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6 HBV HBV (1964) HDV (1977) HCV (1988)

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11 2009

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19 Yotsuyanagi H et al. J Med Virol 2005 Yotsuyanagi H et al. J Hepatol 2002

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21 Universal vaccination (UV) 45 HB 2009

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30 Progress Toward the Elimination of Hepatitis B Virus Transmission Among Health Care Workers in the United States Francis J. Mahoney, et al. Arch Intern Med. 1997;157(22): employees (90%) were eligible to receive hepatitis B vaccine, and 66.5% of them (95% confidence interval, 61.9%- 70.9%) had received 3 doses of hepatitis B vaccine. Studies on long-term protection demonstrate that vaccine induced protection persists at least 11 years even when titers of antibody to hepatitis B surface antigen decline below detectable levels.

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37 HBV HBV HIV 1.7RNA 4.3

38 2008

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45 HBV+HCV 7.3% ( ) 63% 6.3% HBV 19.6% HCV 66.8% HBV:HBsAg(+) HCV:anti-HCV(+) n=842 K. Koike Univ. of Tokyo

46 HCV 1-6 months 20-30% 70-80% Rare 50% 15-30% 5-7%/ HCC F1: 0-1%/year y F2: 1-2%/year F3: 3-5%/year

47 2/3 NS3 protease inhibitors (Telaprevir, etc.) ) NS5B RNA polymerase inhibitors (R1626, R7128, VCH759, etc.) Ursodeoxycholic acid ( ) Glycyrrhizine ( C (iron depletion therapy)

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49 100 (sus stained virologica al respo onse) IFN Peg-IFN IFN IFN IFN Peg-IFN RBV RBV RBV RBV IFN

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51 15/19 44/64 99/168 p< /8 135/ /262 10/35 12/22 35/67 p< /184 65/242 5/28 Cochran-Armitage test

52 SVR. non-svr) (2009: analysis of 1598 cases from 29 institutes)

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1) Garner J. S.: The Hospital Infection Control Practices Advisory Committee, CDC, Guidelines for Isolation Precautions in Hospitals, 1996. http://wonder.cdc.gov/wonder/prevguid/ p0000419/p0000419.asp.

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