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10 1) Karpatkin, S.: Blood, 51: 307, ) Karpatkin, S.: Ann. Intern. Med., 89: 200, ) Brecker, C. and Cronkite, E. P.: J. Appl. Phy siol., 3: 365, ) Mielke, C. H., Jr., et al.: Blood, 34: 204, ) Born, C. V. and Cross, M. J.: J. Physiol., 168: 178, ) Mannucci, P. M. and Sharp, A. A.: Br. J. Haematol., 13: 604, ) Bull, B. S. and Zucker, M. B.: Proc. Soc. Exp. Biol. Med., 120: 296, )ŒÃ cši: Med. Technol., 7: 17, ) Amorosi, E., et al.: Br. J. Haematol., 21: 227, ) McDonald, T. P., et al.: Proc. Soc. Exp. Biol. Med., 115: 684, ) Ginsburg, A. D. and Aster, R. H.: Thromb. Diath. Haemorrh., 27: 407, ) Johnson, C. A., et al.: Blood, 37: 163, ) Rolovic, Z. and Baldini, M.: Scand. J. Haema tol., 6: 25, ) Hirsh, J., et al.: J. Clin. Invest., 47: 466, ) Detwiler, T. C., et al.: Am. J. Physiol., 203: 107, ) Karpatkin, S.: J. Clin. Invest., 48: 1083, ) Karpatkin, S.: J. Clin, Invest., 48: 1073, ) Garg, S. K., et al.: Ann. Intern. Med., 77: 361, ) Branehog, I., et al.: Blood, 45: 551, ) Rivard, G. E. and Lazerson, J.: J. Lab. Clin. Med., 86: 547, ) Sulek, K.: Folia Haematol., 105: 530, ) Murphy, S., et al.: N. Engl. J. Med., 286: 499, ) Garg, S. K., et al.: N. Engl. J. Med., 284: 11, ) x c pžk: úž ïž, 82: 125, ) Garg, S. K., et al.: Blood, 34: 851, ) Chatlerji, A. K., et al.: N. Engl. J. Med., 284: 1440, ) Tohic F. Le., et al.: Thromb. Haemost., 38: 212, ) Khan, I., et al.: Br. J. Haematol., 31: 449, ) Prost-Dvojakovic, R. J., et al.: In gplatelets h (Ultin, O.N., Ed), p. 484, Excerpta Medica, Amsterdam, ) Zucker-Franklin, D. and Karpatkin, S.: N. Engl. J. Med., 297: 517, ) Tohic, F. Le., et al.: N. Engl. J. Med, 298 : 341, ) Robert, A., et al.: Nouv. Presse Med., 7: 739, ) Roper, P. R., et al.: Am. J. Clin, Pathol., 68: 449, ) Cowan, D. H, and Graham, R. C.: Ser. Haematol., 8: 68, ) Maldonado, J. E.: Ser. Haematol., 8: 101, ) Neuvel, C., et al.: Scand. J. Haematol., 21 : 421, ) Kasturi, J. and Saraya, A.: Acta Haematol., 59: 104, ) Levin, P. H.: Ann. Intern. Med., 78: 533, ) Stefanini, M., et al.: Lancet, 1: 400, ) Steinberg, D., et al.: Am. J. Med., 59: 845, ) Cardamore, J. M., et al.: JAMA, 221: 270, ) Cortelazzo, S., et al.: Thromb. Haemost., 43: 127, ) Wu, K. K.: Ann. Intern. Med., 88: 7, ) Weinfeld, A., et al.: Clin. Haematol., 4: 373,

11 AN INVESTIGATION OF PLATELET VOLUME IN VARIOUS HEMATOLOGICAL DISORDERS: RELATIONSHIP BETWEEN PLATELET VOLUME AND PLATELET FUNCTION Hiroshi MOHRI Department of Internal Medicine, Showa University, Fujigaoka Hospital, Yokohama Abstract-Platelet volume was measured in 123 cases with various hematological disorders, usi ng a Coulter Counter, Model ZB-1 with a Channel Analyzer. Normal values of platelet volu me in 50 healthy adults were as follows: mode, 6.71 }0.83ƒÊ3, mean volume, 9.77 }0.95ƒÊ3, and megathrombocyte index (M. I.), }2.87ƒÊ3 In ITP, both platelet volume and the number of megakaryocytes increased. A negative linear relationship was found to exist between volu me and numbers. The abnormal peak of particles smaller than 1.6ƒÊ3 was conspicuous in cases which indicated remarkably low platelet counts, and this peak was regarded as fragments of platelets produced by immunologic aggregation. On the contrary, platelet volume and the num ber of megakaryocytes decreased in hypoplastic anemia. The platelet volume in acute leukemia was lower than normal, especially in cases of acute promyelocytic leukemia with DIC. These platelet volumes gradually returned to normal after complete remission. In the case of paraproteinemia or megaloblastic anemia, platelet volume was always lower than normal, however decreased platelet aggregation improved after plasma exchange or Vit. B12 injection. In the case of malignant lymphoma, PNH and myeloproliferative disorders (MPD), the platelet volume was almost within normal limits. However, there was a negative linear relationship between volume and aggregation in PNH. On the contrary, no relationship was revealed to exist between them in MPD. The present study suggests that larger platelets do not always have greater metabolic potential, but platelet dysfunctions result from not only platelet size but various factors in each hematological disorder.

AUTONOMIC FUNCTIONAL STATE IN RENAL TUBERCULOSIS REPORT III. SERUM CHOLINESTERASE ACTIVITY IN RENAL TUBERCULOSIS Sanai Yamamura The Department of Urol

AUTONOMIC FUNCTIONAL STATE IN RENAL TUBERCULOSIS REPORT III. SERUM CHOLINESTERASE ACTIVITY IN RENAL TUBERCULOSIS Sanai Yamamura The Department of Urology, Kumamoto University College of Medicine (Director: