IF MR 63 2 IF 10 3 IF IF IF A4 9 IF IF IF 11 1 IF IF IF MR IF IF MR Drug Safety Update IF

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1 IF IODINE M DISINFECTANT SOLUTION 10 10w/v 100mL 10g( 1g) PovidoneIodine IF

2 IF MR 63 2 IF 10 3 IF IF IF A4 9 IF IF IF 11 1 IF IF IF MR IF IF MR Drug Safety Update IF

3 CAS

6 Burkholderia cepacia 1) ph 2,3) M 10 10w/v M

7 M 10 IODINE M DISINFECTANT SOLUTION 10 PovidoneIodine Iodine JAN PovidoneIodineJANUSAN PolyvidoneINN (C6H9NO)nI Poly2-oxopyrrolidin-1-ylethyleneiodineIUPAC Iodinated povidonebpep 2-Pyrrolidinone1-ethenyl-homopolymercompound with iodine PVPI

8 99.5 ph 1.0g 100mL ph ) 1 2 3

9 1 0.02mol/L 0.02molL 1mL 2.538mg I 2 4

10 100mL 10g 1g 100mL 10g 1g 2Na ph 4075RH 6 3 ph 5) 4 5

11 51 250mL 500mL M 10 6) M ,3) M mL Draize 7) M Kay and Calandra 8) M

12 Draize 7) A) B) /4 0 1/4 1/2 1/2 3/4 3/ AB5 80 A) A5 10 A) B) C) /2 1/ ABC n3 Kay and Calandra 8) hr) M M

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15 1 2M 10in vitro 6) M 10 clean dirty clean 0.2 dirty 15 2 dirty MRSAE. coli C. albicans 6 15 clean dirty (2) dirty (0.2) Staphylococcus aureus IFO Staphylococcus aureusmrsa Staphylococcus epidermidis ATCC Escherichia coli IFO Proteus vulgaris IFO Pseudomonas aeruginosa IFO Burkholderia cepacia IFO Serratia marcescens IFO Candida albicans IFO

16 3MICin vitro 9) MIC MIC M 10 MIC Staphylococcus aureus IFO Escherichia coli IFO Proteus vulgaris IFO Pseudomonas aeruginosa IFO MIC M 10µg/mL 4 in vitro 9) Escherichia coli IFO 3806 M Kelsey-Sykesin vitro 9) Escherichia coli IFO 3806 Kelsey-Sykes M M 10 w/v 11

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20 1 11) 2 10) 15

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22 13) 1 14) ) 2 16) 3 17) 4 18) 11) 17

23 LD50, TDL0 mg/kg 19) LD50 TDL0 3400mg/kg/ LD5050TDL0 4) mg/kg mg/kg 35 25mg/kg 25mg/kg BUN Na mg/kg SD mg/kg 3Wistar mg/kg 18

24 4) mg/kg PBI 2mg/kg 50mg/kg mgkg PBI 4mgkg 40mg/kg 400mg/kg 52080mg/kg PBI 20mg/kg 80mg/kg mg/kg 6.25mg/kgPBI T3 6.25mg/kg3 PBI 6.25mg/kg 400mg/kg 50mg/kg 19

25 mL 500mL AMX

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27 1 Burkholderia cepasiapseudomonas cepacia medical corner EBM QA p5556p p M DraizeJHAppraisal of the safety of chemicals in foods,drugs and cosmeticsdermal toxicity p KayJHInterpretation of eye irritation testjsoccosmetchem p3240p M DanzigerYet altransient congenital hypothyroidism after topical iodine in pregnancy and lactationarchdischild BarOrDet alfalsepositive Haem Detection Due To Povidone Iodine Lancet OkanoMIrritant contact dermatitis caused by PovidoneIodineJAmAcad Derm 20 (5) JacksonHJet aleffect Of PovidoneIodine On Neonatal Thyroid FunctionLancet (8253) VorherrHet alvaginal Absorption of PovidoneIodineJAMA 244 (23) (4) (ODA)ProgMed 7 (5) REGISTRY of TOXIC EFFECTS of CHEMICAL SUBSTANCESSTN

28 Medical Economics Data,a division of Medical Economics Company IncPHYSICIANS DESK REFERENCE 47 EDITION1993 3The Pharmaceutical PressMARTINDALE The Extra PharmacopoeiaTwentyninth Edition

29 BETADINE INADINE VIDENE TRAUMASEPT 24

30 25

ヒビスコール液A カタログ

ヒビスコール液A カタログ 1 2 3 2002 10 Centers for Disease Control and Prevention CDC A 1. 2. 0.2% 3. 1 A 2 3 4 5 6 7 1 1 1. 2. 3. 2 1. 1 0.2% 10 Pseudomonas aeruginosa ATCC 27853 20 20 Proteus vulgaris ATCC 13315 30 20 Escherichia