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3 Prevalence and characteristics of undiagnosed bipolar disorders in patients with a major depressive episode Charles L. Bowden The University of Texas Health Science Center, School of Medicine, San Antonio, Texas CNS B

4 C A

5 S1-1 S1-2 S1-3 S B 4 S2-1 S2-2

6 S2-3 S C S3-1 JFE S3-2 S3-3 S3-4

7 BPD A BPD BPD BPD DSM5 Dialectical Behavior Therapy Transference Focused Psychotherapy BPD S4-1 BPD S4-2 BPD DBT S4-3 BPD S S5-1 S5-2

8 S5-3 S5-4 S B 12 S6-1 S6-2 S6-3 S6-4

9 C S7-1 S7-2 ADHD S7-3 S comorbidity SSRI S8-1

10 S8-2 S8-3 S B NTT NTT S9-1 S9-2 S9-3 S9-4 NPO S9-5 PIPC Psychiatry in Primary Care in

11 C S10-1 S10-2 S10-3 S10-4 Lewy A 4 S11-1 S11-2 S11-3

12 S S12-1 S12-2 S12-3 S B S13-1

13 S13-2 S S13-4 S13-5

14 heterogeneous mrna WS1-1 WS1-2 WS1-3 WS1-4 mrna B " " WS2-1 WS2-2 WS2-3

15 C WS3-1 WS3-2 WS A WS4-1 WS4-2 WS4-3

16 C C 30% 10 J Clin Psychiatry 64,2 p161-74, Bipolar Disord : BS-1 BS-2 BS-3 BS-4

17 A CS-1 CS-2 CS A

18 JS-1 JS-2 JS-3 JS-4 JS-5 J-MISP Group C ,

19 / A A Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins

20

21

22

23 B / C MSD A Treatment strategies to prevent mood episodes and optimize outcomes in bipolar disorder Charles L. Bowden The University of Texas Health Science Center, School of Medicine, San Antonio, Texas

24 B Meiji Seika C A Heterogeneous!? / / B

25 C / A B C A

26 / 13 JCPTD :

27

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29 1. P ,2 1 2 P1-2 P P , P1-5 Duloxetine OlanzapineMADRS P1-6 P P P1-9 2

30 P P1-11 SSRI P1-12 escitalopram 1, P1-13 The Bcl1 polymorphism of glucocorticoid receptor gene and response to milnacipran and fluvoxamine in depressed patients P1-14 P P1-16 Lamotrigine Stevens-Johnson P ,

31 2. P2-1 1, P2-2 1 P ,4 3, P2-4 ; FK P2-5 1,2 1, P2-6 P P P2-9

32 P2-10 P2-11 1, P , P2-13 1,2 3 3,4 5, P P , ,4 1 2 NPO P

33 3. P3-1 1, P3-2 HPA P3-3 P P3-5 P ,3 12 J 3 P3-7 P3-8 fmri 1,2,3 Jeffrey Miller 1 Ramin Parsey

34 P3-9 BDNF P3-10 HAM-D P3-11 P3-12 NIRS P3-13 NIRS 1 P3-14 NIRS 2 P P3-16 CogState QOL 1, P3-17 TEMPS-A/MPT 1 1 1,2 1 1,

35 P3-18 DSM-4 P3-19 P3-20 P3-21 1, P ,2 1,2 1,2 1 1,2 1,2 1,2 1,2 1,2 2 1 Juntendo University Mood Disorder Project JUMP 2 3 P P3-24 P P

36 P3-27 NIDS P3-28 1,4, P3-29 TEMPS-A P3-30 TCI 1 1,2 1, P P P ,2 1 2 P4-3 CDI

37 P4-4 BDNF P5-1 P P , P P5-5 P P

38 6. P6-1 P6-2 QOL P6-3 P6-4 P6-5 1 Aleksic Branko P NPO MDA-JAPAN P6-7 NIRS P6-8 1, P6-9 EAP 2 1, NPO 3

39 P6-10 1, P7-1 EFT P P7-3 social skills training SST , P7-4

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1 4 1 13 1 4 6 7 2012 7 27 12 50 13 40 1 7 27 13 40 14 30 1 7 28 13 20 14 10 1 Prevalence and characteristics of undiagnosed bipolar disorders in patients with a major depressive episode Charles L. Bowden

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