2007 12 1 871146 IF 1998 9 350mg 250mg 100mg 10mg 10mg Sodium Salicylate Sulpyrine Hydrate Caffeine Hydrate Allobarbital Procaine Hydrochloride 2007 8 31 2007 12 21 1955 2 FAX TEL FAX IF 2007 12 6
IF 1 MR 63 2 IF 10 3 IF 2 IF IF IF 3 IF A4 9 IF IF IF 11 1 IF IF 4 IF IF MR IF IF MR Drug Safety Update IF
1 2 1 2 3 4 5 6 7 CAS 1 2 3 4 5 1 2 3 4 5 6 7 8 9 10 1 2 3 1 2 1 2 3 4 5 6 7 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 1 2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 1 2
1 1 1871 olbe tricker,clamann. ee 2 1910 1912 3 1820 unge 1895 1899. isher 4 1911 asel 1915 astaldi 1914 iba ial 5 inhorn raun ichst ovocain 2 1
1 10mL 2 Sodium Salicylate Sulpyrine Hydrate Caffeine Hydrate Allobarbital Procaine Hydrochloride 3 2
4 C H NaO 160.10 C13H16N NaO4S H2O 351.35 C8 H10N4O2 H O 212.21 C10H10N2O 208.22 C13H10N2O2 HCl 272.77 5 6 Monosodium 2-hydroxybenzoate Monosodium[(1,5-Dimethyl-3-oxo-2-phenyl-2,3- dihydro-1h-pyrazol-4-yl)-(methyl)amino] methanesulfonate monohydrate 1 3 7-Trimethyl-1H-purine-2 6-3H 7H -dione monohydrate 5 5-Di-2-propenyl-2 4 6-1H 3H 5H -pyrimidinetrione 2- Diethylamino ethyl 4-aminobenzoate monohydrochloride 7 CAS CAS 54-21-7 5907-38-0 5743-12-4 52-43-7 51-05-8 3
4 1 2 1 2 100 95 95 100 95 95 95 3 4 158 161 224 225 235 238 172 175 155 158
5 6 7 2.0 20mL H 6.0 8.0 1.0g 100mL H 5.5 6.5 H 5.5 6.5 1.0g 20mL H 5.0 6.0 3 4 9 5 9 6 5
1 1 1 10mL 2 ph ph ph 5.5 6.5 1.8 2.1 3 4 2 1 350mg 250mg 100mg 10mg 10mg 2 10mg 3 3 1 2 (1000 ) () 100 78.5 340 C 6
4 H 5.5 6.5 10mL 1 10 L H 5.800.1mol/L HC 9.6 L H 3.31 10mL 1 10 L H 5.80 0.1mol/L NaOH 10.0 L H 12.40 24 5 6 7 8 9 10 7
1 2 10mL 2.5mL 3 1 2 3 4 1 2 3 4 5 1 2 8
1 2 1 1 10mL 2 2 3 rithing 17.5 17.5 SS 112.5mg kg Sp 87.5mg kg Cf 35.0mg kg Ab 3.5mg kg Pc 3.5mg kg 9
1 1 2 3 4 2 1 2 3 4 5 6 3 4 1 2 3 4 5 10
5 1 4) 5) - -- - - - 6) 1,7 7) 5- -5-(2,3 -- 2 CYP450 3 4 5 11
6 1 2 3 7 1 8) 9) 6) 7) 24 100 14 80 90 2 3 12
1 2 1 2-3 4 5 6 3 4 5 1 2 3 4 5 6 7 13
6 1 [ AST(GOT) ALT(GPT) LDH CK(CPK) ] 2 3 10 4 5 6 7 8 7 1 14
15 2 10 11
8 1 1 1 2 2 AST(GOT) ALT(GPT) Al P 12 16
2 3 4 1 2 3 4 10 5 6 1 9 17
10 1 2 3 4 13) 5 11 12 13 14 1 2 1 2 3 4 3 4 15 18
16 19
1 1 14 10mL 2 15 10mL 3 16 10mL 2 1 17 10mL (i.p) (i.v) 10mL 50 946 mg/kg ( 13.14 ml/kg 813 mg/kg( 11.29 ml/kg) 50 mg/kg 618 560 3,600 2,990 278 106 219 218 171 50.8 10mL 946 813 460 395 329 282 131 113 13 11.3 13 11.3 20
2 17 14.4 mg/kg 30 6 3 360 mg/kg 288 mg/kg 3 4 18 Ouchterloney 21
1 3 2 3 () 4 5 10mL 50 6 7 8 2007 8 31 21900AMX01294000 9 2007 12 21 10 11 1993 12 13 14 1146400A1039 15 22
1 2 1 L.S Goodman and A.Gilman(Ed.) The Pharmacological Basis of Therapeutics,5th Ed.,331(1975) 2,,1779(1976) 3 ( ) (1977) 4 J.T.Wilson, et al. Clin.Pharmacol.Ther.,,635-643(1978) 5 M.Volz,et al. Br.J.Clin.Pharmacol.,,299S-308S(1980) 6 H.Herbert,et al. J.Biol.Chem.,,315 (1957) 7 D.J.Harry,et al. Drug.Metab.Dispos.,,527-546(1977) 8 T.Tsuchiya,et al. J.Pharm.Sci.,,800-801(1971) 9 O.Christ,et al. Arzneim-Forsch.,,1760-01767(1973) 10 Penttila,O.,et al. Brit.Med.J.,,470(1974) 11 Neuvonen,P.J. and Penttila,O. Brit.Med.J.,,535(1974) 12,(1),122(1995) 13,95(1983) ( ) (1977) 15 ( ) (1977) 16 ( ) (1977) 17, (8) 1868 (1973) 18(5),1070(1980) 23
24