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PM!"! 56+ PM2.5+ 789:%&';<!!"#$%&'()*+,-./! 01234! D25JKL! 9MNO! 1, 2-)*+,-" V! :;! 9,10-*.)" +%",-" PM2.5! &'! (! <=>?! @A! BC! /01! 234! E<F G2< HI3!!"#[a]$%" V! :;! PM2.5! (! TU! PQRS @A! D29! /51! 234! 67! 89!

1,2-1,2 NQ (10 µm) PM2.5 1,2 NQ (10 µm) [a] 21.8% 42.6% 1,2 NQ (10 µm) PM2.5 1,2 NQ (10 µm) PM2.5 + μg/ml 24.4% 20.9%,2-PQ+PM2.5 ----- + PM2.5 µg/ml + PM2.5

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( ) H27.12.17 30 H27.4.18 27 25 H27.12.12 42 50 H28.1.16 2015 100 H28.1.29 MSD 70 20 H29.2.12 46 60

( ) / H27.11.9 He M, Ichinose T,et al. 2016 Differences in allergic inflammatory responses between urban PM2.5 and fine particle derived from desert-dust in murine lungs Toxicol. Appl. Pharmacol, 297:41-55 He M, Ichinose T,et al. 2016 Desert dust induces TLRs signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway Toxicol. Appl. Pharmacol, 296:61-72 TV

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