* 1 6 ( ) 20 GOT GPT ( ) 59 3 CT F D T3 *

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1 * 1 6 () 20 GOTGPT () 59 3 CT F D T3 *

2 * () 159 NOS () R 4U T3 500ml 2ml 2g 100ml 25mg PL mg/dl PL 3g/ 3 300mg/ 3 150mg/ WBC 12000/mm 3 CRP 8.8g/mlBS 238mg/dl HOE mg/ R R T3PL 7%PL *

3 * 5 2 ( ) ope 204 ope AGML *

4 * 6 5 NOS () PM11 123mg/dl 68 AM2 AM3 20mg/dl ICU diazepam 180mg/dl 69 AM12 71 CT 73 / 86 6/4 300mg/dl / 1066/ /5 108 R 67 23:00 68 A.M2: CT 77 *

5 * 7 5 () NOS () % Glucose 60ml 400mg/dl 500ml R 10 DIV FPG 277mg/dl R mg/dl 20%Glucose 60ml 400mg/dl 500ml R 10 DIV FPG277mg/dl R mg/dl PL SP 20% R *

6 NPH * 9 3 NPH NOS () PL T3CEZ 10 5 NPH NOS () PL *

7 NPH * 11 3 NPH NOS () hcg coagula D&C free space hcg320 SMBG 338mg/dl GI D&C hcg Villi R N O R10% *

8 NPH * 12 3 NPH NOS () ALP 13 6 NPH ( ) PM7:00 R AM1:002:00 AM3:004:00 AM7:00 R hr 22 R (7/6/7) N (8) 31 / 20 *

9 NPH * 14 6 NPH () NPH ( ) SR 16 2 NPH NOS () R 5%

10 NPH * 17 2 ( ) (A1 2 clipping Hb 8.5g/dl 40ml/30mg / 40mg/ 36 H mg 27 Hb 10.4g/dl 26 50mg2 23 Hb 10.6g/dl R-R-R-N H2 Hb 13.8g/dl 1 NPH 40 2 Clipping RRRN 4 20 PL 5% 0.9% 50% R SP MS T3G G S *

11 * 1 6 NOS () GOT 21 IU/LGPT 26 IU/L HOE GOT:228 IU/LGPT:211 IU/L mg/dLGOT 284 IU/LGPT 507 IU/LGTP 2316 IU/L ALP 710 IU/LLDH288IU/L HOE ( :504 IU/L)HBs HCV () 37 GOT 349 IU/LGPT 682 IU/L 38 IgMHA () 39 MRI 41 GOT 222 IU/LGPT 555 IU/L 227 IU/L 43 GOTGPT 48 GOTGPT PTP GOTGPT GOT 22 IU/LGPT 18 IU/L 1.3 mg/dl *

12 * 2 5 () MRSA HOE901 N 150 () 44 *

13 * 3 5 ( ) L4/5 84 L5S1 root block (25)1T L5S1 root block () ()

14 * ( ) 14 NOS () ( A) 90 Ope 97 (90 ) :00 (+)(+) HOE901 3U 160 (±)(+)(±(+) 158 ( 38.3 () ( 160 (+)(+) 161 HOE901 2U ( 162 ( 163 HOE C HA (AC-17) C () VG A *

15 NPH * 7 5 NPH () EKG EKG R NPH NOS () CT K *

16 NPH * 9 7 NPH () MRI 2 C ( ) *

17 NPH * 10 5 NPH NOS () ( 63 2T 6T ) () T 2T chest X-P R OD S *

18 NPH * 11 6 NOS () 1 1 S58 follow 1 followup Biopsy malignancy+ Biopsy B (()) 7 () () L *

19 NPH * 13 5 NOS ( ) ope 93 Ope (93 ope ) 1 size 45 19mm 14 6 NPH ( ( )

20 * 1 * IDDM mg 2.5ml mg 2.5ml mg 2.5ml HOE ope R HOE901/3103 * 1 *

21 * 1 * IDDM NOS /mm 3 CRP 14.27mg/dl X S6 Ceftriaxone 1g CRP 3.98mg/dl 321 CRP 0.82mg/dl Ceftriaxone 322 Amoxicillin 250mg R S6 Ceftriaxone 2g/ * 1 *

22 * 1 * IDDM SR Cap R 20% P P T R * 1 *

23 * 1 * IDDM NOS R 2 1 * 1 *

24 / / sick day / / / / / / / / 1. HbA1c 0.5IU/kg 2. 1) 2) / /

25 * 1 * (IDDM) R CP P D -T3 C D -P R U40 SP * 1 *

26 * 1 * (IDDM) CT 331 R ETPL S B AM T3 : * 1 *

27 * 1 * (NIDDM) NOS CT 303 OPE OPE 397 HOE papilloma G * 1 *

28 1, 43, 860 (1988) 2, 16, 1631 (2000) 3 The DCCT research group, Diabetes Care 10, 1 (1987) 4 UK prospective diabetes study(ukpds) group, The Lancet 352, 837 (1998) 5,, 195 (1996) 6, 192, 809 (2000) 7 Bradley, C, In Bradley C(ed) Harwood Academic Publishers, 89 (1994) 8,, 12 (2001) 9,,, 153 (1997) 10, 42, 385 (1999) 11,, 38 (1996) 12,,, ( ) 13,,, (1996) 14,,, (2000) 15,,, (2002) 16, 84(9), 1672 (1996) 17,,, (2002) 18 Hannele Yki-Jarvinen, Diabetes Care 24(4), 758 (2001) 19 Jennal L. Jonhnson, Arch Intern Med.156, 259 (1996) 20,,, (1996) 21 Lieberman P, JAMA215, 1106 (1971) 22 Schernthaner G, Diabetes Care 16 (Suppl 3), 155 (1993) 23 Palmer JP, Science 222, 1337 (1983) 24 Fineberg S.E.: Diabetologia 25: ,

HOE901 A S S Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Gly

HOE901 A S S Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Gly 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 S S S Phe Val Asn Gln His Leu Cys Gly Ser His Leu