sisting of only one kind; the intermediary type-one made up of two kinds; the diversified type-one composed of more than three kinds as classified fro

Size: px

Start display at page:

Download "sisting of only one kind; the intermediary type-one made up of two kinds; the diversified type-one composed of more than three kinds as classified fro"

きょういちさかいざわ
5 years ago
Views:

1 ON THE MORPHOLOGICAL ALTERATION OF THE PROSTATE GLAND ON AGING II. A CORRELATIVE HISTOPATHOLOGIC STUDY OF THE LATENT AND MANIFESTED NODULAR HYPERPLASIA OF THE PROSTATE GLAND AND SENILE CHANGES OF THE TESTIS Department Masao Akimoto of Urology, Nippon Medical School (Director: Prof. Hiroshi Kawai) Department of Pathology, Nippon Medical School (Director: Prof. Gompachi Yajima) From 228 cases of the male unselected consecutive autopsies, we selected 45 cases of the group of the macroscopic non-hypertrophic nodular formation with the maximum diameter of the frontal section of the prostate gland being less than 3.5cm (hereinafter abbreviated as the non-hypertrophic type) and out of which, 43 cases carrying the testis, as well as 36 cases of the group of the macroscopic hypertrophic nodular formation with the maximum diameter being more than 3.51cm (hereinafter abbreviated as the hypertrophic type) and out of which, 32 cases carrying the testis, and examined them together with 39 cases of the prostatic removal group (hereinafter abbreviated as the operation case). On the question of whether or not there exists the nodule, we made a microscopic examination of the staining microscopic specimen and used two major characteristics-one showing a clearcut boundary on its surroundings and the other showing a distinctive image pressing upon its surroundings-as a basis, but excluded the early nodule and the prostatic carcinoma from the examples of the present study. In the autopsy cases, many had a few nodule, while the number of the nodules was also small. As for the frequency of nodular formation, however, the rate shown by the group of nodular formation with the maximum diameter (the frontal section of the prostate gland) being more than 3.51cm was higher than that shown by the group of nodular formation with the maximum diameter being less than 3.5cm; but, the rate increased on aging in non-hypertrophic case. In the operation case, the nodule was big irrespective of the age, and the nodules were numerous. By devising the nodular tissue type (I. the cystic type, II. the proliferative type, III. the non-prolifera - ative type, IV. the musculofibrous type) and the nodular classification type (the simple type-one con-

sisting of only one kind; the intermediary type-one made up of two kinds; the diversified type-one composed of more than three kinds as classified from the nodular tissue type), we used them to make

2 sisting of only one kind; the intermediary type-one made up of two kinds; the diversified type-one composed of more than three kinds as classified from the nodular tissue type), we used them to make a comparative study of each case. In the operation case, there were observed the complexity, diversity and non-uniformity; and, such symptoms were already seen even in the case where the nodules were small; hence, it was presumed that these symptoms had something to do with the sudden increase in the nodules. Upon comparing the extra nodular tissue with the intra nodular tissue, mention was made of the prostatic calculus, the prostatic atrophy and the prostatic adenomatous change as a case in which the extra nodular tissue gained an advantage over the intra nodular tissue in properties, degree and number; further, reference was made of the prostatic atrophy, the prostatic adenomatous change, the proliferative change of the glandular epithelium and the cystic change as a case where the operation case advanced more than the autopsy case. The proliferative change of the glandular epithelium was observed in the case where the hypertrophic case stood at advantage over the non-hypertrophic case. The cystic change alone showed a distinctive on aging influence. Cited as what was subjected to the on-aging influence both in the non-hypertrophic case and the hypertrophic case in the testicular histological image were the degenerative atrophy of the Leydig's cell, the hyalinization of the basement membrane and the synthetic atrophic degree; but, as the case in which the difference between the two cases was observed, mention was made of the following. As a case in which the non-hypertrophic case was more subjected to the on-aging influence, reference was made to the degenerative atrophy of the spermatogenic series. Furthermore, as a case in which the hypertrophic case advanced more in terms of degree and proper ties, mention was made of the focal tubular hyalinization. As a case in which a proportional relationship was observed in conection with the prostate gland and the testis, there was the atrophic change in the prostate gland and the testis. As a case in which a pro portional relationship was not clearly established, meanwhile, mention was made of the atrophic change in the prostate gland and the degenerative atrophy of the Leydig's cell. perplasia, benign hyperplasia, benign enlargement, benign prostatic hypertrophy, adedomatous hypertrophy, adenoma, nodular hyperplasia, fibroglandular hy-

24 837 写真1 写真3 写真5 (結節内組織) 番前節紐織型中(1)嚢型, 結節分類型一単純司奎乏, 結化, PAP染寝写真2 を伴う嚢腫色(10 10) (結節内紐織) 帝櫛組織型中中(II)三増 (結節内組織) 結節組織型出(II)増殖型, 結節分類型一単著沌乏製, 腺上皮は活働型で結百を伴う. HE染色(10 10) 殖型, 結節分類型-単純型, 小結節. HE 結節内紐織, 結節組織型-(IV)筋線維型, 結節分類型-単純製, 腺凱織が殆どみら染色(10 10) れない. HE染色(4 10) (結節内組織) 結節組織型-(I)襄 (結節内紐繊)結型十(Iv)筋腺上皮は, 色(4x10) 節紺織型-(III)で線維型, 結節瀕活働型のい型-中は少ない. 丹過殖間型 HE染写真4 写真6 腫型十(II)増殖型, 結節十(II)非増殖型分類型中多彩型, た結節の中中部. HE染色 (1x10)

25 838 写真7 (結節外組織) 大発性結百. HE染腸芝控内に認められた多写真8 色(10 10) (結節外組織) 婆斎蒲及び上形細胞きと潤, 質の増殖中らり, 外腺に近耐引豫部に化前. HE染写真9 (結節外組織) 化, 結石中を伴う高度のヵタル右ド方に結百が認められる. HE染写真10 (雅丸) 精細管の退行変性, 細胞で, に存在する. AZAN染部伽的荒廃像, 完黛た硝子様変性 10) (黒丸) (1 10) どがSertoli氏色 (20 10) 写真11 色上数個の精細管のぢある. HE染色(10x 写真12 (睾丸) 問 (III) 色(20 10) 問細胞の退行萎縮, 大細胞捧と空胞多成検び粗た色素られる中萎縮型である, 殆沼精母細胞孟わづでか HE染色下中時の粒が替め (40 10)

27 1) Andrews, G. S.: J. Chir. Path., 2, 197, 1949.

28 6) Bainborough, A. R.: J. Urol., 68, 329, ) Bracci, V.: J. Geront., 13/Suppl: 205, Excerpta. med. Geront. & Geriat. 2, 179, ) Cammeratt, R.: Virchows Arch., 245, 27, ) Culp, O. S. & Mc Denald, D. R.: J. Urol., 72, 443, ) De Gironcolif.: J. clin. Endoclnol., 14, 626, ) Deming C. L.: Surg., 68, 155, ) Edwards, C. V. et al.: Cancer, 6, 531, ) Engle, E. T.: J. Urol. 74, 379, ) Franks, L. M.: J, Path, & Bact., 68, 603, ) Grassmann, W.: Virchows Arch., 270, 514, ) Howard, L. C.: J. Bone & Joint Surg., 33A, 3, 801, ) Jacoby, M.: Zeit. f. Urol., 14, 6, ) Kahler, J. E.: J. Urol., 41, 557, ) Kimbrough, J. C.: J. Urolh., 76, 287, ) Krogius, A.: Moore, R. A.: J, Urol., 50, 680, 33) Krompecher, E.: Virchows Arch., 257, 284, ) Labess, M.: J. Urol., 68, 893, ) Lewis L. G.: Surg, Clin, North, Am., 30, ) Lowsley, O. S.: Clinical Urol., Williams & Willkins ) Lynch, K. M. & Scott, W. W.: J. Urol., 64, 767, ) Moore, R. A.: J. Urol., 50, 680, J. Urol., 33, 224, Arch. Path., 22, 24, ) Neller, K. und Neuburger, K.: Munch. Med. Wschr., 73, 57, ) Oberndorfer, S.: Hdb. Path, Anat. u. Histol. Bd. IV/3, 435, J. Springer, Berlin. 51) Reischauer, F.: Virchows Arch., 256, 357, ) Schinz, H. R. und Slotopolsky, B.: Abder 53) Sniffen, R. C. et al.: Arch. Path., 51, 293, ) Sommers, S. C.: Am. J. Path., 32, 185, Caner, 10, 345, ) Steele, H. D. et al.: Arch. Path., 54, 94, ) Stumpf, H. H. & Wilens, S. L.: Arch. Int. Med., 91, 304, ) Tillinger, K. G.: Acta. endocrinol., 19, 340, ) Totten, R. S. et al.: Arch, Path., 4, 131, ) Wildegans, H.: Langenbechs Arch. u. Dtsch. Z. chir., 279, 392, ) Zanor, Z. & Raboch, J.: Sehweiz. med. Wschr., 86, 311, 1956.

Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date URL

Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date 1958-01 URL http://hdl.handle.net/2433/111559 Right Type Departmental Bulletin