900 06070ｹ000036ｦ000000ｸ803 6 509060ｷ300apple6ｦ00200000ｸ803 0300036ｦ006036ｦ0-09076 5 ｨｺｨｨ05 08apple09 02ｨｨ0702 0807 apple6ｦ0090403006 56ｦ00003, 0ｹ00307 apple6ｦ0096 509-030900 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 08apple0709060307 0903 006ｦ0 08070ｹ06 500 04apple0007 apple6ｦ0096 5096 56ｦ00ｸ90ｸ7006 70706fl 0300036ｦ006036ｦ003090ｹ0000601076 707 08apple070ｷ30006066ｦ0 6 507 6 5000403apple0000000903 07apple6 76ｦ0006ｦ003. ｨｪ6ｦ0010706 6 56ｦ0apple096ｦ00003 02ｨｨ0702 080702040ｹ00902 006ｦ0096 56ｦ0000900 6 50307apple090ｹ000076 707 0300036ｦ006036ｦ00909apple076 56ｦ00009fl, 01076 7 6ｦ0 0300036ｦ006036ｦ003090ｹ00006010900 010200030109 0807086ｦ0 6ｦ0-0ｸ903 6 5 0307096 7 0000 06apple6ｦ00904 0909 0800apple6 5090ｹ0000706 07080403070209, 6ｦ0 0909 0000 6 509060ｷ300apple6ｦ00200000ｸ803 0300036ｦ006036ｦ003090ｹ00006010903 070ｹ06ｦ06 7076 5. 05016ｦ0096ｦ000-000700 0807 036 500apple08 6ｦ0000306fl 000ｸ700 09 030003, 0ｹ00307 0307096 7076 56ｦ0fl 03016ｦ00000 fl6 502fl000306fl apple0009090603000003000706 01 6 5070608apple09fl03090ｸ9 09 apple07-060304 0300036ｦ006036ｦ003090ｹ00006010903 0207010406076 5 0909 08apple0706036ｦ003090ｹ00006010903 apple6ｦ001076 50ｸ803 010200030701 6 5 070302090ｹ00900 0703 010200030701 090207016ｦ00ｹ0000603-6 50000000706 0300026ｦ00007030ｸ8 09 apple6ｦ0016ｦ0 02006 701076 707 [1, 4]. 05 0ｹ1030703 09 096ｦ001020ｸ90ｹ06ｦ0000306fl 086ｦ003076 700000003090ｹ00006016ｦ0fl 070607 00000007060300 02ｨｨ0702 08apple09 ｨｺｨｨ05, 01070307apple6ｦ0fl 070301apple0ｸ86 56ｦ00003 00076 50ｸ800 08apple00 06036ｦ06 502000009fl 6 5 apple6ｦ000000006 096ｦ06 700070603090100, 08apple076 700070909apple076 56ｦ0000909, 08apple070209026ｦ00103090100 09 02000ｹ000000909 0ｷ300apple00- apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 08apple09 apple6ｦ00100 08apple00 06036ｦ003000200000706 08000200090ｸ8.

130200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ00 ｨｨｨｦｨｺ02050004ｨ 00 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨｨｺｨ ｨｺｨｨ05 29 0100ｨ 04ｨ ｨｮ00050102ｨｹ 0102ｨｺｨｪｨ 0402 0200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ02050004ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 02006ｦ0020909 6ｦ000000ｸ803 02090300apple6ｦ00304apple0ｸ8 09 0607 06036 50000000ｸ803 006ｦ0-020ｸ9 00000906 0807016ｦ0090ｸ86 56ｦ00003, 0ｹ00307 01020900090ｹ00006010900 08apple07fl6 5-02000009fl 02ｨｨ0702 08apple09 ｨｺｨｨ05 6ｦ0006ｦ002076 7090ｹ0000ｸ8 060707036 500030603-6 5040ｸ90ｸ70903 08apple0909006ｦ0016ｦ003 08apple09 0300036ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ0 apple046 70903 07apple6 76ｦ000076 5 6 5 6 70702076 5000706 0307096 7 [8, 9]. 05 096ｦ06 50906090307060309 0703 036ｦ0apple6ｦ0010300apple6ｦ0 09 09006ｦ003090109 apple6ｦ009-6 5090309fl 096ｦ0 0702006 56ｦ00009fl 04 070200000ｸ803 06 02ｨｨ0702 020903000200-0007060300 03000ｹ0000009fl 0307096 7076 50706 070200090009 07 08070603040802000009fl 6 5 01020900090104 01070200 02000306fl 6 5 0409apple07010903 08apple00 00026ｦ003 [10, 22]. ｨｨapple09 07 0900070ｹ0000ｸ803 0300036ｦ006036ｦ0096ｦ003 6 5 6 70702076 5000706 0307096 7 0000 08apple07 07020809030002000007060300 6 5 06apple00 000003 060706036ｦ06 502fl0003 0701070207 4 030006fl0ｷ3006 5, 0900076 7 6ｦ0 07 1ｨC2 020003. ｨｨapple09 0300070800-06036 50000000ｸ803 0300036ｦ006036ｦ0096ｦ003 0ｹ1030703 06apple0701 07016ｦ0090ｸ86 56ｦ0000306fl 09006ｦ0-0ｹ009030002000007 0107apple070ｹ000 ｨC 0701070207 3 030006fl0ｷ3006 5, 0007 0000 070200-0400 6 030006fl0ｷ3006 5. 0307020000 0ｹ00003 6 5 70% 0602040ｹ06ｦ0006 5 08apple07 0702-0809030002000007060300 06090308030703076 5 0307096 7076 50706 070200090009, 6 50ｸ8-096 56ｦ000000706 02ｨｨ0702, 04 apple6ｦ0000000 02000ｹ00000000ｸ803 0700010702076 7090ｹ000-06010903 070200000ｸ803 060706036ｦ06 502fl0003 0703 3 07 12 030006fl0ｷ3006 5. 050ｸ8 0002fl0ｸ903 060200 040ｸ90ｸ70900 03apple09 0309086ｦ0 01020900090ｹ0000601076 707 03000ｹ0000009fl 09 08apple07fl6 50200000906 02ｨｨ0702: 1) 6 50000096ｦ008000700 006ｦ00ｹ06ｦ0-0207, 006ｦ008070309006ｦ00ｸ90ｸ70000 6 7000307appleapple6ｦ06 7090ｹ00006010906 090209 0ｹ103 0702090ｹ00006010906 09000604020003 090209 070603apple0700 apple6ｦ0096 509030900 0800apple6 50ｸ803 060903-08030703076 5 6 5 03000ｹ000000900 00000601070200010903 0ｹ06ｦ006076 5 090209 0604030701 0807 03090804 03apple0703 0703090ｹ00006010903 09000604020003076 5 (06070604 0906030ｸ806, 0900-0604020003070807 07 000ｸ806 030908); 2) 0807 070603apple0700 apple6ｦ0096 509030900 096ｦ0-0702006 56ｦ00009fl 6 5 03000ｹ000000900 00000601070200010903 0000 000200, 006ｦ008070309-006ｦ00ｸ90ｸ70000 08apple076 7apple00060609apple040ｸ90ｸ70906 0ｹ1000ｷ300026ｦ0020903 090209 0ｷ300apple00 - apple6ｦ00200000ｸ806 6ｦ0apple6ｦ003000709 0903 (6 50706086ｦ0020903000200000ｸ806 030908); 3) 0300 020000000700 08apple076 7apple00 09000003000700 apple6ｦ0096 509030900, 006ｦ008070309-006ｦ00ｸ90ｸ70000 0800apple6 5090ｹ000040ｸ9 090207016ｦ00ｹ00006036 5000000040ｸ9 07080403070200 6 707-02076 500076 707 0307096 76ｦ0 ( 026ｦ0060307036ｦ0030709000ｸ806 030908) [22, 24, 25]. ｨｦ0600076 5000706 070607 000000070603000ｸ9 01020900090109 02ｨｨ0702 fl6 5-02fl000306fl 080702090307apple02090903 06090308030703076 5, 01070307apple0ｸ806 030708-0007 07 ｨBfl0600090300 030003, 0ｹ00307 080703090307 0ｹ009060307 00006 5apple0702076 7090ｹ00006010903 026ｦ0010307apple076 5, 07 040602076 502096 56ｦ00ｸ90ｸ70903 01020900090ｹ000-0601040ｸ9 016ｦ0apple03090004, 060307 00040ｸ9 06 0800apple6 5090ｹ0000ｸ80309 070804030702fl0309 6 70702076 500076 707 0307096 76ｦ0, 08apple090307 090306fl 040ｹ009030ｸ86 56ｦ00300 000001070307apple0ｸ800 0603apple04010304apple0007-090702076 7090ｹ00006010900 016ｦ00ｹ00006036 56ｦ0 apple6ｦ00107-6 50ｸ803 0300036ｦ006036ｦ009076 5 [5, 10, 18, 20, 22, 24, 25]. 050903080307-036ｦ0030702076 709fl 09 0102090009016ｦ0 02ｨｨ0702 06026ｦ06 76ｦ0000306fl 0909 07 0ｸ700-0307096 7076 50ｸ803, 070ｹ06ｦ06 7076 50ｸ803 09 07 0ｸ7000607036ｦ003090ｹ00006010903 060903-08030703076 5. ｨｦ 006ｦ00107 000006030703applefl 006ｦ0 060307 06036 507 01020900090ｹ000-06010903 06090308030703076 5 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 06 0800apple- 6 5090ｹ0000ｸ80309 090207016ｦ00ｹ00006036 50000000ｸ80309 070804030702fl0309 6 70702076 5-00076 707 0307096 76ｦ0, 060903080307036ｦ0030702076 709fl 09 0102090009016ｦ0 0300036ｦ0-06036ｦ003090ｹ0000601076 707 apple6ｦ0016ｦ0 6 70702076 500076 707 0307096 76ｦ0 0903000ｸ903 applefl 070607 0000000706030006, 09006ｦ0000900 01070307apple0ｸ803 6 5 applefl 00 0602040ｹ06ｦ0006 5 0807096 50702fl0003 09020200apple00000ｷ309apple076 56ｦ00300 0903 0703 0800apple6 5090ｹ0000ｸ803 0708040307020006 6 70702076 500076 707 0307096 76ｦ0. 046ｦ009 07020000 07 0ｸ70006 09 036ｦ0apple6ｦ0010300apple000706 02fl 040902076 50ｸ803 0300036ｦ006036ｦ009076 5 apple6ｦ0016ｦ0 070607 000000070603000ｸ9 fl6 502fl000306fl 070603apple0700 090209 0807 070603apple0700 006ｦ00ｹ06ｦ00207 096ｦ0 0702006 56ｦ00009fl 06 apple6ｦ000000903 0807fl6 5020000090003 6 70702076 5000ｸ803 07020006, 0ｹ06ｦ0060307 06 0307040007030706 09 apple6 507030706, 0900076 7 6ｦ0 06 6 50000096ｦ008000ｸ803 0903 6 5070900090100076 50000090003 096ｦ0 07026 707 07 0807fl6 502000009fl 07 ｨB000103096 5000ｸ803 08apple0909006ｦ001076 5 08076 50ｸ804000009fl 6 5000403apple090ｹ000apple000800076 707 6ｦ06 502000009fl 09 070ｹ06ｦ06 707-6 50ｸ803 0ｷ300apple00 apple6ｦ00200000ｸ803 06090308030703076 5; 07 apple6ｦ00ｸ76ｦ00003 006ｦ0 0600 fl 6 50009036ｦ0000900 036ｦ0010800 apple6ｦ000000000 0807fl6 50200000900 09 070200046ｦ0fl 6 50ｸ8apple6ｦ00800000007060300 08apple09 000903 08060903090ｹ00006010903 apple6ｦ0060603apple070606036 5 09 07 0702070ｹ0000ｹ0000ｸ803 06090308030703076 5 0807 06apple6ｦ06 5000000090ｸ9 06 0800apple- 6 5090ｹ0000ｸ80309 070804030702fl0309 6 70702076 500076 707 0307096 76ｦ0 [5, 10, 18, 20, 22, 24ｨC27]. 046ｦ007 07apple0703, 036ｦ0010900 036ｦ0apple6ｦ0010300apple000ｸ800 6 709-0800apple03000009090700000ｸ800 060903080307030ｸ8, 016ｦ001 096ｦ006030706000ｸ800 09060109 09apple0903000200000ｸ803 0000apple6 5076 5, apple6ｦ0 09016ｦ0apple 09fl, 07 0ｸ70900 0604 07apple0708000ｸ800 (0ｹ1080902000803090ｹ00006010900) 08apple09086ｦ0 0109, 6 7090800apple030000-09090700000ｸ800, 07060300070807apple0703090ｹ00006010900 0909030000000009fl 6 5 01070603fl03 0ｹ000apple00086ｦ0, 070607 00000007 0304apple000ｷ301076 707 0600 026ｦ0, 09 apple046 70900, 6 50603apple000ｹ06ｦ00ｸ90306fl 08apple09 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ0096ｦ003 09006ｦ0-0ｹ009030002000007 apple000800 0807 06apple6ｦ06 5000000090ｸ9 06 0800apple6 5090ｹ0000ｸ80309 070804030702fl0309 6 70702076 500076 707 0307096 76ｦ0 [5, 10, 18, 20, 22, 24ｨC27]. 070702076 5000ｸ800 070209 fl6 502fl0ｸ90306fl 006ｦ009 07020000 apple6ｦ000000903 060903080307030703 0300036ｦ006036ｦ009076 5 apple6ｦ0016ｦ0 6 5 6 70702076 5000706 0307096 7. ｨｦ0009 6 50603apple000ｹ06ｦ00ｸ90306fl 0000 030702000107 0ｹ06ｦ00ｸ700 (94ｨC97%), 0007 09 6 50ｸ8apple6ｦ00800000ｸ8 090003000006096 5000000, 0ｹ00003 08apple09 0800apple6 5090ｹ0000ｸ803 070804030702fl03 6 70702076 500076 707 0307096 76ｦ0 0807 08apple090ｹ0090000 apple6ｦ0096 5090309fl apple6ｦ000-000006 09000307010609016ｦ00ｷ30909 03016ｦ00009 0307096 76ｦ0 09 006 707 07 0702070ｹ00001 [18]. 016ｦ001 08apple09 0800apple6 5090ｹ0000ｸ803 070804030702fl03 6 70702076 500076 707 0307096 76ｦ0, 036ｦ001 09 08apple09 0300036ｦ006036ｦ0096ｦ003 070009 0000apple00 0107 000706fl03 apple6ｦ0060809apple6ｦ00ｸ90ｸ70906 036ｦ0apple6ｦ0010300apple 09 6 507090009016ｦ00ｸ903 08apple090603040807-07 apple6ｦ0090007, 070603096 76ｦ0fl 006ｦ009 070200040006 090003000006096 50007060309 00070ｹ0000ｸ9 09 0807 0403apple07. ｨｺ6 507036ｦ0 08apple09 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ0, 016ｦ001 09 08apple09 0800apple6 5090ｹ0000ｸ803 070804030702fl03 6 70702076 500076 707 0307096 76ｦ0, fl6 5-02fl000306fl 0ｹ06ｦ006030ｸ803 060804030009010703 08apple0906030408076 5 6 70702076 5000ｸ803 07020006 09 6 70702076 50701apple040800000906, 07 0ｸ80ｹ00007 006ｦ0 6 50ｸ806070300 0903 apple6ｦ0096 5090309fl, 030703fl 006ｦ0 020ｸ9 6ｦ0000306fl apple000800 ｨC 6 5 55ｨC60% 0602040ｹ06ｦ0006 5 [5, 10, 18]. 016ｦ001 08apple6ｦ06 5090207, apple6 507036ｦ0 0007060903 6 709-0800apple03000009090700000ｸ806 036ｦ0apple6ｦ0010300apple, 0ｹ06ｦ00ｸ700 6 507090009016ｦ00003 6 5 0403apple0000000900 0ｹ06ｦ0060ｸ8, 006ｦ0 6 50ｸ806070300 6 70702076 5000706 070209 09 08apple09-0007060903 070200000ｸ803 07 02006 70ｹ000000900. ｨｨ07 08apple090ｹ0090000 0209016 507apple07 09006ｦ003090ｹ00006010903 006ｦ0apple040400000906 apple6 507036ｦ0 006ｦ009 07020000 0ｹ06ｦ006-0307 006ｦ0 020ｸ9 6ｦ0000306fl 08apple09 0300036ｦ006036ｦ0096ｦ003 6 5 096ｦ0 000006 0ｹ000apple0008-000706 fl030100, 6 507090009016ｦ0fl 08apple09 090903000000000909 0807020708000009fl 07020000076 707 6 5 08070603000209 090209 08apple09 08076 507apple070300 6 70702076 50ｸ8 (060900 apple0703 03apple0400066ｦ0) [5, 10, 18]. ｨ 6ｦ006030706000ｸ800 09060109 09apple0903000200000ｸ803 0000apple6 5076 5 (ｨ 05ｨ 04), 07 0900 0909 006ｦ009 07020000 6 56ｦ008000ｸ803 07 ｨB000103096 5000ｸ803 08apple0909006ｦ0-01076 5 00076 50707 apple6ｦ009076 56ｦ0000906 6 70702076 500076 707 0307096 76ｦ0, 006ｦ0 020ｸ9 6ｦ0-0ｸ90306fl 08apple09 0300036ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ0 6 5 6 70702076 5000703 0307096 700 06 0ｹ06ｦ0060307030706 50ｨC68% 0602040ｹ06ｦ0006 5, 6 5 0307 6 5apple0003fl 016ｦ001 08apple09 0800apple6 5090ｹ0000ｸ803 0ｷ300apple00 apple6ｦ00200000ｸ803 070804030702fl03 0903 0ｹ06ｦ0060307036ｦ0 060706036ｦ06 502fl0003 74% 09 6 50ｸ80400 [5, 10, 18, 20, 22, 23, 28]. 050200 040003 0703030003090300, 0ｹ00307 6 5 070302090ｹ00900 0703 0800apple6 5090ｹ0000ｸ803 0708040307020006 090405, 070607 00000007 07 apple07016ｦ00ｹ00006036 50000000ｸ803, 08apple09 01070307apple0ｸ803 ｨ 05ｨ 04 0900076 7 6ｦ0 03076 70403 0ｸ80300 00 09000603-6 50000000ｸ803 060903080307030703 096ｦ0 0702006 56ｦ00009fl, 08apple09 0ｷ300apple00 apple6ｦ00200-

1330 01.07. 0209ｨｺ02ｨｨ00ｨｪｨｦ05 000ｸ803 0300036ｦ006036ｦ0096ｦ003 fl6 502000009fl 096ｦ0060307fl 6 506006 7 6ｦ0 06070ｹ000036ｦ00ｸ903-06fl 06 apple046 7090309 07 0ｸ7000307096 7076 50ｸ80309 060903080307036ｦ00309: 6 707-02076 5000706 0702000ｸ9, apple6 507030706, 076 70204040000090003 [5, 10, 18, 20, 22, 23, 28]. ｨｺ6ｦ0060603apple070606036 56ｦ0 08060903090109 08apple09 02ｨｨ0702 006ｦ0 020ｸ9 6ｦ00ｸ903-06fl 06 0ｹ06ｦ0060307030706 64ｨC95% [18, 22, 23, 29]. ｨ 09030000000009fl 08060903090109 6 5 03000ｹ000000900 0800apple6 50ｸ803 0000 000200 096ｦ0 0702006 56ｦ00009fl 076 7apple6ｦ000090ｹ0096 56ｦ00ｸ90306fl 0ｹ103070ｷ30907006ｦ00200000706 000004060307060ｹ009-6 5070603000ｸ9, 6ｦ006030000090006 09 000001070307apple0706 096ｦ00307apple030708000000070603000ｸ9, 6 5 6ｦ00200000006040003 04 070200000ｸ803 apple6ｦ0096 5096 56ｦ0000306fl 6ｦ0086ｦ00309fl, 076 7-02040400000007060300, 06070002096 507060300, 096ｦ06 7apple040800000007060300. ｨｨapple09 0ｹ1030703 076 702040400000007060300 fl6 502fl000306fl 006ｦ009 07020000 0807060307fl00-000ｸ803 060903080307030703. ｨｨ07 0300apple00 0000 006ｦ0apple6ｦ006036ｦ00009fl 070200-000ｸ800 06036ｦ000076 5fl0306fl 07020000 6 5fl020ｸ80309, 086ｦ00606096 5000ｸ80309, 0300000000 0900090ｷ3096ｦ003096 5000ｸ80309, 00fl03000200000ｸ80309 09 0807 6 50908-000ｸ80309, 08apple076 7apple000606096 50007 0300applefl0ｸ903 086ｦ003fl0300, 09000300apple0006 01 0701apple04086ｦ00ｸ90ｸ7000304, 6 5 030703 0ｹ009060200 01 066 5070006 070200090009. 046ｦ0 02070000 006ｦ0apple6ｦ006036ｦ00ｸ90ｸ7006 707 076 7020404000009fl apple6ｦ0096 5096 56ｦ0000306fl 036ｦ001 006ｦ0090ｸ86 56ｦ000030ｸ806 6ｦ0086ｦ003090107-6ｦ0 09006ｦ003090ｹ00006010906 060900- apple0703. 05070ｹ000036ｦ0000900 0ｹ1030903 6 50403 0806090307086ｦ0030702076 7090ｹ00006010903 060900 apple0703076 5 006ｦ009 07020000 030908090ｹ00007 02fl 08060903090ｹ0000601076 707 06036ｦ00304066ｦ0 070200000ｸ803 06 0ｷ300apple00 apple6ｦ00200000ｸ80309 0300036ｦ006036ｦ0096ｦ00309 09 07 040602076 502000007 090603070ｸ76ｦ00003070603000ｸ9 0107apple01076 50ｸ803 08apple07-0ｷ3000606076 5. ｨｨ060903090ｹ00006010900 apple6ｦ0060603apple070606036 56ｦ0 6 5 6 509 00 6 76ｦ002020ｸ9-0ｷ309006ｦ00ｷ30906, apple00 076 50ｸ803 060900 apple0703076 5, 6 50709 0408 000009fl 09 apple. 0000 036ｦ0apple6ｦ0010300apple000ｸ8 02fl 070200000ｸ803 06 0300036ｦ006036ｦ003090ｹ000-06010903 0807apple6ｦ0080000090003 6 70702076 500076 707 0307096 76ｦ0 09 6 50603apple000ｹ06ｦ00ｸ903-06fl apple00 0107 [18, 22, 23, 29]. ｨｦ0ｹ06ｦ06 7076 50ｸ800 060903080307030ｸ8 08apple09 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ0-06036ｦ0096ｦ003 0000 0603070200 6 50ｸ8apple6ｦ00800000ｸ8, 016ｦ001 08apple09 0800apple6 5090ｹ0000ｸ803 070804030702fl03 09 090006040200036ｦ003 6 70702076 500076 707 0307096 76ｦ0. 05060200 0603-6 50900 0604 0107apple0309016ｦ00200000706 0207016ｦ00209096ｦ00ｷ30909 07020004090006036 56ｦ0 040902076 50ｸ803 0300036ｦ006036ｦ009076 5 apple6ｦ0016ｦ0 070ｹ06ｦ06 7076 50ｸ800 060903080307030ｸ8 0601026ｦ0 0ｸ86 56ｦ00ｸ90306fl 07 0ｸ80ｹ00007 0909 08apple076 507 000901076 50ｸ803 6 5096 76ｦ0-03000200000ｸ803 09 0ｹ0046 506036 50903000200000ｸ803 6 7000309-09 03070007060900 apple07-03076 5, 06apple6ｦ06 50009030002000007 apple00 01090309 060ｹ009036ｦ00ｸ90306fl 0107apple01076 50ｸ800 060903080307030ｸ8 apple6ｦ009 apple6ｦ008000009fl 6 5 6 509 00 0604 07apple0708000ｸ803 08apple09-086ｦ0 01076 5, 086ｦ0apple00060300090906 09 6 76ｦ002020ｸ90ｷ309006ｦ00ｷ30906 [5, 10, 18, 20, 22, 24ｨC27]. ｨｦ0ｹ06ｦ06 7076 50ｸ800 060903080307030ｸ8 04 070200000ｸ803 06 07 09-00070ｹ0000ｸ80309 0ｷ300apple00 apple6ｦ00200000ｸ80309 0300036ｦ006036ｦ0096ｦ00309 apple6ｦ0016ｦ0 apple00-0107 0ｸ86 56ｦ00ｸ903 0800apple6 50ｸ80309 08apple0909006ｦ0016ｦ00309 096ｦ0 0702006 56ｦ00009fl (0800apple6 5090ｹ00007-070ｹ06ｦ06 7076 50ｸ800 060903080307030ｸ8), 07 0ｸ80ｹ00007 070009 07-6ｦ06 502fl0ｸ90306fl 0807 0300apple00 apple6ｦ0096 5090309fl 096ｦ0 0702006 56ｦ00009fl 01 07-0ｸ7000307096 7076 50ｸ803 006ｦ0apple0404000009fl03. ｨｨapple09 apple6ｦ006080702070800000909 07 0900070ｹ0000ｸ803 0300036ｦ006036ｦ009076 5 6 5 0207 000706 09 0300030000000706 07-02fl03 (6 5 09070000 6 5096 76ｦ00300020000076 707 09 0ｹ0046 506036 5090300020000076 707 6ｦ0006ｦ00209096ｦ00307apple076 5) 0703090009apple040ｸ903 0800apple6 5090ｹ00007-070ｹ06ｦ06 7076 50ｸ800 060903080307030ｸ8, 03076 7 6ｦ0 016ｦ001 08apple09 0207016ｦ00209096ｦ00ｷ30909 07080403070200-6 50ｸ803 040902076 5 6 5 6 50906070ｹ0000ｸ803 09 096ｦ0030ｸ802070ｹ0000ｸ803 0703 00026ｦ003 6 707-02076 500076 707 0307096 76ｦ0 00006 5apple0702076 7090ｹ00006016ｦ0fl 060903080307036ｦ00309016ｦ0 07 0ｸ80ｹ00007 0ｸ86 56ｦ00003 08apple00 06036ｦ06 50200006ｦ0 6 50307apple090ｹ00007-070ｹ06ｦ06 707-6 50ｸ80309 006ｦ0apple0404000009fl0309 [5, 10, 18, 20, 22, 24ｨC27]. ｨｦ 0702070ｹ0000ｹ0000ｸ800 060903080307030ｸ8 08apple09 090003apple6ｦ001apple6ｦ000096ｦ00200-000ｸ803 0300036ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ0 6 50603apple000ｹ06ｦ00ｸ90306fl 09006ｦ00ｹ009030002000007 0ｹ06ｦ00ｸ700 (42%), 0ｹ00003 08apple09 0800apple6 5090ｹ0000ｸ803 070804030702fl03 6 70702076 5-00076 707 0307096 76ｦ0 (19%); 08apple09 0ｹ1030703 006ｦ009 07020000 0ｹ06ｦ0060307 070009 07 006ｦ0apple0408096 56ｦ00ｸ90306fl 08apple09 016ｦ0apple0ｷ3090007036ｦ003070900 0307096 7076 50ｸ803 07 0702070ｹ00001 (77%), 096ｦ0030003 08apple09 030007080006036 50000000ｸ803 0300-036ｦ006036ｦ0096ｦ003 6 5 6 70702076 5000706 0307096 7 (49%) 09 apple000800 006ｦ0 020ｸ9 6ｦ0-0ｸ90306fl 08apple09 07 0900070ｹ0000ｸ803 0300036ｦ006036ｦ0096ｦ003 (33%), 6 507090009016ｦ0-0ｸ903 6 5 07020004090006036 500 0602040ｹ06ｦ0006 5 6 5 080709 000903 06036ｦ0 09fl03 070200090009 09 6 50ｸ8apple6ｦ0086ｦ00ｸ90306fl 6 5 apple096 709 0007060309 030ｸ8040ｷ3 096ｦ0-030ｸ802016ｦ0, 060903080307036ｦ003 0100apple00096 76ｦ0, 03apple04 0909000601076 707, 6 5 046 76ｦ0066ｦ0000909 0604030708090200000ｸ803 09 0800apple090706036ｦ00200000ｸ803 apple00020200-0106076 5. 05 070302090ｹ00900 0703 0800apple6 5090ｹ0000ｸ803 0708040307020006 6 70702076 5-00076 707 0307096 76ｦ0 08apple09 0300036ｦ006036ｦ003090ｹ00006010703 0ｷ300apple00 apple6ｦ00200000703 apple6ｦ00100 0ｹ06ｦ0060307036ｦ0 09 6 50ｸ8apple6ｦ00800000007060300 07 0702070ｹ0000ｹ0000ｸ803 060903-08030703076 5 0000 096ｦ06 50906fl03 0703 0207016ｦ00209096ｦ00ｷ30909 0300036ｦ006036ｦ0096ｦ0, 0807-06010702000104 6 507090009016ｦ00ｸ903 0000 06030702000107 6 5060200 06036 50900 08076 50ｸ8-04000009fl 6 5000403apple090ｹ000apple000800076 707 6ｦ06 502000009fl, 06010702000107 096ｦ0 060ｹ00003 apple6ｦ001076 50706 09000307010609016ｦ00ｷ30909 09 03070106090ｹ0000601076 707 070300-016ｦ0 0307096 7076 50ｸ803 07 0702070ｹ00001 [5, 10, 18, 20, 22, 24ｨC27]. ｨｦ 0ｸ7000607036ｦ003090ｹ00006010900 (060906030003000ｸ800) 060903080307030ｸ8 08apple09 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ0 036ｦ0apple6ｦ0010300apple090904-0ｸ90306fl 09006ｦ00ｹ00903000200000706 0ｹ06ｦ0060307030706, 066 5070007 apple6ｦ009090003 09 0000-07 09006ｦ001076 50706 6 50ｸ8apple6ｦ008000000070603000ｸ9. ｨｨ07fl6 50200000900 04 070200-04090006036 56ｦ0 070200000ｸ803 060906030003000ｸ803 070804030702006 50ｸ803 060903-08030703076 5 (6 7090800apple0300apple0309fl, 08070300applefl 6 500066ｦ0, 07060300076ｦ0apple03apple07-086ｦ00309fl, 0ｹ102000103apple07020903000ｸ800 apple6ｦ0060603apple070606036 56ｦ0, 6ｦ000000309fl, 0807-6 50ｸ80400000900 05ｨｦｨｴ, 6 7090800apple01076ｦ06 70402fl0ｷ309fl 09 08apple.) 0703apple6ｦ0086ｦ00003 086ｦ0apple6ｦ000000708026ｦ00603090ｹ00006010906 036ｦ0apple6ｦ0010300apple 6 70204 07010903 09090300-0000000906 6 507 6 5000403apple0000000006 06apple00 00 07apple6 76ｦ0000909036ｦ0 [30, 31]. ｨｬ 070200000ｸ803 06 0300036ｦ006036ｦ0096ｦ00309 apple6ｦ0016ｦ0 6 5 6 70702076 5000706 0307096 7 016ｦ00300010609fl 006ｦ0 020ｸ9 6ｦ0000306fl 07020000 0ｹ00003 6 5 40% 0602040ｹ06ｦ0006 5, 08apple09 0ｹ1030703 006ｦ009 07020000 0ｹ06ｦ0060307 07006ｦ0 0903000003 0300060307 08apple09 apple6ｦ00100 02006 701076 707, 08070ｹ00109, 08000204 070ｹ00007-010904000ｹ000076 707 03apple6ｦ0-01036ｦ0 09 0300026ｦ000070300 01070809, apple00 0107 006ｦ0 020ｸ9 6ｦ0000306fl 08apple09 apple6ｦ00100 030702070ｹ0000706 08000200090ｸ8. ｨｨapple09 030007080006036 50000000ｸ803 0300-036ｦ006036ｦ0096ｦ003 apple6ｦ0016ｦ0 6 5 6 70702076 5000706 0307096 7 09 0300036ｦ006036ｦ0096ｦ003 6 5 03fl6 7010900 0307096 7076 50ｸ800 07 0702070ｹ00109 016ｦ00300010609fl 6 50603apple000ｹ06ｦ00003-06fl 6 707apple6ｦ009 07 0ｹ06ｦ00ｸ700, 0ｹ00003 08apple09 07 0900070ｹ0000ｸ803 040902076 50ｸ803 0300036ｦ006036ｦ0096ｦ003. ｨ 0405ｨｪｨｺｨｬ020004ｨｪ0200ｨｲ0402ｨｹ 05ｨ 020704ｨｦ05ｨｪｨ 0102 0200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ02050004ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨ07 006ｦ0060307fl0ｸ70000 6 5apple0003fl 6 5 000006apple070700010702076 70909 6 500 04-0ｸ70903 03000307 0703 080706036ｦ000076 50109 096ｦ06 70007096ｦ0 fl6 502fl000306fl 010209-00090ｹ00006010906 03000307 (06 07apple 086ｦ00207 07020000076 707, 6ｦ0006ｦ0030000096ｦ0, 06090308030703076 5 070200090009, 0207apple0309apple076 56ｦ0000900 01020900090ｹ00006010706 6 70908070300090ｸ8). ｨｦ 006ｦ00107 0009 06076 5apple00030000000ｸ803 09000603apple04030000-036ｦ00200000ｸ803 03000307 076 5 096ｦ06 700070603090109 0000 08apple00 06036ｦ06 502fl000306fl 6 50709030708000ｸ803 08070603apple07090300 016ｦ001040ｸ9-0209 07 6ｦ0 00016 56ｦ00300040ｸ9 02000ｹ000 0007-096ｦ06 700070603090ｹ0000601040ｸ9 036ｦ00103090104 08apple09 0807 0709apple00-000909 090209 6 50ｸ8fl6 50200000909 02ｨｨ0702. 02006ｦ0020909 02090300apple6ｦ00304apple000ｸ803 6ｦ000000ｸ803 09 0607 06036 50000000ｸ803 006ｦ0 020ｸ9 00000906 0807016ｦ0090ｸ86 56ｦ00003, 0ｹ00307 0300036ｦ006036ｦ0090ｸ8 ｨｺｨｨ05 6 5 6 70702076 5000706 0307096 7 0000 0903000ｸ903 016ｦ0010903-0209 07 070302090ｹ00903000200-

13000203ｨｦｨｺ02ｨｪｨｦｨｺ0402ｨｹ 05ｨ 020704ｨｦ05ｨｪｨ 0102 0200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ02050004ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨ 06060200 076 56ｦ0000900 applefl 6ｦ0 000201076 50ｸ803 03070200010402 6 5 020901-6 507apple00 04 070200000ｸ803 06 02ｨｨ0702 0903000003 06040ｸ70006036 50000000700 09006ｦ00ｹ000000900 0000 030702000107 6 5 096ｦ06 700070603090100, 0007 09 6 5 08apple076 70007-0909apple076 56ｦ0000909 01020900090ｹ0000601076 707 03000ｹ0000009fl 070200090009, 070607-00000007 6 5 08apple070ｷ300060600 02000ｹ0000009fl. ｨｨ07016ｦ0096ｦ00007 6 56ｦ008000700 08apple076 700070603090ｹ00006010700 09006ｦ00ｹ000000900 0ｹ100 070209016 507apple00076 707 0607-00apple086ｦ00009fl 6 50ｸ80607010703070200010402flapple00076 707 09006 709 090307apple6ｦ0 08apple07030009006ｦ009 6ｦ00200026ｦ0-2-036ｦ001apple076 70207 040209006ｦ0: 006 707 09060307-000700 6 50ｸ80607010700 09006ｦ00ｹ000000900 0107appleapple000209apple040003 0607 060300080000000ｸ9 090207016ｦ00ｹ00006036 500000007060309 090003apple6ｦ00ｷ300apple00 apple6ｦ00200000706 07080403070209, 6ｦ0 046 50002090ｹ000000900 04apple076 500fl 006 707 0607 00apple086ｦ00009fl 6 5 08apple070ｷ300060600 02000ｹ0000009fl 036ｦ0apple6ｦ0010300apple0007 02fl 08apple07 0702086ｦ00ｸ90ｸ7006 70706fl apple0706-036ｦ0 07080403070209 [33, 34]. ｨ 06060200 076 56ｦ0000900 09 030700090307apple09006 7 0909070ｹ10009090300076 707 0608000103apple6ｦ0 026ｦ001036ｦ003 006 709 apple076 700006ｦ0090ｸ8 (000507) 6 5 0209016 507apple00 070200000ｸ803 06 0300036ｦ006036ｦ003090ｹ00006010903 0807apple6ｦ0080000090003 6 70702076 500076 707 0307096 76ｦ0 09 006 707 07 0702070ｹ00001, 6 5 0703-02090ｹ00900 0703 0800apple6 5090ｹ0000ｸ803 0ｷ300apple00 apple6ｦ00200000ｸ803 0708040307020006, 04016ｦ0090ｸ86 56ｦ00ｸ903 006ｦ0 08apple076 700070603090ｹ000060109 09006ｦ00ｹ009030700 08076 50ｸ8-0400000900 04apple076 5000006 0909070207apple03 000507-1 09 000507-2 [35, 36]. 05 0ｹ06ｦ006030007060309, 0807016ｦ0096ｦ00007, 0ｹ00307 0607070300070400000900 000507-1/000507-2 00090800 00 0900090ｷ30ｸ8 06036ｦ003090603090ｹ000060109 09006ｦ00ｹ009-0307 0107appleapple000209apple040003 06 006ｦ002090ｹ0090003 6 50307apple090ｹ000076 707 0300036ｦ006036ｦ0-03090ｹ0000601076 707 0807apple6ｦ008000009fl 090405, 070607 00000007 09020204090007-6 707 016ｦ0apple0ｷ3090007036ｦ00307096ｦ0 [36]. ｨ 09040ｹ000000900 0607 00apple086ｦ00009fl 6 5 0209016 507apple00 000006apple070700010702076 7090ｹ00006010903 070200000ｸ803 06070604 090603070200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ00 ｨｨｨｦｨｺ02050004ｨ 00 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨｨｺｨ ｨｺｨｨ05 31 000ｸ803 070607 0000000706030006, 6 50ｸ8fl6 502fl00030ｸ803 08apple09 6ｦ0006ｦ002090900 000006apple076 50909046ｦ00209096ｦ00ｷ3090700000706 016ｦ0apple0309000ｸ8 0807 06apple6ｦ06 5000000090ｸ9 06 0ｷ300apple00 apple6ｦ00200000ｸ80309 0300036ｦ006036ｦ0096ｦ00309 0909 apple046 70903 07apple6 76ｦ000076 5 [5, 8, 9]. ｨｺ0000036 7000001070308000ｸ90300apple006ｦ0fl 030703076 7apple6ｦ00209fl (ｨｺ01ｨｪ) 0706036ｦ0-000306fl 066ｦ0030ｸ803 6 5070603apple00 076 56ｦ000000ｸ803 03000307 0703 096ｦ06 70007060309-0109 6 5 000006apple070700010702076 70909. 046ｦ0 ｨｺ01-030703076 7apple6ｦ003036ｦ003 070200-04090006036 507 0300036ｦ006036ｦ009076 5 0903000ｸ903 0807000908000000040ｸ9 08020703-0007060300, 07 006ｦ00107 08apple09 006ｦ002090ｹ00909 070ｹ06ｦ06 7076 5 6 7000307appleapple6ｦ06 70909, 016ｦ002000ｷ30902090ｷ309apple076 56ｦ000000ｸ803 09 6 50ｸ80607010708apple0703000900076 50ｸ803 6 501020ｸ90ｹ000000906 0300036ｦ006036ｦ009 0903000003 08076 50ｸ804000000040ｸ9 08020703-0007060300; 0000apple00 0107 080207030007060300 0300036ｦ006036ｦ009076 5 08apple09 ｨｺ01ｨｪ apple6ｦ06 5006ｦ0 080207030007060309 03016ｦ00009 6 70702076 500076 707 0307096 76ｦ0, 0007 030003 0000 0300000000 070009 0307apple070407 6 50ｸ8fl6 502fl0ｸ90306fl 006ｦ0 02070000 0701apple04-086ｦ00ｸ90ｸ7006 707 070300016ｦ0 [5, 10, 19, 24]. ｨｨ07060200 6 5000403apple096 50000-00076 707 6 56 500 000009fl 01070003apple6ｦ0060309apple040ｸ90ｸ7006 707 6 5000ｸ70006036 56ｦ0 006ｦ0 01070308000ｸ90300apple000ｸ803 030703076 7apple6ｦ003036ｦ003 0300036ｦ006036ｦ009 0903000003 6 509 010702000ｷ36ｦ0 (0107apple07006ｦ0-0ｹ10202000103) 06 08076 50ｸ8040000000706 0807 0800apple09-0200apple0909 0802070300070603000ｸ9, 0ｹ00307 07 ｨBfl0600fl000306fl 006ｦ002090ｹ0090003 000001apple07096ｦ0 (apple000800 010906030ｸ8) 6 5 0ｷ3000003apple00 07080403070209 09 07 090200-000706 6 56ｦ006010402flapple09096ｦ00ｷ3090006 0807 0800apple090200apple0909 [5, 10, 19, 24]. 026ｦ06 70009030007apple000907006ｦ00006006ｦ0fl 030703076 7apple6ｦ00209fl (02ｨｺｨｪ) 06 01070003apple6ｦ00603000ｸ803 040609020000090003 fl6 502fl000306fl 02040ｹ0040903 09 6 50ｸ8-060701070ｹ0046 506036 50903000200000ｸ803 03000307 0703 096ｦ06 700070603090109 02ｨｨ0702, 070607 00000007 03090009036ｦ00200000ｸ803 0807apple6ｦ00800000906 apple6ｦ009-0300apple0703 0300000000 0,5 0603, 09 00 090006036 50000000ｸ803 6 5 0708apple00 000200-000909 03070ｹ000076 707 0ｹ00906026ｦ0 070ｹ06ｦ06 7076 5 0807apple6ｦ008000009fl, 0ｹ00307 fl6 502fl- 000306fl, 016ｦ001 09096 50006030007, 08apple076 700070603090ｹ000060109 09006ｦ00ｹ009030ｸ803 [5, 10, 19, 24, 32]. ｨｨ07090903apple0700006ｦ0fl 0ｹ103090606090700006ｦ0fl 030703076 7apple6ｦ00209fl (ｨｨｨｴｨｪ) ｨC 03000307, 070600076 56ｦ000000ｸ806 006ｦ0 09060807020009076 56ｦ0000909 0807090903apple0700090902040ｹ06ｦ00ｸ90ｸ70903 apple6ｦ0 09070004010209 000ｸ803 6 5000ｸ70006036 5, 036ｦ0010903 016ｦ001 18 ｨｺ-02020407apple07-2- 000907010609-0-6 7020ｸ90107090ｸ8 090209 18F-L-05O06A, 0ｹ00307 0807096 50702fl0003 016ｦ0apple0309apple076 56ｦ00300 09070309-03090ｹ00006010900 09 020909090702076 7090ｹ00006010900 08apple070ｷ30006060ｸ8 6 70702076 50007-6 707 0307096 76ｦ0 09 6 50ｸ8fl6 502fl0300 020400010ｷ30907006ｦ00200000ｸ800 006ｦ0apple040400-0009fl 07 0807fl6 502000009fl 070ｹ0006 509 000ｸ803 0603apple04010304apple000ｸ803 09090300-0000000906 [5, 10, 19, 24, 26, 32]. 070703fl 07060304080007060300 6ｦ000-00076 707 03000307 6ｦ0 6 5 006ｦ0060307fl0ｸ70000 6 5apple0003fl 0706036ｦ0000306fl 076 7apple6ｦ000090ｹ00000000706, ｨｨｨｴｨｪ 0903000003 6 5000600036ｦ0 6 56ｦ008000700 096ｦ06 700070603090ｹ000-06010700 09006ｦ00ｹ000000900 6 5 000006apple070700010702076 70909 09 07016ｦ0090ｸ86 56ｦ0000306fl 0807020009000ｸ803, 6 5 0ｹ06ｦ006030007060309, 02fl apple6ｦ000000006 096ｦ06 700070603090109 030901apple070300036ｦ006036ｦ009076 5 6 5 6 70702076 5000706 0307096 7, 6 5 070ｷ300000100 06030008000009 090207016ｦ00ｹ00006036 500000007060309 0ｷ300apple00 apple6ｦ00200000706 0708040307-0209, 02fl 096ｦ06 700070603090109 0800apple6 5090ｹ000076 707 090209 6 50307apple090ｹ000076 707 0807apple6ｦ008000009fl 0307096 76ｦ0, apple000ｷ309 096 5076 5 09 000001apple0709076 5 0ｷ300apple00 - apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 6 5 08apple070ｷ300060600 02000ｹ0000009fl, 08apple076 70007-0909apple076 56ｦ00009fl 0309030907apple00090906030000030007060309 09 0ｹ10202000103096 50007060309 02000ｹ0000009fl 0ｷ300apple00 apple6ｦ00200000ｸ803 090207016ｦ00ｹ00006036 50000000ｸ803 0708040307-020006 [5, 10, 19, 24, 26, 32]. ｨｬ0ｹ009030ｸ86 56ｦ0fl 04016ｦ0096ｦ000000ｸ800 6 50ｸ80400 070607 00000007060309 0300036ｦ006036ｦ003090ｹ0000601076 707 ｨｺｨｨ05, 03000307 ｨｨｨｴｨｪ fl6 502fl000306fl 0000096ｦ003000009030ｸ803 02fl 08026ｦ00009apple076 56ｦ00009fl 6ｦ0 00016 56ｦ003000706 036ｦ00103090109 0107030802000106000706 0300apple6ｦ0080909 ｨｺｨｨ05. ｨｦ 00070207030700006ｦ0fl 0ｹ103090606090700006ｦ0fl 01070308000ｸ90300apple006ｦ0fl 030703076 7apple6ｦ00209fl (ｨｦ06ｨｴ01ｨｪ) 6 501020ｸ90ｹ06ｦ00003 6 5000403apple096 50000000700 090209 09006 76ｦ002fl0ｷ3090700000700 6 56 500 00000900 apple6ｦ0 09070004010209 000ｸ803 08apple00086ｦ0apple6ｦ003076 5, 090902040ｹ06ｦ00ｸ90ｸ70903 07 0900070ｹ0000ｸ800 02070307000ｸ8, 0ｹ00307 0807096 50702fl0003 080702040ｹ06ｦ00300 090907 apple6ｦ008000009fl 6 70702076 500076 707 0307096 76ｦ0. 05 000006apple070700010702076 70909 ｨｦ06ｨｴ01ｨｪ 036ｦ0010800 090608070200-0904000306fl 06 0ｷ30002000ｸ9 apple6ｦ000000006 096ｦ06 700070603090109 0ｷ300apple00 apple6ｦ00200-000ｸ803 030901apple070300036ｦ006036ｦ009076 5 09 08apple076 700070909apple076 56ｦ00009fl 0ｹ1020200-0103096 50007060309 02000ｹ0000009fl 0ｷ300apple00 apple6ｦ00200000ｸ803 090207016ｦ00ｹ00006036 50000-000ｸ803 0708040307020006 [5, 10, 19, 24, 26, 32]. ｨｴ02000103apple070ｹ1000ｷ300026ｦ002076 7apple6ｦ00209fl (ｨｴｨｴ07), fl6 502flfl0600 6 5060807-03076 76ｦ003000200000ｸ803 03000307 0703 096ｦ06 700070603090109, 030003 0000 0300-000000 07 ｨB000103096 50007 0703apple6ｦ0086ｦ00003 03fl0800060300 0607060307fl0009fl 070200000ｸ803, 080703076 76ｦ00003 6 5 030708090ｹ00006010706 096ｦ06 700070603090100 09 0807096 50702fl0003 01070003apple070209apple076 56ｦ00300 000006apple07 09006ｦ003090ｹ00006010900 08apple070ｷ30006060ｸ8. ｨｨapple09 ｨｴｨｴ07-0906060200 076 56ｦ0000909 070200000ｸ803 06 0ｷ300apple00 apple6ｦ00200000ｸ80309 0300036ｦ006036ｦ0096ｦ00309 apple6ｦ0016ｦ0 6 50ｸ8fl6 502fl0ｸ90306fl 07-0ｸ7000307096 7076 50ｸ800 0909030000000009fl 090708070300000ｷ3096ｦ002076 5, 06 08apple00-07 026ｦ0 6ｦ000090003 6 507 6 5060003 07036 500 000009fl03 080702090307apple02000ｸ803 0300 020000000ｸ803 6 5070200, 000207apple036ｦ00ｷ3090006 090209 070306040306036 5090003 6ｦ00200026ｦ0-apple0903036ｦ0. 040006030703applefl 006ｦ0 apple6ｦ00608apple070603apple6ｦ00000000007060300 09 0300076 7070ｹ009060200000007060300 07 0ｸ7000307096 7076 50ｸ803 090903000000000906 08apple09 07 0900070ｹ0000ｸ803 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ0096ｦ003 04 6ｦ00003-06fl 08apple07060200 090300 07020000 090209 0300000000 076 7apple6ｦ000090ｹ00000000ｸ800 02070104060ｸ8 0300 020000000ｸ803 04060307060ｹ0096 50ｸ803 6 50ｸ8060701076ｦ003080209-0304 000ｸ803 6 5070200, 060707036 5000306036 5040ｸ90ｸ70903 apple6ｦ00608070207080000090ｸ9 07080403070209 [5, 10, 19, 24, 26, 32].

1332 01.07. 0209ｨｺ02ｨｨ00ｨｪｨｦ05 6 707 0ｹ100 07030002096ｦ0020000076 707 026ｦ0010307apple6ｦ0 apple0706036ｦ0 (VEGF) 0807016ｦ0-096ｦ00207, 0ｹ00307 6 50ｸ80607010906 04apple076 5000000 0607 00apple086ｦ00009fl 6ｦ00000076 707 0002016ｦ0 6ｦ00606070ｷ30909apple04000306fl 6 7026ｦ06 5000ｸ803 07 apple6ｦ0090703 06 0300036ｦ0-06036ｦ003090ｹ00006010903 0807apple6ｦ0080000090003 6 70702076 500076 707 0307096 76ｦ0 09 006 707 07 0702070ｹ00001. ｨｨapple09 0ｹ1030703 6 50ｸ8fl6 502000007 06040ｸ70006036 50000000700 0600090800000900 0ｹ100 070209016 507apple00076 707 04apple076 500fl VEGF 6 5 09006ｦ0-03090100 0ｹ10202000103096 500076 707 08apple0703096 507070804030702006 5076 707 02000ｹ000-0009fl [37]. ｨ 06060200 076 56ｦ0000900 0607 00apple086ｦ00009fl 036ｦ003apple090106000ｸ803 0300036ｦ002020708apple07030009006ｦ009 6 5 0608090000070307096 7076 50706 0809 0107060309 070200000ｸ803 0807016ｦ0096ｦ00207, 0ｹ00307 006ｦ002090ｹ00900 08apple076ｦ00103096 509apple07-6 56ｦ000000ｸ803 090209 6ｦ00103096 5000ｸ803 0207apple03 0800026ｦ00309006ｦ0090ｸ8 02 09 05 fl6 502fl000306fl 070603076 500apple000ｸ803 08apple00 09010307apple0703 006ｦ002090ｹ009fl 090207016ｦ00ｹ00006036 50000000706 090003apple6ｦ00ｷ300apple00 apple6ｦ00200000706 07080403070209. 050ｸ8fl6 502000007 036ｦ0010800, 0ｹ00307 030700090307apple09006 7 0607 00apple086ｦ00009fl 6 5 0209016 507apple00 0800026ｦ00309006ｦ0090ｸ8 02 09 05 fl6 502fl000306fl 006ｦ0 0008000ｸ803 03000307 0703 08apple076 700070909apple076 56ｦ00009fl apple000ｷ309 096 56ｦ0 09 090606000309-006ｦ00ｷ30909 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 [38]. ｨ 03030400076 709060307030903090ｹ00006010906 03000307 (ｨ 0707), 07060007-6 56ｦ000000ｸ806 006ｦ0 0909040ｹ000000909 03016ｦ000006 50706 0ｹ1010608apple0006060909 apple6ｦ009-02090ｹ0000ｸ803 03070200010402flapple000ｸ803 036ｦ0apple0100apple076 5, 0807 06apple6ｦ06 5000000090ｸ9 06 09096 5000603000ｸ80309 03000307 6ｦ00309 6 70906030702076 7090ｹ00006010706 0701apple6ｦ0-060109 09006ｦ00ｹ009030002000007 07020000 0ｹ0046 506036 5090300020000 09 03070ｹ00000 [39ｨC41]. ｨｦ0607 07 09006ｦ00ｹ009030ｸ8 02fl 09 000003090209016ｦ00ｷ30909 0007-6 50707 apple6ｦ009076 56ｦ0000906 apple6ｦ00902090ｹ0000706 6 70906030708apple09apple07 0ｸ8 6ｦ00003090300-026ｦ0 01 0ｹ10809030002096ｦ0020000070304 6ｦ00003096 7000004 (0300036ｦ006036ｦ0090ｸ8 apple6ｦ0016ｦ0), 6 70209070209 apple0902flapple00070304 01090602070304 00020104 (6 7020907 026ｦ0060307-036ｦ0) 09 07 0ｸ7000304 02000601070ｷ309036ｦ0apple00070304 6ｦ00003096 7000004 (0209030207-036ｦ0). 0200036ｦ006036ｦ003090ｹ00006010900 6ｦ0 000007016ｦ0apple0ｷ3090007030ｸ8 0903000ｸ903 6 7090603070603apple04010304apple04, 060307 00040ｸ9 0607 090207016ｦ00ｹ00006036 50000000ｸ80309 086ｦ008090202flapple000ｸ80309 0ｹ1080000 090307036ｦ00309, 0307apple090709 086ｦ00809020207-036ｦ00309 09 086ｦ008090202flapple000ｸ80309 03000009006 70907036ｦ00309, 6 5 01070307apple0ｸ803, 07 006ｦ00107, 090303040007apple006ｦ00103096 50007060300 0ｹ10809030002096ｦ00200-00076 707 6ｦ00003096 700006ｦ0 0500r 00ｨｺ4 6 506006 7 6ｦ0 070306040306036 5040003. 05 03016ｦ0-00006 50ｸ803 07 apple6ｦ0090ｷ36ｦ003 6 509060ｷ300apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 apple6ｦ0016ｦ0 08apple0706036ｦ0030ｸ8, 6 5 030703 0ｹ009060200 0ｷ300apple00 apple6ｦ00200000ｸ803, 070303000ｹ000006ｦ0 0807090903096 5006ｦ0fl 0ｹ1010608apple00060609fl 08apple0706036ｦ0030608000ｷ30902090ｹ0000601076 707 6ｦ00003096 700006ｦ0 09 08apple0706036ｦ0030608000ｷ30902090ｹ00006010706 010906020706 020706-026ｦ0036ｦ0090ｸ8, 0ｹ1010608apple00060609fl 00076 5076 707 036ｦ0apple0100apple00076 707 08apple07030009-006ｦ0 P501S 070303000ｹ06ｦ0000306fl 6 5 98% 0602040ｹ06ｦ0006 5 [42]. ｨｨapple6ｦ00103090ｹ00006010700 6 50000 apple00000900 096ｦ06 700070603090ｹ00006010706 ｨ 0707-086ｦ000000209 0708apple00 00020000000ｸ803 6ｦ0000309030002 (01 0ｷ30903070100apple6ｦ00309006ｦ003, 6 509030000-03090004, 08apple070300090004 S-100, 0309apple000709 00070304 03apple6ｦ0000601apple09080ｷ309-070000070304 026ｦ0010307apple04-1, 0502 15-3, 0502 125) 0807096 50702fl0003 0708apple00 0002fl0300 6 70906030708apple09006ｦ0 0200080007060300 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 0909 000009096 500060300076 707 0800apple6 5090ｹ000076 707 apple6ｦ001076 507-6 707 070ｹ06ｦ06 76ｦ0 6 5 72,5% 0602040ｹ06ｦ0fl03 [39ｨC41]. 0000ｨｮ0004ｨ 00 0200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ07ｨｦ ｨｨｨｦｨｺ02050004ｨ ｨｹ 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 00000ｹ000000900 02ｨｨ0702 08apple09 ｨｺｨｨ05 fl6 502fl000306fl 06020708000706 096ｦ0 6ｦ00ｹ00006, 6 5 apple000400000909 01070307apple0706 070ｹ0000000 6 56ｦ0080000 01070308-02000106000ｸ806 0807 0307 ｨC 07080309036ｦ00200000700 06070ｹ000036ｦ0000900 apple6ｦ009-02090ｹ0000ｸ803 0300apple6ｦ008006 503090ｹ00006010903 03000307 076 5 6 5 apple6ｦ003016ｦ003 00 09000706 02000ｹ000 000706 0603apple6ｦ003006 70909 [8, 9, 14]. 05076 7026ｦ0060007 6ｦ000000ｸ803 02090300apple6ｦ00304apple0ｸ8 09 0607 06036 50000000ｸ803 006ｦ0 020ｸ9 00-0009fl03, 0800apple000ｹ00906020000000ｸ800 00090800 03000307 0ｸ8 02000ｹ0000009fl 02ｨｨ0702 6ｦ0006ｦ002076 7090ｹ0000ｸ8 03000307 6ｦ003, 08apple09030000fl00030ｸ803 08apple09 apple6ｦ00100 08apple00 06036ｦ003000200000706 08000200090ｸ8 06 0807apple6ｦ0080000090003 0307096 76ｦ0 [8, 9]. 0709apple04apple6 7090ｹ00006010700 02000ｹ000000900 070200000ｸ803 06 02ｨｨ0702 060ｹ009036ｦ0000306fl 6 7026ｦ06 5000ｸ803 026ｦ0010307apple0703, 0708apple00 0002fl0ｸ90ｸ70903 08apple07 07020809030002000007060300 09 016ｦ00ｹ00006036 507 0903 0809090009, 030703fl 08apple090007060903 07 02006 70ｹ000000900 030702000107 15ｨC20% 086ｦ00ｷ3090000036ｦ003 09 07016ｦ0090ｸ86 56ｦ0000306fl 006ｦ009 07020000 0ｹ10202000103096 5000ｸ803 04 070200-000ｸ803 06 0300036ｦ006036ｦ0096ｦ00309 030702000107 6 5 6 70702076 5000703 0307096 700 09, 6 7026ｦ06 5000ｸ803 07 apple6ｦ0090703, 08apple09 070200040903 07 0900070ｹ0000ｸ803 0807apple6ｦ008000009fl03 [5, 6, 10, 18, 20, 43]. ｨｨapple09 0309apple04apple6 7090ｹ000-06010703 02000ｹ000000909 070303000ｹ06ｦ0000306fl 066ｦ0036ｦ0fl 6 50ｸ80607016ｦ0fl 6 50ｸ80809-6 56ｦ0000307060300 070200000ｸ803, 0300 096ｦ0006ｦ0 6 50ｸ808096 56ｦ0000307060309 0607-06036ｦ06 502fl0003 8ｨC11 030006fl0ｷ3006 5, 6ｦ0 07 00076 707 090ｹ0006ｦ0fl 6 50ｸ808096 56ｦ000-0307060300 20ｨC25% [5, 6, 10, 18, 20, 43]. 05016ｦ0096ｦ000000700 070607-00000007 6ｦ00103046ｦ002000007 08apple09 0300036ｦ006036ｦ003090ｹ00006010703 ｨｺｨｨ05, 0807-06010702000104 02fl 00006 707 036ｦ0apple6ｦ0010300apple006ｦ0 6 50ｸ80607016ｦ0fl 0ｹ06ｦ0060307036ｦ0 0807fl6 502000009fl 07 0900070ｹ0000ｸ803 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5. 00040ｹ0006 56ｦ0fl 0300apple6ｦ00809fl (00ｨｪ) 006ｦ009 07020000 0406080004006ｦ0, 00060209 08apple09030000fl000306fl 08apple09 0300036ｦ006036ｦ0096ｦ003 6 70702076 500076 707 0307096 76ｦ0 036ｦ0-02076 707 07 ｨB00036ｦ0; 07 0ｸ70008apple0909006ｦ000000ｸ803 060ｹ009036ｦ0000306fl 0307-036ｦ00200000700 07 02040ｹ000000900 0307096 76ｦ0 [5, 21, 44, 45]. ｨｮ6ｦ0060307036ｦ0 0807020708090300020000076 707 07036 500036ｦ0 08apple09 08apple076 500 00000909 00ｨｪ 060706036ｦ06 502fl0003 40ｨC80%, 0300 096ｦ0006ｦ0 6 50ｸ808096 56ｦ0000307060309 0300-00fl000306fl 0703 1 07 5 030006fl0ｷ3006 5, 07 00076 707 090ｹ0006ｦ0fl 07 0ｸ76ｦ0fl 6 50ｸ808096 56ｦ0000307060300 006ｦ0 020ｸ9 6ｦ0000306fl 04 5ｨC15% 070200000ｸ803. 046ｦ0 02070000 08apple09030000000009fl 00ｨｪ 04 6ｦ0000306fl 070603090ｹ000 0706036ｦ0-03070ｹ00007 6 50ｸ80607010706 0ｹ06ｦ0060307030ｸ8 apple00030906060906 09 01070003apple0702fl apple07-06036ｦ0 0300036ｦ006036ｦ009076 5 6 5 0307096 700, 0007 0000 04 6ｦ0000306fl 046 50002090ｹ0090300 0009apple000ｷ309 096 500040ｸ9 09 07 0ｸ7040ｸ9 6 50ｸ808096 56ｦ0000307060300 [5, 21, 44, 45]. 05 0807060200 000900 6 707 0ｸ8 006ｦ0 06030ｸ80100 0309apple04apple6 70909 09 02040ｹ000-6 50706 0300apple6ｦ0080909 6 5 000006apple070700010702076 70909 6 507090009010207 00076 50700 6 50ｸ806070107030003000702076 7090ｹ0000700 006ｦ008apple6ｦ06 50200000900 ｨC apple6ｦ0 09070309apple04apple6 709fl, 01070307apple6ｦ0fl 08apple00 06036ｦ06 502fl0003 0607 0706 03070ｹ0000ｹ0000700 010700036ｦ00103000700 090209 0006010700036ｦ00103000700 6 50709 000606036 50900 apple6ｦ0-0907090902040ｹ00000090003 006ｦ0 070804030702006 5040ｸ9 030904000000. 05 0307-030000036ｦ0 6 50000 apple000009fl 060300apple0007036ｦ00106090ｹ00006010706 apple6ｦ0 09070309apple04apple6 70909 (05ｨｪｨｺ07) 06036ｦ00207 apple006ｦ0020000070603000ｸ9 0ｹ10202000103096 5000700 0309apple04apple6 7090ｹ00006010700 02000ｹ000000900 030007080006036 50000000ｸ803 0ｷ300apple00 - apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 apple6ｦ0016ｦ0 c 060703apple6ｦ0000000090003 04 076 50200-036 507apple090300020000076 707 016ｦ00ｹ00006036 56ｦ0 0809090009 070200000ｸ803 09 000909-010706 0807060200070800apple6ｦ00ｷ3090700000706 0200036ｦ0020000070603000ｸ9. ｨｦ 000903 0909 06040ｸ70006036 50000000ｸ803 08apple000903040ｸ70006036 5 05ｨｪｨｺ07 fl6 502fl000306fl 0307, 0ｹ00307 6 5 070302090ｹ00900 0703 0307036ｦ0020000076 707 07 02040ｹ0000009fl 6 707-02076 500076 707 0307096 76ｦ0 07006ｦ0 07 000608000ｹ0096 56ｦ00003 0000 030702000107 0207-016ｦ00200000ｸ806 01070003apple070200 apple0706036ｦ0 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ0-09076 5, 0007 09 046 50002090ｹ000000900 08apple07 07020809030002000007060309 0809090009, 070607 00000007 08apple09 0800apple6 5090ｹ00007 apple6ｦ0 0907apple0009090603000003000ｸ803 07 09-00070ｹ0000ｸ803 09 030007080006036 50000000ｸ803 0807apple6ｦ008000009fl03; 05ｨｪｨｺ07 0406-0800040007 08apple09030000fl000306fl 6 5 02000ｹ000000909 07 0900070ｹ0000ｸ803 09 030007-080006036 50000000ｸ803 086ｦ0apple00000309036ｦ0030709000ｸ803 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 ｨｺｨｨ05 [5, 46ｨC50].

130200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ00 ｨｨｨｦｨｺ02050004ｨ 00 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨｨｺｨ ｨｺｨｨ05 33 050000 apple00000900 6 5 000006apple070700010702076 7090ｸ9 030003000702076 70909 6 76ｦ003036ｦ0-0007086ｦ0 000001060002026ｦ0 0608070607 06036 5076 56ｦ00207 apple6ｦ0096 50903090ｸ9 0800apple0608000103096 500076 707, 020400010ｷ30907006ｦ002000007 0ｸ76ｦ0 fl0ｸ7006 707 09 07apple- 6 76ｦ00007060703apple6ｦ000fl0ｸ90ｸ7006 707 006ｦ008apple6ｦ06 502000009fl apple6ｦ0 09070309apple04apple- 6 70909 ｨC 6 76ｦ003036ｦ0-000708-apple6ｦ0 09070300apple6ｦ0080909 (0704ｨｺｨｪ). 05076 5apple00-030000006ｦ0fl 01070308000ｸ90300apple006ｦ0fl 09 apple07 0703070300030009016ｦ0, 03070ｹ00007 apple6ｦ006060ｹ009030ｸ86 56ｦ00ｸ90ｸ76ｦ0fl 08apple0700010ｷ3090ｸ9 07080403070209 09 07080309-036ｦ0020000040ｸ9 0709076 5040ｸ9 03070807030003apple090ｸ9, 0807096 50702fl0003 6 5 0906036ｦ0000ｷ3090700000703 apple0008090300 07 00076 5apple000300000007 060107000ｷ3000003apple09apple076 56ｦ00300 0603apple076 707 006ｦ0 070804030702006 50703 070ｹ06ｦ06 700 ( 0009 08076 5apple00-08 000009fl 0701apple04086ｦ00ｸ90ｸ70903 09 07apple076 50ｸ803 03016ｦ0000006) 030ｸ806fl0ｹ009 08040ｹ001076 5 6 50ｸ8060701070ｹ10000apple6 70003090ｹ0000601076 707 090902040ｹ0000009fl [51ｨC54]. 05 070302090ｹ00900 0703 0307036ｦ0020000076 707 07 02040ｹ0000009fl 6 707-02076 500076 707 0307096 76ｦ0 0704ｨｺｨｪ 0807096 50702fl0003 01070003apple070209apple076 56ｦ00300 apple070603 0ｷ300apple00 apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 6 5 85% 09 046 50002090ｹ0090300 0807016ｦ0096ｦ003000200 0300 096ｦ0000ｸ8 6 50ｸ808096 56ｦ0000307060309. ｨｹ6 502flfl0600 020400010ｷ30907006ｦ002000007 0ｸ76ｦ0 fl0ｸ70903 03000307 0703 02000ｹ0000009fl, 0704ｨｺｨｪ 0307080003 08apple09030000fl030006fl 08apple09 apple000ｷ309 096 56ｦ003 0ｷ300apple00 - apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 0807060200 08apple076 500 000009fl 0207016ｦ002000007-6 707 090209 0307036ｦ0020000076 707 07 02040ｹ0000009fl 0307096 76ｦ0 0009 046 7apple07090ｸ8 apple6ｦ0096 5090309fl 0600apple000009000ｸ803 0807 070ｹ0000ｸ803 0ｹ10202000103076 5 [51ｨC54]. ｨｴ0202000103096 50007060300 03090309070300apple6ｦ0080909 08apple09 02ｨｨ0702 000909016ｦ0fl 09 09006ｦ00ｹ009030002000007 04060304086ｦ00003 0ｹ10202000103096 50007060309 02000ｹ0000009fl 070200000ｸ803 06 0300036ｦ006036ｦ0096ｦ00309 apple6ｦ0016ｦ0 apple046 70706 0207-016ｦ00209096ｦ00ｷ30909, 08070ｹ103070304 07006ｦ0 6 5 070600076 5000703 08apple09030000fl000306fl 6 5 02000ｹ000000909 03090309070ｹ0046 506036 50903000200000ｸ803 0300036ｦ006036ｦ003090ｹ000-06010903 0708040307020006 [5, 11, 55, 56]. 0503apple6ｦ003006 709fl 08apple0903000000-0009fl 060906030003000706 03090309070300apple6ｦ0080909 02ｨｨ0702 066 5fl096ｦ0006ｦ0 06 6 5070903070800070603000ｸ9 06 00apple08096 56ｦ00009fl 08apple076 7apple00060609apple076 56ｦ00009fl 070600076 500076 707 070804030702006 5076 707 08apple070ｷ30006066ｦ0 09 0906060003090009apple07-6 56ｦ00000076 707 0807apple6ｦ008000009fl 090405 [8, 9]. ｨ 096 50006030007, 0ｹ00307 0300036ｦ006036ｦ003090ｹ00006010906 ｨｺｨｨ05 08apple07fl6 502fl0003 00090901040ｸ9 0ｹ0046 50603-6 509030002000007060300 01 0ｷ309030706036ｦ00309016ｦ003, 03076 7 6ｦ0 016ｦ001 6 707apple03070007-0300apple6ｦ00809fl (096ｦ001020ｸ90ｹ06ｦ00ｸ90ｸ76ｦ0fl06fl 6 5 0309apple04apple6 7090ｹ00006010706 090209 0300 09016ｦ0030000030709000706 016ｦ00603apple6ｦ00ｷ30909) 07 040602076 502096 56ｦ00003 6 50ｸ8-0607010906 08apple070ｷ3000003 08070207080903000200000ｸ803 07036 50003076 5 006ｦ0 02000ｹ000-000900 016ｦ001 0607 060307apple07000ｸ8 0800apple6 5090ｹ0000706 07080403070209, 036ｦ001 09 6 509060ｷ300apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5, 6 5 030703 0ｹ009060200 0ｷ300apple00 - apple6ｦ00200000ｸ803 0300036ｦ006036ｦ009076 5 [5, 11, 55, 56]. ｨ 02010004ｨｮ0004ｨ 00 05 066 5fl0909 06 00000401020700000ｸ803 apple0706030703 07000107096ｦ0 0702006 56ｦ000-0307060309 apple6ｦ001 08apple00 06036ｦ003000200000706 08000200090ｸ8 06 0300036ｦ006036ｦ003090ｹ00006010903 0807apple6ｦ0080000090003 6 70702076 500076 707 0307096 76ｦ0 08apple00 06036ｦ06 5-02fl0003 0607 0706 6ｦ00103046ｦ0020000040ｸ9 08apple07 02000304 06076 5apple00030000000706 0700010702076 70909. 050ｸ80607016ｦ0fl 0ｹ06ｦ0060307036ｦ0 0601apple0ｸ8030ｸ803 0207apple03 02ｨｨ0702, apple6ｦ0096 509030900 0300036ｦ006036ｦ009076 5 6 5 6 70702076 5000703 0307096 700 006ｦ0 02070000 07 0ｸ7006 707 04apple00076 707 08apple076 7apple00060609apple040ｸ90ｸ7006 707 03000ｹ0000009fl 06090603000300076 707 0300036ｦ006036ｦ003090ｹ0000601076 707 070804030702006 507-6 707 08apple070ｷ30006066ｦ0, 0409010906 0608000103apple 03000307 076 5 apple6ｦ000000006 09 066 507006 5apple00030000000706 096ｦ06 700070603090109 6 50307apple090ｹ000076 707 0807apple6ｦ00800-0009fl 0307096 76ｦ0, 036ｦ00207 026ｦ06 70708apple09fl03000ｸ806 01020900090ｹ00006010906 08apple076 7000709, 000909016ｦ0fl 0ｹ10202000103096 50007060300 0608000ｷ3096ｦ0020000076 707 02000ｹ0000009fl ｨC 6 50703 0300 6ｦ00103046ｦ00200000ｸ800 6 50708apple07060ｸ8, 01070307apple0ｸ800 03apple00 040ｸ903 00036ｦ0020000076 707 6ｦ0006ｦ00209096ｦ0 09 apple6ｦ009apple6ｦ0 07030109 07080309-036ｦ00200000ｸ803 0807 0307 076 5 02fl 0903 apple0004000009fl. 05ｨｨｨ 05ｨｦ01 00ｨ ｨｪ00ｨｺ02ｨｪｨｬｨｺ01 1.Ruijter E., van De Kaa C., Miller G. et al. Molecular genetics and epidemiology of prostate carcinoma // Endocrin. Rev. 1999. Vol. 20. P. 22ｨC45. 2.076ｦ000060700 01.ｨｨ., ｨ 03fl000903076 5 00.04. ｨｴ0809 0003090702076 709fl 09 090702076 709fl apple6ｦ0016ｦ0 08apple00 06036ｦ003000200000706 08000200090ｸ8 // ｨｨapple6ｦ00103090ｹ00006016ｦ0fl 0700010702076 709fl. 2001. 6ｧ8 6. 05. 3ｨC7. 3.0507apple07 00006 5 02.05. 0501apple090009006 7 0304080601076 707 006ｦ0060002000009fl, 06036ｦ000 6ｦ0apple03000700 07 060200 076 56ｦ0000900 086ｦ00ｷ309000003076 5, 01026ｦ00606090209-016ｦ00ｷ309fl apple6ｦ0016ｦ0 08apple00 06036ｦ003000200000706 08000200090ｸ8 // ｨｨapple6ｦ00103090ｹ000-06016ｦ0fl 0700010702076 709fl. 2001. 6ｧ8 6. 05. 8ｨC16. 4.Boyle P., Maisonneuve P., Napalkov P. Incidence of prostate cancer will double by the year 2030: arguments // Europ. J. Urol. 1996. Vol. 29 (suppl. 2). P. 3ｨC9. 5.026ｦ0apple030ｸ800076 5 03.05., 076ｦ006 6ｦ0apple 03.05., 00096 70702006 5 04.05., ｨｪapple04-026ｦ000076 5 07.00. 0200036ｦ006036ｦ003090ｹ00006010900 07080403070209 6 70702076 500076 707 0307096 76ｦ0 // ｨｨapple6ｦ00103090ｹ00006016ｦ0fl 000006apple070309apple04apple6 709fl (apple0401076 507 0603-6 507 02fl 6 5apple6ｦ00ｹ00006). 05ｨｨ, 2002. 05. 476ｨC485. 6.Gandola L., Navarria P., Lombardi F. Treatment of single brain metastases // Forum (Genova). 2001. Vol. 11. N 1. P. 38ｨC58. 7.Taillibert S., Delattre J. Metastatic tumors of the nervous system // J. Neurooncol. 2005. Vol. 75. 6ｧ8 10. P. 1ｨC3. 8.0509 07apple00000107 04.05. 0200036ｦ006036ｦ003090ｹ00006016ｦ0fl 0ｷ300apple00 apple6ｦ00200006ｦ0fl 070200090000: 00076 50ｸ800 0807 0307 0ｸ8 6 5 08apple070209026ｦ00103090100 09 02000ｹ000-000909. ｨｺ070603076 5 00/05, 2005. 380 06. 9.0206apple6ｦ0080003076 5 01.07. 04076 50ｸ800 0807 0307 0ｸ8 6 5 096ｦ06 700070603090100, 08apple070209026ｦ00103090100 09 02000ｹ000000909 0300036ｦ006036ｦ003090ｹ0000601076 707 0807apple6ｦ0-08000009fl 6 70702076 500076 707 0307096 76ｦ0 04 0700010702076 7090ｹ00006010903 070200-000ｸ803: 026 50307apple0002. 090606. ｭ -apple6ｦ0 0300. 006ｦ00401. ｨｺ070603076 5 00/05, 2006. 50 06. 10. 00096 70702006 5 04.05., 0709096ｦ0030402020900 ｨｰ.07. 0102090009016ｦ0 09 096ｦ06 7-0007060309016ｦ0 0300036ｦ006036ｦ009076 5 090207016ｦ00ｹ00006036 50000000ｸ803 0708040307020006 6 5 6 70702076 5000706 0307096 7 // 05000603000901 08apple6ｦ00103090ｹ00006010706 00006 5apple070207-6 70909. 1997. 6ｧ8 3. 05. 251ｨC259. 11. 030ｸ80ｹ001076 5 02.03., 0707apple 0400076 56ｦ0 05.02., ｨｦapple0002 04.06. 09 apple. 0000-016ｦ0apple06036 50000006ｦ0fl 0300apple6ｦ00809fl 08apple09 0300036ｦ006036ｦ0096ｦ003 6 5 6 70702076 5000706 0307096 7 // 05000603000901 03070601076 50601076 707 0700010702076 7090ｹ0000601076 707 07-0ｸ70006036 56ｦ0. 2004. 6ｧ8 1. 05. 5ｨC6. 12. Black P. Brain metastases: current status and recommended guidelines for management // Neurosurgery. 1979. Vol. 5. 6ｧ8 5. P. 617ｨC631. 13. Wen P.Y., Loeffler J.S. Brain metastases // Curr Treat Options Oncol. 2000. Vol. 1. 6ｧ8 5. P. 447ｨC458. 14. 0509 07apple00000107 04.05., 0206apple6ｦ0080003076 5 01.07. 020103046ｦ00200000ｸ800 08apple07 0200030ｸ8 apple006ｦ00209096ｦ00ｷ30909 0608000ｷ3096ｦ002090909apple076 56ｦ000000706 02000ｹ000-0007- 096ｦ06 700070603090ｹ00006010706 080703070ｸ709 0700010702076 7090ｹ00006010903 070200000ｸ803 06 0300036ｦ006036ｦ003090ｹ00006010903 0807apple6ｦ0080000090003 6 70702076 50007-6 707 0307096 76ｦ0 // ｨ 096 500060309fl 6 50ｸ806040903 040ｹ000 000ｸ803 096ｦ06 500 00000906. 05006 500apple07-016ｦ06 5016ｦ00906010906 apple006 7090700 (0006030006036 5. 006ｦ0040109). 2005. 6ｧ8 6. 05. 91ｨC96. 15. 0509 07apple00000107 04.05., ｨｰ0002fl0109006ｦ0 ｨｪ.05., 0109apple090ｹ000000107 04.07., 0206apple6ｦ0080003076 5 01.07. 09 apple. 05036ｦ003090603090ｹ00006016ｦ0fl 070ｷ30000016ｦ0 0300-3

1334 01.07. 0209ｨｺ02ｨｨ00ｨｪｨｦ05 036ｦ006036ｦ003090ｹ0000601076 707 0807apple6ｦ008000009fl 090405 ( 0006fl0309020003000906 0800apple0907 006ｦ0 020ｸ9 000009fl) // 050708apple07060ｸ8 0700010702076 70909. 2005. 6ｧ8 1. 05. 19ｨC20. 16. 02030300 076 5 03.ｨｨ. 0200036ｦ006036ｦ003090ｹ00006010900 07080403070209. 02., 1984. 187 06. 17. ｨｨ02000300006 5 05.05. 040001070307apple0ｸ800 6ｦ006080001030ｸ8 01020900090109, 096ｦ06 7-00070603090109 09 086ｦ00202096ｦ003096 500076 707 02000ｹ0000009fl 070200000ｸ803 06 0300036ｦ0-06036ｦ003090ｹ00006010903 0807apple6ｦ0080000090003 6 70702076 500076 707 0307096 76ｦ0 // ｨｨ6ｦ002-02096ｦ003096 5006ｦ0fl 0300 090ｷ309006ｦ0 09 apple006ｦ0 090209036ｦ00ｷ309fl. 1998. 6ｧ8 1. 05. 11ｨC15. 18. ｨｺ070307 6ｦ000076 5 02.ｨｨ., ｨ 07090402fl 04.02., 05070600076 5 04.05. 0200036ｦ0-06036ｦ003090ｹ00006010900 07080403070209 6 70702076 500076 707 0307096 76ｦ0. 0109006 5, 1973. 194 06. 19. 0104apple6ｦ003040900 02.06. ｨｦ0803090309096ｦ00ｷ309fl 096ｦ06 700070603090109 0300036ｦ0-06036ｦ009076 5 6 5 6 70702076 5000706 0307096 7 04 0700010702076 7090ｹ00006010903 070200000ｸ803: 026 50307apple0002. 090606. ｭ 016ｦ000. 0300. 006ｦ00401. ｨｬ026ｦ0, 2000. 20 06. 20. 016ｦ0apple6ｦ0036ｦ000 05.03., 0500030000076 56ｦ0 05.03., 03apple0ｸ903076 5000ｷ3010906 02.05. 09 apple. ｨｨapple07 0200030ｸ8 096ｦ06 700070603090109 09 0309apple04apple6 70909 0300036ｦ006036ｦ003090ｹ00006010903 0708040307020006 0307096 76ｦ0 // 05000603000901 03070601076 50601076 707 0700-010702076 7090ｹ0000601076 707 07 0ｸ70006036 56ｦ0. 2004. 6ｧ8 1. 05. 3ｨC4. 21. 02090309006ｦ0 ｨ.ｨｨ., 04apple00006 56ｦ0 ｨｪ.05., 046ｦ006030200036ｦ0046 5090209 05.ｨｺ., 05070201076 56ｦ0 02.ｨ., 0109apple076 5 02.02. 00040ｹ0006 56ｦ0fl 0300apple6ｦ00809fl 0300036ｦ0-06036ｦ009076 5 6 5 6 70702076 5000706 0307096 7 0708040307020006 apple6ｦ00902090ｹ0000706 0207016ｦ0-0209096ｦ00ｷ30909 // 026ｦ003-020ｸ8 VI 0008006 707 000706 apple070606090606010706 07000107-02076 7090ｹ00006010706 0107000200apple00000ｷ30909 (02., 26ｨC28 0007fl applefl 2002 6 7.). 02., 2002. 05. 38ｨC41. 22. 036ｦ0 0ｹ00900 ｨ.05., 036ｦ0 0ｹ009006ｦ0 ｨ.ｨｨ., 016ｦ002010400 05.ｨｺ. 0200036ｦ006036ｦ0-03090ｹ00006010906 apple6ｦ001 0307096 76ｦ0. 00., 1974. 192 06. 23. 0400apple060006fl000ｷ3 05.ｨ. 0102090009016ｦ0 09 0307apple020702076 709fl 0300036ｦ006036ｦ0-03090ｹ0000601076 707 apple6ｦ0016ｦ0 6 70702076 500076 707 0307096 76ｦ0: 05090606. ｭ 016ｦ000. 0300. 006ｦ00401. 02., 1954. 343 06. 24. 056ｦ0026ｦ0apple076 5 03.ｨ. 0200036ｦ006036ｦ0090ｸ8 0708040307020006 6 5 6 70702076 5000706 0307096 7: 026 50307apple0002. 090606. ｭ 016ｦ000. 0300. 006ｦ00401. 05ｨｨ, 2004. 19 06. 25. Kaal E.C.A., Taphoorn M.J.B., Vecht C.J. Symptomatic management and imaging of brain metastases // J. Neurooncol. 2005. Vol. 75. 6ｧ8 10. P. 15ｨC20. 26. 050706006ｦ0apple006 5090ｹ0 02.ｨｦ., 02090309006ｦ0 ｨ.ｨｨ., 016ｦ00606090200 05.00. 09 apple. 05096ｦ06 70007060309016ｦ0 09 02000ｹ000000900 0300036ｦ006036ｦ003090ｹ0000601076 707 0807apple6ｦ00800-0009fl 0000apple6 5000706 0609060300030ｸ8 04 0700010702076 7090ｹ00006010903 070200000ｸ803 // ｨｺ070606090606010906 0700010702076 7090ｹ00006010906 0804apple006ｦ002. 2002. 6ｧ8 4. 05. 25ｨC30. 27. 050706006ｦ0apple006 5090ｹ0 02.ｨｦ. 01020900090ｹ00006010900 08apple07fl6 502000009fl 0300036ｦ0-06036ｦ009076 5 6 70702076 500076 707 0307096 76ｦ0 // 05000603000901 03070601076 50601076 707 0700-010702076 7090ｹ0000601076 707 07 0ｸ70006036 56ｦ0. 2004. 6ｧ8 1. 05. 4ｨC5. 28. 07040603076 5 02.05., 05096 7apple096ｦ00006010906 01.ｨ., 05030702flapple076 56ｦ0 05.ｨｨ. ｨｨapple6ｦ00103090ｹ00006016ｦ0fl 000006apple070702036ｦ00200030702076 709fl. 040908000906 04076 56 707apple07, 2003. 260 06. 29. 02 6ｦ004006 5-01070006036ｦ000030900076 506010906 02.00. ｨｨ06090307086ｦ003070207-6 709fl 08apple09 070804030702fl03 6 70702076 500076 707 0307096 76ｦ0. 02., 1973. 200 06. 30. 0500 01076 56ｦ0 00.02., ｨｺ6ｦ0 0000 02.05. ｨｨ6ｦ0apple6ｦ000000708026ｦ00603090ｹ00006010900 096ｦ0 0702006 56ｦ00009fl. 02., 1977. 135 06. 31. 04076 50901076 5 07.02., 076ｦ0000ｷ3006 5 ｨｰ.07., ｨｺ04 0706 05.05. 09 apple. 02000307-0ｸ8 000307010609016ｦ00ｷ30909 6 5 0402040ｹ00400000909 016ｦ00ｹ00006036 56ｦ0 0809090009 070200000ｸ803 06 apple6ｦ00608apple070603apple6ｦ0000000000ｸ80309 0207apple036ｦ00309 090207016ｦ00ｹ000-06036 50000000ｸ803 00076 50707 apple6ｦ009076 56ｦ0000906 // ｨｨapple07 0200030ｸ8 086ｦ00202096ｦ0-03096 5000706 080703070ｸ709 6 5 0700010702076 70909 (6ｦ000030702076 709fl 006ｦ0040ｹ0000ｸ803 0804 0209016ｦ00ｷ30906). ｨｪ. IｨCII. 02., 2002. 05. 605ｨC612. 32. 076ｦ0000ｷ3006 5 ｨｰ.07., 0104apple6ｦ003040900 02.06., 016ｦ008apple6ｦ002076 5 05.05., 0707000ｹ06ｦ0apple076 56ｦ0 ｨｦ.05. 05076 5apple00030000000ｸ800 0807 0307 0ｸ8 01 096ｦ06 700070603090100 0300036ｦ006036ｦ009076 5 6 5 6 70702076 5000706 0307096 7 // ｨｦ00010702076 709fl: 030007apple09fl 09 08apple6ｦ0010309016ｦ0. 2004. 6ｧ8 1. 05. 29ｨC35. 33. 0507 apple076 707apple06016ｦ0fl 00.04., 04apple000001076 56ｦ0 05.ｨｨ. 020200026ｦ0-2-036ｦ001apple076 70207 04020900 6 5 0608090000070307096 7076 50706 0809 0107060309 070200000ｸ803 08apple09 000006apple070700010702076 7090ｹ00006010903 096ｦ0 0702006 56ｦ00009fl03 // 02010304-6ｦ00200000ｸ800 6 50708apple07060ｸ8 00006 5apple0702076 70909 09 000006apple070309apple04apple6 70909: 05. 006ｦ0040ｹ0. 03apple. ｨｺ070603076 5 00/05, 1999. 05. 43. 34. 05036ｦ0apple0ｹ000000107 02.02. 05096ｦ0090307 000606036 50900 0000apple6 5000706 09 0903030400-000706 060906030003: 00076 50ｸ800 0800apple0608000103096 50ｸ8 02fl 01020900090ｹ00006010706 000006apple070309apple04apple6 70909 09 000006apple07apple006ｦ00009036ｦ0030702076 70909 // 01020900090ｹ000-06016ｦ0fl 000006apple0709030304000702076 709fl 0309apple04apple6 7090ｹ00006010903 096ｦ0 0702006 56ｦ0-000906 6 70702076 500076 707 0307096 76ｦ0. ｨｮ. 1. 05ｨｨ, 2001. 05. 56ｨC91. 35. 096 500036ｦ000076 56ｦ0 00.02. 0009016 507apple0702076 709fl. 0109006 5, 1986. 371 06. 36. Lampl Y., Paniri Y., Eshel Y. LDH isoenzymes in cerebrospinal fluid in various brain tumours // J. of Neurology, Neurosurgery, and Psychiatry. 1990. Vol. 53. P. 697ｨC699. 37. Stockhammer G., Obwegeser A., Kostron H., Schumacher P. et al. Vascular endothelial growth factor (VEGF) is elevated in brain tumor cysts and correlates with tumor progression. // Acta Neuropathol (Berl). 2000. Vol. 100. 6ｧ8 1. P. 101ｨC105. 38. Friedberg M.H., Glantz M.J., Klempner M.S., Cole B.F., Perides G. Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis // Cancer. 1998. Vol. 82. 6ｧ8 5. P. 923ｨC930. 39. 0107apple040400076 5 02.07., 006ｦ0030300006 56ｦ0 05.05. ｨ 03030400076 709060307030903090ｹ00006010700 0909040ｹ000000900 0ｹ1010608apple0006060909 0ｹ10809030002096ｦ0020000076 707 6ｦ0000309-6 700006ｦ0 BER EP4 09 apple046 70903 03016ｦ000000608000ｷ30902090ｹ00006010903 6ｦ0000309-6 70000076 5 6 5 0800apple6 5090ｹ0000ｸ803 09 0300036ｦ006036ｦ003090ｹ00006010903 070804030702fl03 6 70702076 500076 707 0307096 76ｦ0 // 02apple03096 5 086ｦ0030702076 70909. 1998. 6ｧ8 6. 05. 15ｨC21. 40. ｨｨ0003apple076 5 05.05., ｨｺ6ｦ00603020900 04.ｨｪ. 09 apple. ｨｺ0401076 507 06036 507 0807 0903030400076 709060307030903090ｹ00006010706 096ｦ06 700070603090100 0708040307020006 0ｹ00002076 500016ｦ0. 016ｦ0096ｦ00000, 2000. 287 06. 41. Kleihues P., Cavenee W.K. Pathology and Genetics of Tumors of the Nervous System. Metastatic Tumors of the CNS // WHO Classification of Tumors. Lyon: IARC Press, 2000. P. 249ｨC253. 42. Sheridan T., Herawi M., Epstein L., Illei P.B. The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate // Am. J. Surg. Pathol. 2007, Sep. Vol. 31. 6ｧ8 9. ｨｺ. 1351ｨC1355. 43. Nussbaum E.S., Djalilian H.R., Cho K.H., Hall W.A. Brain metastases. Histology, multiplicity, surgery, and survival // Cancer. 1996. Vol. 78. N 8. P. 1781ｨC1788. 44. Lutterbach J., Bartelt S., Ostertag C. Long-term survival in patients with brain metastases // J. Cancer Res. Clin. Oncol. 2002. Vol. 128. 6ｧ8 8. P. 417ｨC425. 45. Bonerandi J.J., Hesse S. Treatment of brain metastases of malignant melanoma: value of fotemustine // Drugs Today. 1996. Vol. 32 (Suppl. E). P. 29ｨC34. 46. Brown P.D., Brown C.A., Pollock B.E., Gorman D.A., Foote R.L. Stereotactic radiosurgery for patients with ｰradioresistant ｱ brain metastases // Neurosurgery. 2002. Vol. 51. 6ｧ8 3. ｨｺ. 656ｨC665. 47. Kim S.H., Chao S.T., Toms S.A., Vogelbaum M.A., Barnett G.H., Suh J.H., Weil R.J. Stereotactic radiosur-

130200ｨｪ0205ｨｪ02ｨｪｨ ｨｮ000501ｨｦ00 ｨｨｨｦｨｺ02050004ｨ 00 07ｨｦ00ｨｦ0504ｨｦ07ｨｦ 02ｨｦｨ 0702 ｨｨｨｺｨ ｨｺｨｨ05 35 gical treatment of parenchymal brain metastases from prostate adenocarcinoma // Surg. Neurol. 2008 Jun. Vol. 69. 6ｧ8 6. ｨｺ. 641ｨC646. 48. Modha A., Shepard S.R., Gutin P.H. Surgery of brain metastases ｨC Is there still a place for it? // J. Neurooncol. 2005. Vol. 75. 6ｧ8 10. P. 21ｨC29. 49. Chang S.D., Lee E., Sakamoto G.T., Brown N.P., Adler J.R. Stereotactic radiosurgery in patient with multiple brain metastases // Neurosurg. Focus. 2000. Vol. 9. 6ｧ8 2. ｨｺ. 6ｨC10. 50. Chang E.L., Selek U., Hassenbusch S.J. et al. Outcome variation among ｰradioresistant ｱ brain metastases treated with stereotactic radiosurgery // Neurosurgery. 2005. Vol. 56. 6ｧ8 5. ｨｺ. 936ｨC945. 51. Yamamoto M., Ide M., Nishio S., Urakawa Y. Gamma Knife radiosurgery for numerous brain metastases: is this a safe treatment? // Int. J. Radiat. Oncol. Biol. Phys. 2002. Vol. 53. 6ｧ8 5. P. 1279ｨC1283. 52. Vesagas T.S., Aguilar J.A., Mercado E.R., Mariano M.M. Gamma knife radiosurgery and brain metastases: local control, survival, and quality of life // J. Neurosurg. 2002. Vol. 97 (5 Suppl). P. 507ｨC 510. 53. Pan H.C., Sheehan J., Stroila M., Steiner M., Steiner L. Gamma knife surgery for brain metastases from lung cancer // J. Neurosurg. 2005. Vol. 102 (Suppl). P. 128ｨC133. 54.Nam T.K., Lee J.I., Jung Y.J., Im Y.S. et al. Gamma knife surgery for brain metastases in patients harboring four or more lesions: survival and prognostic factors // J. Neurosurg. 2005. Vol. 102 (Suppl). P. 147ｨC150. 55. ｨｨ07 04 006ｦ0fl ｨ.05. 04076 50ｸ806 6 50001 ｨC 00076 50ｸ800 6 507090307080007060309 03090309070300apple6ｦ0080909: 03000307 6ｦ002 6 5 02000ｹ000000909 090207016ｦ00ｹ00006036 50000-000ｸ803 0708040307020006 // 05076 5apple00030000006ｦ0fl 0700010702076 709fl. 2002. ｨｪ. 4. 6ｧ8 1. 05. 12ｨC16. 56. 01070006036ｦ000030900076 56ｦ0 02.02. 05076 5apple00030000000700 0607060307fl000900 09 0800apple0608000103096 50ｸ8 03090309070300apple6ｦ0080909 090207016ｦ00ｹ00006036 50000000ｸ803 0708040307020006 6 70702076 500076 707 0307096 76ｦ0 // 05076 5apple00030000006ｦ0fl 0700010702076 709fl. 2002. ｨｪ. 4. 6ｧ8 3. 05. 144ｨC149. METASTATIC BRAIN LESION IN PROSTATE CANCER K.G. Airapetov In the paper main aspects of the problem of metastatic brain lesion in prostate cancer are considered. The most urgent questions, such as high frequency of latent forms of brain lesion, narrow spectrum of the methods of early and timely diagnostics of cerebral lesions, unfavourable clinical prognosis, and low efficacy of special treatment, were accentuated and analyzed. Similar complex analysis of the problem is necessary for the elaboration of effective methods of diagnostics and treatment of this severe disease. Key words: prostate cancer, metastatic brain lesion. 3*

13REFERENCES 1. Ruijter E., van De Kaa C., Miller G. et al. 1999. Molecular genetics and epidemiology of prostate carcinoma. Endocrin. Rev. 20: 22ｨC45. 2. Khanson K.P., Imyanitov E.N. 2001. [Epidemiology and biology of prostate cancer]. Prakticheskaya onkologiya. 6: 3ｨC7. (In Russian). 3. Vorob'ev A.V. 2001. [Screening of the male population, the standard examination of patients, classification of prostate cancer]. Prakticheskaya onkologiya. (6): 8ｨC16. (In Russian). 4. Boyle P., Maisonneuve P., Napalkov P. 1996. Incidence of prostate cancer will double by the year 2030: arguments. Europ. J. Urol. 29(suppl. 2): 3ｨC9. 5. Martynov B.V., Gaydar B.V., Shchigolev Yu.S., Trufanov G.E. 2002. [Metastatic brain tumor]. In: Prakticheskaya neyrokhirurgiya (rukovodstvo dlya vrachey). [Practical Neurosurgery (manual for physicians)]. St. Petersburg: 476ｨC485. (In Russian). 6. Gandola L., Navarria P., Lombardi F. Treatment of single brain metastases. Forum (Genova). 2001. 11(1): 38ｨC 58. 7. Taillibert S., Delattre J. 2005. Metastatic tumors of the nervous system. J. Neurooncol. 75(10): 1ｨC3. 8. Sidorenko Yu.S. 2005. Metastaticheskaya tserebral'naya bolezn': novye podkhody v profilaktike i lechenii. [Metastatic disease is cerebral, new approaches to prevention and treatment]. Rostov-on-Don: 380 p. (In Russian). 9. Ayrapetov K.G. 2006. Novye podkhody v diagnostike, profilaktike i lechenii metastaticheskogo porazheniya golovnogo mozga u onkologicheskikh bol'nykh. Avtoref. dis. ｭ d-ra med. nauk. [New approaches in diagnosis, prevention and treatment of metastatic brain lesions in patients with cancer. Doctor's Thesis Abstract]. Rostov-on-Don: 50 p. (In Russian). 10. Shchigolev Yu.S., Gizatullin Sh.Kh. 1997. [Clinic and diagnosis of metastases of malignant tumors in the brain]. Vestnik prakticheskoy nevrologii. (3): 251ｨC259. (In Russian). 11. Bychkov M.B., Gorbunova V.A., Orel N.F. et al. 2004. [Drug therapy for brain metastases]. Vestnik moskovskogo onkologicheskogo obshchestva. (1): 5ｨC6. (In Russian). 12. Black P. 1979. Brain metastases: current status and recommended guidelines for management. Neurosurgery. 5(5): 617ｨC631. 13. Wen P.Y., Loeffler J.S. 2000. Brain metastases. Curr Treat Options Oncol. 1(5): 447ｨC458. 14. Sidorenko Yu.S., Ayrapetov K.G. 2005. [Actual problems of the implementation of a specialized medicaldiagnostic help cancer patients with metastatic brain damage]. Izvestiya vysshikh uchebnykh zavedeniy. Severo- Kavkazskiy region (estestv. nauki). (6): 91ｨC96. (In Russian). 15. Sidorenko Yu.S., Shelyakina T.V., Kirichenko Yu.G., Ayrapetov K.G. et al. 2005. [Statistical evaluation of metastatic lesions of the CNS (the ten-year period of observation)]. Voprosy onkologii. (1): 19ｨC20. (In Russian). 16. Akhmedov B.P. 1984. Metastaticheskie opukholi. [Metastatic tumors]. Moscow: 187 p. (In Russian). 17. Pletnev D.D. 1998. [Some aspects of the clinic, diagnosis and palliative treatment of patients with metastatic brain]. Palliativnaya meditsina i reabilitatsiya. (1): 11ｨC15. (In Russian). 18. Romodanov A.P., Zozulya Yu.A., Sosnov Yu.D. 1973. Metastaticheskie opukholi golovnogo mozga. [Metastatic brain tumor]. Kiev: 194 p. (In Russian). 19. Kuramshin A.F. 2000. Optimizatsiya diagnostiki metastazov v golovnoy mozg u onkologicheskikh bol'nykh. Avtoref. dis. ｭ kand. med. nauk. [Optimizing diagnosis of brain metastases in cancer patients. PhD Thesis Abstract]. Ufa: 20 p. (In Russian). 20. Karakhan V.B., Semenova Zh.B., Bryukhovetskiy A.S. et al. 2004. [Problems of diagnosis and surgery of metastatic brain tumors]. Vestnik moskovskogo onkologicheskogo obshchestva. (1): 3ｨC4. (In Russian).

1321. Mikhina Z.P., Yur'eva T.V., Naskhletashvili D.R., Volkova M.I., Kirov A.A. 2002. [Radiation therapy for brain metastases of tumors of different localizations]. In: Materialy VI ezhegodnoy rossiyskoy onkologicheskoy konferentsii (Moskva, 26ｨC28 noyabrya 2002 g.). [Proceedings of the VI annual Russian oncology conference (Moscow, 26ｨC28 November 2002)]. Moscow: 38ｨC41. (In Russian). 22. Babchin I.S., Babchina I.P., Kalkun V.R. 1974. Metastaticheskiy rak mozga. [Metastatic brain cancer]. Leningrad: 192 p. (In Russian). 23. Nersesyants S.I. 1954. Klinika i morfologiya metastaticheskogo raka golovnogo mozga. Dis. ｭ kand. med. nauk. [The clinic and morphology of metastatic brain cancer. PhD Thesis]. Moscow: 343 p. (In Russian). 24. Safarov B.I. 2004. Metastazy opukholey v golovnoy mozg. Avtoref. dis. ｭ kand. med. nauk. [Metastatic tumors to brain. PhD Thesis Abstract]. St. Petersburg: 19 p. (In Russian). 25. Kaal E.C.A., Taphoorn M.J.B., Vecht C.J. 2005. Symptomatic management and imaging of brain metastases. J. Neurooncol. 75(10): 15ｨC20. 26. Voynarevich A.O., Mikhina Z.P., Kassil' V.L. et al. 2002. [Diagnosis and treatment of metastatic lesions of the nervous system in cancer patients]. Rossiyskiy onkologicheskiy zhurnal. (4): 25ｨC30. (In Russian). 27. Voynarevich A.O. 2004. [Clinical manifestations of brain metastases]. Vestnik Moskovskogo onkologicheskogo obshchestva. (1): 4ｨC5. (In Russian). 28. Gustov A.V., Sigrianskiy K.I., Stolyarova Zh.P. 2003. Prakticheskaya neyrooftal'mologiya. [Practical Neuro Ophthalmology]. Nizhny Novgorod: 260 p. (In Russian). 29. Abashev-Konstantinovskiy A.L. 1973. Psikhopatologiya pri opukholyakh golovnogo mozga. [Psychopathology in brain tumors]. Moscow: 200 p. (In Russian). 30. Dedkova E.M., Raben A.S. 1977. Paraneoplasticheskie zabolevaniya. [Paraneoplastic diseases]. Moscow: 135 p. (In Russian). 31. Novikov G.A., Gantsev Sh.Kh., Rudoy S.V. et al. 2002. [Detoxification methods to improve the quality of life of patients with common forms of malignant neoplasms]. In: Problemy palliativnoy pomoshchi v onkologii (antologiya nauchnykh publikatsiy). [Problems of palliative care in oncology (anthology of scientific publications)]. Vol. IｨCII. Moscow: 605ｨC612. (In Russian). 32. Gantsev Sh.Kh., Kuramshin A.F., Kapralov V.V., Goncharova O.V. 2004. [Current approaches to the diagnosis of brain metastases]. Onkologiya: teoriya i praktika. (1): 29ｨC35. (In Russian). 33. Dobrogorskaya L.N., Yurenkova S.P. 1999. [Alpha-2-macroglobulin in the cerebrospinal fluid of patients with neuro oncology]. In: Aktual'nye voprosy nevrologii i neyrokhirurgii. Sbornik nauchnykh trudov. [Topical Issues of Neurology and Neurosurgery. Collection of scientific papers]. Rostov-on-Don: p. 43. (In Russian). 34. Starchenko ｧ.ｧ. 2001. [Interaction of nervous and immune systems: new perspectives for clinical neurosurgery and neyroreanimatologii]. In: Klinicheskaya neyroimmunologiya khirurgicheskikh zabolevaniy golovnogo mozga. [Clinical neuroimmunology surgical diseases of the brain]. Part. 1. St. Petersburg: 56ｨC91. (In Russian). 35. Tsvetanova E.M. 1986. Likvorologiya. [Likvorologiya]. Kiev: 371 p. (In Russian). 36. Lampl Y., Paniri Y., Eshel Y. 1990. LDH isoenzymes in cerebrospinal fluid in various brain tumours. J. of Neurology, Neurosurgery, and Psychiatry. 53: 697ｨC699. 37. Stockhammer G., Obwegeser A., Kostron H., Schumacher P. et al. 2000. Vascular endothelial growth factor (VEGF) is elevated in brain tumor cysts and correlates with tumor progression. Acta Neuropathol (Berl). 100(1): 101ｨC105. 38. Friedberg M.H., Glantz M.J., Klempner M.S., Cole B.F., Perides G. 1998. Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis. Cancer. 82(5): 923ｨC930. 39. Korshunov A.G., Lakhteeva S.V. 1998. [Immunohistochemical study of the expression of the epithelial antigen EP4 BER and other tissue-specific antigen in primary and metastatic brain tumors]. Arkhiv patologii. (6): 15ｨC 21. (In Russian).

1340. Petrov S.V., Raykhlin N.T. et al. 2000. Rukovodstvo po immunogistokhimicheskoy diagnostike opukholey cheloveka. [Guidelines for immunohistochemical diagnosis of human tumors]. Kazan: 287 p. (In Russian). 41. Kleihues P., Cavenee W.K. 2000. Pathology and Genetics of Tumors of the Nervous System. Metastatic Tumors of the CNS. In: WHO Classification of Tumors. Lyon, IARC Press: 249ｨC253. 42. Sheridan T., Herawi M., Epstein L., Illei P.B. 2007. The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate. Am. J. Surg. Pathol. Sep. 31(9): 1351ｨC1355. 43. Nussbaum E.S., Djalilian H.R., Cho K.H., Hall W.A. 1996. Brain metastases. Histology, multiplicity, surgery, and survival. Cancer. 78(8): 1781ｨC1788. 44. Lutterbach J., Bartelt S., Ostertag C. 2002. Long-term survival in patients with brain metastases. J. Cancer Res. Clin. Oncol. 128(8): 417ｨC425. 45. Bonerandi J.J., Hesse S. 1996. Treatment of brain metastases of malignant melanoma: value of fotemustine. Drugs Today. 32(Suppl. E): 29ｨC34. 46. Brown P.D., Brown C.A., Pollock B.E., Gorman D.A., Foote R.L. 2002. Stereotactic radiosurgery for patients with ｰradioresistant ｱ brain metastases. Neurosurgery. 51(3): 656ｨC665. 47. Kim S.H., Chao S.T., Toms S.A., Vogelbaum M.A., Barnett G.H., Suh J.H., Weil R.J. 2008. Stereotactic radiosurgical treatment of parenchymal brain metastases from prostate adenocarcinoma. Surg. Neurol. Jun.69(6): 641ｨC646. 48. Modha A., Shepard S.R., Gutin P.H. 2005. Surgery of brain metastases 6ﾓ1 Is there still a place for it? J. Neurooncol. 75(10): 21ｨC29. 49. Chang S.D., Lee E., Sakamoto G.T., Brown N.P., Adler J.R. 2000. Stereotactic radiosurgery in patient with multiple brain metastases. Neurosurg. Focus. 9(2): 6ｨC10. 50. Chang E.L., Selek U., Hassenbusch S.J. et al. 2005. Outcome variation among ｰradioresistant ｱ brain metastases treated with stereotactic radiosurgery. Neurosurgery. 56(5): 936ｨC945. 51. Yamamoto M., Ide M., Nishio S., Urakawa Y. 2002. Gamma Knife radiosurgery for numerous brain metastases: is this a safe treatment? Int. J. Radiat. Oncol. Biol. Phys. 53(5): 1279ｨC1283. 52. Vesagas T.S., Aguilar J.A., Mercado E.R., Mariano M.M. 2002. Gamma knife radiosurgery and brain metastases: local control, survival, and quality of life. J. Neurosurg. 97(5 Suppl): 507ｨC510. 53. Pan H.C., Sheehan J., Stroila M., Steiner M., Steiner L. 2005. Gamma knife surgery for brain metastases from lung cancer. J. Neurosurg. 102(Suppl): 128ｨC133. 54. Nam T.K., Lee J.I., Jung Y.J., Im Y.S. et al. 2005. Gamma knife surgery for brain metastases in patients harboring four or more lesions: survival and prognostic factors. J. Neurosurg. 102(Suppl): 147ｨC150. 55. Poddubnaya I.V. 2002. [New century ｨC new opportunities chemotherapy: Temodal in the treatment of malignant tumors]. Sovremennaya onkologiya. 4(1): 12ｨC16. (In Russian). 56. Konstantinova M.M. 2002. [Current state and prospects of chemotherapy of malignant brain tumors]. Sovremennaya onkologiya. 4(3): 144ｨC149. (In Russian).