Challenges in Global Health: New Opportunities for the Private Sector Tuesday, July 27, 2010 DNDi Fighting Neglected Tropical Diseases Through Partner
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1 Challenges in Global Health: New Opportunities for the Private Sector Tuesday, July 27, 2010 DNDi Fighting Neglected Tropical Diseases Through Partnering Dr. Jean-Pierre Paccaud, PhD Business Development Director, DNDi
2 2
3 3
4 837 in 2009* *Source: IMS Health,
5 : : Total : 1,556 12% 1.3% Source: Chirac P, Torreele E. Lancet May 12;
6 (NTD) 6
7 7
8 (PDPs) NTD : 8
9 & PDP Human hookworm vaccine initiative Vaccine Development Program HIV/AIDS TB Malaria NTD Diarrhea Respiratory Source: & 9
10 Indian Council for Medical Research (ICMR) Kenya Medical Research Institute (KEMRI) Malaysian MOH Oswaldo Cruz Foundation Brazil Médecins Sans Frontières (MSF) Institut Pasteur France WHO/TDR (permanent observer) DNDi: (R&D) 2003 USA Brazil Geneva Coordination Team + consultants DRC 7 worldwide offices Kenya India Malaysia 10
11 : ) DNDi 11
12 Discovery Activities Compound mining Chemical classes Target-based Screening a robust pipeline January 2010 HAT LO Consortium Scynexis Pace Univ. VL LO Consortium Advinus CDRI Chagas LO Consortium CDCO Epichem Murdoch Univ FUOP Major Collaborators Sources for hit and lead compounds: GSK, Anacor, Merck, Pfizer, Novartis (GNF, NITD), GATB, Screening Resources: Eskitis, Institut Pasteur Korea, Univ. Dundee, Reference screening centres: LSHTM, Swiss Tropical Institute, University of Antwerp Nitroimidazole backup (HAT) Oxaborole (HAT) Alternative formulations Amphotericin B (VL) Drug combination (Chagas) Exploratory Fexinidazole (HAT) Combination therapy (VL in Asia) Combination therapy (VL in Africa) Paromomycin AmBisome Miltefosine Combination therapy (VL in Latin America) in preparation Paediatric benznidazole (Chagas) Azoles E1224 (Chagas) Exploratory 6 to 8 new treatments by 2014 NECT Nifurtimox - Eflornithine Co- Administration Stage 2 HAT ASMQ (Malaria) Fixed-Dose Artesunate/ Mefloquine ASAQ (Malaria) Fixed-Dose Artesunate/ Amodiaquine 12
13 2007 ASAQ (Malaria) Fixed-Dose Artesunate/ Amodiaquine DNDi sanofi-aventis (France) 2008 Farmanguinhos ASMQ (Malaria) Fixed-Dose Artesunate/ Mefloquine (Brazil) Cipla (India) 2009 NECT Nifurtimox - Eflornithine Co-Administration Stage 2 HAT National Control Programs MSF / Epicentre Bayer / sanofi aventis WHO 13
14 Long-Term projects DNDi Medium-term projects Short-term projects 14
15 DNDi DNDi : : : (MSF) : 15
16 DNDi : 16
17 Accessing resources across the entire development process: Compound & Screens Chemistry. 17
18 Accessing resources across the entire development process: & Chemistry : Upfronts, milestones) Anacor Anacor : 18
19 Accessing resources across the entire development process: Compounds, screens & Chemistry Pfizer : Pfizer hit to lead outlicensable 19
20 Accessing resources across the entire development process: Compounds, screens & Chemistry 20
21 Accessing resources across the entire development process: Proof of concept cgmp batches PK/PD. 21
22 Accessing resources across the entire development process: Proof of concept cgmp batches Scynexis: Advinus: Aptuit:. 22
23 Accessing resources across the entire development process: IND compounds. 23
24 Accessing resources across the entire development process: : Clinical compounds 24
25 Accessing resources across the entire development process: Approved 25
26 Accessing resources across the entire development process: Approved ASAQ DNDi (Coarsucam ) 26
27 DNDi ( ) 27
28 28
29 ! Thank you! PDPs
Contents
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