トピックス 新メンバーの紹介 長田研究室に7名のメンバーが新たに加わることとなり 10月18日に歓迎会を開催しました 皆様 どうぞ宜しくお願い致します ① ② ③ ④ ⑤ ⑥ ⑦ 安部 弘 理化学研究所 先任研究員 田中 弦太郎 長岡技術科学大学4年 研修生 冨樫 英人 長岡技術科学大学4年 研修生

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1 Antibiotics Laboratory Antibiotics Laboratory News TEL: Contents No. 35: January 2013 EDITORS: ( )

2 トピックス 新メンバーの紹介 長田研究室に7名のメンバーが新たに加わることとなり 10月18日に歓迎会を開催しました 皆様 どうぞ宜しくお願い致します ① ② ③ ④ ⑤ ⑥ ⑦ 安部 弘 理化学研究所 先任研究員 田中 弦太郎 長岡技術科学大学4年 研修生 冨樫 英人 長岡技術科学大学4年 研修生 王 毅楠 慶應義塾大学大学院 博士課程3年 パートタイマー 程 志強 中国科学院 理研IPA 吉岡 昌子 パートタイマー 大橋 佳樹 東京電機大学3年 パートタイマー 上段左から 安部さん 田中くん 冨樫くん 王くん 程くん 下段左から 吉岡さん 大橋くん 2012野依サマースクールへの参加 お茶の水女子大学 博士後期課程2年 JRA 吉澤 江里子 野依サマースクールは今回で4回目の開催で 理研外での開催は初めてだそうです 分野外 海外の学 生との交流を目的に 2泊3日 島根県くにびきメッセで開催されました 私は去年からJRAで働かせて頂いて おり 今回で2回目の参加です 前回の参加の時に英語で研究内容の説明をするのに悪戦苦闘したのも喉元過ぎれば何とやらで なんとか なるだろうと楽観的にポスター発表当日を迎えてしまいました が 今回も結局 緊張やら英語能力の限界で 黙り込んでしまい 聞きにきてくれている方に このポスターで言いたいことは何 じゃあ一番伝えたい図は どれ などと どんどんと易しい質問を投げかけてもらい 何とか答えられるかどうかといった具合でした 今回 ポスター賞を戴くことが出来ましたが 審査員の方から 内容は面白いのに 説明しようという気が感 じられなかった という感想を貰い 英語能力がどうしようもないのに 碌な準備をしなかった自分を反省しまし た セミナーなどが終了した最終日には 参加者全員で松江城を観光し 出雲大社にお参りしました ちょうど旧 暦の神在月で全国の神様が出雲に集結していた時期でしたので 出雲大社に逗留中だっただろう英語の神 様にも私の祈りが届いた筈だと信じています

3 ( ) ( ) The Japanese Cancer Association OB OB A Wierzba

4 川谷誠 博士 日本癌学会 奨励賞受賞祝賀会 にて 祝 和田 章 博士のご結婚 11月10日 和田章さんと知子さんの結婚式 披露宴が都内にて行われました お二人は理研の幹事会で知り 合われたそうです 当日の披露宴では 和装からウエディングドレスへのお色直しもあり とても華やかで心温ま る会となりました お二人とも どうぞ末永くお幸せに ケーキ入刀のシーン 出席したメンバーと一緒に

5 (12 19 ) Aspergillus Clark University Hibbett

6 "", "p38", "LAP TGF-β ", "", " ", "PK-NRP ", " ", "Aspergillus fumigatus Af293 ", "LAP TGF-β ", " TGF-β ", " bil5 BIL ", Joanne Chory " BIL4", "BIL7 ", " bil2 ATP ", Davaapurev Bekh-Ochir " bil3 ", "IAAIAA ", " FOX ", " AmPR1", " ",,

7 P "Structure and Function of P450revI in Reveromycin A Biosynthesis", Takahashi S., Nagano S., Nogawa T., Takagi H., Uramoto M., Kanoh N., Shiro Y., and Osada H. Advances in Natural Products Science and Development of Natural Medicine, Chunchon, Korea, November 20, 2012 Isolation of new microbial metabolites in Chemical Biology Core Facility, Ueki M. GRDC Symposium 2012, Seoul, Korea, November 12, 2012 Target identification of bioactive small molecules, Osada H. Protuboxepin A, a marine fungal metabolite, inducing metapase arrest and chromosomal misalignment in tumor cells, Asam Y., Jang J.H., Soung N.K., He L, J.W., Oh H., Muroi M., Osada H., kim B.Y., and Ahn J.S. 24th EORTC-NCI-AACR: Symposium on Molecular Targets and Cancer Therapeutics, Dublin, Ireland, November 6-9, 2012 High-Throughput screening to identify small molecule inhibitors of PK27 Kip1 Ubiquitination. Watanabe N., Ooi L.C., and Osada H. International Symposium on Natural Products Chemistry and Chemical Biology 2012, Hangzhou, China, November 23-26, 2012 Integrative approach for target identification of bioactive compounds, Osada H. The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Kyoto, Japan, October 31-November 1, 2012 Proteome-based profiling approach to predict targets of bioactive small molecules using two-dimensional fluorescence differential gel electrophoresis (2D-DIGE), Muroi M. and Osada H. The 1st official conference of the international chemical biology society, Boston, USA, October 4-5, 2012 Proteome- and cell morphology-based target identification for RKB3564F070, a new cytotoxic fungal metabolite, Kawatani M., Aono H., Nogawa T., Muroi M., Futamura Y., and Osada H. Phosphorylation-dependent protein-protein interaction modules as potential molecular targets for cancer therapy. Curr. Drug Targets, 13, (2012). Watanabe N., and Osada H. Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity in spite of close relationship to acyl protein thioesterases. J. Lipid Res. 53, (2012). Burger M., Zimmermann T.J., Kondoh Y., Stege P., Watanabe N., Osada H., Waldmann H., and Vetter I.R. Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba. Chem. Biol., in press., Motoyama, T., Hayashi, T., Hirota, H., Ueki, M., and Osada, H. Boronic acid inhibitors of acyl protein thioesterase 1 and 2. ChemBioChem, in press, Zimmermann T.J., Burger M., Tashiro E., Kondoh Y., Martinez N.E., Gormer K., Rosin-steiner S., Shimizu T. Ozaki S., Mikoshiba K., Watanabe N., Hall D., Vetter I.R., Osada H., Hedberg C., and Waldmann H. High-throughput screening identifies small molecule inhibitors of molecular chaperones. Curr. Pharm. Des., in press, Kondoh Y., and Osada H. Morphobase, an encyclopedic cell morphology database, and its use for drug target identification." Chem. Biol., in press, Futamura Y., Kawatani M., Kazami S., Tanaka K., Muroi M., Shimizu T., Tomita K., Watanabe N., and Osada H. "Creation of novel reveromycin derivatives by alcohol-added fermentation" J. Antibiot., in press, Nogawa T., Takahashi S., Sekiyama Y., Takagi H., Uramoto, M., Koshino H., Kawatani M., Shimizu T., and Osada H. "Pin1",, 70 (8), (2012).

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